The Unique Expression and Function of miR-424 in Human Placental Trophoblasts1
Open accessAbstract
Placental hypoperfusion causes cellular hypoxia and is associated with fetal growth restriction and preeclampsia. In response to hypoxia, the repertoire of genes expressed in placental trophoblasts changes, which influences key cellular processes such as differentiation and fusion. Diverse miRNAs were recently found to modulate the cellular response to hypoxia. Here we show that miR-424, which was previously shown to be upregulated by hypoxia in nontrophoblastic cell types, is uniquely downregulated in primary human trophoblasts by hypoxia or chemicals known to hinder cell differentiation. We also identify FGFR1 as a direct target of miR-424 in human trophoblasts. This effect is unique to miR-424 and is not seen with other members of this miRNA family that are expressed in trophoblasts, such as miR-15 and miR-16. Our findings establish a unique role for miR-424 during differentiation of human trophoblasts.
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Micro-RNAs identified as being differentially expressed under hypoxia include miR-93, miR-205, miR-224, MiR-335, MiR-424, miR-451, miR-491 and mIR-34a.
“Many of these Other micro-RNAs identified as being differentially expressed under hypoxia include miR-93, miR-205, miR-224, MiR-335, MiR-424, miR-451 and miR-491 (396, 397), and mIR-34a (154), but little is known regarding their functional significance at present.”
From Placental Origins of Chronic Disease (2016) · cites this paper as [397]
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- Authors
- Mouillet, J.-F., Donker, R. B., Mishima, T., Cronqvist, T., Chu, T., & Sadovsky, Y.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Sadovsky, Yoel
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-08-01
- Volume
- 89
- Issue
- 2
- Pages
- 25-25
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- PMC
- PMC4076361
- OpenAlex
- W2110190175
- Cited by
- 47
- References
- 62
- Citations by year
- 2023: 4 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 6 · 2018: 6 · 2017: 4 · 2016: 4 · 2015: 7 · 2014: 7 · 2013: 2
- FWCI
- 7.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biology of Reproduction (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- BioOne Complete (BioOne) (submittedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD071707, R01HD065893)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- miR-424, placental trophoblast, hypoxia, trophoblast differentiation, FGFR1, microRNA target regulation, miR-15, miR-16, placental hypoperfusion, fetal growth restriction, preeclampsia, trophoblast fusion
- MeSH terms
- Hypoxia, Cell Differentiation, Cells, Cultured, Female, Humans, Placenta, Pregnancy, Trophoblasts, Down-Regulation, MicroRNAs, Cell Line, Tumor, MAP Kinase Kinase 1, Receptor, Fibroblast Growth Factor, Type 1
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