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Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour
Abstract
Summary: The five‐subunit WASH complex generates actin networks that participate in endocytic trafficking, migration and invasion in various cell types. Loss of one of the two subunits WASH or strumpellin in mice is lethal, but little is known about their role in mammals in vivo. We explored the role of strumpellin, which has previously been linked to hereditary spastic paraplegia, in the mouse melanocytic lineage. Strumpellin knockout in melanocytes revealed abnormal endocytic vesicle morphology but no impairment of migration in vitro or in vivo and no change in coat colour. Unexpectedly,WASH and filamentous actin could still localize to vesicles in the absence of strumpellin, although the shape and size of vesicles was altered. Blue native PAGE revealed the presence of two distinct WASH complexes, even in strumpellin knockout cells, revealing that the WASH complex can assemble and localize to endocytic compartments in cells in the absence of strumpellin.
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The WASH complex functions in endocytic recycling, maintenance of endolysosomal network integrity, exocytosis, cell adhesion, and cell migration.
“The WASH complex functions in the endocytic recycling of various types of membrane proteins, maintenance of endolysosomal network integrity, exocytosis, cell adhesion, and cell migration (11-23).”
From Hereditary spastic paraplegia SPG8 mutations impair CAV1-dependent, integrin-mediated cell adhesion (2020) · cites this paper as [20]
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Endosomal retrieval of cargo: Retromer is not alone
McNally, K. E., & Cullen, P. J. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.06.005 · Cited by 169
Hereditary spastic paraplegia SPG8 mutations impair CAV1-dependent, integrin-mediated cell adhesion
Lee, S., Park, H., Zhu, P.-P., Jung, S.-Y., Blackstone, C., & Chang, J. (2020) · Science Signaling · doi:10.1126/scisignal.aau7500 · Cited by 22
Metadata
- Authors
- Tyrrell, B. J., Woodham, E. F., Spence, H. J., Strathdee, D., Insall, R. H., & Machesky, L. M.
- Affiliations
- Cancer Research UK Beatson Institute College of Medical Veterinary and Life Sciences University of Glasgow Glasgow UK
- ORCID
- Insall, Robert H.
- Venue
- Pigment Cell & Melanoma Research
- Publisher
- Wiley
- Published
- 2016-09
- Volume
- 29
- Issue
- 5
- Pages
- 559-571
- ISSN
- 1755-1471
- 1755-148X
- PMC
- PMC5082549
- Cited by
- 21
- References
- 3
- Language
- en
- Funders
- Cancer Research UK (A15673, A15672, A17196)
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