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Clinical and public health implications of periodontal and systemic diseases: An overview
Abstract
Severe periodontitis is defined by extensive loss of the tooth attachment apparatus. It is the sixth most common human disease and is estimated to affect 11.2% of the global adult population, hence representing a significant healthcare, social, and economic burden. Since the 1990s, multiple epidemiologic, experimental, and interventional studies have evidenced how periodontitis may also impact systemic health and it has been independently associated with the majority of chronic noncommunicable diseases. The evidence supporting these associations, mainly focusing on diabetes, pregnancy complications, and cardiovascular disease, was thoroughly reviewed in 2012 by an international consensus workshop. In the last 5 years, however, important advances have been made, not only in our understanding of the etiopathogenesis of periodontitis, or concerning the mounting evidence regarding the independent associations between periodontitis, diabetes, and cardiovascular disease, but also with many other systemic diseases including metabolic disease and obesity, rheumatoid arthritis, certain cancers, respiratory diseases, and cognitive disorders including Alzheimer's disease. This review describes these scientific advances by gathering together the existing evidence on the importance and relevance of the associations between periodontitis and many systemic diseases.
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Self-citationPeriodontal disease and adverse pregnancy outcomes
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Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities
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The oral microbiome: diversity, biogeography and human health
Baker, J. L., Mark Welch, J. L., Kauffman, K. M., McLean, J. S., & He, X. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00963-6 · Cited by 661
Association between periodontitis and severity of COVID‐19 infection: A case–control study
Marouf, N., Cai, W., Said, K. N., Daas, H., Diab, H., Chinta, V. R., Hssain, A. A., Nicolau, B., Sanz, M., & Tamimi, F. (2021) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13435 · Cited by 380
Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities
Li, X., Wang, H., Yu, X., Saha, G., Kalafati, L., Ioannidis, C., Mitroulis, I., Netea, M. G., Chavakis, T., & Hajishengallis, G. (2022) · Cell · doi:10.1016/j.cell.2022.03.043 · Cited by 328
The oral–gut microbiome axis in health and disease
Kunath, B. J., De Rudder, C., Laczny, C. C., Letellier, E., & Wilmes, P. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01075-5 · Cited by 316
Metadata
- Authors
- Genco, R. J., & Sanz, M.
- Venue
- Periodontology 2000
- Publisher
- Wiley
- Published
- 2020-05-08
- Volume
- 83
- Issue
- 1
- Pages
- 7-13
- ISSN
- 0906-6713 (ISSN-L)
- 1600-0757
- OpenAlex
- W3022548569
- Cited by
- 665
- References
- 30
- FWCI
- 57.59
- Type
- journal article
- Language
- en
- Open access
- closed
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