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Cited by 306

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Leukocytes, cytokines, growth factors and hormones in human skeletal muscle and blood after uphill or downhill running

Malm, Christer, Sjödin, Bertil, Sjöberg, Berit, Lenkei, Rodica, Renström, Per, Lundberg, Ingrid E., Ekblom, Björn·2004·The Journal of Physiology
DOI 10.1113/jphysiol.2003.056598
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Abstract

Muscular adaptation to physical exercise has previously been described as a repair process following tissue damage. Recently, evidence has been published to question this hypothesis. The purpose of this study was to investigate inflammatory processes in human skeletal muscle and epimysium after acute physical exercise with large eccentric components. Three groups of subjects (n= 19) performed 45 min treadmill running at either 4 deg (n= 5) or 8 deg (n= 9) downhill or 4 deg uphill (n= 5) and one group served as control (n= 9). One biopsy was taken from each subject 48 h post exercise. Blood samples were taken up to 7 days post exercise. Compared to the control group, none of the markers of inflammation in muscle and epimysium samples was different in any exercised group. Only subjects in the Downhill groups experienced delayed onset of muscle soreness (DOMS) and increased serum creatine kinase activity (CK). The detected levels of immunohistochemical markers for T cells (CD3), granulocytes (CD11b), leukaemia inhibitory factor (LIF) and hypoxia‐inducible factor 1β (HIF‐1β) were greater in epimysium from exercised subjects with DOMS ratings >3 (0–10 scale) compared to exercised subjects without DOMS but not higher than controls. Eccentric physical exercise (downhill running) did not result in skeletal muscle inflammation 48 h post exercise, despite DOMS and increased CK. It is suggested that exercise can induce DOMS by activating inflammatory factors present in the epimysium before exercise. Repeated physical training may alter the content of inflammatory factors in the epimysium and thus reduce DOMS.

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Cites

  • The Acute Immune Response to Exercise: What Does It Mean?

    Gabriel, H., & Kindermann, W. (1997) · International Journal of Sports Medicine · doi:10.1055/s-2007-972698 · Cited by 166 · cited 2×

    “…and hormones in blood Changes in leukocyte distribution, function and antigen expression in response to physical exercise are well described (Gabriel & Kindermann, 1997; Pedersen, 1997; Mackinnon, 1999; Malm et al. 1999) and the intention of this study was to investigate possible…”
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Research works printed but not linked: 43

  1. 10.1249/00003677-199800260-00004 · DOI
  2. 10.1152/jappl.1983.54.1.80 · DOI · Paper page
  3. 10.1111/j.1365-2990.1997.tb01195.x · DOI
  4. 10.1016/0022-510X(94)90211-9 · DOI
  5. 10.1016/S0962-8924(98)01359-2 · DOI · Paper page
  6. 10.1042/cs0880119 · DOI
  7. 10.1182/asheducation-2000.1.166 · DOI
  8. Cannon JG, 1989, Increased interleukin 1 beta in human skeletal muscle after exercise, Am J Physiol, 257, R451
  9. 10.1139/h96-014 · DOI
  10. 10.1139/h99-020 · DOI · Paper page
  11. 10.1097/00024382-199904000-00002 · DOI
  12. Fielding RA, 1993, Acute phase response in exercise. III. Neutrophil and IL‐1 beta accumulation in skeletal muscle, Am J Physiol, 265, R166
  13. 10.1139/y00-036 · DOI
  14. 10.1046/j.1469-7580.1999.19430323.x · DOI · Paper page
  15. 10.1002/1097-4598(200010)23:10<1586::AID-MUS17>3.0.CO;2-A · DOI
  16. 10.1152/ajpheart.1999.276.2.H679 · DOI · Paper page
  17. 10.1046/j.1365-201X.1996.492235000.x · DOI
  18. 10.1016/0167-5699(94)90006-X · DOI · Paper page
  19. 10.1016/S1359-6101(96)00029-9 · DOI · Paper page
  20. 10.1002/ana.410310109 · DOI
  21. 10.1016/0022-1759(95)00064-H · DOI
  22. 10.1016/S0960-8966(98)00111-4 · DOI
  23. 10.1152/jappl.1996.80.3.1006 · DOI
  24. 10.2165/00007256-199520010-00003 · DOI · Paper page
  25. MacKinnon LT, 1999, Advances in Exercise Immunology
  26. 10.1111/j.1469-7793.1999.0583v.x · DOI · Paper page
  27. 10.1152/jappl.1999.86.2.461 · DOI
  28. 10.1111/j.1469-7793.2000.00243.x · DOI · Paper page
  29. 10.1007/BF00307814 · DOI
  30. 10.1006/bbrc.2000.2934 · DOI
  31. Pedersen BK, 1997, Exercise Immunology
  32. 10.1126/science.276.5317.1345 · DOI
  33. 10.1097/00001756-199808240-00029 · DOI
  34. 10.1007/BF00418457 · DOI
  35. 10.1159/000028102 · DOI
  36. 10.1152/jappl.2000.89.6.2325 · DOI · Paper page
  37. 10.1006/dbio.1997.8803 · DOI · Paper page
  38. 10.1249/00005768-199507000-00011 · DOI · Paper page
  39. 10.1136/ard.54.8.654 · DOI
  40. Um HD, 1996, Fas mediates apoptosis in human monocytes by a reactive oxygen intermediate dependent pathway, J Immunol, 156, 3469, 10.4049/jimmunol.156.9.3469 · DOI
  41. 10.2165/00007256-199927010-00004 · DOI
  42. Yu JG, 2003, The mode of myofibril remodelling in human skeletal muscle affected by DOMS induced by eccentric contractions, Histochem Cell Biol, 119, 383, 10.1007/s00418-003-0522-7 · DOI
  43. Yu JG, 2002, Eccentric contractions leading to DOMS do not cause loss of desmin nor fibre necrosis in human muscle, Histochem Cell Biol, 118, 29, 10.1007/s00418-002-0423-1 · DOI

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Metadata

Authors
Malm, C., Sjödin, B., Sjöberg, B., Lenkei, R., Renström, P., Lundberg, I. E., & Ekblom, B.
Venue
The Journal of Physiology
Publisher
Wiley
Published
2004-04-21
Volume
556
Issue
3
Pages
983-1000
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1113/jphysiol.2003.056598
OpenAlex
W2171507288
Cited by
306
References
1
FWCI
9.75
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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