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Cited by 262

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Mechanisms of lysosomal positioning and movement

Open access
Cabukusta, Birol, Neefjes, Jacques·2018·Traffic
DOI 10.1111/tra.12587
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Abstract

Lysosomes are highly dynamic organelles that can move rapidly throughout the cell. They distribute in a rather immobile pool located around the microtubule‐organizing center in a “cloud,” and a highly dynamic pool in the cell periphery. Their spatiotemporal characteristics allow them to carry out multiple biological functions, such as cargo degradation, antigen presentation and plasma membrane repair. Therefore, it is not surprising that lysosomal dysfunction underlies various diseases, including cancer, neurodegenerative and autoimmune diseases. In most of these biological events, the involvement of lysosomes is dependent on their ability to move throughout the cytoplasm, to find and fuse to the correct compartments to receive and deliver substrates for further handling. These dynamics are orchestrated by motor proteins moving along cytoskeletal components. The complexity of the mechanisms responsible for controlling lysosomal transport has recently been appreciated and has yielded novel insights into interorganellar communication, as well as lipid‐protein interplay. In this review, we discuss the current understanding of the mechanisms of lysosomal transport and the molecular machineries that control this mobility.

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Metadata

Authors
Cabukusta, B., & Neefjes, J.
Venue
Traffic
Publisher
Wiley
Published
2018-07-17
Volume
19
Issue
10
Pages
761-769
ISSN
  • 1398-9219 (ISSN-L)
  • 1600-0854
DOI
10.1111/tra.12587
OpenAlex
W2808041642
Cited by
262
References
19
FWCI
11.12
Type
journal article
Language
en
Open access
hybrid

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