High Somatic Symptom Burdens and Functional Gastrointestinal Disorders

Sayuk, Gregory S.; Elwing, Jill E.; Lustman, Patrick J.; Clouse, Ray E.

doi:10.1016/j.cgh.2006.11.024

Cited by 26Psychosomatic Disorders and Their TreatmentsGastrointestinal motility and disordersFibromyalgia and Chronic Fatigue Syndrome Research

High Somatic Symptom Burdens and Functional Gastrointestinal Disorders

Sayuk, Gregory S., Elwing, Jill E., Lustman, Patrick J., Clouse, Ray E.·2007·Clinical Gastroenterology and Hepatology

DOI 10.1016/j.cgh.2006.11.024

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Abstract

Background & aims Unexplained, multi-system somatic symptoms and syndromes, the hallmark features of somatization, are prevalent in patients with functional gastrointestinal disorders (FGIDs). We studied outpatients attending a gastroenterology clinic to see whether current somatic symptom burdens (a somatization state measure) or number of prior functional diagnoses (a somatization trait measure) could predict the presence of an FGID over structural gastrointestinal disease, and whether the predictive value was dependent on comorbid depression or anxiety disorders.Methods Clinical data from 327 consecutive new referrals to an outpatient gastroenterology practice were reviewed, 187 with an FGID and 140 with a structural illness. Somatization state and trait were measured by using self-reported current symptoms and functional diagnoses recorded in the medical history, respectively. Psychiatric comorbidity (depression or anxiety disorders) was extracted from chart review.Results FGID subjects endorsed more somatization state symptoms, had more somatization trait diagnoses, and had greater likelihood of psychiatric comorbidity (P < .001 for each). Logistic regression analysis adjusting for age and sex differences showed that each of these features independently predicted the likelihood of an FGID over structural disease (P < .05 for each). When high ratings on the somatization measures were present together with psychiatric comorbidity, the positive predictive value exceeded 0.95.Conclusions Higher burdens of either current somatic symptoms or functional diagnoses in the medical history are strong predictors of an FGID in outpatients presenting with gastrointestinal complaints. The mechanism is not solely dependent on a relationship with affective disorders, which independently predicts FGID, at least in part, through another path.

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Sayuk et al. reported that a higher burden of current somatic symptoms was a strong predictor of functional bowel disease in outpatients presenting with GI complaints.
“Sayuk et al. (46) reported that a higher burden of the current somatic symptoms was a strong predictor of a functional bowel disease in outpatients presenting with GI complaints.”
From Psychosocial Distress and Somatic Symptoms in Community Subjects With Irritable Bowel Syndrome: A Psychological Component Is the Rule (2009) · cites this paper as [46]

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Authors: Sayuk, G. S., Elwing, J. E., Lustman, P. J., & Clouse, R. E.
Affiliations: Washington University in St. Louis (US)
Corresponding author: Sayuk, Gregory S.
ORCID: Sayuk, Gregory S.
Elwing, Jill E.
Lustman, Patrick J.
Venue: Clinical Gastroenterology and Hepatology
Publisher: Elsevier BV
Published: 2007-05
Volume: 5
Issue: 5
Pages: 556-562
ISSN: 1542-3565 (ISSN-L)
DOI: 10.1016/j.cgh.2006.11.024
OpenAlex: W2059872565
Cited by: 26
References: 70
Citations by year: 2025: 3 · 2024: 1 · 2022: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 3
FWCI: 0.61
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Clinical Gastroenterology and Hepatology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK063202, DK 63202)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Keywords: functional gastrointestinal disorders, somatization, somatic symptom burden, psychiatric comorbidity, depression, anxiety disorders, diagnostic prediction, outpatients
MeSH terms: Adult, Anxiety Disorders, Depressive Disorder, Female, Gastrointestinal Diseases, Humans, Male, Middle Aged, Predictive Value of Tests, Retrospective Studies, Somatoform Disorders, Logistic Models, Cost of Illness

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High Somatic Symptom Burdens and Functional Gastrointestinal Disorders

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