Cited by 36Neural dynamics and brain functionMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Chronometric readout from a memory trace: Gamma-frequency field stimulation recruits timed recurrent activity in the rat CA3 network

Fujisawa, Shigeyoshi, Matsuki, Norio, Ikegaya, Yuji·2004·The Journal of Physiology

Abstract

Synchronous population activity is prevalent in neurones of the central nervous system and experimentally captured as oscillatory electric fields, the frequency of which can represent the state of the neural circuit, e.g. theta (approximately 5 Hz) and gamma (approximately 40 Hz). Such field oscillations, however, are not merely a result of coherent neuronal activity. They may also play active roles in information processing in the brain. In this study, we observed that, in cultured hippocampal slices, CA3 pyramidal cells responded to single-pulse stimuli with monosynaptic and polysynaptic potentials and firing spikes which occurred after variable latencies. The variability of the spike latencies was greatly reduced in the presence of weak electric field oscillations, especially the oscillation in the gamma-band frequency range, that per se induced only small fluctuations in the subthreshold membrane potential, and this effect was inhibited by blockade of NMDA receptor activity. Furthermore, the latency of the firing spikes changed if the stimulus was applied at a different phase of the imposed gamma oscillations. These results may suggest that the background field oscillations serve as an extracellular time reference and assure accurate and stable decoding of a memory trace present in cortical feedback networks.

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Crossref · 10.1113/jphysiol.2004.066639

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36 of 36 references verified0 citation errors · 0 not checkable

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  • External oscillating electric fields modulate the firing pattern of individual neurons in rat hippocampal slices.

    “Clearly the external fields were modulating the firing pattern of individual neurons.”

    From The electromagnetic will (2021) · cites this paper as [67]

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Authors
Fujisawa, S., Matsuki, N., & Ikegaya, Y.
Affiliations
The University of Tokyo (JP)
Venue
The Journal of Physiology
Publisher
Wiley
Published
2004-11
Volume
561
Issue
1
Pages
123-131
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
OpenAlex
W2142063073
Cited by
36
References
36
Citations by year
2025: 5 · 2023: 1 · 2021: 1 · 2020: 2 · 2015: 1 · 2014: 3 · 2013: 4 · 2012: 2
FWCI
1.01
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
gamma oscillations, hippocampal CA3, field oscillations, spike latency, NMDA receptor, memory traces, hippocampal slices
MeSH terms
Action Potentials, Animals, Association Learning, Electric Stimulation, Hippocampus, Memory, Short-Term, Organ Culture Techniques, Periodicity, Reaction Time, Receptors, N-Methyl-D-Aspartate, Rats, Wistar, Rats

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