Iron Dysregulation and Neurodegeneration: The Molecular Connection
Abstract
Iron is essential for many biological processes however excess concentrations can be harmful to many tissues. Its amounts must therefore be carefully regulated in all cells of the body including those in the brain. Increased amounts of iron have been reported in many neurodegenerative disorders. Whether this increased iron contributes to neurodegeneration has been considered controversial. In this review, we discuss some recently identified anomalies in proteins linked with iron metabolism which signify a critical role for iron dysregulation in neurodegeneration.
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Ferritin H-deficient mice synthesize ferritins consisting of only L-subunit homopolymers, which lack ferroxidase activity and have lower iron-incorporation capability.
“the synthesized ferritins consist of only L-subunit homopolymers (85), which lack ferroxidase activity and has lower iron-incorporation capability (183).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [183]
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- Authors
- Lee, D. W.
- Affiliations
- Buck Institute for Research on Aging (US)
- Corresponding author
- Lee, D. W.
- ORCID
- Lee, D. W.
- Venue
- Molecular Interventions
- Publisher
- CLOCKSS Archive
- Published
- 2006-04-01
- Volume
- 6
- Issue
- 2
- Pages
- 89-97
- ISSN
- 1534-0384 (ISSN-L)
- OpenAlex
- W2063829525
- Cited by
- 80
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 8 · 2013: 5 · 2012: 4
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Interventions (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS041264, NS41264)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- iron dysregulation, neurodegeneration, iron metabolism, iron overload, brain iron, neurodegenerative diseases
- MeSH terms
- Hemochromatosis Protein, Frataxin, Solute Carrier Family 11, Member 2, Animals, Ceruloplasmin, Humans, Iron, Membrane Proteins, Metalloproteins, Mice, Transgenic, Models, Biological, Mutation, Nerve Degeneration, Histocompatibility Antigens Class I, Phosphotransferases (Alcohol Group Acceptor), Iron Metabolism Disorders, Neurodegenerative Diseases, Cation Transport Proteins, Iron-Binding Proteins, Iron-Regulatory Proteins, Mice, Heme Oxygenase-1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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