Indole and Tryptophan Metabolism: Endogenous and Dietary Routes to Ah Receptor Activation

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

Wikoff, W. R., Anfora, A. T., Liu, J., Schultz, P. G., Lesley, S. A., Peters, E. C., & Siuzdak, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812874106 · Cited by 2,677

Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22

Zelante, T., Iannitti, R. G., Cunha, C., De Luca, A., Giovannini, G., Pieraccini, G., Zecchi, R., D’Angelo, C., Massi-Benedetti, C., Fallarino, F., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.003 · Cited by 2,614

2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

Poland, A., & Knutson, J. C. (1982) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.22.040182.002505 · Cited by 2,515

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

Opitz, C. A., Litzenburger, U. M., Sahm, F., Ott, M., Tritschler, I., Trump, S., Schumacher, T., Jestaedt, L., Schrenk, D., Weller, M., et al. (2011) · Nature · doi:10.1038/nature10491 · Cited by 1,898

Activation of the Aryl Hydrocarbon Receptor by Structurally Diverse Exogenous and Endogenous Chemicals

Denison, M. S., & Nagy, S. R. (2003) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.135828 · Cited by 1,895

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

Quintana, F. J., Basso, A. S., Iglesias, A. H., Korn, T., Farez, M. F., Bettelli, E., Caccamo, M., Oukka, M., & Weiner, H. L. (2008) · Nature · doi:10.1038/nature06880 · Cited by 1,865

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

Veldhoen, M., Hirota, K., Westendorf, A. M., Buer, J., Dumoutier, L., Renauld, J.-C., & Stockinger, B. (2008) · Nature · doi:10.1038/nature06881 · Cited by 1,634

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

Mezrich, J. D., Fechner, J. H., Zhang, X., Johnson, B. P., Burlingham, W. J., & Bradfield, C. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903670 · Cited by 1,601

Immune System Impairment and Hepatic Fibrosis in Mice Lacking the Dioxin-Binding Ah Receptor

Fernandez-Salguero, P., Pineau, T., Hilbert, D. M., McPhail, T., Lee, S. S. T., Kimura, S., Nebert, D. W., Rudikoff, S., Ward, J. M., & Gonzalez, F. J. (1995) · Science · doi:10.1126/science.7732381 · Cited by 1,075

Indole as an intercellular signal in microbial communities

Lee, J.-H., & Lee, J. (2010) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2009.00204.x · Cited by 1,059

Serum Indoxyl Sulfate Is Associated with Vascular Disease and Mortality in Chronic Kidney Disease Patients

Barreto, F. C., Barreto, D. V., Liabeuf, S., Meert, N., Glorieux, G., Temmar, M., Choukroun, G., Vanholder, R., & Massy, Z. A. (2009) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03980609 · Cited by 929

Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development.

Schmidt, J. V., Su, G. H., Reddy, J. K., Simon, M. C., & Bradfield, C. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6731 · Cited by 891

Aryl hydrocarbon receptor ligands in cancer: friend and foe

Murray, I. A., Patterson, A. D., & Perdew, G. H. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3846 · Cited by 883

The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation

Bansal, T., Alaniz, R. C., Wood, T. K., & Jayaraman, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906112107 · Cited by 868

The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells

Qiu, J., Heller, J. J., Guo, X., Chen, Z.-M. E., Fish, K., Fu, Y.-X., & Zhou, L. (2012) · Immunity · doi:10.1016/j.immuni.2011.11.011 · Cited by 859

Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation

Li, Y., Innocentin, S., Withers, D. R., Roberts, N. A., Gallagher, A. R., Grigorieva, E. F., Wilhelm, C., & Veldhoen, M. (2011) · Cell · doi:10.1016/j.cell.2011.09.025 · Cited by 820

Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles

Kiss, E. A., Vonarbourg, C., Kopfmann, S., Hobeika, E., Finke, D., Esser, C., & Diefenbach, A. (2011) · Science · doi:10.1126/science.1214914 · Cited by 801

Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor

Reyes, H., Reisz-Porszasz, S., & Hankinson, O. (1992) · Science · doi:10.1126/science.256.5060.1193 · Cited by 777

The Search for Endogenous Activators of the Aryl Hydrocarbon Receptor

Nguyen, L. P., & Bradfield, C. A. (2008) · Chemical Research in Toxicology · doi:10.1021/tx7001965 · Cited by 709

Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

Nguyen, N. T., Kimura, A., Nakahama, T., Chinen, I., Masuda, K., Nohara, K., Fujii-Kuriyama, Y., & Kishimoto, T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014465107 · Cited by 685

Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract

Monteleone, I., Rizzo, A., Sarra, M., Sica, G., Sileri, P., Biancone, L., MacDonald, T. T., Pallone, F., & Monteleone, G. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.007 · Cited by 656

Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

DiNatale, B. C., Murray, I. A., Schroeder, J. C., Flaveny, C. A., Lahoti, T. S., Laurenzana, E. M., Omiecinski, C. J., & Perdew, G. H. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq024 · Cited by 634

Loss of teratogenic response to 2,3,7,8‐tetrachlorodibenzo‐ p ‐dioxin (TCDD) in mice lacking the Ah (dioxin) receptor

Mimura, J., Yamashita, K., Nakamura, K., Morita, M., Takagi, T. N., Nakao, K., Ema, M., Sogawa, K., Yasuda, M., Katsuki, M., et al. (1997) · Genes to Cells · doi:10.1046/j.1365-2443.1997.1490345.x · Cited by 626

Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Bjeldanes, L. F., Kim, J. Y., Grose, K. R., Bartholomew, J. C., & Bradfield, C. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.21.9543 · Cited by 588

Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

Pilotte, L., Larrieu, P., Stroobant, V., Colau, D., Dolušić, E., Frédérick, R., De Plaen, E., Uyttenhove, C., Wouters, J., Masereel, B., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113873109 · Cited by 572

Association of the Ah receptor with the 90-kDa heat shock protein.

Perdew, G. H. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68314-0 · Cited by 509

Aryl Hydrocarbon Receptor-Mediated Signal Transduction

Rowlands, J. C., & Gustafsson, J.-Å. (1997) · Critical Reviews in Toxicology · doi:10.3109/10408449709021615 · Cited by 497

Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans.

Shapiro, T. A., Fahey, J. W., Wade, K. L., Stephenson, K. K., & Talalay, P. (2001) · PubMed · Cited by 476

Indole is an inter-species biofilm signal mediated by SdiA

Lee, J., Jayaraman, A., & Wood, T. K. (2007) · BMC Microbiology · doi:10.1186/1471-2180-7-42 · Cited by 470

Indirubin and Indigo Are Potent Aryl Hydrocarbon Receptor Ligands Present in Human Urine

Adachi, J., Mori, Y., Matsui, S., Takigami, H., Fujino, J., Kitagawa, H., Miller, C. A., Kato, T., Saeki, K., & Matsuda, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100238200 · Cited by 407

Hepatitis B Virus X-Associated Protein 2 Is a Subunit of the Unliganded Aryl Hydrocarbon Receptor Core Complex and Exhibits Transcriptional Enhancer Activity

Meyer, B. K., Pray-Grant, M. G., Vanden Heuvel, J. P., & Perdew, G. H. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.2.978 · Cited by 386

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Hubbard, T. D., Murray, I. A., Bisson, W. H., Lahoti, T. S., Gowda, K., Amin, S. G., Patterson, A. D., & Perdew, G. H. (2015) · Scientific Reports · doi:10.1038/srep12689 · Cited by 377

Differential Effects of Epinephrine, Norepinephrine, and Indole on Escherichia coli O157:H7 Chemotaxis, Colonization, and Gene Expression

Bansal, T., Englert, D., Lee, J., Hegde, M., Wood, T. K., & Jayaraman, A. (2007) · Infection and Immunity · doi:10.1128/iai.00630-07 · Cited by 358

Certain photooxidized derivatives of tryptophan bind with very high affinity to the Ah receptor and are likely to be endogenous signal substances.

Rannug, A., Rannug, U., Rosenkranz, H. S., Winqvist, L., Westerholm, R., Agurell, E., & Grafström, A. K. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47743-5 · Cited by 357

Lesions of Aryl-hydrocarbon Receptor–deficient Mice

Fernandez-Salguero, P. M., Ward, J. M., Sundberg, J. P., & Gonzalez, F. J. (1997) · Veterinary Pathology · doi:10.1177/030098589703400609 · Cited by 352

Activation of the Ah Receptor by Tryptophan and Tryptophan Metabolites

Heath-Pagliuso, S., Rogers, W. J., Tullis, K., Seidel, S. D., Cenijn, P. H., Brouwer, A., & Denison, M. S. (1998) · Biochemistry · doi:10.1021/bi980087p · Cited by 331

The Uremic Toxin 3-Indoxyl Sulfate Is a Potent Endogenous Agonist for the Human Aryl Hydrocarbon Receptor

Schroeder, J. C., DiNatale, B. C., Murray, I. A., Flaveny, C. A., Liu, Q., Laurenzana, E. M., Lin, J. M., Strom, S. C., Omiecinski, C. J., Amin, S., et al. (2010) · Biochemistry · doi:10.1021/bi901786x · Cited by 330

Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors.

Ema, M., Ohe, N., Suzuki, M., Mimura, J., Sogawa, K., Ikawa, S., & Fujii-Kuriyama, Y. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)46990-6 · Cited by 329

Microbiome-Derived Tryptophan Metabolites and Their Aryl Hydrocarbon Receptor-Dependent Agonist and Antagonist Activities

Jin, U.-H., Lee, S.-O., Sridharan, G., Lee, K., Davidson, L. A., Jayaraman, A., Chapkin, R. S., Alaniz, R., & Safe, S. (2014) · Molecular Pharmacology · doi:10.1124/mol.113.091165 · Cited by 327

Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells

Chinni, S. R., Li, Y., Upadhyay, S., Koppolu, P. K., & Sarkar, F. H. (2001) · Oncogene · doi:10.1038/sj.onc.1204365 · Cited by 315

Oxidation of Indole by Cytochrome P450 Enzymes

Gillam, E. M. J., Notley, L. M., Cai, H., De Voss, J. J., & Guengerich, F. P. (2000) · Biochemistry · doi:10.1021/bi001229u · Cited by 313

Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice

Bradlow, H. L., Michnovicz, J. J., Telang, N. T., & Osborne, M. P. (1991) · Carcinogenesis · doi:10.1093/carcin/12.9.1571 · Cited by 304

Evidence That the Co-chaperone p23 Regulates Ligand Responsiveness of the Dioxin (Aryl Hydrocarbon) Receptor

Kazlauskas, A., Poellinger, L., & Pongratz, I. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13519 · Cited by 302

Induction of pulmonary indoleamine 2,3-dioxygenase by interferon.

Yoshida, R., Imanishi, J., Oku, T., Kishida, T., & Hayaishi, O. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.1.129 · Cited by 292

Nuclear Localization and Export Signals of the Human Aryl Hydrocarbon Receptor

Ikuta, T., Eguchi, H., Tachibana, T., Yoneda, Y., & Kawajiri, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.5.2895 · Cited by 287

The Suggested Physiologic Aryl Hydrocarbon Receptor Activator and Cytochrome P4501 Substrate 6-Formylindolo[3,2-b]carbazole Is Present in Humans

Wincent, E., Amini, N., Luecke, S., Glatt, H., Bergman, J., Crescenzi, C., Rannug, A., & Rannug, U. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808321200 · Cited by 279

bHLH-PAS proteins in cancer

Bersten, D. C., Sullivan, A. E., Peet, D. J., & Whitelaw, M. L. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3621 · Cited by 267

A ligand for the aryl hydrocarbon receptor isolated from lung

Song, J., Clagett-Dame, M., Peterson, R. E., Hahn, M. E., Westler, W. M., Sicinski, R. R., & DeLuca, H. F. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232562899 · Cited by 264

Role of the Aryl Hydrocarbon Receptor in Carcinogenesis and Potential as a Drug Target

Safe, S., Lee, S.-O., & Jin, U.-H. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft128 · Cited by 264

Increased serum kynurenine/tryptophan ratio correlates with disease progression in lung cancer

Suzuki, Y., Suda, T., Furuhashi, K., Suzuki, M., Fujie, M., Hahimoto, D., Nakamura, Y., Inui, N., Nakamura, H., & Chida, K. (2010) · Lung Cancer · doi:10.1016/j.lungcan.2009.05.001 · Cited by 261

Inducible, receptor-dependent protein-DNA interactions at a dioxin-responsive transcriptional enhancer.

Denison, M. S., Fisher, J. M., & Whitlock, J. P. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2528 · Cited by 260

The Aryl Hydrocarbon Receptor-Activating Effect of Uremic Toxins from Tryptophan Metabolism: A New Concept to Understand Cardiovascular Complications of Chronic Kidney Disease

Sallée, M., Dou, L., Cerini, C., Poitevin, S., Brunet, P., & Burtey, S. (2014) · Toxins · doi:10.3390/toxins6030934 · Cited by 255

Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms

Schefold, J. C., Zeden, J.-P., Fotopoulou, C., von Haehling, S., Pschowski, R., Hasper, D., Volk, H.-D., Schuett, C., & Reinke, P. (2009) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfn739 · Cited by 251

Aryl Hydrocarbon Hydroxylase Induction in Rat Tissues by Naturally Occurring Indoles of Cruciferous Plants 2

(1975) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/54.4.985 · Cited by 245

Antimicrobial Activity of Selected Phytochemicals against Escherichia coli and Staphylococcus aureus and Their Biofilms

Monte, J., Abreu, A., Borges, A., Simões, L., & Simões, M. (2014) · Pathogens · doi:10.3390/pathogens3020473 · Cited by 233

Cutting Edge: Activation of the Aryl Hydrocarbon Receptor by 2,3,7,8-Tetrachlorodibenzo- p -dioxin Generates a Population of CD4+CD25+ Cells with Characteristics of Regulatory T Cells

Funatake, C. J., Marshall, N. B., Steppan, L. B., Mourich, D. V., & Kerkvliet, N. I. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4184 · Cited by 218

Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands

Rannug, U., Rannug, A., Sjöberg, U., Li, H., Westerholm, R., & Bergman, J. (1995) · Chemistry & Biology · doi:10.1016/1074-5521(95)90090-x · Cited by 213

Chemoprevention of spontaneous endometrial cancer in female Donryu rats by dietary indole-3-carbinol.

Kojima, T., Tanaka, T., & Mori, H. (1994) · PubMed · Cited by 191

Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation

Jellinck, P. H., Gekforkert, P., Riddick, D. S., Okey, A. B., Michnovicz, J. J., & Bradlow, H. L. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90258-x · Cited by 190

Structure—activity relationships of dietary indoles: A proposed mechanism of action as modifiers of xenobiotic metabolism

Bradfield, C. A., & Bjeldanes, L. F. (1987) · Journal of Toxicology and Environmental Health · doi:10.1080/15287398709531021 · Cited by 189

Induction of Estradiol Metabolism by Dietary Indole-3-carbinol in Humans

Michnovicz, J. J., & Bradlow, H. L. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.11.947 · Cited by 181

Tryptophan-Catabolizing Enzymes – Party of Three

Ball, H. J., Fedelis, F. F., Bakmiwewa, S. M., Hunt, N. H., & Yuasa, H. J. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00485 · Cited by 174

Quantitative aspects of tryptophan metabolism in humans and other species: a review

Leklem, J. E. (1971) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/24.6.659 · Cited by 172

Physiological studies of tryptophan transport and tryptophanase operon induction in Escherichia coli

Yanofsky, C., Horn, V, & Gollnick, P. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.19.6009-6017.1991 · Cited by 169

Indole-3-carbinol and 3,3′-diindolylmethane induce apoptosis in human prostate cancer cells

Nachshon-Kedmi, M., Yannai, S., Haj, A., & Fares, F. A. (2003) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(03)00004-8 · Cited by 168

The Aryl Hydrocarbon Receptor Is Required for Developmental Closure of the Ductus Venosus in the Neonatal Mouse

Lahvis, G. P., Pyzalski, R. W., Glover, E., Pitot, H. C., McElwee, M. K., & Bradfield, C. A. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.008888 · Cited by 168

Aryl Hydrocarbon Receptor Activation by TCDD Reduces Inflammation Associated with Crohn's Disease

Benson, J. M., & Shepherd, D. M. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfq360 · Cited by 164

Identification of the Tryptophan Photoproduct 6-Formylindolo[3,2-b]carbazole, in Cell Culture Medium, as a Factor That Controls the Background Aryl Hydrocarbon Receptor Activity

Öberg, M., Bergander, L., Håkansson, H., Rannug, U., & Rannug, A. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi154 · Cited by 163

Ultraviolet-B Exposure of Human Skin Induces Cytochromes P450 1A1 and 1B1

Katiyar, S. K., Mukhtar, H., & Matsui, M. S. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00876.x · Cited by 159

A Phase I Study of Indole-3-Carbinol in Women: Tolerability and Effects

Reed, G. A., Peterson, K. S., Smith, H. J., Gray, J. C., Sullivan, D. K., Mayo, M. S., Crowell, J. A., & Hurwitz, A. (2005) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0121 · Cited by 159

Hepatic microsomal metabolism of indole to indoxyl, a precursor of indoxyl sulfate

Banoğlu, E., Jha, G. G., & King, R. J. (2001) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/bf03226377 · Cited by 159

Indole-3-Carbinol and Prostate Cancer

Sarkar, F. H., & Li, Y. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.12.3493s · Cited by 158

Expression of the Human Aryl Hydrocarbon Receptor Complex in Yeast

Miller, C. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.52.32824 · Cited by 146

Identification and functional characterization of indole-3-acetamide-mediated IAA biosynthesis in plant-associated Fusarium species

Tsavkelova, E. A., Oeser, B., Oren‐Young, L., Israeli, M., Sasson, Y., Tudzynski, B., & Sharon, A. (2011) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2011.10.005 · Cited by 138

Identification of Cinnabarinic Acid as a Novel Endogenous Aryl Hydrocarbon Receptor Ligand That Drives IL-22 Production

Lowe, M. M., Mold, J. E., Kanwar, B., Huang, Y., Louie, A., Pollastri, M. P., Wang, C., Patel, G., Franks, D. G., Schlezinger, J. J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087877 · Cited by 136

AhR Ligands, Malassezin, and Indolo[3,2-b]Carbazole are Selectively Produced by Malassezia furfur Strains Isolated from Seborrheic Dermatitis

Gaitanis, G., Magiatis, P., Σταθοπούλου, Κ., Bassukas, I. D., Alexopoulos, E. C., Velegraki, A., & Skaltsounis, A. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701252 · Cited by 135

Characterization of the Mouse Cyp1B1 Gene

Zhang, L., Savas, Ü., Alexander, D. L., & Jefcoate, C. R. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.9.5174 · Cited by 135

Activation of the Ah Receptor by Extracts of Dietary Herbal Supplements, Vegetables, and Fruits

Jeuken, A., Keser, B., Khan, E. M., Brouwer, A., Koeman, J. H., & Denison, M. S. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030252u · Cited by 130

Fecal skatole and indole and breath methane and hydrogen in patients with large bowel polyps or cancer

Karlin, D. A., Mastromarino, A. J., Jones, R., Stroehlein, J. R., & Lorentz, O. (1985) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/bf00391888 · Cited by 130

Lactobacillus bulgaricus OLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis

Takamura, T., Harama, D., Fukumoto, S., Nakamura, Y., Shimokawa, N., Ishimaru, K., Ikegami, S., Makino, S., Kitamura, M., & Nakao, A. (2011) · Immunology and Cell Biology · doi:10.1038/icb.2010.165 · Cited by 127

Ligand Selectivity and Gene Regulation by the Human Aryl Hydrocarbon Receptor in Transgenic Mice

Flaveny, C. A., Murray, I. A., Chiaro, C. R., & Perdew, G. H. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.054825 · Cited by 124

Protein-DNA interactions at a dioxin-responsive enhancer. Mutational analysis of the DNA-binding site for the liganded Ah receptor.

Shen, E. S., & Whitlock, J. P. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50499-9 · Cited by 124

Association of Indoxyl Sulfate with Heart Failure among Patients on Hemodialysis

Cao, X., Chen, J., Zou, J., Zhong, Y., Teng, J., Ji, J., Chen, Z., Liu, Z., Shen, B., Nie, Y., et al. (2014) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.04730514 · Cited by 122

Mechanistic Insights into the Events That Lead to Synergistic Induction of Interleukin 6 Transcription upon Activation of the Aryl Hydrocarbon Receptor and Inflammatory Signaling

DiNatale, B. C., Schroeder, J. C., Francey, L. J., Kusnadi, A. R., & Perdew, G. H. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.118570 · Cited by 117

Constitutive regulation ofCYP1B1by the aryl hydrocarbon receptor (AhR) in pre‐malignant and malignant mammary tissue

Yang, X., Solomon, S. E., Fraser, L. R., Trombino, A. F., Liu, D., Sonenshein, G. E., Hestermann, E. V., & Sherr, D. H. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21630 · Cited by 114

Use of 2-Azido-3-[125I]iodo-7,8-dibromodibenzo-p-dioxin as a Probe to Determine the Relative Ligand Affinity of Human versus Mouse Aryl Hydrocarbon Receptor in Cultured Cells

Ramadoss, P., & Perdew, G. H. (2004) · Molecular Pharmacology · doi:10.1124/mol.66.1.129 · Cited by 114

Indoles mitigate the development of experimental autoimmune encephalomyelitis by induction of reciprocal differentiation of regulatory T cells and Th17 cells

Rouse, M. D., Singh, N. P., Nagarkatti, P. S., & Nagarkatti, M. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12205 · Cited by 113

Aspartate Aminotransferase Generates Proagonists of the Aryl Hydrocarbon Receptor

Bittinger, M. A., Nguyen, L. P., & Bradfield, C. A. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.3.550 · Cited by 112

Regulation of CYP1A1 Transcription via the Metabolism of the Tryptophan-Derived 6-Formylindolo[3,2-b]carbazole

Wei, Y., Bergander, L. V., Rannug, U., & Rannug, A. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.2037 · Cited by 110

Indole Transport across Escherichia coli Membranes

Piñero-Fernández, S., Chimerel, C., Keyser, U. F., & Summers, D. (2011) · Journal of Bacteriology · doi:10.1128/jb.01477-10 · Cited by 110

Differential Gene Regulation by the Human and Mouse Aryl Hydrocarbon Receptor

Flaveny, C. A., Murray, I. A., & Perdew, G. H. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp308 · Cited by 108

The metabolism of methylsulfinylalkyl‐ and methylthioalkyl‐glucosinolates by a selection of human gut bacteria

Luang‐In, V., Narbad, A., Nueno‐Palop, C., Mithen, R. F., Bennett, M. H., & Rossiter, J. T. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300377 · Cited by 104

Evidence for Ligand-Mediated Selective Modulation of Aryl Hydrocarbon Receptor Activity

Murray, I. A., Morales, J. L., Flaveny, C. A., DiNatale, B. C., Chiaro, C. R., Gowda, K., Amin, S., & Perdew, G. H. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.061788 · Cited by 104

Ah receptor represses acute-phase response gene expression without binding to its cognate response element

Patel, R. D., Murray, I. A., Flaveny, C. A., Kusnadi, A. R., & Perdew, G. H. (2009) · Laboratory Investigation · doi:10.1038/labinvest.2009.24 · Cited by 103

Mechanism of action and development of selective aryl hydrocarbon receptor modulators for treatment of hormone-dependent cancers (Review)

Safe, S. H., & McDougal, A. J. (2002) · International Journal of Oncology · doi:10.3892/ijo.20.6.1123 · Cited by 101

Role of bile acids and metabolic activity of colonic bacteria in increased risk of colon cancer after cholecystectomy

Zuccato, E., Venturi, M., Leo, G. D., Colombo, L., Bértolo, C., Doldi, S. B., & Mussini, E. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01316508 · Cited by 101

Evidence for an Aryl Hydrocarbon Receptor-Mediated Cytochrome P450 Autoregulatory Pathway

Chiaro, C. R., Patel, R. D., Marcus, C. B., & Perdew, G. H. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.038968 · Cited by 101

Role of multiple efflux pumps in Escherichia coli in indole expulsion

Kawamura‐Sato, K., Shibayama, K., Horii, T., Iimuma, Y., Arakawa, Y., & Ohta, M. (1999) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1999.tb08748.x · Cited by 101

Characterization of the Activated Form of the Aryl Hydrocarbon Receptor in the Nucleus of HeLa Cells in the Absence of Exogenous Ligand

Singh, S. S., Hord, N. G., & Perdew, G. H. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0190 · Cited by 100

Aryl hydrocarbon receptor response to indigoids in vitro and in vivo

Guengerich, F. P., Martin, M. V., McCormick, W. A., Nguyen, L. P., Glover, E. A., & Bradfield, C. A. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.01.002 · Cited by 99

Activation of the aryl hydrocarbon receptor pathway may ameliorate dextran sodium sulfate‐induced colitis in mice

Takamura, T., Harama, D., Matsuoka, S., Shimokawa, N., Nakamura, Y., Okumura, K., Ogawa, H., Kitamura, M., & Nakao, A. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2010.35 · Cited by 98

Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator–dependent system in gut

Ito, S., Chen, C., Satoh, J., Yim, S., & Gonzalez, F. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31647 · Cited by 98

Multiple Roles of Ligand in Transforming the Dioxin Receptor to an Active Basic Helix-Loop-Helix/PAS Transcription Factor Complex with the Nuclear Protein Arnt

Lees, M. J., & Whitelaw, M. L. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.8.5811 · Cited by 98

Aryl Hydrocarbon Receptor (AHR)-Active Pharmaceuticals Are Selective AHR Modulators in MDA-MB-468 and BT474 Breast Cancer Cells

Jin, U.-H., Lee, S., & Safe, S. H. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.195339 · Cited by 97

Malassezia-derived indoles activate the aryl hydrocarbon receptor and inhibit Toll-like receptor-induced maturation in monocyte-derived dendritic cells

Vlachos, C., Schulte, B. M., Magiatis, P., Adema, G. J., & Gaitanis, G. (2012) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2012.11014.x · Cited by 97

Expression and Activity of Aryl Hydrocarbon Receptors in Development and Cancer

Gasiewicz, T. A., Henry, E. C., & Collins, L. L. (2008) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v18.i4.10 · Cited by 94

2,3,7,8-Tetrachlorodibenzo-p-dioxin increases the expression of genes in the human epidermal differentiation complex and accelerates epidermal barrier formation

Sutter, C. H., Bodreddigari, S., Campion, C., Wible, R. S., & Sutter, T. R. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr205 · Cited by 93

The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology

Nukaya, M., Moran, S., & Bradfield, C. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809613106 · Cited by 91

Changing the Face of Kynurenines and Neurotoxicity: Therapeutic Considerations

Bohár, Z., Toldi, J., Fülöp, F., & Vécsei, L. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16059772 · Cited by 90

Nucleocytoplasmic Shuttling of the Aryl Hydrocarbon Receptor

Ikuta, T., Tachibana, T., Watanabe, J. A., Yoshida, M., Yoneda, Y., & Kawajiri, K. (2000) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a022633 · Cited by 90

Role of the xenobiotic receptor in inflammatory bowel disease

Arsenescu, R. I., Arsenescu, V., Zhong, J., Nasser, M. S., Melinte, R., Dingle, C. R. W., Swanson, H. I., & de Villiers, W. J. S. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21463 · Cited by 88

Different Structural Requirements of the Ligand Binding Domain of the Aryl Hydrocarbon Receptor for High- and Low-Affinity Ligand Binding and Receptor Activation

Backlund, M., & Ingelman‐Sundberg, M. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.2.416 · Cited by 87

Biochemical and Structural Properties of Mouse Kynurenine Aminotransferase III

Han, Q., Robinson, H. H., Cai, T., Tagle, D. A., & Li, J. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01272-08 · Cited by 85

Development of a Selective Modulator of Aryl Hydrocarbon (Ah) Receptor Activity that Exhibits Anti-Inflammatory Properties

Murray, I. A., Gowda, K., DiNatale, B. C., Flaveny, C. A., Chiaro, C. R., Lin, J.-M., Sharma, A. K., Amin, S., & Perdew, G. H. (2010) · Chemical Research in Toxicology · doi:10.1021/tx100045h · Cited by 84

Possible roles of excess tryptophan metabolites in cancer

Chung, K., & Gadupudi, G. S. (2010) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20588 · Cited by 81

3,3′-Diindolylmethane alleviates oxazolone-induced colitis through Th2/Th17 suppression and Treg induction

Huang, Z. D., Jiang, Y., Yang, Y., Shao, J., Sun, X., Chen, J., Dong, L., & Zhang, J. (2012) · Molecular Immunology · doi:10.1016/j.molimm.2012.09.007 · Cited by 78

Aryl hydrocarbon receptor-mediated induction of microsomal drug-metabolizing enzyme activity by indirubin and indigo

Sugihara, K., Kitamura, S., Yamada, T., Okayama, T., Ohta, S., Yamashita, K. H., Yasuda, M., Fujii‐Kuriyama, Y., Saeki, K., Matsui, S., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.04.066 · Cited by 77

Indole-3-Carbinol Triggers Aryl Hydrocarbon Receptor-dependent Estrogen Receptor (ER)α Protein Degradation in Breast Cancer Cells Disrupting an ERα-GATA3 Transcriptional Cross-Regulatory Loop

Marconett, C. N., Sundar, S. N., Poindexter, K. M., Stueve, T. R., Bjeldanes, L. F., & Firestone, G. L. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-08-0689 · Cited by 75

Ah Receptor Antagonism Represses Head and Neck Tumor Cell Aggressive Phenotype

DiNatale, B. C., Smith, K. M., John, K., Gowda, K., Amin, S., & Perdew, G. H. (2012) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-12-0216 · Cited by 73

Time on Dialysis and Cancer Risk After Kidney Transplantation

Wong, G., Turner, R. M., Chapman, J. R., Howell, M., Lim, W. H., Webster, A. C., & Craig, J. C. (2012) · Transplantation · doi:10.1097/tp.0b013e31827743b4 · Cited by 70

The Aryl Hydrocarbon Receptor Ligand ITE Inhibits TGFβ1-Induced Human Myofibroblast Differentiation

Lehmann, G. M., Xi, X., Kulkarni, A. A., Olsen, K. C., Pollock, S. J., Baglole, C. J., Gupta, S., Casey, A. E., Huxlin, K. R., Sime, P. J., et al. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.12.025 · Cited by 63

Differential Regulation of Th17 and T Regulatory Cell Differentiation by Aryl Hydrocarbon Receptor Dependent Xenobiotic Response Element Dependent and Independent Pathways

Mohinta, S., Kannan, A., Gowda, K., Amin, S., Perdew, G. H., & August, A. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv046 · Cited by 58

A biological basis for depression in pancreatic cancer

Botwinick, I. C., Pursell, L., Yu, G., Cooper, T. B., Mann, J. J., & Chabot, J. A. (2014) · HPB · doi:10.1111/hpb.12201 · Cited by 57

Aryl Hydrocarbon Receptor–Dependent Stanniocalcin 2 Induction by Cinnabarinic Acid Provides Cytoprotection against Endoplasmic Reticulum and Oxidative Stress

Joshi, A., Carter, D., Harper, T. A., & Elferink, C. J. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.222265 · Cited by 55

3-Methylindole Metabolites Induce Lung CYP1A1 and CYP2F1 Enzymes by AhR and Non-AhR Mechanisms, Respectively

Weems, J. M., & Yost, G. S. (2010) · Chemical Research in Toxicology · doi:10.1021/tx9004506 · Cited by 55

The Aryl Hydrocarbon Receptor Is Constitutively Active in Advanced Prostate Cancer Cells

Richmond, O. H., Ghotbaddini, M., Allen, C., Walker, A., Zahir, S. T., & Powell, J. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095058 · Cited by 53

Aryl hydrocarbon receptor antagonism mitigates cytokine-mediated inflammatory signalling in primary human fibroblast-like synoviocytes

Lahoti, T. S., John, K., Hughes, J. M., Kusnadi, A. R., Murray, I. A., Gowda, K., Amin, S., & Perdew, G. H. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202639 · Cited by 53

A Bistable Switch Underlying B-Cell Differentiation and Its Disruption by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Bhattacharya, S., Conolly, R. B., Kaminski, N. E., Thomas, R. S., Andersen, M. E., & Zhang, Q. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq035 · Cited by 51

An aryl hydrocarbon receptor induces VEGF expression through ATF4 under glucose deprivation in HepG2

Terashima, J., Tachikawa, C., Kudo, K., Habano, W., & Ozawa, S. (2013) · BMC Molecular Biology · doi:10.1186/1471-2199-14-27 · Cited by 50

2,3,7,8-Tetrachlorodibenzo-p-dioxin Alters the Differentiation of Alloreactive CD8+T Cells Toward a Regulatory T Cell Phenotype by a Mechanism that is Dependent on Aryl Hydrocarbon Receptor in CD4+T Cells

Funatake, C. J., Marshall, N. B., & Kerkvliet, N. I. (2008) · Journal of Immunotoxicology · doi:10.1080/15476910802019037 · Cited by 48

ITE, A Novel Endogenous Nontoxic Aryl Hydrocarbon Receptor Ligand, Efficiently Suppresses EAU and T-Cell–Mediated Immunity

Nugent, L. F., Shi, G., Vistica, B. P., Ogbeifun, O., Hinshaw, S. J. H., & Gery, I. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-11479 · Cited by 45

Aryl Hydrocarbon Receptor in Breast Cancer—A Newly Defined Prognostic Marker

Saito, R., Miki, Y., Hata, S., Takagi, K., Iida, S., Oba, Y., Ono, K., Ishida, T., Suzuki, T., Ohuchi, N., et al. (2013) · Hormones and Cancer · doi:10.1007/s12672-013-0160-z · Cited by 42

An aryl hydrocarbon receptor conformation acts as the functional core of nuclear dioxin signaling

Kronenberg, S. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.12.2286 · Cited by 42

Cytochrome P450 4A11 expression in human keratinocytes: effects of ultraviolet irradiation

Gonzalez, M., Marteau, C., Franchi, J., & Migliore‐Samour, D. (2001) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2001.04490.x · Cited by 36

Total Myrosinase Activity Estimates in Brassica Vegetable Produce

Dosz, E. B., Ku, K., Juvik, J. A., et al. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf501692c · Cited by 35

Indole-3-carbinol suppresses NF-κB activity and stimulates the p53 pathway in pre-B acute lymphoblastic leukemia cells

Safa, M., Tavasoli, B., Shabestari, R. M., Kiani, F., Kashiri, M., Ebrahimi, S., & Kazemi, A. (2015) · Tumor Biology · doi:10.1007/s13277-014-3035-1 · Cited by 34

Characterization of the rabbit CYP1A1 and CYP1A2 genes: Developmental and dioxin-inducible expression of rabbit liver P4501A1 and P4501A2

Strom, D. K., Postlind, H., & Tukey, R. H. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90745-i · Cited by 31

IDENTIFICATION OF AN ENHANCER REGION THAT DIRECTS ARYL HYDROCARBON RECEPTOR-MEDIATED CONSTITUTIVE AND INDUCED EXPRESSION*

Zhang, L., Alexander, D. L., & Jefcoate, C. R. E. (1998) · Cited by 27

The uremic toxin indoxyl sulfate acts as a pro- or antioxidant on LDL oxidation

Praschberger, M., Hermann, M., Wanner, J., Jirovetz, L., Exner, M., Kapiotis, S., Gmeiner, B. M. K., & Laggner, H. (2014) · Free Radical Research · doi:10.3109/10715762.2014.898294 · Cited by 8

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

Agus, A., Planchais, J., & Sokol, H. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.05.003 · Cited by 3,180

The gut-brain axis

Mayer, E. A., Nance, K., & Chen, S. (2022) · Annual Review of Medicine · doi:10.1146/annurev-med-042320-014032 · Cited by 813

Interaction Between the Microbiota, Epithelia, and Immune Cells in the Intestine

Kayama, H., Okumura, R., & Takeda, K. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-070119-115104 · Cited by 747

Gut microbiome interactions with drug metabolism, efficacy, and toxicity

Wilson, I. D., & Nicholson, J. K. (2017) · Translational Research · doi:10.1016/j.trsl.2016.08.002 · Cited by 656

Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor

Alexeev, E. E., Lanis, J. M., Kao, D. J., Campbell, E. L., Kelly, C. J., Battista, K. D., Gerich, M. E., Jenkins, B. R., Walk, S. T., Kominsky, D. J., et al. (2018) · The American Journal of Pathology · doi:10.1016/j.ajpath.2018.01.011 · Cited by 532