The DOI matches its Crossref record; 281 of the 281 references it cites were found in a registry or an index.
Dissecting impulsivity and its relationships to drug addictions
Open accessAbstract
Addictions are often characterized as forms of impulsive behavior. That said, it is often noted that impulsivity is a multidimensional construct, spanning several psychological domains. This review describes the relationship between varieties of impulsivity and addiction‐related behaviors, the nature of the causal relationship between the two, and the underlying neurobiological mechanisms that promote impulsive behaviors. We conclude that the available data strongly support the notion that impulsivity is both a risk factor for, and a consequence of, drug and alcohol consumption. While the evidence indicating that subtypes of impulsive behavior are uniquely informative—either biologically or with respect to their relationships to addictions—is convincing, multiple lines of study link distinct subtypes of impulsivity to low dopamine D2 receptor function and perturbed serotonergic transmission, revealing shared mechanisms between the subtypes. Therefore, a common biological framework involving monoaminergic transmitters in key frontostriatal circuits may link multiple forms of impulsivity to drug self‐administration and addiction‐related behaviors. Further dissection of these relationships is needed before the next phase of genetic and genomic discovery will be able to reveal the biological sources of the vulnerability for addiction indexed by impulsivity.
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“Taq1A polymorphisms at the D2 receptor has been well-studied and known to influence impulsive behavior [154].”
From Food Addiction and Psychosocial Adversity: Biological Embedding, Contextual Factors, and Public Health Implications (2020) · cites this paper as [154]
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“It appears that the brain regions underlying performance on these various tasks are overlapping with those implicated in reversal learning, though there are also functional dissociations (Jentsch et al., 2014).”
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BackgroundSufficiency of Mesolimbic Dopamine Neuron Stimulation for the Progression to Addiction
Pascoli, V., Terrier, J. E., Hiver, A., & Lüscher, C. (2015) · Neuron · doi:10.1016/j.neuron.2015.10.017 · Cited by 317
“As this behavior developed during acquisition, it may contribute, along with innate impulsivity (Economidou et al., 2009; Broos et al., 2012; Jentsch et al., 2014), in establishing the resistance to punishment.”
Metadata
- Authors
- Jentsch, J. D., Ashenhurst, J. R., Cervantes, M. C., Groman, S. M., James, A. S., & Pennington, Z. T.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Jentsch, J. David
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2014-03-21
- Volume
- 1327
- Issue
- 1
- Pages
- 1-26
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- PMC
- PMC4360991
- OpenAlex
- W2144085253
- Cited by
- 281
- References
- 281
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 29 · 2023: 27 · 2022: 21 · 2021: 23 · 2020: 26 · 2019: 31 · 2018: 17 · 2017: 30 · 2016: 27 · 2015: 19 · 2014: 9
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (DAR01031852)
- National Institute on Drug Abuse (R21DA038377, R01DA031852, T32DA024635)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- impulsivity, drug addiction, alcohol consumption, dopamine D2 receptor, serotonergic neurotransmission, monoaminergic neurotransmission, frontostriatal circuits, addiction risk factors, neurobiology of addiction
- MeSH terms
- Animals, Brain, Disease Susceptibility, Humans, Impulsive Behavior, Nerve Tissue Proteins, Synaptic Transmission, Neurons, Risk Factors, Down-Regulation, Behavior, Addictive, Receptors, Dopamine D2, Substance-Related Disorders, Translational Research, Biomedical, Serotonergic Neurons
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