Significant life extension by ten percent dietary restriction
Open accessAbstract
Although it is well documented that dietary restriction (DR) increases the life span of rodents and other animals, this increase is observed at relatively high levels of DR, in which rodents are typically fed 40% less than that consumed by rodents fed ad libitum. It is generally assumed that lower levels of DR will have a lesser impact on life span; however, there are very little published data on the effect of low levels of DR on life span. In this study, we show that 10% DR increased life span to almost the same extent as 40% DR. While both 10% and 40% DR resulted in similar changes in non‐neoplastic lesions, 10% DR had no significant effect on the incidence of neoplasia (except for pituitary adenoma), and 40% DR resulted in a significant reduction (40%) in neoplasia. These data clearly demonstrate that the life span of F344 rats does not increase linearly with the level of DR; rather, even a low level of DR can substantially affect life span. This rodent study has important translational implications because it suggests that a modest reduction in calories might have significant health benefits for humans.
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Prolonged life in the 40% caloric restriction rats, but not in 10%, was accompanied by significant reduction in aging-associated pathology, such as neoplasia, indicating that higher caloric restriction induces longevity while delaying chronic pathology.
“Interestingly however, prolonged life in the 40% caloric restriction rats, but not in 10%, was accompanied by significant reduction in aging-associated pathology, such as neoplasia, indicating that higher caloric restriction induces longevity while delaying chronic pathology (Richardson et al, 2015).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Richardson et al, 2015
The benefits of caloric restriction observed in humans have also been reported in other species, such as rats, mice, and monkeys.
“The benefits of caloric restriction observed in humans have also been reported in other species, such as rats, mice, and monkeys (Colman et al, 2009;Richardson et al, 2015;Youm et al, 2016).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Richardson et al, 2015
In rats, a 10% caloric restriction prolonged lifespan at the same level as 40% caloric restriction.
“In a separate study on rats, a 10% caloric restriction prolonged lifespan at the same level as 40% caloric restriction (Richardson et al, 2015).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Richardson et al, 2015
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Microglia Priming with Aging and Stress
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- Authors
- Richardson, A., Austad, S. N., Ikeno, Y., Unnikrishnan, A., & McCarter, R. J.
- Affiliations
- Oklahoma City VA Medical Center (US)
- University of Alabama at Birmingham (US)
- The University of Texas at San Antonio Health Science Center (US)
- University of Oklahoma Health Sciences Center (US)
- Pennsylvania State University (US)
- Corresponding author
- Richardson, Arlan
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2015-12-22
- Volume
- 1363
- Issue
- 1
- Pages
- 11-17
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- PMC
- PMC4836177
- OpenAlex
- W2202911070
- Cited by
- 25
- References
- 20
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 2
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Annals of the New York Academy of Sciences (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (R01 AG045693)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- dietary restriction, lifespan extension, cancer, pituitary adenoma, non-neoplastic lesions, F344 rats, caloric restriction, aging
- MeSH terms
- Animals, Body Weight, Cause of Death, Diet, Life Expectancy, Male, Caloric Restriction, Rats
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