Resequencing and association analysis of OXTR with autism spectrum disorder in a J apanese population
Open accessAbstract
AIMS: The oxytocin receptor (OXTR) is implicated in the pathophysiology of autism spectrum disorder (ASD). A recent study found a rare non-synonymous OXTR gene variation, rs35062132 (R376G), associated with ASD in a Japanese population. In order to investigate the association between rare non-synonymous OXTR variations and ASD, we resequenced OXTR and performed association analysis with ASD in a Japanese population. METHODS: We resequenced the OXTR coding region in 213 ASD patients. Rare non-synonymous OXTR variations detected by resequencing were genotyped in 213 patients and 667 controls. RESULTS: We detected three rare non-synonymous variations: rs35062132 (R376G/C), rs151257822 (G334D), and g.8809426G>T (R150S). However, there was no significant association between these rare non-synonymous variations and ASD. CONCLUSIONS: Our present study does not support the contribution of rare non-synonymous OXTR variations to ASD susceptibility in the Japanese population.
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There have been generally positive results of OXT in adults with ASD, with trials showing improvements in repetitive behaviors, social reciprocity, and emotion recognition.
“There have been generally positive results of OXT in adults with ASD, with trials showing improvements in repetitive behaviors, social reciprocity, and emotion recognition [75–77].”
From An Update on Psychopharmacological Treatment of Autism Spectrum Disorder (2022) · cites this paper as [76]
All OXT trials in adults with ASD studied only short-term benefits (within a few weeks).
“However, all these trials studied only short-term benefits (within a few weeks) of OXT administration.”
From An Update on Psychopharmacological Treatment of Autism Spectrum Disorder (2022) · cites this paper as [76]
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Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688 · see citing works
Oxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037 · see citing works
The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood
Lichtenstein, P., Carlström, E., Råstam, M., Gillberg, C., & Anckarsäter, H. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10020223 · Cited by 738 · see citing works
Optimal outcome in individuals with a history of autism
Fein, D., Barton, M., Eigsti, I., Kelley, E., Naigles, L., Schultz, R. T., Stevens, M., Helt, M., Orinstein, A., Rosenthal, M., et al. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12037 · Cited by 584 · see citing works
Positive Association of the Oxytocin Receptor Gene (OXTR) with Autism in the Chinese Han Population
Wu, S., Jia, M., Ruan, Y., Liu, J., Guo, Y., Mei, S., Gong, X., Zhang, Y., Yang, X., & Zhang, D. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.013 · Cited by 553 · see citing works
Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism
Jacob, S., Brune, C. W., Carter, C. S., Leventhal, B. L., Lord, C., & Cook, E. H. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.02.001 · Cited by 425 · see citing works
Lerer, E., Levi, S., Salomon, S., Darvasi, A., Yirmiya, N., & Ebstein, R. P. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002087 · Cited by 349 · see citing works
A sociability gene? Meta-analysis of oxytocin receptor genotype effects in humans
Bakermans‐Kranenburg, M. J., & van IJzendoorn, M. H. (2013) · Psychiatric Genetics · doi:10.1097/ypg.0b013e3283643684 · Cited by 217 · see citing works
Liu, X., Kawamura, Y., Shimada, T., Otowa, T., Koishi, S., Sugiyama, T., Nishida, H., Hashimoto, O., Nakagami, R., Tochigi, M., et al. (2010) · Journal of Human Genetics · doi:10.1038/jhg.2009.140 · Cited by 195 · see citing works
Genes Controlling Affiliative Behavior as Candidate Genes for Autism
Yrigollen, C. M., Han, S. S., Kochetkova, A., Babitz, T., Chang, J. T., Volkmar, F. R., Leckman, J. F., & Grigorenko, E. L. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.11.015 · Cited by 172 · see citing works
Campbell, D. B., Datta, D., Jones, S. T., Batey Lee, E., Sutcliffe, J. S., Hammock, E. A. D., & Levitt, P. (2011) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-010-9071-2 · Cited by 170 · see citing works
Watanabe, Y., Muratake, T., Kaneko, N., et al. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.03.011 · Cited by 77 · see citing works
Self-citationYamasue, H. (2012) · Brain and Development · doi:10.1016/j.braindev.2012.08.010 · Cited by 57 · see citing works
Nunokawa, A., Watanabe, Y., Kaneko, N., et al. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.10.016 · Cited by 48 · see citing works
Self-citationMa, W.-J., Hashii, M., Munesue, T., Hayashi, K., Yagi, K., Yamagishi, M., Higashida, H., & Yokoyama, S. (2013) · Molecular Autism · doi:10.1186/2040-2392-4-22 · Cited by 42 · see citing works
Egawa, J., Watanabe, Y., Nunokawa, A., Endo, T., Kaneko, N., Tamura, R., Sugiyama, T., & Someya, T. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2011.09.001 · Cited by 17 · see citing works
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An Update on Psychopharmacological Treatment of Autism Spectrum Disorder
Aishworiya, R., Valica, T., Hagerman, R., & Restrepo, B. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01183-1 · Cited by 233 · see citing works
Novel rare variations of the oxytocin receptor (OXTR) gene in autism spectrum disorder individuals
Liu, X., Kawashima, M., Miyagawa, T., Otowa, T., Latt, K. Z., Thiri, M., Nishida, H., Sugiyama, T., Tsurusaki, Y., Matsumoto, N., et al. (2015) · Human Genome Variation · doi:10.1038/hgv.2015.24 · Cited by 18 · see citing works
- Authors
- Egawa, J., Watanabe, Y., Shibuya, M., Endo, T., Sugimoto, A., Igeta, H., Nunokawa, A., Inoue, E., & Someya, T.
- Affiliations
- Niigata University (JP)
- Corresponding author
- Watanabe, Yuichiro
- Venue
- Psychiatry and Clinical Neurosciences
- Publisher
- Wiley
- Published
- 2014-07-07
- Volume
- 69
- Issue
- 3
- Pages
- 131-135
- ISSN
- 1323-1316 (ISSN-L)
- 1440-1819
- OpenAlex
- W1482111919
- Cited by
- 10
- References
- 16
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2017: 1 · 2015: 3
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Psychiatry and Clinical Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, oxytocin receptor, genetic susceptibility, Japanese population, genetic association
- MeSH terms
- Autism Spectrum Disorder, Adolescent, Adult, Female, Genotype, Humans, Japan, Male, Genetic Variation, Case-Control Studies, Receptors, Oxytocin, Genetic Predisposition to Disease, Asian People, Young Adult, Genetic Association Studies
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