The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
SYMPOSIUM REVIEW: Lipid microdomains and the regulation of ion channel function: Channels and rafts
Open accessAbstract
Many types of ion channel localize to cholesterol and sphingolipid-enriched regions of the plasma membrane known as lipid microdomains or 'rafts'. The precise physiological role of these unique lipid microenvironments remains elusive due largely to difficulties associated with studying these potentially extremely small and dynamic domains. Nevertheless, increasing evidence suggests that membrane rafts regulate channel function in a number of different ways. Raft-enriched lipids such as cholesterol and sphingolipids exert effects on channel activity either through direct protein-lipid interactions or by influencing the physical properties of the bilayer. Rafts also appear to selectively recruit interacting signalling molecules to generate subcellular compartments that may be important for efficient and selective signal transduction. Direct interaction with raft-associated scaffold proteins such as caveolin can also influence channel function by altering gating kinetics or by affecting trafficking and surface expression. Selective association of ion channels with specific lipid microenvironments within the membrane is thus likely to be an important and fundamental regulatory aspect of channel physiology. This brief review highlights some of the existing evidence for raft modulation of channel function.
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Cites
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Omega-3 Fatty Acids and Cardiovascular Disease
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(n-3) Fatty Acids and Cardiovascular Health: Are Effects of EPA and DHA Shared or Complementary?
Mozaffarian, D., & Wu, J. H. Y. (2012) · The Journal of Nutrition · doi:10.3945/jn.111.149633 · Cited by 368
Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1
Bae, C., Gnanasambandam, R., Nicolai, C., Sachs, F., & Gottlieb, P. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219777110 · Cited by 313
Cholesterol in brain disease: Sometimes determinant and frequently implicated
Martín, M. G., Pfrieger, F., & Dotti, C. G. (2014) · The EMBO Reports · doi:10.15252/embr.201439225 · Cited by 304
Dysregulation of lipids in Alzheimer’s disease and their role as potential biomarkers
Wong, M. W., Braidy, N., Poljak, A., Pickford, R., Thambisetty, M., & Sachdev, P. S. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.01.008 · Cited by 223
Metadata
- Authors
- Dart, C.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2010-08-31
- Volume
- 588
- Issue
- 17
- Pages
- 3169-3178
- ISSN
- 0022-3751 (ISSN-L)
- OpenAlex
- W1543809086
- Cited by
- 268
- References
- 59
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- green
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- Dart, C. (2010). SYMPOSIUM REVIEW: Lipid microdomains and the regulation of ion channel function: Channels and rafts. The Journal of Physiology. https://doi.org/10.1113/jphysiol.2010.191585
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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