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Dissecting impulsivity and its relationships to drug addictions
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Addictions are often characterized as forms of impulsive behavior. That said, it is often noted that impulsivity is a multidimensional construct, spanning several psychological domains. This review describes the relationship between varieties of impulsivity and addiction‐related behaviors, the nature of the causal relationship between the two, and the underlying neurobiological mechanisms that promote impulsive behaviors. We conclude that the available data strongly support the notion that impulsivity is both a risk factor for, and a consequence of, drug and alcohol consumption. While the evidence indicating that subtypes of impulsive behavior are uniquely informative—either biologically or with respect to their relationships to addictions—is convincing, multiple lines of study link distinct subtypes of impulsivity to low dopamine D2 receptor function and perturbed serotonergic transmission, revealing shared mechanisms between the subtypes. Therefore, a common biological framework involving monoaminergic transmitters in key frontostriatal circuits may link multiple forms of impulsivity to drug self‐administration and addiction‐related behaviors. Further dissection of these relationships is needed before the next phase of genetic and genomic discovery will be able to reveal the biological sources of the vulnerability for addiction indexed by impulsivity.
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“Taq1A polymorphisms at the D2 receptor has been well-studied and known to influence impulsive behavior [154].”
From Food Addiction and Psychosocial Adversity: Biological Embedding, Contextual Factors, and Public Health Implications (2020) · cites this paper as [154]
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Ligier, F., Giguère, C., Notredame, C.-É., LESAGE, A. D., Renaud, J., & Séguin, M. (2020) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-019-0308-x · Cited by 31
Anton, R. F., Schacht, J. P., Voronin, K. E., & Randall, P. K. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13417 · Cited by 33
Alves, M. B., Laureano, D. P., Dalle Molle, R., Machado, T. D., Salvador, A. P. D. A., Miguel, P. M., Lupinsky, D., Dalmaz, C., & Silveira, P. P. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.03.010 · Cited by 30
Amphetamine disrupts dopamine axon growth in adolescence by a sex-specific mechanism in mice
Reynolds, L. M., Hernandez, G., MacGowan, D., Popescu, C., Nouel, D., Cuesta, S., Burke, S., Savell, K. E., Zhao, J., Restrepo-Lozano, J. M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39665-1 · Cited by 30
“These enduring changes to the prefrontal cortex result in lasting impairments in impulse control 53,55 , notably in action inhibition – a known index of vulnerability for addiction 56,57 .”
InfluentialHuang, S., Dai, Y., Zhang, C., Yang, C. C., Huang, Q., Hao, W., & Shen, H. (2020) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2020.108040 · Cited by 30
Cannady, R., Nimitvilai, S., Jennings, S. D., Woodward, J. J., & Mulholland, P. J. (2020) · eNeuro · doi:10.1523/eneuro.0077-20.2020 · Cited by 30
“, 2011) and functional deficits in this region are associated with impulsive drug consumption (Jentsch et al., 2014; Starski et al., 2019).”
BackgroundA Role for Serotonin in Modulating Opposing Drive and Brake Circuits of Impulsivity
Desrochers, S. S., Spring, M. G., & Nautiyal, K. M. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.791749 · Cited by 29
Wiskerke, J., James, M. H., & Aston‐Jones, G. (2019) · Brain Research · doi:10.1016/j.brainres.2019.04.017 · Cited by 29
Role of basolateral amygdala dopamine D2 receptors in impulsive choice in acute cocaine-treated rats
Li, Y., Zuo, Y., Yu, P., Ping, X., & Cui, C. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.03.039 · Cited by 29
Weafer, J. J., Gorka, S. M., Hedeker, D., Džemidžić, M., Kareken, D. A., Phan, K. L., & de Wit, H. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.61 · Cited by 31
“All rights reserved 0893-133X/17 www.neuropsychopharmacology.org The behavioral links between inhibition and reward are supported by evidence that the two are related at a neurobiological level (Jentsch et al, 2014).”
Bernosky‐Smith, K. A., Qiu, Y., Feja, M., Lee, Y. B., Loughlin, B., Li, J., & Bass, C. E. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.12.029 · Cited by 28
“Several studies also implicate dopamine in impulsivity (see [5] for review).”
Zlebnik, N. E., & Carroll, M. E. (2015) · Psychopharmacology · doi:10.1007/s00213-014-3744-6 · Cited by 28
“Therefore, impulsive behavior not only predisposes an individual to develop substance use problems (de Wit 2009; Jentsch et al. 2014), but it also influences the likelihood of relapse after a period of abstinence (Doran et al.”
Pérez, L. J. G., Cardullo, S., Cellini, N., Sarlo, M., Monteanni, T., Bonci, A., Terraneo, A., Gallimberti, L., & Madeo, G. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02568-2 · Cited by 28
“Across species, there is a strong association between low dopamine D2 receptor levels and high impulsivity, a trait that is both a risk factor for, and a consequence of, drug abuse [74, 75].”
BackgroundAlcaro, A., Brennan, A., & Conversi, D. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.635932 · Cited by 30
Brain Microstructure and Impulsivity Differ between Current and Past Methamphetamine Users
Andres, T., Ernst, T., Oishi, K., Greenstein, D., Nakama, H., & Chang, L. (2016) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-016-9675-8 · Cited by 28
“However, since greater impulsivity is a core feature of addictions (Jentsch et al. 2014), it may also be a premorbid risk-factor for Meth use disorder, as shown in non-drug using siblings of stimulant users (Ersche et al.”
BackgroundMethodInfluentialWhich came first: Cannabis use or deficits in impulse control?
Rinehart, L., & Spencer, S. M. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110066 · Cited by 30
“Research in animal models indicates that high impulsivity is correlated with substance abuse susceptibility (Jentsch et al., 2014).”
BackgroundUnique features of stimulus-based probabilistic reversal learning.
Harris, C., Aguirre, C. G., Kolli, S., Das, K., Izquierdo, A., & Soltani, A. (2021) · Behavioral Neuroscience · doi:10.1037/bne0000474 · Cited by 27
Discounting of qualitatively different delayed health outcomes in current and never smokers.
Friedel, J. E., DeHart, W. B., Frye, C. C. J., Rung, J. M., & Odum, A. L. (2015) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000062 · Cited by 28
“Impulsivity encompasses several different phenomena (Broos et al., 2012; de Wit, 2008; Jentsch et al., 2014) and includes relative insensitivity to delayed outcomes, often referred to as impulsive choice.”
BackgroundA Behavioral Genetic Perspective on Non-Cognitive Factors and Academic Achievement
Tucker–Drob, E. M., & Harden, K. P. (2017) · Cambridge University Press eBooks · doi:10.1017/9781316340301.007 · Cited by 27
Ventral striatal regulation of CREM mediates impulsive action and drug addiction vulnerability
Miller, M. L., Ren, Y., Szutorisz, H., Warren, N. A., Tessereau, C., Egervári, G., Mlodnicka, A., Kapoor, M., Chaarani, B., Morris, C. V., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.80 · Cited by 26
Tucker, J. A., Cheong, J., Chandler, S. D., Lambert, B. H., Kwok, H., & Pietrzak, B. (2016) · Addiction · doi:10.1111/add.13492 · Cited by 26
Self-control and online game addiction in early adult gamers
Safarina, N., & Halimah, L. (2019) · Journal of Physics Conference Series · doi:10.1088/1742-6596/1375/1/012094 · Cited by 25
Gains and Losses: Resilience to Social Defeat Stress in Adolescent Female Mice
Pantoja-Urbán, A. H., Richer, S., Mittermaier, A., Giroux, M., Nouel, D., Hernández, G., & Flores, C. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.06.014 · Cited by 29
Thompson, A. B., Stolyarova, A., Ying, Z., Zhuang, Y., Gómez‐Pinilla, F., & Izquierdo, A. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.08.045 · Cited by 25
“Low D2 expression is predictive of addiction vulnerability, indicating that animals exposed to methamphetamine are at higher risk for subsequent drug-taking (Jentsch et al., 2014; Tournier et al., 2013; Sweitzer et al., 2012).”
BackgroundLinsenbardt, D. N., Smoker, M. P., Janetsian-Fritz, S. S., & Lapish, C. C. (2016) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-016-0475-7 · Cited by 25
“One challenge in accurately quantifying this relationship is that both impulsivity and alcohol use disorders (AUDs) are heterogeneous constructs, influenced by a number of factors, such as sensation seeking, positive/negative urgency, or a lack of planning (Coskunpinar, Dir, & Cyders, 2013; Dalley et al., 2011; de Wit…”
BackgroundAssociation between impulsivity and neural activation to alcohol cues in heavy drinkers
Burnette, E. M., Grodin, E. N., Lim, A. C., MacKillop, J., Karno, M. P., & Ray, L. A. (2019) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2019.110986 · Cited by 27
Effect of alcohol on the sense of agency in healthy humans
Pirro, S. D., Lush, P., Parkinson, J., Duka, T., Critchley, H., & Badiani, A. (2019) · Addiction Biology · doi:10.1111/adb.12796 · Cited by 27
“It has been hypothesized that the facilitation of IB in individuals with PD treated with dopaminergic medications might be related to impulsivity(27)), which is thought to depend on dopaminergic transmission.(57) The fact that impulse control disorders (eg, pathological gambling, hypersexuality, compulsive shopping, a…”
BackgroundCorticolimbic DCC gene co-expression networks as predictors of impulsivity in children
Restrepo-Lozano, J. M., Pokhvisneva, I., Wang, Z., Patel, S. H., Meaney, M. J., Silveira, P. P., & Flores, C. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01533-7 · Cited by 24
“Altered connections and communication between prefrontal and striatal regions appear to be at the core of this behavioral trait (1), but the underlying neurobiological processes, as well as early markers of vulnerability, are yet to be discovered (2-4).”
Striatal Activity and Reward Relativity: Neural Signals Encoding Dynamic Outcome Valuation
Webber, E. S., Mankin, D. E., & Cromwell, H. C. (2016) · eNeuro · doi:10.1523/eneuro.0022-16.2016 · Cited by 23
“Alterations in reward comparison could occur in addiction and result from inabilities to update value adaptively (Grigson, 2000; Schultz, 2011; Jentsch et al., 2014).”
BackgroundFlaudias, V., Teisseidre, F., de Chazeron, I., Chalmeton, M., Bertin, C., Izaute, M., Chakroun, N., Pereira, B., Brousse, G., & Maurage, P. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.12.118 · Cited by 21
Gaming disorder and bidirectional relationships with aggression and impulsivity
Jeong, H., Lee, H. K., Kweon, Y., Yim, H. W., & Lee, S. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2019.12.003 · Cited by 27
Metadata
- Authors
- Jentsch, J. D., Ashenhurst, J. R., Cervantes, M. C., Groman, S. M., James, A. S., & Pennington, Z. T.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Jentsch, J. David
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2014-03-21
- Volume
- 1327
- Issue
- 1
- Pages
- 1-26
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- PMC
- PMC4360991
- OpenAlex
- W2144085253
- Cited by
- 281
- References
- 281
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 29 · 2023: 27 · 2022: 21 · 2021: 23 · 2020: 26 · 2019: 31 · 2018: 17 · 2017: 30 · 2016: 27 · 2015: 19 · 2014: 9
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (DAR01031852)
- National Institute on Drug Abuse (R21DA038377, R01DA031852, T32DA024635)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- impulsivity, drug addiction, alcohol consumption, dopamine D2 receptor, serotonergic neurotransmission, monoaminergic neurotransmission, frontostriatal circuits, addiction risk factors, neurobiology of addiction
- MeSH terms
- Animals, Brain, Disease Susceptibility, Humans, Impulsive Behavior, Nerve Tissue Proteins, Synaptic Transmission, Neurons, Risk Factors, Down-Regulation, Behavior, Addictive, Receptors, Dopamine D2, Substance-Related Disorders, Translational Research, Biomedical, Serotonergic Neurons
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