The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments

Cites (253)

Items 201–253 of 253

1. Independent Effects of Testosterone on Lipid Oxidation and VLDL-TG Production
   Høst, Christian, Gormsen, Lars C., Christensen, Britt, Jessen, Niels, Hougaard, David M., Christiansen, Jens S., Pedersen, Steen B., Jensen, Michael D., Nielsen, Søren, Gravholt, Claus H. · 2013 · Diabetes
2. The effects of testosterone on body composition in obese men are not sustained after cessation of testosterone treatment
   Ng Tang Fui, Mark, Hoermann, Rudolf, Zajac, Jeffrey D., Grossmann, Mathis · 2017 · Clinical Endocrinology
3. TRPM8 as the rapid testosterone signaling receptor: Implications in the regulation of dimorphic sexual and social behaviors
   Adithya Mohandass, Vivek Krishnan, Ekaterina Gribkova, Swapna Asuthkar, Padmamalini Baskaran, Yelena Nersesyan, Zahir Hussain, Leslie M. Wise, Robert E. George, Nadarra L. Stokes et al. · 2020 · The FASEB Journal
4. Testosterone with Dutasteride, but Not Anastrazole, Improves Insulin Sensitivity in Young Obese Men: A Randomized Controlled Trial
   Juang, Patricia S., Peng, Susan, Allehmazedeh, Kambiz, Shah, Ansal, Coviello, Andrea D., Herbst, Karen L. · 2014 · The Journal of Sexual Medicine
5. A placebo-controlled randomized study with testosterone in Klinefelter syndrome: beneficial effects on body composition
   Christian Høst, Anders Bojesen, Mogens Erlandsen, Kristian Ambjørn Groth, Kurt Kristensen, Anne Grethe Jurik, Niels Birkebæk, Claus Højbjerg Gravholt · 2019 · Endocrine Connections
6. Aktuelles zur Adipositas (mit und ohne Diabetes)
   Andreas Hamann · 2017 · Der Diabetologe
7. Cross-sectional and longitudinal determinants of serum sex hormone binding globulin (SHBG) in a cohort of community-dwelling men
   Gyawali, Prabin, Martin, Sean A., Heilbronn, Leonie K., Vincent, Andrew D., Jenkins, Alicia J., Januszewski, Andrzej S., Taylor, Anne W., Adams, Robert J. T., O’Loughlin, Peter D., Wittert, Gary A. · 2018 · PLOS ONE
8. Bicalutamide monotherapy preserves bone mineral density, muscle strength and has significant health‐related quality of life benefits for osteoporotic men with prostate cancer
   Vivek K. Wadhwa, Robin Weston, Nigel J. Parr · 2010 · British Journal of Urology
9. Muscle-specific androgen receptor deletion shows limited actions in myoblasts but not in myofibers in different muscles in vivo
   Kesha Rana, Maria W S Chiu, Patricia K. Russell, Jarrod P. J. Skinner, Nicole KL Lee, Barbara Christianne Fam, Jeffrey D. Zajac, Helen E. MacLean · 2016 · Journal of Molecular Endocrinology
10. Testosterone replacement therapy of opioid-induced male hypogonadism improved body composition but not pain perception: a double-blind, randomized, and placebo-controlled trial
    Glintborg, Dorte, Vaegter, Henrik Bjarke, Christensen, Louise Lehmann, Bendix, Emma, Graven-Nielsen, Thomas, Andersen, Per Grünwald, Andersen, Marianne · 2020 · European Journal of Endocrinology
11. Hypogonadism: Easy to define, hard to diagnose, and controversial to treat
    Joshua Sterling, Aaron Bernie, Ranjith Ramasamy · 2015 · Canadian Urological Association Journal
12. 17β-estradiol lowers triglycerides in adipocytes via estrogen receptor α and it may be attenuated by inflammation
    Fei Luo, Wenyu Huang, Yuan Guo, Guiyun Ruan, Ran Peng, Xiangping Li · 2017 · Lipids in Health and Disease
13. Obesity and neuroinflammatory phenotype in mice lacking endothelial megalin
    Fernando Benito Bartolomé, Desireé Antequera, Eva Tavares, Consuelo Pascual, Rosário Maldonado, Antoni Camins, Eva Carro · 2017 · Journal of Neuroinflammation
14. The androgen receptor is required for maintenance of bone mass in adult male mice
    Wu, Jianyao, Henning, Petra, Sjögren, Klara, Koskela, Antti, Tuukkanen, Juha, Movérare-Skrtic, Sofia, Ohlsson, Claes · 2019 · Molecular and Cellular Endocrinology
15. SHBG-C57BL/ksJ-db/db: A New Mouse Model to Study SHBG Expression and Regulation During Obesity Development
    Cristina Sáez‐López, Marta Rivera-Giménez, Cristina Hernández, Rafael Simó, David M. Selva · 2015 · Endocrinology
16. Estrogen receptor-α in female skeletal muscle is not required for regulation of muscle insulin sensitivity and mitochondrial regulation
    Iñigo, Melissa R., Amorese, Adam J., Tarpey, Michael D., Balestrieri, Nicholas P., Jones, Keith G., Patteson, Daniel J., Jackson, Kathryn C., Torres, Maria.J., Lin, Chien-Te, Smith, Cody D. et al. · 2020 · Molecular Metabolism
17. Loss of androgen receptor promotes adipogenesis but suppresses osteogenesis in bone marrow stromal cells
    Chiung‐Kuei Huang, Kuo‐Pao Lai, Jie Luo, Meng‐Yin Tsai, Hong‐Yo Kang, Yuhchyau Chen, Soo Ok Lee, Chawnshang Chang · 2013 · Stem Cell Research
18. Selective estrogen receptor (ER)β activation provokes a redistribution of fat mass and modifies hepatic triglyceride composition in obese male mice
    González-Granillo, Marcela, Savva, Christina, Li, Xidan, Ghosh Laskar, Moumita, Angelin, Bo, Gustafsson, Jan-Åke, Korach-André, Marion · 2020 · Molecular and Cellular Endocrinology
19. Testosterone improves muscle fiber asset and exercise performance in a metabolic syndrome model
    Erica Sarchielli, Paolo Comeglio, Sandra Filippi, Ilaria Cellai, Giulia Guarnieri, Daniele Guasti, Elena Rapizzi, Giulia Rastrelli, Danièle Bani, Gabriella Barbara Vannelli et al. · 2020 · Journal of Endocrinology
20. Castration-induced changes in mouse epididymal white adipose tissue
    Daniel Floryk, Shinji Kurosaka, Ryuta Tanimoto, Guang Yang, Alexei A. Goltsov, Sanghee Park, Timothy C. Thompson · 2011 · Molecular and Cellular Endocrinology
21. Hepatic Glucose Intolerance Precedes Hepatic Steatosis in the Male Aromatase Knockout (ArKO) Mouse
    Van Sinderen, Michelle L., Steinberg, Gregory R., Jørgensen, Sebastian B., To, Sarah Q., Knower, Kevin C., Clyne, Colin D., Honeyman, Jane, Chow, Jenny D., Herridge, Kerrie A., Jones, Margaret E. E. et al. · 2014 · PLoS ONE
22. Clomiphene Citrate Effectively Increases Testosterone in Obese, Young, Hypogonadal Men
    Sachin V. Bendre, Pamela J. Murray · 2015 · Reproductive System & Sexual Disorders
23. Long-Term Antitumor Activity and Safety of Enzalutamide Monotherapy in Hormone Naïve Prostate Cancer: 3-Year Open Label Followup Results
    Tombal, Bertrand, Borre, Michael, Rathenborg, Per, Werbrouck, Patrick, Van Poppel, Hendrik, Heidenreich, Axel, Iversen, Peter, Braeckman, Johan, Heracek, Jiri, Baron, Benoit et al. · 2018 · Journal of Urology
24. Testosterone therapy preserves muscle strength and power in aging men with type 2 diabetes—a randomized controlled trial
    Line Velling Magnussen, Lars G. Hvid, A. Hermann, DAVID MICHAEL HOUGAARD, Bibi Gram, Paolo Caserotti, Marianne Andersen · 2017 · Andrology
25. Complex structure and regulation of the ABP/SHBG gene
    DAVID R. JOSEPH, Patrick M. Sullivan, Yanmin Wang · 1991 · The Journal of Steroid Biochemistry and Molecular Biology
26. Abnormal lipid/lipoprotein metabolism and high plasma testosterone levels in male but not female aromatase-knockout mice
    Amano, Akiko, Kondo, Yoshitaka, Noda, Yoshihiro, Ohta, Mitsuhiro, Kawanishi, Noriaki, Machida, Shuichi, Mitsuhashi, Kazuteru, Senmaru, Takafumi, Fukui, Michiaki, Takaoka, Osamu et al. · 2017 · Archives of Biochemistry and Biophysics
27. Testosterone deficiency caused by castration increases adiposity in male rats in a tissue-specific and diet-dependent manner
    Baik, Myunggi, Jeong, Jin Young, Park, Seung Ju, Yoo, Seon Pil, Lee, Jin Oh., Lee, Jae Sung, Haque, Md Najmul, Lee, Hyun-Jeong · 2020 · Genes & Nutrition
28. MANAGEMENT OF ENDOCRINE DISEASE: Rationale and current evidence for testosterone therapy in the management of obesity and its complications
    Bruno Lapauw, Jean‐Marc Kaufman · 2020 · European Journal of Endocrinology
29. The androgen receptor in the testicular feminized (Tfm) mouse may be a product of internal translation initiation.
    W W He, Jonathan K. Lindzey, James L. Prescott, M. Vijay Kumar, D. J. Tindall · 1994 · PubMed
30. Testosterone Reduces Body Fat in Male Mice by Stimulation of Physical Activity Via Extrahypothalamic ERα Signaling
    Kim, Na Ri, David, Karel, Corbeels, Katrien, Khalil, Rougin, Antonio, Leen, Schollaert, Dieter, Deboel, Ludo, Ohlsson, Claes, Gustafsson, Jan-Åke, Vangoitsenhoven, Roman et al. · 2021 · Endocrinology
31. Male hypogonadism causes obesity associated with impairment of hepatic gluconeogenesis in mice
    Aoki, Akira, Fujitani, Kohei, Takagi, Kohei, Kimura, Tomoki, Nagase, Hisamitsu, Nakanishi, Tsuyoshi · 2016 · Biological & Pharmaceutical Bulletin
32. Effects of castration on adipose tissue growth and regrowth in the male rat
    Irving M. Faust, P. R. Johnson, John G. Kral · 1984 · Metabolism
33. Lean, fat and bone masses are influenced by orchidectomy in the rat. A densitometric X-ray absorptiometric study.
    M F Moreau, Hélène Libouban, Érick Legrand, Michel Félix Baslé, Maurice Audran, Daniel Chappard · 2001 · PubMed
34. Hematopoietic androgen receptor deficiency promotes visceral fat deposition in male mice without impairing glucose homeostasis
    Rubinow, K. B., Wang, S., den Hartigh, L. J., Subramanian, S., Morton, G. J., Buaas, F. W., Lamont, D., Gray, N., Braun, R. E., Page, S. T. · 2015 · Andrology
35. The androgen receptor in the hypothalamus positively regulates hind-limb muscle mass and voluntary physical activity in adult male mice
    Michele V. Clarke, Patricia K. Russell, Jeffrey D. Zajac, Rachel A. Davey · 2019 · The Journal of Steroid Biochemistry and Molecular Biology
36. Sex differences in white adipose tissue expansion: emerging molecular mechanisms.
    S. Bond, A. Calkin, B. Drew · 2021 · Clinical science
37. Mechanisms of androgenic action in adipose tissue
    Alain Veilleux, Karine Blouin · 2009 · Clinical Lipidology
38. Combination of low-dose testosterone and vildagliptin confers cardioprotection in castrated obese rats
    Apiwan Arinno, Nattayaporn Apaijai, Puntarik Kaewthep, Wasana Pratchayasakul, Thidarat Jaiwongkam, Sasiwan Kerdphoo, Siriporn Chaisin Chattipakorn, Nipon Chattipakorn · 2019 · Journal of Endocrinology
39. True
    2000 · International Journal of Obesity
40. The Role of 5α-Reductase Inhibition in Men Receiving Testosterone Replacement Therapy
    Gruntmanis, Ugis · 2012 · JAMA
41. Tfm Lac: A second isolation of testicular feminization in mice
    Politch, J. A., Fox, T. O., Houben, P., Bullock, L., Lovell, D. · 1988 · Biochemical Genetics
42. Finasteride, prostate cancer, and weight gain: Evidence for genetic or environmental factors that affect cancer outcomes during finasteride treatment
    Song, YoonJu, Tangen, Catherine, Goodman, Phyllis, Parnes, Howard L., Lucia, M. Scott, Thompson, Ian M., Kristal, Alan R. · 2008 · The Prostate
43. The androgen receptor in bone marrow progenitor cells negatively regulates fat mass
    Patricia K. Russell, Salvatore P. Mangiafico, Barbara Christianne Fam, Michele V. Clarke, Evelyn S Marin, Sofianos Andrikopoulos, Kristine M. Wiren, Jeffrey D. Zajac, Rachel A. Davey · 2018 · Journal of Endocrinology
44. Androgen receptor deficiency in monocytes/macrophages does not alter adiposity or glucose homeostasis in male mice
    Rubinow, KatyaB, Houston, Barbara, Wang, Shari, Goodspeed, Leela, Ogimoto, Kayoko, Morton, GregoryJ, McCarty, Christopher, Braun, RobertE, Page, StephanieT · 2018 · Asian Journal of Andrology
45. Testosterone-loaded GM1 micelles targeted to the intracellular androgen receptor for the specific induction of genomic androgen signaling
    Peinetti, Nahuel, Cuello Rubio, Mariana Micaela, Sosa, Liliana Del Valle, Scalerandi, María Victoria, Alasino, Roxana Valeria, Peyret, Victoria, Nicola, Juan Pablo, Beltramo, Dante Miguel, Quintar, Amado Alfredo, Maldonado, Cristina Alicia · 2020 · International Journal of Pharmaceutics
46. Enhancing Cancer Drug Discovery through Novel Cell Signaling Pathway Panel Strategy
    Liang Schweizer, Litao Zhang · 2013 · Cancer Growth and Metastasis
47. Human sex hormone-binding globulin does not provide metabolic protection against diet-induced obesity and dysglycemia in mice
    Sofer, Yael, Nevo, Nava, Vechoropoulos, Michal, Shefer, Gabi, Osher, Etty, Landis, Nathan, Tordjman, Karen, Hammond, Geoffrey L, Stern, Naftali · 2018 · Endocrine Connections
48. Spinal cord repair: future directions
    Fawcett, J W · 1992 · Spinal Cord
49. Stem cell activation in adults can reverse detrimental changes in body composition to reduce fat and increase lean mass in both sexes
    Wiren, Kristine M., Hashimoto, Joel G., Zhang, Xiao-Wei · 2011 · Journal of Cellular Biochemistry
50. Aromatase deficiency in hematopoietic cells improves glucose tolerance in male mice through skeletal muscle-specific effects
    Rubinow, Katya B., den Hartigh, Laura J., Goodspeed, Leela, Wang, Shari, Oz, Orhan K. · 2020 · PLOS ONE
51. Sex Hormone-Binding Globulin (SHBG)
    Geoffrey L. Hammond, Kevin N. Hogeveen · 2003 · Encyclopedia of Hormones
52. The Changing Face of Innovation in Drug Discovery
    Litao Zhang, Carl P. Decicco · 2014 · Wiley eBooks
53. 47,XXY Klinefelter Syndrome Is Associated with an Increased Risk of Insulin Resistance: The Impact of Hypogonadism and Visceral Obesity
    Francesca Panimolle, Antonio Francesco Radicioni · 2017 · Frontiers in diabetes