Skeletal Muscle as an Endocrine Organ: The Role of Myokines in Exercise Adaptations

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

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The Human Plasma Proteome

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Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member

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The Extracellular Matrix: Not Just Pretty Fibrils

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Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases

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Principles of interleukin (IL)-6-type cytokine signalling and its regulation

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Muscles, exercise and obesity: skeletal muscle as a secretory organ

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The anti-inflammatory effects of exercise: Mechanisms and implications for the prevention and treatment of disease

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Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation

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Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

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Role of Extracellular Matrix in Adaptation of Tendon and Skeletal Muscle to Mechanical Loading

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Antioxidants prevent health-promoting effects of physical exercise in humans

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Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40

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Interleukin-6 and chronic inflammation

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Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway

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Myostatin Mutation Associated with Gross Muscle Hypertrophy in a Child

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Interleukin-6 in Biology and Medicine

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IL-8 Directly Enhanced Endothelial Cell Survival, Proliferation, and Matrix Metalloproteinases Production and Regulated Angiogenesis

Li, A., Dubey, S., Varney, M. L., Davé, B. J., & Singh, R. K. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3369 · Cited by 1,324 · see citing works

Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

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Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism

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IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans

Steensberg, A., Fischer, C. P., Keller, C., Møller, K., & Pedersen, B. K. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00074.2003 · Cited by 1,135 · see citing works

Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6

Steensberg, A., van Hall, G., Osada, T., Sacchetti, M., Saltin, B., & Pedersen, B. K. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00237.x · Cited by 1,095 · see citing works

Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis

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Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

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Nampt/PBEF/Visfatin Regulates Insulin Secretion in β Cells as a Systemic NAD Biosynthetic Enzyme

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Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase

Carey, A. L., Steinberg, G. R., Macaulay, S. L., Thomas, W. G., Holmes, A. G., Ramm, G., Prelovsek, O., Hohnen-Behrens, C., Watt, M. J., James, D. E., et al. (2006) · Diabetes · doi:10.2337/db05-1404 · Cited by 898 · see citing works

Voluntary running suppresses tumor growth through epinephrine- and IL-6-dependent NK cell mobilization and redistribution

Pedersen, L., Idorn, M., Olofsson, G. H., Lauenborg, B., Nookaew, I., Hansen, R. H., Johannesen, H. H., Becker, J. C., Pedersen, K. S., Dethlefsen, C., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.01.011 · Cited by 888 · see citing works

Interleukin-6 Is an Essential Regulator of Satellite Cell-Mediated Skeletal Muscle Hypertrophy

Serrano, A. L., Baeza-Raja, B., Perdiguero, E., Jardí, M., & Muñoz-Cánoves, P. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.011 · Cited by 873 · cited 1× · see citing works

Aberrant repair and fibrosis development in skeletal muscle

Mann, C. J., Perdiguero, E., Kharraz, Y., Aguilar, S., Pessina, P., Serrano, A. L., & Muñoz-Cánoves, P. (2011) · Skeletal Muscle · doi:10.1186/2044-5040-1-21 · Cited by 853 · see citing works

The effect of acute exercise on serum brain-derived neurotrophic factor levels and cognitive function.

FERRIS, L. T., WILLIAMS, J. S., & SHEN, C.-L. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31802f04c7 · Cited by 849 · see citing works

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

Kim, K. H., Jeong, Y. T., Oh, H., Kim, S. H., Cho, J. M., Kim, Y.-N., Kim, S. S., Kim, D. H., Hur, K. Y., Kim, H. K., et al. (2013) · Nature Medicine · doi:10.1038/nm.3014 · Cited by 774 · see citing works

Interleukin-6 stimulates lipolysis and fat oxidation in humans

van Hall, G., Steensberg, A., Sacchetti, M., Fischer, C., Keller, C., Schjerling, P., Hiscock, N., Møller, K., Saltin, B., Febbraio, M. A., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021687 · Cited by 767 · see citing works

Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression

Agudelo, L. Z., Femenía, T., Orhan, F., Porsmyr-Palmertz, M., Goiny, M., Martinez-Redondo, V., Correia, J. C., Izadi, M., Bhat, M., Schuppe-Koistinen, I., et al. (2014) · Cell · doi:10.1016/j.cell.2014.07.051 · Cited by 739 · see citing works

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

Mauer, J., Chaurasia, B., Goldau, J., Vogt, M. C., Ruud, J., Nguyen, K. D., Theurich, S., Hausen, A. C., Schmitz, J., Brönneke, H. S., et al. (2014) · Nature Immunology · doi:10.1038/ni.2865 · Cited by 727 · see citing works

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

Matthews, V. B., Åström, M.-B., Chan, M. H. S., Bruce, C. R., Krabbe, K. S., Prelovsek, O., Åkerström, T., Yfanti, C., Broholm, C., Mortensen, O. H., et al. (2009) · Diabetologia · doi:10.1007/s00125-009-1364-1 · Cited by 722 · cited 1× · see citing works

Protection from obesity and diabetes by blockade of TGF-β/smad3 signaling

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CCN proteins: multifunctional signalling regulators

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Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running

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β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors

Roberts, L. D., Boström, P., O’Sullivan, J. F., Schinzel, R. T., Lewis, G. D., Dejam, A., Lee, Y.-K., Palma, M. J., Calhoun, S., Georgiadi, A., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.003 · Cited by 643 · see citing works

Running-induced systemic cathepsin B secretion is associated with memory function

Moon, H. Y., Becke, A., Berron, D., Becker, B., Sah, N., Benoni, G., Janke, E., Lubejko, S. T., Greig, N. H., Mattison, J. A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.025 · Cited by 628 · see citing works

Neurotrophin signalling in health and disease

Chao, M. V., Rajagopal, R., & Lee, F. S. (2006) · Clinical Science · doi:10.1042/cs20050163 · Cited by 626 · see citing works

Leucocytes, cytokines and satellite cells: what role do they play in muscle damage and regeneration following eccentric exercise?

Paulsen, G., Mikkelsen, U. R., Raastad, T., & Peake, J. M. (2026) · PubMed · doi:10.22029/eir.2012.1668 · Cited by 572 · see citing works

Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry

Jedrychowski, M. P., Wrann, C. D., Paulo, J. A., Gerber, K. K., Szpyt, J., Robinson, M. M., Nair, K. S., Gygi, S. P., & Spiegelman, B. M. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.08.001 · Cited by 568 · see citing works

Searching for the exercise factor: is IL-6 a candidate?

Pedersen (2003) · Journal of Muscle Research and Cell Motility · doi:10.1023/a:1026070911202 · Cited by 564 · see citing works

Type beta transforming growth factor is an inhibitor of myogenic differentiation.

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Apelin Stimulates Glucose Utilization in Normal and Obese Insulin-Resistant Mice

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Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen content

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Time course of proteolytic, cytokine, and myostatin gene expression after acute exercise in human skeletal muscle

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The potential of endurance exercise-derived exosomes to treat metabolic diseases

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Regulation of muscle mass by growth hormone and IGF‐I

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Interleukin‐6 production in contracting human skeletal muscle is influenced by pre‐exercise muscle glycogen content

Steensberg, A., Febbraio, M. A., Osada, T., Schjerling, P., van Hall, G., Saltin, B., & Pedersen, B. K. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00633.x · Cited by 444 · see citing works

Lactate sensitive transcription factor network in L6 cells: activation of MCT1 and mitochondrial biogenesis

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Dynamic regulation of circulating microRNA during acute exhaustive exercise and sustained aerobic exercise training

Baggish, A. L., Hale, A., Weiner, R. B., Lewis, G. D., Systrom, D., Wang, F., Wang, T. J., & Chan, S. Y. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.213363 · Cited by 431 · see citing works

Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise

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Expression of IGF-I splice variants in young and old human skeletal muscle after high resistance exercise

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Interleukin-10 Prevents Diet-Induced Insulin Resistance by Attenuating Macrophage and Cytokine Response in Skeletal Muscle

Hong, E., Ko, H. J., Cho, Y.-R., Kim, H., Ma, Z., Yu, T. Y., Friedline, R. H., Kurt‐Jones, E. A., Finberg, R. W., Fischer, M. A., et al. (2009) · Diabetes · doi:10.2337/db08-1261 · Cited by 412 · see citing works

IL-6 and TNF-α expression in, and release from, contracting human skeletal muscle

Steensberg, A., Keller, C., Starkie, R. L., Osada, T., Febbraio, M. A., & Pedersen, B. K. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00255.2002 · Cited by 410 · see citing works

Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis

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Diversity in the contribution of interleukin‐10 to T‐cell‐mediated immune regulation

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A trauma‐like elevation of plasma cytokines in humans in response to treadmill running

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Carbohydrate ingestion influences skeletal muscle cytokine mRNA and plasma cytokine levels after a 3-h run

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A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise

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Irisin – a myth rather than an exercise-inducible myokine

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Bone Strength: Current Concepts

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Muscle specific microRNAs are regulated by endurance exercise in human skeletal muscle

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Mechanical load increases muscle IGF-I and androgen receptor mRNA concentrations in humans

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Expression of IGF-I splice variants in young and old human skeletal muscle after high resistance exercise

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Cytokine changes after a marathon race

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Can physical exercise in old age improve memory and hippocampal function?

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Increased secretion and expression of myostatin in skeletal muscle from extremely obese women

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Exercise training-induced lowering of inflammatory (CD14+CD16+) monocytes: a role in the anti-inflammatory influence of exercise?

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Evidence against a Beneficial Effect of Irisin in Humans

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Acute IL-6 Treatment Increases Fatty Acid Turnover in Elderly Humans in Vivo and in Tissue Culture in Vitro

Petersen, E. W., Carey, A. L., Sacchetti, M., Steinberg, G. R., Macaulay, S. L., Febbraio, M. A., & Pedersen, B. K. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00257.2004 · Cited by 311 · see citing works

Transforming growth factor-β and myostatin signaling in skeletal muscle

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Leukocytes, cytokines, growth factors and hormones in human skeletal muscle and blood after uphill or downhill running

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Dynamics of the skeletal muscle secretome during myoblast differentiation

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The miRNA Plasma Signature in Response to Acute Aerobic Exercise and Endurance Training

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Skeletal muscle NAMPT is induced by exercise in humans

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Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis

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Acute Exercise Induces FGF21 Expression in Mice and in Healthy Humans

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Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications

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Plasma cytokine changes in relation to exercise intensity and muscle damage

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CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK

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