Effectiveness of high‐intensity interval training on peripheral brain‐derived neurotrophic factor in adults: A systematic review and network meta‐analysis
Open accessAbstract
Background: High‐intensity interval training (HIIT) has emerged as an alternative training method to increase brain‐derived neurotrophic factor (BDNF) levels, a crucial molecule involved in plastic brain changes. Its effect compared to moderate‐intensity continuous training (MICT) is controversial. We aimed to estimate, and to comparatively evaluate, the acute and chronic effects on peripheral BDNF levels after a HIIT, MICT intervention or a control condition in adults. Methods: The CINAHL, Cochrane, PubMed, PEDro, Scopus, SPORTDiscus, and Web of Science databases were searched for randomized controlled trials (RCTs) from inception to June 30, 2023. A network meta‐analysis was performed to assess the acute and chronic effects of HIIT versus control condition, HIIT versus MICT and MICT versus control condition on BDNF levels. Pooled standardized mean differences (SMDs) and their 95% confidence intervals (95% CIs) were calculated for RCTs using a random‐effects model. Results: A total of 22 RCTs were selected for the systematic review, with 656 participants (aged 20.4–79 years, 34.0% females) and 20 were selected for the network meta‐analysis. Network SMD estimates were significant for HIIT versus control condition (1.49, 95% CI: 0.61, 2.38) and MICT versus control condition (1.08, 95% CI: 0.04, 2.12) for acutely BDNF increase. However, pairwise comparisons only resulted in a significant effect for HIIT versus control condition. Conclusions: HIIT is the best training modality for acutely increasing peripheral BDNF levels in adults. HIIT may effectively increase BDNF levels in the long term.
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A recent network meta-analysis confirmed that HIT could induce greater BDNF production than AT.
“A recent network meta-analysis confirmed that HIT could induce greater BDNF production than AT [51].”
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- Authors
- Rodríguez‐Gutiérrez, E., Torres‐Costoso, A., Saz‐Lara, A., Bizzozero‐Peroni, B., Guzmán‐Pavón, M. J., Sánchez‐López, M., & Martínez‐Vizcaíno, V.
- Affiliations
- University of Castilla-La Mancha (ES)
- Health and Social Research Center Universidad de Castilla‐La Mancha Cuenca Spain
- Universidad de la República de Uruguay (UY)
- Universidad Autónoma de Chile (CL)
- ORCID
- Venue
- Scandinavian Journal of Medicine & Science in Sports
- Publisher
- Wiley
- Published
- 2023-09-20
- Volume
- 34
- Issue
- 1
- Pages
- e14496-e14496
- ISSN
- 0905-7188 (ISSN-L)
- 1600-0838
- OpenAlex
- W4386887063
- Cited by
- 42
- References
- 76
- Citations by year
- 2026: 12 · 2025: 15 · 2024: 14 · 2023: 1
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Scandinavian Journal of Medicine and Science in Sports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- RUIdeRA - Institutional University Repository (University of Castilla-La Mancha) (submittedVersion, cc-by-nc-nd)
- Funders
- Universidad de Castilla-La Mancha
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- high-intensity interval training, brain-derived neurotrophic factor, moderate-intensity continuous training, acute exercise effects, long-term training effects, exercise training comparison, adults
- MeSH terms
- High-Intensity Interval Training, Adult, Brain, Female, Humans, Male, Oxygen Consumption, Brain-Derived Neurotrophic Factor
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