Cited by 686Neuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors StudyReceptor Mechanisms and Signaling

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Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

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Hansen, Kasper B., Wollmuth, Lonnie P., Bowie, Derek, Furukawa, Hiro, Menniti, Frank S., Sobolevsky, Alexander I., Swanson, Geoffrey T., Swanger, Sharon A., Greger, Ingo H., Nakagawa, Terunaga, McBain, Chris J., Jayaraman, Vasanthi, Low, Chian-Ming, Dell’Acqua, Mark L., Diamond, Jeffrey S., Camp, Chad R., Perszyk, Riley E., Yuan, Hongjie, Traynelis, Stephen F.·2021·Pharmacological Reviews

DOI 10.1124/pharmrev.120.000131PMC PMC8626789

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Abstract

Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the mammalian central nervous system, are mediated via signaling by ionotropic glutamate receptors (iGluRs). These ligand-gated ion channels are critical to brain function and are centrally implicated in numerous psychiatric and neurologic disorders. There are different classes of iGluRs with a variety of receptor subtypes in each class that play distinct roles in neuronal functions. The diversity in iGluR subtypes, with their unique functional properties and physiologic roles, has motivated a large number of studies. Our understanding of receptor subtypes has advanced considerably since the first iGluR subunit gene was cloned in 1989, and the research focus has expanded to encompass facets of biology that have been recently discovered and to exploit experimental paradigms made possible by technological advances. Here, we review insights from more than 3 decades of iGluR studies with an emphasis on the progress that has occurred in the past decade. We cover structure, function, pharmacology, roles in neurophysiology, and therapeutic implications for all classes of receptors assembled from the subunits encoded by the 18 ionotropic glutamate receptor genes. SIGNIFICANCE STATEMENT: Glutamate receptors play important roles in virtually all aspects of brain function and are either involved in mediating some clinical features of neurological disease or represent a therapeutic target for treatment. Therefore, understanding the structure, function, and pharmacology of this class of receptors will advance our understanding of many aspects of brain function at molecular, cellular, and system levels and provide new opportunities to treat patients.

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Ca2+-Dependent Inactivation of GluN2A and GluN2B NMDA Receptors Occurs by a Common Kinetic Mechanism
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Homomeric GluA2(R) AMPA receptors can conduct when desensitized
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Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors
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GluN2D-mediated excitatory drive onto medial prefrontal cortical PV+ fast-spiking inhibitory interneurons
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Silence Analysis of AMPA Receptor Mutated at the CaM-Kinase II Phosphorylation Site
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Distribution of Extracellular Glutamate in the Neuropil of Hippocampus
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Blockade of NMDA receptor channels by 9-aminoacridine and its derivatives
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A Subtype-Selective, Use-Dependent Inhibitor of Native AMPA Receptors
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Effect of D ‐cycloserine in conjunction with fear extinction training on extracellular signal‐regulated kinase activation in the medial prefrontal cortex and amygdala in rat
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Protons Potentiate GluN1/GluN3A Currents by Attenuating Their Desensitisation
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The novel antidepressant ketamine enhances dentate gyrus proliferation with no effects on synaptic plasticity or hippocampal function in depressive‐like rats
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The unique properties of glutamate receptor channels
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Full and Partial Agonism of Ionotropic Glutamate Receptors Indicated by Molecular Dynamics Simulations
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A Eukaryotic Specific Transmembrane Segment is Required for Tetramerization in AMPA Receptors
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Glutamate receptor antibodies directed against AMPA receptors subunit 3 peptide B (GluR3B) can be produced in DBA/2J mice, lower seizure threshold and induce abnormal behavior
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AMPA Receptor-Positive Allosteric Modulators for the Treatment of Schizophrenia: An Overview of Recent Patent Applications
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Reduced Curvature of Ligand-Binding Domain Free-Energy Surface Underlies Partial Agonism at NMDA Receptors
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Molecular Determinants Controlling NMDA Receptor Synaptic Incorporation
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Role of GluR1 in Activity-Dependent Motor System Development
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Extracellular Ca2+ ions reduce NMDA receptor conductance and gating
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Expression of Glycine-Activated Diheteromeric NR1/NR3 Receptors in Human Embryonic Kidney 293 Cells Is NR1 Splice Variant-Dependent
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Constitutive Activation of the N-Methyl-d-aspartate Receptor via Cleft-spanning Disulfide Bonds
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Ligand-Binding Residues Integrate Affinity and Efficacy in the NMDA Receptor
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Conformational Flexibility of the Ligand-Binding Domain Dimer in Kainate Receptor Gating and Desensitization
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GSG1L regulates the strength of AMPA receptor-mediated synaptic transmission but not AMPA receptor kinetics in hippocampal dentate granule neurons
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Screening for AMPA receptor auxiliary subunit specific modulators
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Role of the Ion Channel Extracellular Collar in AMPA Receptor Gating
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Neto1 associates with the NMDA receptor/amyloid precursor protein complex
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A novel gene, Btcl1, encoding CUB and LDLa domains is expressed in restricted areas of mouse brain
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The NMDAR subunit NR3A interacts with microtubule-associated protein 1S in the brain
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GluN3A promotes NMDA spiking by enhancing synaptic transmission in Huntington's disease models
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Involvement of extracellular signal-regulated kinase (ERK) in the short and long-lasting antidepressant-like activity of NMDA receptor antagonists (zinc and Ro 25-6981) in the forced swim test in rats
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Kainate receptors regulate development of glutamatergic synaptic circuitry in the rodent amygdala
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Modulation of neurite outgrowth by activation of calcium‐permeable kainate receptors expressed by rat nociceptive‐like dorsal root ganglion neurons
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Neto-Mediated Intracellular Interactions Shape Postsynaptic Composition at the Drosophila Neuromuscular Junction
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Immunization with the glutamate receptor-derived peptide GluR3B induces neuronal death and reactive gliosis, but confers partial protection from pentylenetetrazole-induced seizures
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Specific involvement of postsynaptic GluN2B-containing NMDA receptors in the developmental elimination of corticospinal synapses
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CaMKII-Dependent Phosphorylation of the GTPase Rem2 Is Required to Restrict Dendritic Complexity
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Dose‐dependent suppression of human photoparoxysmal response with the competitive AMPA/kainate receptor antagonist BGG492: Clear PK/PD relationship
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GluD2 Endows Parallel Fiber–Purkinje Cell Synapses with a High Regenerative Capacity
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The LILI Motif of M3-S2 Linkers Is a Component of the NMDA Receptor Channel Gate
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NYX‐458 Improves Cognitive Performance in a Primate Parkinson's Disease Model
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Subtype-selective antagonism of N-methyl-d-aspartate receptor ion channels by synthetic conantokin peptides
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Organic blockers escape from trapping in the AMPA receptor channels by leaking into the cytoplasm
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Site within N-Methyl-D-aspartate Receptor Pore Modulates Channel Gating
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Genomic organization, proposed alternative splicing mechanisms, and RNA editing structure of GRIK1
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The Quaternary Structure of a Calcium-Permeable AMPA Receptor: Conservation of Shape and Symmetry across Functionally Distinct Subunit Assemblies
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Genetic Variation in N-Methyl-D-Aspartate Receptor Subunit NR3A but Not NR3B Influences Susceptibility to Alzheimer’s Disease
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Conantokin-Br fromConus brettinghamiand Selectivity Determinants for the NR2D Subunit of the NMDA Receptor
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Differential Effects of an NR2B NAM and Ketamine on Synaptic Potentiation and Gamma Synchrony: Relevance to Rapid-Onset Antidepressant Efficacy
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Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors
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Effect of NMDA receptor antagonist on proliferation of neurospheres from embryonic brain
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Cerebellar Regulation Mechanisms Learned From Studies on GluRδ2
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GluR‐ and TrkB‐mediated maturation of GABAA receptor function during the period of eye opening
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NMDA receptor NR2B subunit over‐expression increases cerebellar granule cell migratory activity
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C-Terminal Interactors of the AMPA Receptor Auxiliary Subunit Shisa9
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Determination of Binding Site Residues Responsible for the Subunit Selectivity of Novel Marine-Derived Compounds on Kainate Receptors
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Developmental switch in the kinase dependency of long-term potentiation depends on expression of GluA4 subunit-containing AMPA receptors
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Steered Molecular Dynamics Simulations Predict Conformational Stability of Glutamate Receptors
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Amino-terminal domains of kainate receptors determine the differential dependence on Neto auxiliary subunits for trafficking
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NMDA Receptors Containing GluN2B/2C/2D Subunits Mediate an Increase in Glutamate Release at Hippocampal CA3–CA1 Synapses
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Modulation of AMPA Receptor Gating by the Anticonvulsant Drug, Perampanel
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NMDA receptor channel gating control by the pre-M1 helix
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Site of Action of Brain Neurosteroid Pregnenolone Sulfate at the N-Methyl-D-Aspartate Receptor
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A Tetrazolyl-Substituted Subtype-Selective AMPA Receptor Agonist
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Role of GluA3 AMPA Receptor Subunits in the Presynaptic and Postsynaptic Maturation of Synaptic Transmission and Plasticity of Endbulb−Bushy Cell Synapses in the Cochlear Nucleus
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Mechanisms of ketamine and its metabolites as antidepressants
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Authors: Hansen, K. B., Wollmuth, L. P., Bowie, D., Furukawa, H., Menniti, F. S., Sobolevsky, A. I., Swanson, G. T., Swanger, S. A., Greger, I. H., Nakagawa, T., McBain, C. J., Jayaraman, V., Low, C.-M., Dell’Acqua, M. L., Diamond, J. S., Camp, C. R., Perszyk, R. E., Yuan, H., & Traynelis, S. F.
Affiliations: Northwestern University (US)
Corresponding author: Traynelis, Stephen F.
ORCID: Hansen, Kasper B.
Wollmuth, Lonnie P.
Bowie, Derek
Furukawa, Hiro
Menniti, Frank S.
Sobolevsky, Alexander I.
Swanson, Geoffrey T.
Swanger, Sharon A.
Greger, Ingo H.
Nakagawa, Terunaga
McBain, Chris J.
Jayaraman, Vasanthi
Low, Chian-Ming
Dell’Acqua, Mark L.
Diamond, Jeffrey S.
Camp, Chad R.
Perszyk, Riley E.
Yuan, Hongjie
Traynelis, Stephen F.
Venue: Pharmacological Reviews
Publisher: Elsevier BV
Published: 2021-10
Volume: 73
Issue: 4
Pages: 1469-1658
ISSN: 0031-6997 (ISSN-L)
DOI: 10.1124/pharmrev.120.000131
PMC: PMC8626789
OpenAlex: W3214054678
Cited by: 686
References: 2,576
Citations by year: 2026: 123 · 2025: 198 · 2024: 160 · 2023: 115 · 2022: 81 · 2021: 9
FWCI: 13.86
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Pharmacological Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
Funders: National Institutes of Health (5f31ns113530-02)
Biotechnology and Biological Sciences Research Council (BB/N002113/1)
National Institute of Mental Health (R56MH123474, R21MH127404, R01MH085926, R01MH123474)
National Cancer Institute (R01CA206573)
National Institute of General Medical Sciences (P20GM103546, R35GM122528)
National Institute of Neurological Disorders and Stroke (F31‐NS113530, R01NS105804, R56NS040701, R01NS083660, R01NS040701, R01NS088479, R01NS111745, RF1NS113632, R01NS105502, R01NS107253, R35NS111619, R37NS083660, R01NS116055, R01NS097536)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD082373)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: ionotropic glutamate receptors, ligand-gated ion channels, glutamate, receptor subtypes, receptor structure, receptor pharmacology, excitatory neurotransmission, neurophysiology, neurological disorders, mental illness, therapeutic target
MeSH terms: Animals, Central Nervous System, Humans, Receptors, Glutamate, Neurotransmitter Agents, Glutamic Acid, Receptors, Ionotropic Glutamate

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Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

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