Synaptic modifications at the CA3–CA1 synapse after chronic AMPA receptor blockade in rat hippocampal slices
Open accessAbstract
Maintenance of dendritic spines, the postsynaptic elements of most glutamatergic synapses in the central nervous system, requires continued activation of AMPA receptors. In organotypic hippocampal slice cultures, chronic blockade of AMPA receptors for 14 days induces a substantial loss of dendritic spines on CA1 pyramidal neurons. Here, using serial section electron microscopy, we show that loss of dendritic spines is paralleled by a significant reduction in synapse density. In contrast, we observed an increased number of asymmetric synapses onto the dendritic shaft, suggesting that spine retraction does not inevitably lead to synapse elimination. Functional analysis of the remaining synapses revealed that hippocampal circuitry compensates for the anatomical loss of synapses by increasing synaptic efficacy. Moreover, we found that the observed morphological and functional changes were associated with altered bidirectional synaptic plasticity. We conclude that continued activation of AMPA receptors is necessary for maintaining structure and function of central glutamatergic synapses.
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Neurotransmitters including norepinephrine, serotonin and glutamate, as well as stress-induced release of neuropeptides and steroids, can influence synapse number and function.
“Neurotransmitters, including norepinephrine,76, 77, 78 serotonin79, 80, 81 and glutamate,82,83 as well as stress-induced release of neuropeptides26,34,84,85 and steroids,86, 87, 88 can influence synapse number and function.”
From Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress (2014) · cites this paper as [82]
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Structural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,500 · see citing works
Homeostatic plasticity in the developing nervous system
Turrigiano, G. G., & Nelson, S. B. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1327 · Cited by 2,485 · see citing works
Activity-dependent scaling of quantal amplitude in neocortical neurons
Turrigiano, G. G., Leslie, K. R., Desai, N. S., Rutherford, L. C., & Nelson, S. B. (1998) · Nature · doi:10.1038/36103 · Cited by 2,226 · see citing works
Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
Trachtenberg, J. T., Chen, B. E., Knott, G. W., Feng, G., Sanes, J. R., Welker, E., & Svoboda, K. (2002) · Nature · doi:10.1038/nature01273 · Cited by 1,927 · see citing works
Dudek, S. M., & Bear, M. F. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4363 · Cited by 1,708 · see citing works
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Engert, F., & Bonhoeffer, T. (1999) · Nature · doi:10.1038/19978 · Cited by 1,664 · see citing works
Matsuzaki, M., Ellis-Davies, G. C. R., Nemoto, T., Miyashita, Y., Iino, M., & Kasai, H. (2001) · Nature Neuroscience · doi:10.1038/nn736 · Cited by 1,563 · cited 2× · see citing works
“spines and associated PSDs correlates with the number of synaptic AMPA, but not NMDA receptors (Nusser et al. 1998; Takumi et al. 1999; Matsuzaki et al. 2001), we determined the relative contribution of AMPA and NMDA receptors to spontaneous synaptic transmission.”
BackgroundInfluentialLong-term dendritic spine stability in the adult cortex
Grutzendler, J., Kasthuri, N., & Gan, W.-B. (2002) · Nature · doi:10.1038/nature01276 · Cited by 1,198 · cited 2× · see citing works
“…changes that occur over a large time scale, ranging from seconds (Fischer et al. 1998; Dunaevsky et al. 1999; Korkotian & Segal, 2001) to tens of minutes or even days (Engert & Bonhoeffer, 1999; Maletic-Savatic et al. 1999; Grutzendler et al. 2002; Trachtenberg et al. 2002; Richards et al. 2005).”
BackgroundRapid Dendritic Morphogenesis in CA1 Hippocampal Dendrites Induced by Synaptic Activity
Maletić‐Savatić, M., Malinow, R., & Svoboda, K. (1999) · Science · doi:10.1126/science.283.5409.1923 · Cited by 1,189 · see citing works
Transient and persistent dendritic spines in the neocortex in vivo
Holtmaat, A. J. G. D., Trachtenberg, J. T., Wilbrecht, L., Shepherd, G. M., Zhang, X., Knott, G. W., & Svoboda, K. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.003 · Cited by 1,131 · see citing works
Harris, K. M., Jensen, F. E., & Tsao, B. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-07-02685.1992 · Cited by 990 · see citing works
Rapid Actin-Based Plasticity in Dendritic Spines
Fischer, M., Kaech, S., Knutti, D., & Matus, A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80467-5 · Cited by 905 · see citing works
Organotypic slice cultures: a technique has come of age
Gähwiler, B. H. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01122-3 · Cited by 887 · see citing works
Self-citationEvidence for a Role of Dendritic Filopodia in Synaptogenesis and Spine Formation
Ziv, N. E., & Smith, S. J. (1996) · Neuron · doi:10.1016/s0896-6273(00)80283-4 · Cited by 863 · see citing works
Cell Type and Pathway Dependence of Synaptic AMPA Receptor Number and Variability in the Hippocampus
Nusser, Z., Lujan, R., Laube, G., Roberts, J. D. B., Molnar, E., & Somogyi, P. (1998) · Neuron · doi:10.1016/s0896-6273(00)80565-6 · Cited by 804 · see citing works
Synaptogenesis Via Dendritic Filopodia in Developing Hippocampal Area CA1
Fiala, J. C., Feinberg, M., Popov, V., & Harris, K. M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-21-08900.1998 · Cited by 758 · see citing works
The small pyramidal neuron of the rat cerebral cortex. The perikaryon, dendrites and spines
Peters, A., & Kaiserman‐Abramof, I. R. (1970) · American Journal of Anatomy · doi:10.1002/aja.1001270402 · Cited by 740 · see citing works
Different modes of expression of AMPA and NMDA receptors in hippocampal synapses
Takumi, Y., Ramírez-León, V., Laake, P., Rinvik, E., & Ottersen, O. P. (1999) · Nature Neuroscience · doi:10.1038/10172 · Cited by 675 · see citing works
Experience-dependent and cell-type-specific spine growth in the neocortex
Holtmaat, A., Wilbrecht, L., Knott, G. W., Welker, E., & Svoboda, K. (2006) · Nature · doi:10.1038/nature04783 · Cited by 631 · see citing works
Genesis of dendritic spines: insights from ultrastructural and imaging studies
Yuste, R., & Bonhoeffer, T. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1300 · Cited by 628 · see citing works
Inactivity produces increases in neurotransmitter release and synapse size
Murthy, V. N., Schikorski, T., Stevens, C. F., & Zhu, Y. (2001) · Neuron · doi:10.1016/s0896-6273(01)00500-1 · Cited by 612 · see citing works
Miniature synaptic events maintain dendritic spines via AMPA receptor activation
McKinney, R. A., Capogna, M., Dürr, R., Gähwiler, B. H., & Thompson, A. S. M. (1999) · Nature Neuroscience · doi:10.1038/4548 · Cited by 523 · see citing works
Self-citationAdaptation to Synaptic Inactivity in Hippocampal Neurons
Thiagarajan, T. C., Lindskog, M., & Tsien, R. W. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.037 · Cited by 482 · see citing works
Developmental regulation of spine motility in the mammalian central nervous system
Dunaevsky, A., Tashiro, A., Majewska, A., Mason, C., & Yuste, R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13438 · Cited by 412 · see citing works
Christof Koch, A., & Zador, A. M. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00413.1993 · Cited by 374 · see citing works
From form to function: calcium compartmentalization in dendritic spines
Yuste, R., Majewska, A. K., & Holthoff, K. (2000) · Nature Neuroscience · doi:10.1038/76609 · Cited by 370 · see citing works
Activity Coregulates Quantal AMPA and NMDA Currents at Neocortical Synapses
Watt, A. J., van Rossum, M. C. W., MacLeod, K. M., Nelson, S. B., & Turrigiano, G. G. (2000) · Neuron · doi:10.1016/s0896-6273(00)81202-7 · Cited by 350 · see citing works
Postsynaptic expression of homeostatic plasticity at neocortical synapses
Wierenga, C. J., Ibata, K., & Turrigiano, G. G. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5217-04.2005 · Cited by 306 · see citing works
Portera-Cailliau, C., Pan, D. T., & Yuste, R. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-18-07129.2003 · Cited by 269 · see citing works
Morphological variations in the dendritic spines of the neocortex
Jones, E. G., & Powell, T. P. S. (1969) · Journal of Cell Science · doi:10.1242/jcs.5.2.509 · Cited by 261 · see citing works
Majewska, A., Brown, E., Ross, J., & Yuste, R. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-05-01722.2000 · Cited by 248 · see citing works
Rate and extent of recovery from dark rearing in the visual cortex of the mouse
Valverde, F. (1971) · Brain Research · doi:10.1016/0006-8993(71)90302-7 · Cited by 235 · see citing works
Debanne, D., Gähwiler, B. H., & Thompson, S. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.3.1148 · Cited by 233 · see citing works
Self-citationHasbani, M. J., Schlief, M. L., Fisher, D. A., & Goldberg, M. P. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-07-02393.2001 · Cited by 208 · see citing works
Regulation of Spine Calcium Dynamics by Rapid Spine Motility
Majewska, A. K., Tashiro, A., & Yuste, R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-22-08262.2000 · Cited by 201 · see citing works
Kirov, S. A., Petrak, L. J., Fiala, J. C., & Harris, K. M. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.04.053 · Cited by 172 · see citing works
Glutamate induces the rapid formation of spine head protrusions in hippocampal slice cultures
Richards, D. A., Mateos, J. M., Hugel, S., de Paola, V., Caroni, P., Gähwiler, B. H., & McKinney, R. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501881102 · Cited by 161 · see citing works
Self-citationA Morphological Correlate of Synaptic Scaling in Visual Cortex
Wallace, W., & Bear, M. F. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1110-04.2004 · Cited by 139 · see citing works
NMDA receptor activation limits the number of synaptic connections during hippocampal development
Lüthi, A., Schwyzer, L., Mateos, J. M., Gähwiler, B. H., & McKinney, R. A. (2001) · Nature Neuroscience · doi:10.1038/nn744 · Cited by 138 · see citing works
Self-citationMüller, M., Gähwiler, B. H., Rietschin, L., & Thompson, S. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.1.257 · Cited by 134 · see citing works
Self-citationBacci, A., Coco, S., Pravettoni, E., Schenk, U., Armano, S., Frassoni, C., Verderio, C., Camilli, P. V. D., & Matteoli, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06588.2001 · Cited by 126 · see citing works
Regulation of Dendritic Spine Motility in Cultured Hippocampal Neurons
Korkotian, E., & Segal, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06115.2001 · Cited by 105 · see citing works
Drakew, A., ̈ller, M. M., Ga¨hwiler, B. H., Thompson, S. M., & Frotscher, M. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00379-w · Cited by 73 · see citing works
Umeda, T., Ebihara, T., & Okabe, S. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.09.010 · Cited by 52 · see citing works
Savić, N., Lüthi, A., Gähwiler, B. H., & McKinney, R. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0831035100 · Cited by 17 · see citing works
Self-citation
Flagged first, then by citations
1 of the 46 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach
Lu, W., Shi, Y., Jackson, A. C., Bjorgan, K., During, M. J., Sprengel, R., Seeburg, P. H., & Nicoll, R. A. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.027 · Cited by 660 · see citing works
Dendritic Spines: The Locus of Structural and Functional Plasticity
Sala, C., & Segal, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00012.2013 · Cited by 465 · see citing works
Auditory dysfunction in schizophrenia: integrating clinical and basic features
Javitt, D. C., & Sweet, R. A. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn4002 · Cited by 363 · see citing works
Miller, O. H., Moran, J. T., & Hall, B. J. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.07.028 · Cited by 200 · see citing works
Anesthetics Rapidly Promote Synaptogenesis during a Critical Period of Brain Development
Roo, M. D., Klauser, P., Briner, A., Nikonenko, I., Méndez, P., Dayer, A. G., Kiss, J. Z., Müller, D., & Vutskits, L. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007043 · Cited by 172 · see citing works
Long-Term Relationships between Synaptic Tenacity, Synaptic Remodeling, and Network Activity
Minerbi, A., Kahana, R., Goldfeld, L., Kaufman, M., Marom, S., & Ziv, N. E. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000136 · Cited by 166 · see citing works
Segal, M. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07270.x · Cited by 152 · see citing works
Heine, M., Thoumine, O. R., Mondin, M., Tessier, B., Giannone, G., & Choquet, D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804007106 · Cited by 138 · see citing works
Excitatory amino acid involvement in dendritic spine formation, maintenance and remodelling
McKinney, R. A. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.178905 · Cited by 133 · see citing works
Self-citationDendritic spines: Morphological building blocks of memory
Segal, M. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.06.007 · Cited by 123 · see citing works
Maras, P. M., Molet, J., Chen, Y., Rice, C., Ji, S. G., Solodkin, A., & Baram, T. Z. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.12 · Cited by 118 · see citing works
O-GlcNAc transferase regulates excitatory synapse maturity
Lagerlöf, O., Hart, G. W., & Huganir, R. L. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1621367114 · Cited by 106 · see citing works
Coexpressed Auxiliary Subunits Exhibit Distinct Modulatory Profiles on AMPA Receptor Function
Khodosevich, K. V., Jacobi, E., Farrow, P., Schulmann, A., Rusu, A., Zhang, L., Sprengel, R., Monyer, H., & von Engelhardt, J. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.004 · Cited by 80 · see citing works
Cysteine String Protein-α Prevents Activity-Dependent Degeneration in GABAergic Synapses
García-Junco-Clemente, P., Cantero, G., Gómez-Sánchez, L., Linares-Clemente, P., Martínez-López, J. A., Luján, R., & Fernández-Chacón, R. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0924-10.2010 · Cited by 79 · see citing works
Hampson, R. E., Miller, F., Palchik, G. A., & Deadwyler, S. A. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.039 · Cited by 66 · see citing works
Activity of the AMPA receptor regulates drebrin stabilization in dendritic spine morphogenesis
Takahashi, H., Yamazaki, H., Hanamura, K., Sekino, Y., & Shirao, T. (2009) · Journal of Cell Science · doi:10.1242/jcs.043729 · Cited by 62 · see citing works
Immune System in the Brain: A Modulatory Role on Dendritic Spine Morphophysiology?
Bitzer-Quintero, O. K., & González‐Burgos, I. (2012) · Neural Plasticity · doi:10.1155/2012/348642 · Cited by 63 · see citing works
The Dendritic Spines of Interneurons Are Dynamic Structures Influenced by PSA-NCAM Expression
Guirado, R., Pérez-Rando, M., Sanchez-Matarredona, D., Castillo-Gómez, E., Liberia, T., Rovira-Esteban, L., Varea, E., Crespo, C., Blasco‐Ibáñez, J. M., & Nácher, J. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht156 · Cited by 58 · see citing works
Alteration of Synaptic Network Dynamics by the Intellectual Disability Protein PAK3
Dubos, A., Combeau, G., Bernardinelli, Y., Barnier, J., Hartley, O., Gaertner, H., Boda, B., & Muller, D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3252-11.2012 · Cited by 54 · see citing works
Vutskits, L. (2012) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31826a1178 · Cited by 53 · see citing works
Perez‐Cruz, C., Simon, M., Czéh, B., Flügge, G., & Fuchs, E. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06622.x · Cited by 51 · see citing works
Costa, L., Santangelo, F., Volsi, G. L., & Ciranna, L. (2008) · Hippocampus · doi:10.1002/hipo.20488 · Cited by 48 · see citing works
Tuning into diversity of homeostatic synaptic plasticity.
Lee, K. F. H., Soares, C., & Beique, J.-C. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.03.016 · Cited by 54 · see citing works
Kuwajima, M., Špaček, J., & Harris, K. M. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.04.061 · Cited by 45 · see citing works
Jiang, H., Liu, J., Xi, K., Liu, L., Kong, L.-Y., Cai, J., Cai, S.-Q., Han, X.-Y., Song, J., Yang, X., et al. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.2678-20.2021 · Cited by 43 · see citing works
EphA Signaling Promotes Actin-based Dendritic Spine Remodeling through Slingshot Phosphatase
Zhou, L., Jones, E. V., & Murai, K. K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.302802 · Cited by 36 · see citing works
Corner, M. A. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.08.001 · Cited by 37 · see citing works
Ardalan, M., Wegener, G., Rafati, A. H., & Nyengaard, J. R. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw098 · Cited by 37 · see citing works
Luczynski, P., Moquin, L., & Gratton, A. P. (2015) · Stress · doi:10.3109/10253890.2015.1073256 · Cited by 33 · see citing works
nArgBP2 regulates excitatory synapse formation by controlling dendritic spine morphology
Lee, S., Kim, Y., Han, J.-K., Park, H.-Y., Lee, U., Na, M., Jeong, S., Chung, C., Cestra, G., & Chang, S. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1600944113 · Cited by 32 · see citing works
Corner, M. A., Baker, R. E., & VANPELT, J. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.06.008 · Cited by 29 · see citing works
Alexander, T. C., Simecka, C. M., Kiffer, F. C., Groves, T. R., Anderson, J. E., Carr, H., Wang, J., Carter, G., & Allen, A. R. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.12.008 · Cited by 29 · see citing works
Letrozole Potentiates Mitochondrial and Dendritic Spine Impairments Induced byβAmyloid
Chang, P. K. ‐., Boridy, S., McKinney, R. A., & Maysinger, D. (2013) · Journal of Aging Research · doi:10.1155/2013/538979 · Cited by 28 · see citing works
Self-citationBencsik, N., Szíber, Z., Liliom, H., Tárnok, K., Borbély, S., Gulyás, M., Rátkai, A. E., Szűcs, A. L., Hazai, D., Ellwanger, K., et al. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201501114 · Cited by 23 · see citing works
A critical period for learning and plastic changes at hippocampal CA1 synapses
Sakimoto, Y., Shintani, A., Yoshiura, D., Goshima, M., Kida, H., & Mitsushima, D. (2022) · Scientific Reports · doi:10.1038/s41598-022-10453-z · Cited by 23 · see citing works
Rößler, N., Jungenitz, T., Sigler, A., Bird, A., Mittag, M., Rhee, J. S., Deller, T., Cuntz, H., Brose, N., Schwarzacher, S. W., et al. (2023) · Open Biology · doi:10.1098/rsob.230063 · Cited by 22 · see citing works
Moyer, C. E., Delevich, K. M., Fish, K. N., Asafu-Adjei, J. K., Sampson, A. R., Dorph‐Petersen, K., Lewis, D. A., & Sweet, R. A. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.06.024 · Cited by 22 · see citing works
Chang, P. K. ‐., Prenosil, G. A., Verbich, D., Gill, R., & McKinney, R. A. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12638 · Cited by 23 · see citing works
Self-citationSex Differences in the Role of CNIH3 on Spatial Memory and Synaptic Plasticity
Frye, H. E., Izumi, Y., Harris, A. N., Williams, S. B., Trousdale, C., Sun, M.-Y., Sauerbeck, A. D., Kummer, T. T., Mennerick, S. J., Zorumski, C. F., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.07.014 · Cited by 20 · see citing works
Crosby, G. J., Culley, D. J., & Patel, P. M. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181cd795d · Cited by 13 · see citing works
Zhu, W., Yang, F., Cai, X., Zhang, W., Zhang, J., Cai, M., Li, X., Xiang, J. Y., & Cai, D. (2020) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-020-01845-x · Cited by 12 · see citing works
Pinzón-Parra, C. A., Coatl-Cuaya, H., Díaz, A., Guevara, J., Moreno, A. R., & Flores, G. (2021) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2021.102054 · Cited by 10 · see citing works
Src-mediated phosphorylation of βPix-b regulates dendritic spine morphogenesis
Shin, M.-S., Song, S., Shin, J. E., Lee, S.-H., Huh, S., & Park, D. (2019) · Journal of Cell Science · doi:10.1242/jcs.224980 · Cited by 10 · see citing works
Takahashi, H., & Naito, Y. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-4-431-56550-5_10 · Cited by 10 · see citing works
Gao, A. Y. L., Inglebert, Y., Shi, R., Ilie, A., Popić, J., Mustian, J., Sonenberg, N., Orlowski, J., & McKinney, R. A. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167529 · Cited by 3 · see citing works
Self-citationHomeostasis of dendritic spines in hippocampal CA1 cells
Mestrallet, C. A. (2011) · UCL Discovery (University College London) · Cited by 2 · see citing works
Dendritic Spine Plasticity and Memory Formation
Ammassari‐Teule, M., & Segal, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21113-9 · Cited by 1 · see citing works
Effects of neuronal Nogo-A on properties of excitatory synapses of the sensorimotor cortex
Case, A. M. (2011) · Loyola eCommons (Loyola University of Chicago)
Characterization of HDAC4's role in brain
Darcy, M. (2010)
Sandi, C. (2014) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718297966.793492714
Satiation is associated with OGT-dependent regulation of excitatory synapsesPreprint
Pozo, M. P. D., Bhattacharjee, M., Tripathi, A., Boafo, T., Galizia, S., Medini, P., Druzin, M., & Lagerlöf, O. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.02.673689
- Authors
- Mateos, J. M., Lüthi, A., Savic, N., Stierli, B., Streit, P., Gähwiler, B. H., & McKinney, R. A.
- Affiliations
- Friedrich Miescher Institute (CH)
- University of Zurich (CH)
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2007-05-04
- Volume
- 581
- Issue
- 1
- Pages
- 129-138
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC2075211
- OpenAlex
- W1601226735
- Cited by
- 53
- References
- 46
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 4 · 2012: 6
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- AMPA receptor blockade, dendritic spines, CA3-CA1 synapses, hippocampus, synaptic density, synaptic efficacy, bidirectional synaptic plasticity, glutamatergic synapses, synaptic pruning, pyramidal neurons
- MeSH terms
- Animals, Cells, Cultured, Dendritic Cells, Electrophysiology, Hippocampus, Synaptic Transmission, Neuronal Plasticity, Quinoxalines, Synapses, Receptors, N-Methyl-D-Aspartate, Pyramidal Cells, Receptors, AMPA, Excitatory Amino Acid Antagonists, Excitatory Postsynaptic Potentials, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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