Cited by 135Neural dynamics and brain functionNeuroscience and Neuropharmacology ResearchSleep and Wakefulness Research

Effects of ionophoresed noradrenaline on the spontaneous activity of neurones in rat primary somatosensory cortex.

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Armstrong‐James, M, Fox, K·1983·The Journal of Physiology

Abstract

Changes in spontaneous activity of rat S1 cortical neurones with identified receptive fields were investigated in reply to ionophoresed noradrenaline (NA). Extracellular levels of NA were maintained constant by continuous electrochemical analysis at the carbon fibre recording tip of the multibarrel micro‐electrode. In the absence of NA there were clear differences in spike amplitude, firing rate and pattern of firing of deep (800‐1400 micron) and superficial (0‐800 micron) cells. Superficial cells responded to low (5 X 10(‐8) to 5 X 10(‐7) M) NA concentrations with simple inhibition. Recovery occurred within a minute or so of extracellular NA concentrations falling below detectable (10(‐8) M) levels. Increases in local concentration merely stopped cells firing. In contrast, cells located in the deep zone could often be excited by very low NA concentrations (less than 10(‐8) M), with inhibition occurring at levels 10‐100 times greater. Most cells, however, were inhibited, with threshold doses for a 50% change in firing rate much higher than for superficial cells. Some cells in the deep zone showed sustained increases in firing rate following an ionophoretic trial. This could occur for periods of up to 1 h after ceasing a trial. Such effects could be produced by levels as low as 10(‐7) M‐NA. Interspike interval analysis for deep cells suggested that their spontaneous activity resembled that established for slow‐wave sleep. During and after excitation by NA the pattern of firing of small groups of these cells changed to that established for the waking state. The effect could persist for up to 1 h following a short (2‐5 min) ionophoretic trial.

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Crossref · 10.1113/jphysiol.1983.sp014542

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Authors
Armstrong‐James, M., & Fox, K.
ORCID
Fox, K
Venue
The Journal of Physiology
Publisher
Wiley
Published
1983-02
Volume
335
Issue
1
Pages
427-447
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
OpenAlex
W2050773308
Cited by
135
References
23
Citations by year
2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 1
FWCI
4.15
Type
journal article
Language
en
Open access
Locations
  • The Journal of Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
norepinephrine, iontophoresis, primary somatosensory cortex, spontaneous neuronal activity, cortical depth, firing rate, firing patterns, slow-wave sleep, waking state
MeSH terms
Action Potentials, Animals, Iontophoresis, Male, Neurons, Norepinephrine, Rats, Inbred Strains, Sensory Thresholds, Somatosensory Cortex, Time Factors, Rats

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