Effects of resveratrol in patients with type 2 diabetes mellitus on skeletal muscle SIRT1 expression and energy expenditure
Abstract
OBJECTIVES: The primary aims of the study were to examine the effect of resveratrol on skeletal muscle SIRT1 expression and energy expenditure in subjects with Type 2 diabetes mellitus (T2DM). BACKGROUND: Animal and in vivo studies indicate that resveratrol increases SIRT1 expression that stimulates PGC1α activity. Subsequent upregulation of AMPK and GLUT4 expression are associated with improved insulin sensitivity in peripheral tissues. METHODS: Ten subjects with T2DM were randomized in a double-blind fashion to receive 3g resveratrol or placebo daily for 12 weeks. Secondary outcomes include measures of AMPK, p-AMPK and GLUT4 expression levels, energy expenditure, physical activity levels, distribution of abdominal adipose tissue and skeletal muscle fiber type composition, body weight, HbA1c, plasma lipid subfraction, adiponectin levels, and insulin sensitivity. RESULTS: There was a significant increase in both SIRT1 expression (2.01 vs. 0.86 arbitrary units [AU], p = .016) and p-AMPK to AMPK expression ratio (2.04 vs. 0.79 AU, p = .032) in the resveratrol group compared with the placebo group. Although the percentage of absolute change (8.6 vs. -13.9%, p = .033) and percentage of predicted resting metabolic rate (RMR; 7.8 vs. -13.9%, p = .013) were increased following resveratrol, there was a significant reduction in average daily activity (-38 vs. 43.2%, p = .028) and step counts (-39.5 vs. 11.8%, p = .047) when compared with placebo. CONCLUSIONS: In patients with T2DM, treatment with resveratrol regulates energy expenditure through increased skeletal muscle SIRT1 and AMPK expression. These findings indicate that resveratrol may have beneficial exercise-mimetic effects in patients with T2DM.
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Resveratrol activates both AMPK and sirtuin 1 in insulin-sensitive peripheral tissues, especially skeletal muscles.
“In these studies, treatment with resveratrol has proved to activate both fuel-sensors AMPK and sirtuin 1 in insulin-sensitive peripheral tissues, especially skeletal muscles.”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [150]
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Antioxidant effects of resveratrol in the cardiovascular system
Xia, N., Daiber, A., Förstermann, U., & Li, H. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13492 · Cited by 576 · see citing works
Health benefits of resveratrol: Evidence from clinical studies
Singh, A. P., Singh, R., Verma, S. S., Rai, V., Kaschula, C. H., Maiti, P., & Gupta, S. C. (2019) · Medicinal Research Reviews · doi:10.1002/med.21565 · Cited by 523 · see citing works
“In one patient, mild elevation in ALT was reported while in other, mild hypoglycemia and diarrhea were observed.(253) In addition, bleeding and bruising effects may be seen due to antiplatelet effects of resveratrol, especially, in the patients using blood anticoagulants such as clopidogrel (Plavix), enoxaparin (Loven…”
BackgroundResveratrol and diabetes: from animal to human studies.
Szkudelski, T., & Szkudelska, K. (2015) · Biochimica et Biophysica Acta · doi:10.1016/j.bbadis.2014.10.013 · Cited by 322 · see citing works
Sirtuins Link Inflammation and Metabolism
Vachharajani, V., Liu, T., Wang, X., Hoth, J. J., Yoza, B. K., & McCall, C. E. (2016) · Journal of Immunology Research · doi:10.1155/2016/8167273 · Cited by 326 · see citing works
“In animalmodels of diabetes, SIRT1 activation increases energy expenditure and improves insulin sensitivity [49, 50].”
Dietary polyphenols as antidiabetic agents: Advances and opportunities
Sun, C., Zhao, C., Çapanoğlu, E., Paoli, P., Simal‐Gándara, J., Ramkumar, K. M., Wang, S., Buleu, F. N., Pah, A.-M., Turi, V., et al. (2020) · Food Frontiers · doi:10.1002/fft2.15 · Cited by 303 · see citing works
“Upregulation of GLUT4 by AMPK phosphorylation in skeletal muscle has also been observed in a clinical trial carried out in a cohort of diabetic subjects (Goh et al., 2014).”
BackgroundDietary polyphenols and type 2 diabetes: Human Study and Clinical Trial
Cao, H., Ou, J., Chen, L., Zhang, Y., Szkudelski, T., Delmas, D., Daglia, M., & Xiao, J. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1492900 · Cited by 293 · see citing works
The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases
Jiao, F., & Gong, Z. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/6782872 · Cited by 293 · see citing works
“It is also widely expressed in several human tissues and organ, including the brain [77], liver [78], heart [79], skeletal muscle [80], pancreas [81], and adipose tissue [82].”
BackgroundResveratrol: from enhanced biosynthesis and bioavailability to multitargeting chronic diseases
Pannu, N., & Bhatnagar, A. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.11.075 · Cited by 289 · see citing works
Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases
Mirabelli, M., Chiefari, E., Arcidiacono, B., Corigliano, D. M., Brunetti, F. S., Maggisano, V., Russo, D., Foti, D. P., & Brunetti, A. (2020) · Nutrients · doi:10.3390/nu12041066 · Cited by 272 · see citing works
Caloric restriction mimetics: towards a molecular definition
Madeo, F., Pietrocola, F., Eisenberg, T., & Kroemer, G. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4391 · Cited by 264 · see citing works
Current evidence on the effect of dietary polyphenols intake on chronic diseases
Costa, C., Tsatsakis, A. M., Mamoulakis, C., Teodoro, M., Briguglio, G., Caruso, E., Tsoukalas, D., Margina, D. M., Dardiotis, E., Kouretas, D., et al. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.10.023 · Cited by 262 · see citing works
Esser, N., Paquot, N., & Scheen, A. J. (2014) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2015.974804 · Cited by 252 · see citing works
Jakab, J., Miškić, B., Mikšić, Š., Juranić, B., Ćosić, V., Schwarz, D., & Včev, A. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s281186 · Cited by 256 · see citing works
“In another study on patients with T2DM, RSV increased SIRT1 and AMPK expression in muscles.(135) However, its prophylactic administration to non-obese individuals showed no significant effect on insulin sensitivity, blood pressure, and body composition.”
BackgroundResveratrol supplementation: Where are we now and where should we go?
Novelle, M. G., Wahl, D., Diéguez, C., Bernier, M., & de Cabo, R. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.01.002 · Cited by 247 · see citing works
“, 011) and T2DM patients (Goh et al., 2014).”
InfluentialFunctional foods and dietary supplements for the management of dyslipidaemia
Hunter, P. M., & Hegele, R. A. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.210 · Cited by 226 · see citing works
Resveratrol and endothelial function: A literature review
Parsamanesh, N., Asghari, A., Sardari, S., Tasbandi, A., Jamialahmadi, T., Xu, S., & Sahebkar, A. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105725 · Cited by 210 · see citing works
Milardi, D., Gazit, E., Radford, S. E., Xu, Y., Gallardo, R. U., Caflisch, A., Westermark, G. T., Westermark, P., Rosa, C. L., & Ramamoorthy, A. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00981 · Cited by 199 · see citing works
Zhu, X., Wu, C., Qiu, S., Yuan, X., & Li, L. (2017) · Nutrition & Metabolism · doi:10.1186/s12986-017-0217-z · Cited by 196 · see citing works
“[27] provided an important evidence to support that resveratrol is a potential glucose-lowering agent in T2DM patients, either through SIRT1 or AMPK activation.”
BackgroundResveratrol and diabetes: A critical review of clinical studies
Öztürk, E., Arslan, A. K. K., Yerer, M. B., & Bishayee, A. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.08.070 · Cited by 184 · see citing works
Brown, K., Theofanous, D., Britton, R. G., Aburido, G., Pepper, C., Undru, S. S., & Howells, L. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020747 · Cited by 190 · see citing works
Hausenblas, H. A., Schoulda, J. A., & Smoliga, J. M. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400173 · Cited by 175 · see citing works
Food Polyphenols and Type II Diabetes Mellitus: Pharmacology and Mechanisms
Naz, R., Saqib, F., Awadallah, S. M., Wahid, M., Latif, M. F., Iqbal, I., & Mubarak, M. S. (2023) · Molecules · doi:10.3390/molecules28103996 · Cited by 175 · see citing works
Sattarinezhad, A., Roozbeh, J., Yeganeh, B. S., Omrani, G. R., & Shams, M. (2018) · Diabetes & Metabolism · doi:10.1016/j.diabet.2018.05.010 · Cited by 148 · see citing works
“[14] used doses of 500 mg/day of resveratrol with 500-mg increments every 3 days to a maximum of 3 g/day for 12 weeks in 10 diabetes patients: there were no significant changes in serum creatinine levels in any patient at the end of the study.”
MethodSin, T. K., Yung, B. Y., & Siu, P. M. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000369718 · Cited by 141 · see citing works
Resveratrol, human health and winemaking perspectives
Pastor, R. F., Restani, P., Di Lorenzo, C., Orgiu, F., Teissedre, P.-L., Stockley, C., Ruf, J. C., Quini, C. I., Garcìa Tejedor, N., Gargantini, R., et al. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1400517 · Cited by 123 · see citing works
Rovira‐Llopis, S., Apostolova, N., Bañuls, C., Muntané, J., Rocha, M., & Víctor, V. M. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7313 · Cited by 120 · see citing works
“…evidence obtained in vitro , in vivo , and in patients supports the beneficial effect of resveratrol on diabetes; it increases mitochondrial biogenesis, metabolic rate, insulin sensitivity, and glucose tolerance, and protects against premature death due to a HFD in mice (23, 98, 160, 285, 310).”
SIRT1-FOXOs activity regulates diabetic complications
Jalgaonkar, M. P., Parmar, U. M., Kulkarni, Y. A., & Oza, M. J. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.106014 · Cited by 117 · see citing works
The beneficial therapeutic effects of plant‐derived natural products for the treatment of sarcopenia
Bagherniya, M., Mahdavi, A., Mashhadi, N. S., Banach, M., von Haehling, S., Johnston, T. P., & Sahebkar, A. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13057 · Cited by 118 · see citing works
“Resveratrol has a critical role in contractile protein accumulation and muscle strength by improving overall muscle function, as well as causing an enhancement in muscle fibre cross-sectional area.(49,95,96) These resveratrol-mediated changes appear to contribute to the enhancement of satellite cell proliferation in t…”
BackgroundThe role of nutraceuticals in the prevention of cardiovascular disease
Sosnowska, B., Penson, P. E., & Banach, M. (2017) · Cardiovascular Diagnosis and Therapy · doi:10.21037/cdt.2017.03.20 · Cited by 113 · see citing works
“The mechanism of action of resveratrol in the treatment of diabetes mellitus seems to be multifactorial; resveratrol may have antioxidant properties, increase AMPK activation, and increase internalization of glucose through modulating glucose transporter expression (98-100).”
BackgroundCaloric Restriction Mimetics in Nutrition and Clinical Trials
Hofer, S. J., Davinelli, S., Bergmann, M., Scapagnini, G., & Madeo, F. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.717343 · Cited by 109 · see citing works
Madkour, M. I., El-Serafi, A. T., Jahrami, H., Sherif, N. M., Hassan, R. E., Awadallah, S. M., & Faris, M. E. (2019) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2019.107801 · Cited by 112 · see citing works
“This relationship was further supported in the animal models of diabetes when SIRT1 activation improved insulin sensitivity and increased energy expenditure [47,48].”
BackgroundResultSignificance of Resveratrol in Clinical Management of Chronic Diseases
Wahab, A., Gao, K., Jia, C., Zhang, F., Tian, G., Murtaza, G., & Chen, J. (2017) · Molecules · doi:10.3390/molecules22081329 · Cited by 108 · see citing works
“5–3 g/day) and hypoglycemic agents for 3 months no decrease in glucose metabolic markers and HbA1c level was observed [83].”
BackgroundHuman Sirtuin Regulators: The “Success” Stories
Curry, A. M., White, D. S., Donu, D., & Cen, Y. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.752117 · Cited by 105 · see citing works
Krawczyk, M., Burzyńska-Pędziwiatr, I., Woźniak, L. A., & Bukowiecka‐Matusiak, M. (2023) · Biomolecules · doi:10.3390/biom13091402 · Cited by 114 · see citing works
Tabrizi, R., Tamtaji, O. R., Lankarani, K. B., Akbari, M., Dadgostar, E., Dabbaghmanesh, M. H., Kolahdooz, F., Shamshirian, A., Momen–Heravi, M., & Asemi, Z. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1529654 · Cited by 99 · see citing works
“Increased gene expression of skeletal muscle SIRT1and AMPK suggesting potential beneficial exercisemimetic effects (Goh et al. 2014).”
BackgroundRegulation of SERCA pumps expression in diabetes
Zarain‐Herzberg, Á., García‐Rivas, G., & Estrada‐Avilés, R. (2014) · Cell Calcium · doi:10.1016/j.ceca.2014.09.005 · Cited by 98 · see citing works
“that treatment with Resveratrol may have exercise-mimetic effects in patients with T2DM [50].”
BackgroundSIRT1/SREBPs-mediated regulation of lipid metabolism
Shen, S., Shen, M., Kuang, L., Yang, K., Wu, S., Liu, X., Wang, Y., & Wang, Y. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.107037 · Cited by 98 · see citing works
Plant extracts in prevention of obesity
Wang, H., Xiang, J., Qi, Z., & Du, . (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1852171 · Cited by 81 · see citing works
“Interestingly, resveratrol upregulated the expression of AMPK and SIRT1, which are closely associated with the improvement in energy metabolism and muscle mitochondrial respiration in obese men and type 2 diabetics (Goh et al. 2014; Timmers et al. 2011).”
BackgroundKomorowska, D., Radzik, T., Kalenik, S., & Rodacka, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810627 · Cited by 82 · see citing works
“These results indicated that resveratrol may have beneficial exercise-mimetic effects in type 2 diabetes patients [120].”
BackgroundJózkowiak, M., Hutchings, G., Jankowski, M., Kulcenty, K. I., Mozdziak, P. E., Kempisty, B., Spaczyński, R., & Piotrowska‐Kempisty, H. (2020) · Cells · doi:10.3390/cells9061418 · Cited by 76 · see citing works
“Diabetes mellitus exercise-like effects in patients with type 2 diabetes mellitus via energy expenditure regulation, associated with increased SIRT-1 and AMPK expression in skeletal muscle [62]”
BackgroundResveratrol for adults with type 2 diabetes mellitus
Jeyaraman, M. M., Al‐Yousif, N., Mann, A. S., Dolinsky, V. W., Rabbani, R., Zarychanski, R., & Abou-Setta, A. M. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011919.pub2 · Cited by 74 · see citing works
“Goh 2014 {published data only} * Goh KP, Lee HY, Lau DP, Supaat W, Chan YH, Koh AF.”
BackgroundInfluentialMechanisms Underlying the Antidiabetic Activities of Polyphenolic Compounds: A Review
Nie, T., & Cooper, G. J. S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.798329 · Cited by 70 · see citing works
“Resveratrol (Penumathsa et al., 2008; Do et al., 2012; Goh et al., 2014) and curcumin (Na et al., 2011) have been shown to activate AMPK with a concomitant increase in GLUT-4 levels or translocation to the cell membrane.”
BackgroundGarcía-Martínez, B. I., Ruíz-Ramos, M., Pedraza‐Chaverrí, J., Santiago‐Osorio, E., & Mendoza-Núñez, V. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087422 · Cited by 73 · see citing works
Are epigenetic drugs for diabetes and obesity at our door step?
Arguelles, A. O., Meruvu, S., Bowman, J. D., & Choudhury, M. (2015) · Drug Discovery Today · doi:10.1016/j.drudis.2015.12.001 · Cited by 70 · see citing works
Mousavi, S. M., Milajerdi, A., Sheikhi, A., Kord‐Varkaneh, H., Feinle‐Bisset, C., Larijani, B. A., & Esmaillzadeh, A. (2018) · Obesity Reviews · doi:10.1111/obr.12775 · Cited by 67 · see citing works
“Four trials (35,36,40,45) recommended either a special diet or a physical activity programme with the resveratrol supplementation.”
BackgroundInfluentialPreconception resveratrol intake against infertility: Friend or foe?
Ochiai, A., & Kuroda, K. (2019) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12303 · Cited by 66 · see citing works
Protective role of mitoquinone against impaired mitochondrial homeostasis in metabolic syndrome
Yang, J., Suo, H., & Song, J. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1809344 · Cited by 66 · see citing works
Navarro, G., Martínez‐Pinilla, E., Ortiz, R., Noé, V., Ciudad, C. J., & Franco, R. (2018) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12359 · Cited by 63 · see citing works
Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus
Martiniaková, M., Šarocká, A., Pénzes, N., Bíro, R., Kováčová, V., Mondočková, V., Ševčíková, A., Čierniková, S., & Omelka, R. (2025) · Nutrients · doi:10.3390/nu17020275 · Cited by 62 · see citing works
Abdollahi, S., Salehi‐Abargouei, A., Toupchian, O., Sheikhha, M. H., Fallahzadeh, H., Rahmanian, M., Tabatabaie, M., & Mozaffari–Khosravi, H. (2019) · Phytotherapy Research · doi:10.1002/ptr.6487 · Cited by 57 · see citing works
“Moreover, it has been proposed that resting metabolic rate (RMR) increased following resveratrol supplementation through AMPK activation (Goh et al., 2014).”
BackgroundAkbari, M., Tamtaji, O. R., Lankarani, K. B., Tabrizi, R., Dadgostar, E., Haghighat, N., Kolahdooz, F., Ghaderi, A., Mansournia, M. A., & Asemi, Z. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-1198-x · Cited by 57 · see citing works
Raimundo, A., Félix, F. I. B., Andrade, R., García‐Conesa, M., González‐Sarrías, A., Gilsa-Lopes, J., Ó, D. D., Raimundo, A., Ribeiro, R. T., Rodriguez‐Mateos, A., et al. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02189-1 · Cited by 55 · see citing works
Resveratrol interferes with the aggregation of membrane-bound human-IAPP: A molecular dynamics study
Lolicato, F., Raudino, A., Milardi, D., & Rosa, C. L. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.01.047 · Cited by 55 · see citing works
“In particular resveratrol (trans-3,5,40-trihydroxystilben), has evidenced significant beneficial effects in patients with T2DM [20].”
BackgroundCao, X., Liao, W., Xia, H., et al. (2022) · Nutrients · doi:10.3390/nu14183755 · Cited by 54 · see citing works
“1 50–75 23/23 26 week 200 parallel Goh [22] 2014 Singapore T2DM 0 40–69 5/5 12 week 3000 parallel”
Exercise Pills: At the Starting Line
Li, S., & Laher, I. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.08.014 · Cited by 54 · see citing works
“Resveratrol Phytochemical Cardiovascular PGC-1//NO Mitochondrial biogenesis Angiogenesis [13,86–101]”
BackgroundMomtaz, S., Maghsoudi, A. S., Abdolghaffari, A. H., Jasemi, E., Rezazadeh, S., Hassani, S., Ziaee, M., Abdollahi, M. R., Behzad, S., & Nabavi, S. M. (2019) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2019.1648376 · Cited by 55 · see citing works
Dietary stimulators of GLUT4 expression and translocation in skeletal muscle: A mini‐review
Gannon, N. P., Conn, C. A., & Vaughan, R. A. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400414 · Cited by 53 · see citing works
Polley, K. R., Jenkins, N. T., O’Connor, P. J., & McCully, K. K. (2015) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2015-0370 · Cited by 51 · see citing works
“Some studies show upregulation of mitochondria and the pathways that lead to increased mitochondrial capacity (Timmers et al. 2011; Goh et al. 2014), while others show minimal (Voduc et al. 2014) or attenuated training adaptations (Gliemann et al. 2013; Olesen et al. 2014; Scribbans et al. 2014;…”
BackgroundResultInfluentialZhao, H., Zhang, Y., Shu, L., Song, G., & Ma, H. (2019) · Drug Design Development and Therapy · doi:10.2147/dddt.s203833 · Cited by 51 · see citing works
“Fourth, resveratrol can activate AMPdependent protein kinase.(23) Figure 5 Relative proteins expression of insulin signaling pathway after resveratrol treatment.”
BackgroundSIRT1 signaling pathways in sarcopenia: Novel mechanisms and potential therapeutic targets
Yang, L., Liu, D., Jiang, S., Li, H., Chen, L., Wu, Y., Essien, A. E., Opoku, M., Naranmandakh, S., Liu, S., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116917 · Cited by 54 · see citing works
Maissan, P., Mooij, E., & Barberis, M. (2021) · Biology · doi:10.3390/biology10030194 · Cited by 50 · see citing works
Ali, S. A., Singh, G., & Datusalia, A. K. (2021) · Phytotherapy Research · doi:10.1002/ptr.7068 · Cited by 49 · see citing works
“A proof-of-concept study stated that daily supplementation of resveratrol for (12 weeks) showed antidiabetic effect by inducing the expression of GLUT4, p- AMPK and SIRT1 in skeletal muscles of patients with type 2 diabetes mellitus (Goh et al., 2014).”
BackgroundChristenson, J., Whitby, S. J., Mellor, D., Thomas, J., McKune, A., Roach, P. D., & Naumovski, N. (2016) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2016.0035 · Cited by 47 · see citing works
“40 Overall, risk of bias did not appear to influence study outcome with respect to body weight, BMI, or inflammatory markers.”
InfluentialZeraattalab-Motlagh, S., Jayedi, A., & Shab‐Bidar, S. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab250 · Cited by 48 · see citing works
Basavarajappa, S. C., & Nandini, C. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.12.031 · Cited by 46 · see citing works
Resveratrol supplementation and type 2 diabetes: a systematic review and meta-analysis
Delpino, F. M., & Figueiredo, L. M. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1875980 · Cited by 45 · see citing works
“The smallest sample size was ten individuals (Goh et al. 2014), and the highest 179 (Bo et al.”
BackgroundInfluentialCao, M., Lu, X., Liu, G., Su, Y., Li, Y., & Zhou, J. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5400 · Cited by 45 · see citing works
“Furthermore, the results of an in vivo study indicated that RSV increases SIRT1 expression and stimulates PGC-1a activity in skeletal muscle (24).”
RetractedResveratrol Counteracts Insulin Resistance—Potential Role of the Circulation
Wong, R. H. X., & Howe, P. R. C. (2018) · Nutrients · doi:10.3390/nu10091160 · Cited by 44 · see citing works
“The mechanisms through which resveratrol may improve insulin sensitivity in T2DM are complex, encompassing reduced adiposity and changes in gene expression and activity of key enzymes [19,23].”
BackgroundInfluentialGu, W., Geng, J., Zhao, H., et al. (2022) · International Journal of Clinical Practice · doi:10.1155/2022/9734738 · Cited by 43 · see citing works
“*e eligible studies included seven studies conducted in Iran [19–25], three studies reported from China [26–28], two studies reported from India [29, 30], and one study each performed in Australia [31], Egypt [32], Netherlands [33], Singapore [34], Japan [35], Spain [36], and Italy [37].”
Coadjuvants in the Diabetic Complications: Nutraceuticals and Drugs with Pleiotropic Effects
Pereira, T. D. M. C., Pimenta, F. S., Porto, M. L., Baldo, M. P., Campagnaro, B. P., Gava, A. L., Meyrelles, S. S., & Vasquez, E. C. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081273 · Cited by 43 · see citing works
“[138] showed improvement of insulin sensitivity via SIRT1 through 3000 mg of resveratrol for 12 weeks in type-2 diabetic patients.”
BackgroundTargeting Abdominal Obesity and Its Complications with Dietary Phytoestrogens
Kuryłowicz, A., Cakala, M., & Puzianowska‐Kuźnicka, M. (2020) · Nutrients · doi:10.3390/nu12020582 · Cited by 43 · see citing works
In Search of New Therapeutic Targets in Obesity Treatment: Sirtuins
Kuryłowicz, A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040572 · Cited by 43 · see citing works
Resveratrol for patients with chronic obstructive pulmonary disease
Beijers, R. J. H. C. G., Gosker, H. R., & Schols, A. M. W. J. (2017) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000444 · Cited by 41 · see citing works
Hypoglycemic Effect of Resveratrol: A Systematic Review and Meta-Analysis
García-Martínez, B. I., Ruíz-Ramos, M., Pedraza‐Chaverrí, J., Santiago‐Osorio, E., & Mendoza-Núñez, V. M. (2021) · Antioxidants · doi:10.3390/antiox10010069 · Cited by 39 · see citing works
“(2014) [34] RCT double-blind 3 g/day 12 weeks 10 subjects with T2DM 56 ± 6 Glucose and insulin levels, HbA1c, HOMA-IR Tendency of a decrease in HbA1c, no significant changes in insulin sensitivity”
Peripheral targets in obesity treatment: a comprehensive update
Chatzigeorgiou, A., Kandaraki, E., Papavassiliou, A. G., & Koutsilieris, M. (2014) · Obesity Reviews · doi:10.1111/obr.12163 · Cited by 40 · see citing works
García-Martínez, B. I., Ruíz-Ramos, M., Pedraza‐Chaverrí, J., Santiago‐Osorio, E., & Mendoza-Núñez, V. M. (2022) · Molecules · doi:10.3390/molecules27165232 · Cited by 39 · see citing works
“Published data included in review (n = 11) IRCT2016100716876N2, NCT02704494 (Sattarinezhad, 2019) [35], IRCT2015080223336N2 (Khodabandehloo, 2018) [30], IRCT2015072523336N1 (Seyyedebrahimi, 2018) [31], IRCT2015012420765N1 (Javid, 2016) [29], ACTRN12613000717752 (Thazhath, 2016) [39], IRCT201111198129N1 (Movahed, 2013)…”
BackgroundResultInfluentialMa, N., & Zhang, Y. (2022) · Medicine · doi:10.1097/md.0000000000030049 · Cited by 38 · see citing works
“[26] Conversely, our results showed that resveratrol treatment not only decreased inflammation but also improved kidney function and insulin resistance in the elderly patients with type 2 diabetes mellitus A study found that resveratrol supplementation shows the anti-inflammatory effects and regulates energy expenditu…”
Lin, C., Sun, X., & Lin, A.-X. (2016) · Renal Failure · doi:10.3109/0886022x.2015.1128236 · Cited by 38 · see citing works
Hajighasem, A., Farzanegi, P., Mazaheri, Z., Naghizadeh, M., & Salehi, G. (2018) · PeerJ · doi:10.7717/peerj.5522 · Cited by 38 · see citing works
“Similarly, previous studies reported that resveratrol supplement can improve NAFLD through overexpression of Sirt1 and activation of AMPK-alpha pathway (Goh et al., 2014; Wang et al., 2016).”
BackgroundActivation of AMPK by Medicinal Plants and Natural Products: Its Role in Type 2 Diabetes Mellitus
Francini, F., Schinella, G. R., & Rı́os, J.-L. (2018) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557519666181128120726 · Cited by 37 · see citing works
Zhao, H., Song, A., Zhang, Y., Shu, L., Song, G., & Ma, H. (2018) · Obesity · doi:10.1002/oby.22348 · Cited by 36 · see citing works
“Bias risk assessment outcome The bias risk assessment for the included studies (16-25) is shown in Figure 1.”
BackgroundThe role of resveratrol in diabetes and obesity associated with insulin resistance
Hoca, M., Becer, E., & Vatansever, H. S. (2021) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2021.1893338 · Cited by 36 · see citing works
Nutrigenomics in Regulating the Expression of Genes Related to Type 2 Diabetes Mellitus
Felisbino, K., Granzotti, J. G., Bello-Santos, L., & Guiloski, I. C. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.699220 · Cited by 36 · see citing works
“…Luteolin and genistein can cause acetylation of histone H3 and cause hypermethylation of genes and cause inhibition, as well as resveratrol and folic acid (Han, 2003; Collins et al., 2007; Berner et al., 2011; Vetterli et al., 2011; Goh et al., 2014; Boyanapalli and Kong, 2015; Li et al., 2015).”
BackgroundTshivhase, A. M., Matsha, T. E., & Raghubeer, S. (2024) · Scientific Reports · doi:10.1038/s41598-023-50084-6 · Cited by 38 · see citing works
“7e,f), as shown by previous research 49 .”
Guo, X., Li, J., Tang, J., & Li, D. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1349076 · Cited by 35 · see citing works
“…Konno et al., 2013; Kumar and Joghee, 2013; Movahed et al., 2013; Poulsen et al., 2013; Anton et al., 2014; Bashmakov et al., 2014; Chachay et al., 2014; Goh et al., 2014; Witte et al., 2014; Chen et al., 2015; Macedo et al., 2015; Heebøll et al., 2016; Thazhath et al., 2016; Zortea et al., 2016).”
BackgroundResultInfluentialCapozzi, A., Saucier, C., Bisbal, C., & Lambert, K. (2022) · Molecules · doi:10.3390/molecules27196594 · Cited by 37 · see citing works
Sin, T. K., Tam, B. T., Yu, A. P., Yip, S. P., Yung, B. Y., Chan, L., Wong, S. C. C., Rudd, J. A., & Siu, P. M. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv175 · Cited by 33 · see citing works
Nyambuya, T. M., Nkambule, B. B., Mazibuko-Mbeje, S. E., Mxinwa, V., Mokgalaboni, K., Orlando, P., Silvestri, S., Louw, J., Tiano, L., & Dludla, P. V. (2020) · Molecules · doi:10.3390/molecules25235645 · Cited by 33 · see citing works
“, 2014 [39] Singapore Total = 10 (n = 5 controls/n = 5 intervention) Average = 56 (100%) T2D patients, oral hypoglycemic agents, received resveratrol at a dose of 3 g or placebo for 3 months Resveratrol regulated energy expenditure through increased skeletal muscle NAD-dependent deacetylase sirtuin-1 (SIRT1) and 5′ AM…”
BackgroundGarcía‐Viñuales, S., Sciacca, M. F. M., Lanza, V., Santoro, A. M., Grasso, G., Tundo, G. R., Sbardella, D., Coletta, M., Grasso, G., Rosa, C. L., et al. (2021) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2021.105072 · Cited by 33 · see citing works
Nuclear receptors and AMPK: can exercise mimetics cure diabetes?
Wall, C. E., Yu, R. T., Atkins, A. R., Downes, M., & Evans, R. M. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0073 · Cited by 32 · see citing works
Sin, T. K., Yu, A. P., Yung, B. Y., Yip, S. P., Chan, L., Wong, S. C. C., Rudd, J. A., & Siu, P. M. (2015) · Acta Diabetologica · doi:10.1007/s00592-015-0767-3 · Cited by 32 · see citing works
“Previous studies have unravelled that resveratrol dose-dependently increased glucose uptake in L6 myotubes in the absence of insulin stimulation [25] and the expression of SIRT1 and GLUT4 was concomitantly increased in the skeletal muscle of type 2 diabetic patients supplemented with resveratrol [26].”
BackgroundImplications of Resveratrol on Glucose Uptake and Metabolism
León, D., Uribe, E. A., Zambrano, Á., & Salas, M. (2017) · Molecules · doi:10.3390/molecules22030398 · Cited by 32 · see citing works
“A clinical study on a cohort of 10 male diabetic patients revealed that a 12-week RSV treatment induced the upregulation of GLUT4 by AMPK phosphorylation in skeletal muscle [37], revealing one of the putative molecular targets that may induce the observed antidiabetic effects of RSV.”
BackgroundReguero, M., de Cedrón, M. G., Wagner, S., Reglero, G., Quintela, J. C., & de Molina, A. R. (2021) · Cancers · doi:10.3390/cancers13040866 · Cited by 31 · see citing works
“[212] Resveratrol Part of a randomized, double-blind, parallel group trial (10 men T2DM 12 wk 2 g/d) No changes in BMI, AT mass ↑ resting EE, SIRT1, AMPK expression in muscle”
BackgroundAbdelhaleem, I. A., Brakat, A. M., Adayel, H. M., Asla, M. M., Rizk, M. A., & Aboalfetoh, A. Y. (2021) · Medicina Clínica · doi:10.1016/j.medcli.2021.06.028 · Cited by 30 · see citing works
Gonçalves, A. C., Gaspar, D., Flores‐Félix, J. D., Falcão, A. C., Alves, G., & Silva, L. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094652 · Cited by 32 · see citing works
“It was also reported that its supplementation (3 g/day) for 12 weeks increased skeletal muscle SIRT1 expression and energy expenditure by upregulating AMPK expression in patients with type 2 diabetes mellitus [170].”
BackgroundResveratrol, a Multitasking Molecule That Improves Skeletal Muscle Health
Toniolo, L., Concato, M., & Giacomello, E. (2023) · Nutrients · doi:10.3390/nu15153413 · Cited by 29 · see citing works
“In turn, mitochondrial activity and PGC-1-alpha modulation have been demonstrated to be strictly associated with better fatty acid oxidation and lipid metabolism [7].”
BackgroundInfluentialPrasad, C., Imrhan, V., Juma, S., Maziarz, M., Prasad, A., Tiernan, C., & Vijayagopal, P. (2015) · Metabolites · doi:10.3390/metabo5040733 · Cited by 28 · see citing works
“Resveratrol consumption (1000 mg/d for 45 days) significantly lowered fasting glucose, insulin concentrations, hemoglobin A-1c levels, and insulin sensitivity (HOMA-IR) in subjects with type 2 diabetes [89].”
Rezaeiamiri, E., Bahramsoltani, R., & Rahimi, R. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.02.006 · Cited by 28 · see citing works
Najafi, M., Nikpayam, O., Tavakoli‐Rouzbehani, O. M., Papi, S., Bioky, A. A., Ahmadiani, E. S., & Sohrab, G. (2021) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2021.102224 · Cited by 27 · see citing works
Sartang, M. M., Mazloom, Z., Sohrabi, Z., Sherafatmanesh, S., & Barati‐Boldaji, R. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.01.012 · Cited by 26 · see citing works
- Authors
- Goh, K. P., Lee, H. Y., Lau, D. P., Supaat, W., Chan, Y. H., & Koh, A. F. Y.
- Affiliations
- Khoo Teck Puat Hospital (SG)
- Venue
- International Journal of Sport Nutrition and Exercise Metabolism
- Publisher
- Human Kinetics
- Published
- 2014-02
- Volume
- 24
- Issue
- 1
- Pages
- 2-13
- ISSN
- 1526-484X (ISSN-L)
- 1543-2742
- OpenAlex
- W2103667012
- Cited by
- 187
- References
- 0
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 12 · 2023: 20 · 2022: 15 · 2021: 24 · 2020: 22 · 2019: 9 · 2018: 17 · 2017: 17 · 2016: 9 · 2015: 10 · 2014: 10
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Sport Nutrition and Exercise Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Medical Research Council
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- resveratrol, type 2 diabetes, SIRT1, AMPK, skeletal muscle, energy expenditure, resting metabolic rate, insulin sensitivity, GLUT4, PGC-1α, physical activity, adiponectin, HbA1c
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Resveratrol, Basal Metabolism, Diabetes Mellitus, Type 2, Double-Blind Method, Energy Metabolism, Physical Exertion, Humans, Insulin Resistance, Male, Middle Aged, Plant Extracts, Rest, Stilbenes, Transcription Factors, Exercise, Muscle, Skeletal, Vitis, Glucose Transporter Type 4, AMP-Activated Protein Kinases, Sirtuin 1
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