Cited by 686Neuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors StudyReceptor Mechanisms and Signaling

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Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

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Hansen, Kasper B., Wollmuth, Lonnie P., Bowie, Derek, Furukawa, Hiro, Menniti, Frank S., Sobolevsky, Alexander I., Swanson, Geoffrey T., Swanger, Sharon A., Greger, Ingo H., Nakagawa, Terunaga, McBain, Chris J., Jayaraman, Vasanthi, Low, Chian-Ming, Dell’Acqua, Mark L., Diamond, Jeffrey S., Camp, Chad R., Perszyk, Riley E., Yuan, Hongjie, Traynelis, Stephen F.·2021·Pharmacological Reviews

DOI 10.1124/pharmrev.120.000131PMC PMC8626789

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Abstract

Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the mammalian central nervous system, are mediated via signaling by ionotropic glutamate receptors (iGluRs). These ligand-gated ion channels are critical to brain function and are centrally implicated in numerous psychiatric and neurologic disorders. There are different classes of iGluRs with a variety of receptor subtypes in each class that play distinct roles in neuronal functions. The diversity in iGluR subtypes, with their unique functional properties and physiologic roles, has motivated a large number of studies. Our understanding of receptor subtypes has advanced considerably since the first iGluR subunit gene was cloned in 1989, and the research focus has expanded to encompass facets of biology that have been recently discovered and to exploit experimental paradigms made possible by technological advances. Here, we review insights from more than 3 decades of iGluR studies with an emphasis on the progress that has occurred in the past decade. We cover structure, function, pharmacology, roles in neurophysiology, and therapeutic implications for all classes of receptors assembled from the subunits encoded by the 18 ionotropic glutamate receptor genes. SIGNIFICANCE STATEMENT: Glutamate receptors play important roles in virtually all aspects of brain function and are either involved in mediating some clinical features of neurological disease or represent a therapeutic target for treatment. Therefore, understanding the structure, function, and pharmacology of this class of receptors will advance our understanding of many aspects of brain function at molecular, cellular, and system levels and provide new opportunities to treat patients.

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Schauder, D., Kuybeda, O., Zhang, J., Klymko, K., Bartesaghi, A., Borgnia, M. J., Mayer, M. L., & Subramaniam, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217549110 · Cited by 60
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Amico-Ruvio, S. A., & Popescu, G. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2009.12.4276 · Cited by 60
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Gardinier, K. M., Gernert, D. L., Porter, W. J., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00125 · Cited by 60
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Zampini, V., Liu, J. K., Diana, M. A., Maldonado, P. P., Brunel, N., & Dieudonné, S. (2016) · eLife · doi:10.7554/elife.15872 · Cited by 60
A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons
Swanger, S. A., Vance, K. M., Acker, T. M., Zimmerman, S. S., DiRaddo, J. O., Myers, S. J., Bundgaard, C., Mosley, C. A., Summer, S. L., Menaldino, D. S., et al. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00329 · Cited by 60
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Chan, K., Nestor, J., Huerta, T. S., Certain, N., Moody, G. R., Kowal, C., Huerta, P. T., Volpe, B. T., Diamond, B., & Wollmuth, L. P. (2020) · Nature Communications · doi:10.1038/s41467-020-15224-w · Cited by 60
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Everts, I., Petroski, R. E., Kizelsztein, P., Teichberg, V. I., Heinemann, S. F., & Hollmann, M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-03-00916.1999 · Cited by 59
Evaluation of glutamate concentration transient in the synaptic cleft of the rat calyx of Held
Budisantoso, T., Harada, H., Kamasawa, N., Fukazawa, Y., Shigemoto, R., & Matsui, K. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.241398 · Cited by 59
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Bokesch, P. M., Izykenova, G. A., Justice, J. B., Easley, K. A., & Dambinova, S. A. (2006) · Stroke · doi:10.1161/01.str.0000221295.14547.c8 · Cited by 59
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Atlason, P. T., Garside, M. L., Meddows, E., Whiting, P. J., & McIlhinney, R. A. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702778200 · Cited by 59
Cornichon2 Dictates the Time Course of Excitatory Transmission at Individual Hippocampal Synapses
Boudkkazi, S., Bréchet, A., Schwenk, J., & Fakler, B. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.031 · Cited by 59
Two Blocking Sites of Amino-Adamantane Derivatives in Open N-Methyl-d-Aspartate Channels
Sobolevsky, A. I., & Koshelev, S. G. (1998) · Biophysical Journal · doi:10.1016/s0006-3495(98)77844-0 · Cited by 59
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Sukumaran, M., Rossmann, M., Shrivastava, I. H., Dutta, A., Bahar, İ., & Greger, I. H. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.17 · Cited by 59
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Swanson, G. T., & Heinemann, S. F. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.639ba.x · Cited by 59
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Creed, M. C., Kaufling, J., Fois, G. R., Jalabert, M., Yuan, T., Lüscher, C., Georges, F. E., & Bellone, C. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1703-16.2016 · Cited by 59
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Groveman, B. R., Feng, S., Fang, X., Pflueger, M., Lin, S.-X., Bienkiewicz, E. A., & Yu, X. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08413.x · Cited by 59
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Lu, C., Hwang, S. J., Phend, K. D., et al. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09522.2002 · Cited by 59
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Balík, A., Penn, A. C., Nemoda, Z., & Greger, I. H. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1045 · Cited by 59
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Bats, C., Soto, D., Studniarczyk, D., Farrant, M., & Cull-Candy, S. G. (2012) · Nature Neuroscience · doi:10.1038/nn.3107 · Cited by 59
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Miyazaki, T., Yamasaki, M., Takeuchi, T., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0934-10.2010 · Cited by 59
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Koike‐Tani, M., Kanda, T., Saitoh, N., Yamashita, T., & Takahashi, T. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.142547 · Cited by 59
Targeting the NMDA receptor subunit NR2B for treating or preventing age-related memory decline
Wang, D., Jacobs, S., & Tsien, J. Z. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.941286 · Cited by 59
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Verkhratsky, A., & Chvátal, A. (2020) · Neurochemical Research · doi:10.1007/s11064-019-02750-3 · Cited by 59
Ion permeation properties of the glutamate receptor channel in cultured embryonic Drosophila myotubes.
Chang, H., Ciani, S., & Kidokoro, Y. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020107 · Cited by 58
Negative allosteric modulation of wild-type and mutant AMPA receptors by GYKI 53655.
Partin, K. M., & Mayer, M. L. (1996) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08680-8 · Cited by 58
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Sun, H. Y., & Dobrunz, L. E. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2746-06.2006 · Cited by 58
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Cunha, R. A., Malva, J. O., & Ribeiro, J. A. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01272-2 · Cited by 58
Inhibition of NMDA receptors induces delayed neuronal maturation and sustained proliferation of progenitor cells during neocortical development
Hirasawa, T., Wada, H., Kohsaka, S., & Uchino, S. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10795 · Cited by 58
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Ryu, K., Yokoyama, M., Yamashita, M., & Hirano, T. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.11.075 · Cited by 58
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Henson, M. A., Larsen, R. S., Lawson, S. N., Pérez‐Otaño, I., Nakanishi, N., Lipton, S. A., & Philpot, B. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042327 · Cited by 58
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Banke, T. G., Greenwood, J. R., Christensen, J. K., Liljefors, T., Traynelis, S. F., Schousboe, A., & Pickering, D. S. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03052.2001 · Cited by 58
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Self-citation
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Zhang, W., Devi, S. P. S., Tomita, S., & Howe, J. R. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12519 · Cited by 58
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Louros, S. R., Hooks, B. M., Litvina, E. Y., Carvalho, A. L., & Chen, C. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.04.054 · Cited by 57
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Self-citation
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Han, T. H., Dharkar, P., Mayer, M. L., & Serpe, M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1500458112 · Cited by 57
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Kvist, T., Greenwood, J. R., Hansen, K. B., Traynelis, S. F., & Bräuner‐Osborne, H. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.08.003 · Cited by 56
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Ogden, K. K., & Traynelis, S. F. (2013) · Molecular Pharmacology · doi:10.1124/mol.113.085209 · Cited by 56
Self-citation
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Chaudhry, C., Weston, M. C., Schuck, P., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.86 · Cited by 56
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Wenke, N. K., Kreye, J., Andrzejak, E., van Casteren, A., Leubner, J., Murgueitio, M. S., Reincke, S. M., Secker, C., Schmidl, L., Geis, C., et al. (2019) · Annals of Neurology · doi:10.1002/ana.25460 · Cited by 56
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Rajani, V., Sengar, A. S., & Salter, M. W. (2020) · Molecular Brain · doi:10.1186/s13041-020-0563-z · Cited by 56
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Mielnik, C. A., Binko, M. A., Chen, Y., Funk, A. J., Johansson, E. M., Intson, K., Sivananthan, N., Islam, R., Milenkovic, M., Horsfall, W., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-020-00859-4 · Cited by 56
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Ihle, E. C., & Patneau, D. K. (2000) · Molecular Pharmacology · doi:10.1124/mol.58.6.1204 · Cited by 55
Interactions between two divalent ion binding sites in N -methyl- d -aspartate receptor channels
Sharma, G., & Stevens, C. F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.14170 · Cited by 55
Expression of AMPA‐glutamate Receptor B Subunit in Rat Hippocampal GABAergic Neurons
Racca, C., Catania, M. V., Monyer, H., & Sakmann, B. J. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01303.x · Cited by 55
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Shaffer, C. L., Osgood, S. M., Smith, D. L., Liu, J., & Trapa, P. E. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.07.008 · Cited by 55
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Mellone, M., Pelucchi, S., Alberti, L. D., Genazzani, A. A., Luca, M. D., & Gardoni, F. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12968 · Cited by 55
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Armstrong, S. P., Banks, P. J., McKitrick, T. J. W., Geldart, C. H., Edge, C. J., Babla, R., Simillis, C., Franks, N. P., & Dickinson, R. (2012) · Anesthesiology · doi:10.1097/aln.0b013e31825ada2e · Cited by 55
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Nisticò, R., Florenzano, F., Mango, D., Ferraina, C., Grilli, M., Prisco, S. D., Nobili, A., Saccucci, S., D’Amelio, M., Morbin, M., et al. (2015) · Scientific Reports · doi:10.1038/srep09035 · Cited by 55
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Claiborne, C. F., McCauley, J. A., Libby, B. E., Curtis, N. R., Diggle, H. J., Kulagowski, J. J., Michelson, S. R., Anderson, K. D., Claremon, D. A., Freidinger, R. M., et al. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(02)01061-2 · Cited by 55
N‐methyl‐D‐aspartate receptor agonists modulate homocysteine‐induced developmental abnormalities
Rosenquist, T. H., Schneider, A. M., & Monaghan, D. T. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.12.1523 · Cited by 55
Myelin Proteolipid Protein Complexes with v Integrin and AMPA Receptors In Vivo and Regulates AMPA-Dependent Oligodendrocyte Progenitor Cell Migration through the Modulation of Cell-Surface GluR2 Expression
Harlow, D. E., Saul, K. E., Komuro, H., & Macklin, W. B. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.5151-14.2015 · Cited by 55
Interactions of erythro-ifenprodil, threo-ifenprodil, erythro-iodoifenprodil, and eliprodil with subtypes of σ receptors
Hashimoto, K., & London, E. D. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)00763-w · Cited by 55
Molecular mechanisms of NMDA receptor-mediated excitotoxicity: Implications for neuroprotective therapeutics for stroke
Wang, Y., & Li, V. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.194713 · Cited by 55
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Correia, S. S., Duarte, C. B., Faro, C., Pires, E., & Carvalho, A. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m205587200 · Cited by 54
Potentiation of GluN2C/D NMDA Receptor Subtypes in the Amygdala Facilitates the Retention of Fear and Extinction Learning in Mice
Ogden, K. K., Khatri, A., Traynelis, S. F., & Heldt, S. A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.241 · Cited by 54
Self-citation
Selective Expression of Ligand-Gated Ion Channels in L5 Pyramidal Cell Axons
Christie, J. M., & Jahr, C. E. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2387-09.2009 · Cited by 54
Cornichons Control ER Export of AMPA Receptors to Regulate Synaptic Excitability
Brockie, P. J., Jensen, M., Mellem, J. E., Jensen, E., Yamasaki, T., Wang, R., Maxfield, D., Thacker, C. M., Hoerndli, F. J., Dunn, P. J., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.07.028 · Cited by 54
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Dolman, N. P., Troop, H. M., More, J. C. A., Alt, A. J., Knauss, J. L., Nisticò, R., Jack, S., Morley, R. M., Bortolotto, Z. A., Roberts‎, P., et al. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm050584l · Cited by 54
Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine
Frydenvang, K., Lash, L. L., Naur, P., Postila, P. A., Pickering, D. S., Smith, C. M., Gajhede, M., Sasaki, M., Sakai, R., Pentikäinen, O. T., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808547200 · Cited by 54
Self-citation
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Yamasaki, M., Okada, R., Takasaki, C., Toki, S., Fukaya, M., Natsume, R., Sakimura, K., Mishina, M., Shirakawa, T., & Watanabe, M. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1811-14.2014 · Cited by 54
Subconductance States of a Mutant NMDA Receptor Channel Kinetics, Calcium, and Voltage Dependence
Premkumar, L. S., Qin, F., & Auerbach, A. L. (1997) · The Journal of General Physiology · doi:10.1085/jgp.109.2.181 · Cited by 54
The effect of competitive antagonist chain length on NMDA receptor subunit selectivity
FENG, B., MORLEY, R., Jane, D. E., & Monaghan, D. T. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.11.004 · Cited by 54
GluRδ2 Assembles Four Neurexins intoTrans-Synaptic Triad to Trigger Synapse Formation
Lee, S., Uemura, T., Yoshida, T., & Mishina, M. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5584-11.2012 · Cited by 54
GRIN2D/GluN2D NMDA receptor: Unique features and its contribution to pediatric developmental and epileptic encephalopathy
Camp, C. R., & Yuan, H. (2019) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2019.12.007 · Cited by 54
Self-citation
TARP γ-7 selectively enhances synaptic expression of calcium-permeable AMPARs
Studniarczyk, D., Coombs, I. D., Cull-Candy, S. G., & Farrant, M. (2013) · Nature Neuroscience · doi:10.1038/nn.3473 · Cited by 54
Expression and heteromeric interactions of non-N-methyl-d-aspartate glutamate receptor subunits in the developing and adult cerebellum
Ripellino, J. A., Neve, R. L., & Howe, J. R. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00296-0 · Cited by 54
Allosteric Interactions between NMDA Receptor Subunits Shape the Developmental Shift in Channel Properties
Sun, W., Hansen, K. B., & Jahr, C. E. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.018 · Cited by 54
Self-citation
Surface Expression, Function, and Pharmacology of Disease-Associated Mutations in the Membrane Domain of the Human GluN2B Subunit
Vyklický, V., Krausová, B. H., Černý, J., Ladislav, M., Smejkalová, T., Kysilov, B., Kořı́nek, M., Danačíková, Š., Hořák, M., Chodounská, H., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00110 · Cited by 54
Structure and mechanism of AMPA receptor — auxiliary protein complexes
Chen, S., & Gouaux, E. (2019) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2019.01.011 · Cited by 54
SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function
Bae, M. H., Roh, J. D., Kim, Y.-J., Kim, S. S., Han, H. M., Yang, E., Kang, H., Lee, S., Kim, J. Y., Kang, R., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202012632 · Cited by 54
AMPA Receptors Commandeer an Ancient Cargo Exporter for Use as an Auxiliary Subunit for Signaling
Harmel, N., Cokić, B., Zolles, G., Berkefeld, H., Mauric, V., Fakler, B., Stein, V., & Klöcker, N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030681 · Cited by 53
Structure−Activity Relationship Studies on N3-Substituted Willardiine Derivatives Acting as AMPA or Kainate Receptor Antagonists
Dolman, N. P., More, J. C. A., Alt, A. J., Knauss, J. L., Troop, H. M., Bleakman, D., Collingridge, G. L., & Jane, D. E. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm051086f · Cited by 53
Mibampator (LY451395) randomized clinical trial for agitation/aggression in Alzheimer's disease
Trzepacz, P. T., Cummings, J., Konechnik, T., Forrester, T. D., Chang, C., Dennehy, E. B., Willis, B. A., Shuler, C., Tabas, L. B., & Lyketsos, C. (2013) · International Psychogeriatrics · doi:10.1017/s1041610212002141 · Cited by 53
Partial Agonism and Antagonism of the Ionotropic Glutamate Receptor iGLuR5
Hald, H., Naur, P., Pickering, D. S., Sprogøe, D., Madsen, U., Timmermann, D. B., Ahring, P. K., Liljefors, T., Schousboe, A., Egebjerg, J., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700137200 · Cited by 53
N-Methyl-d-aspartate (NMDA) Receptor NR2 Subunit Selectivity of a Series of Novel Piperazine-2,3-dicarboxylate Derivatives: Preferential Blockade of Extrasynaptic NMDA Receptors in the Rat Hippocampal CA3-CA1 Synapse
Costa, B. M., Feng, B., Tsintsadze, T. S., Morley, R. M., Irvine, M. W., Tsintsadze, V., Lozovaya, N. A., Jane, D. E., & Monaghan, D. T. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.156752 · Cited by 53
Tyr702 Is an Important Determinant of Agonist Binding and Domain Closure of the Ligand-Binding Core of GluR2
Frandsen, A., Pickering, D. S., Vestergaard, B., Kasper, C., Nielsen, B. B., Greenwood, J. R., Campiani, G., Fattorusso, C., Gajhede, M., Schousboe, A., et al. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.002931 · Cited by 53
Divergent Pharmacological Activity of Novel Marine-Derived Excitatory Amino Acids on Glutamate Receptors
Sanders, J. M., Ito, K., Settimo, L., Pentikäinen, O. T., Shoji, M., Sasaki, M., Johnson, M. S., Sakai, R., & Swanson, G. T. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.086389 · Cited by 53
Self-citation
Synaptic expression of the high-affinity kainate receptor subunit KA2 in hippocampal cultures
Roche, K. W., & Huganir, R. L. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00253-f · Cited by 53
C-terminal Domains of N-Methyl-d-aspartic Acid Receptor Modulate Unitary Channel Conductance and Gating
Maki, B. A., Aman, T. K., Amico-Ruvio, S. A., Kussius, C. L., & Popescu, G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.390013 · Cited by 53
Chronic NMDA Exposure Accelerates Development of GABAergic Inhibition in the Superior Colliculus
Aamodt, S. M., Shi, J., Colonnese, M. T., Veras, W., & Constantine‐Paton, M. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.3.1580 · Cited by 53
An NMDA Receptor-Dependent Mechanism Underlies Inhibitory Synapse Development
Gu, X., Zhou, L., & Lü, W. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.061 · Cited by 53
Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule
Vyklický, V., Krausová, B. H., Černý, J., Balík, A., Zapotocky, M., Novotný, M., Hemelíková, K., Smejkalová, T., Kaniaková, M., Kořı́nek, M., et al. (2015) · Scientific Reports · doi:10.1038/srep10935 · Cited by 53
Lessons from crystal structures of kainate receptors
Møllerud, S., Frydenvang, K., Pickering, D. S., & Kastrup, J. S. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.05.014 · Cited by 53
Ionotropic glutamate receptors: Which ones, when, and where in the mammalian neocortex
Hadzic, M., Jack, A., & Wahle, P. (2017) · Journal of Comparative Neurology · doi:10.1002/cne.24103 · Cited by 53
An Epilepsy-Associated GRIN2A Rare Variant Disrupts CaMKIIα Phosphorylation of GluN2A and NMDA Receptor Trafficking
Vieira, M. M., Nguyen, T., Wu, K., Badger, J. D., Collins, B. M., Anggono, V., Lü, W., & Roche, K. W. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108104 · Cited by 53
Genetic ablation of NMDA receptor subunit NR3B in mouse reveals motoneuronal and nonmotoneuronal phenotypes
Niemann, S., Kanki, H., Fukui, Y., Takao, K., Fukaya, M., Hynynen, M., Churchill, M., Shefner, J. M., Bronson, R. T., Brown, R. H., et al. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05774.x · Cited by 52
PKC phosphorylates GluA1-Ser831 to enhance AMPA receptor conductance
Jenkins, M. A., & Traynelis, S. F. (2012) · Channels · doi:10.4161/chan.18648 · Cited by 52
Self-citation
AMPA receptor positive allosteric modulators: a patent review
Pirotte, B., Francotte, P., Goffin, E., & Tullio, P. D. (2013) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2013.770840 · Cited by 52
ACET is a highly potent and specific kainate receptor antagonist: Characterisation and effects on hippocampal mossy fibre function
Amici-Dargan, S., Clarke, V. R. J., Alushin, G. M., Sherwood, J. L., Nisticò, R., Bortolotto, Z. A., Ogden, A. M. L., Bleakman, D., Doherty, A. J., Lodge, D., et al. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.08.016 · Cited by 52
SPD 502: A Water-Soluble and In Vivo Long-Lasting Ampa Antagonist with Neuroprotective Activity
Nielsen, E. Ø., Varming, T., Mathiesen, C., Jensen, L. H., Møller, A., Gouliaev, A. H., Wätjen, F., & Drejer, J. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38297-7 · Cited by 52
Presynaptic kainate receptor‐mediated facilitation of glutamate release involves Ca2+–calmodulin and PKA in cerebrocortical synaptosomes
Moreno, A. R., & Sihra, T. S. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.01.071 · Cited by 52
NMDA and benzodiazepine receptors have synergistic and antagonistic effects on precursor cells in adult hippocampal neurogenesis
Petrus, D. S., Fabel, K. S., Kronenberg, G., Winter, C., Steiner, B., & Kempermann, G. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06579.x · Cited by 52
A distinct thermoreceptive subregion of lamina I in nucleus caudalis of the owl monkey
Craig, A. D., Zhang, E., & Blomqvist, A. G. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990208)404:2 · Cited by 52
Kainate Receptor–Mediated Inhibition of Glutamate Release Involves Protein Kinase A in the Mouse Hippocampus
Negrete‐Díaz, J. V., Sihra, T. S., Delgado-Garcia, J. M., & Moreno, A. R. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00280.2006 · Cited by 52
Molecular Mechanism of AMPA Receptor Modulation by TARP/Stargazin
Ben-Yaacov, A., Gillor, M., Haham, T., Parsai, A., Qneibi, M., & Stern-Bach, Y. (2017) · Neuron · doi:10.1016/j.neuron.2017.01.032 · Cited by 52
In the Telencephalon, GluN2C NMDA Receptor Subunit mRNA is Predominately Expressed in Glial Cells and GluN2D mRNA in Interneurons
Alsaad, H. A., DeKorver, N. W., Mao, Z., Dravid, S. M., Arikkath, J., & Monaghan, D. T. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2526-7 · Cited by 52
A conserved glycine harboring disease-associated mutations permits NMDA receptor slow deactivation and high Ca2+ permeability
Amin, J. B., Leng, X., Gochman, A., Zhou, H., & Wollmuth, L. P. (2018) · Nature Communications · doi:10.1038/s41467-018-06145-w · Cited by 52
Self-citation
From bedside‐to‐bench: What disease‐associated variants are teaching us about the NMDA receptor
Amin, J. B., Moody, G. R., & Wollmuth, L. P. (2020) · The Journal of Physiology · doi:10.1113/jp278705 · Cited by 52
Self-citation
Postsynaptic Serine Racemase Regulates NMDA Receptor Function
Wong, J. M., Folorunso, O. O., Barragan, E. V., Berciu, C., Harvey, T. L., DeChellis-Marks, M. R., Glausier, J. R., MacDonald, M. L., Coyle, J. T., Balu, D. T., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1525-20.2020 · Cited by 52
Substitution for PCP, disruption of prepulse inhibition and hyperactivity induced by N-methyl-D-aspartate receptor antagonists: preferential involvement of the NR2B rather than NR2A subunit.
Chaperon, F., Müller, W., Auberson, Y. P., Tricklebank, M. D., & Neijt, H. C. (2003) · PubMed · doi:10.1097/01.fbp.0000091471.79060.ed · Cited by 51
Solid-Phase Synthesis of Polyamine Toxin Analogues: Potent and Selective Antagonists of Ca2+-Permeable AMPA Receptors
Kromann, H., Krikštolaitytė, S., Andersen, A. J., Andersen, K. V., Krogsgaard‐Larsen, P., Jaroszewski, J. W., Egebjerg, J., & Strømgaard, K. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm020314s · Cited by 51
GluR3 Flip and Flop: Differences in Channel Opening Kinetics
Pei, W., Huang, Z., & Niu, L. (2007) · Biochemistry · doi:10.1021/bi062213s · Cited by 51
Three-Dimensional Structure of the Ligand-Binding Core of GluR2 in Complex with the Agonist ( S ) - ATPA: Implications for Receptor Subunit Selectivity
Lunn, M.-L., Hogner, A., Stensbøl, T. B., Gouaux, E., Egebjerg, J., & Kastrup, J. S. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm021020+ · Cited by 51
Pharmacological Characterization of Ro 63-1908 (1-[2-(4-Hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol), a Novel Subtype-Selective N-Methyl-d-Aspartate Antagonist
Gill, R., Alanine, A. I., Bourson, A., Büttelmann, B., Fischer, G., Heitz, M., Kew, J. N. C., Levet‐Trafit, B., Lorez, H. P., Malherbe, P., et al. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.034322 · Cited by 51
Retinal Circuitry Balances Contrast Tuning of Excitation and Inhibition to Enable Reliable Computation of Direction Selectivity
Poleg-Polsky, A., & Diamond, J. S. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4013-15.2016 · Cited by 51
Self-citation
Conformational Plasticity in the Transsynaptic Neurexin-Cerebellin-Glutamate Receptor Adhesion Complex
Cheng, S., Seven, A. B., Wang, J., Skiniotis, G., & Özkan, E. (2016) · Structure · doi:10.1016/j.str.2016.11.004 · Cited by 51
Moderate AMPA receptor clustering on the nanoscale can efficiently potentiate synaptic current
Savtchenko, L. P., & Rusakov, D. A. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0167 · Cited by 51
Asynchronous Movements Prior to Pore Opening in NMDA Receptors
Kazi, R., Gan, Q., Talukder, I., Markowitz, M., Salussolia, C. L., & Wollmuth, L. P. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5780-12.2013 · Cited by 51
Self-citation
Dynamics of the S1S2 Glutamate Binding Domain of GluR2 Measured Using 19F NMR Spectroscopy
Ahmed, A. H., Loh, A. P., Jane, D. E., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610077200 · Cited by 51
GABAergic synapses in hippocampus exocytose aspartate on to NMDA receptors: quantitative immunogold evidence for co-transmission
Gundersen, V., Holten, A. R., & Storm‐Mathisen, J. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.01.017 · Cited by 51
Sites in the fourth membrane-associated domain regulate alcohol sensitivity of the NMDA receptor
Honse, Y., Ren, H., Lipsky, R. H., & Peoples, R. W. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2003.11.006 · Cited by 51
A Toolkit for Orthogonal and in vivo Optical Manipulation of Ionotropic Glutamate Receptors
Levitz, J., Popescu, A. T., Reiner, A., & Isacoff, E. Y. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00002 · Cited by 51
Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits
Lind, G. E., Mou, T., Tamborini, L., Pomper, M. G., Micheli, C. D., Conti, P., Pinto, A., & Hansen, K. B. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707752114 · Cited by 51
Self-citation
Selective targeting of unipolar brush cell subtypes by cerebellar mossy fibers
Balmer, T. S., & Trussell, L. O. (2019) · eLife · doi:10.7554/elife.44964 · Cited by 51
GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior
Nakamoto, C., Kawamura, M., Nakatsukasa, E., Natsume, R., Takao, K., Watanabe, M., Abe, M., Takeuchi, T., & Sakimura, K. (2020) · PLoS ONE · doi:10.1371/journal.pone.0229288 · Cited by 51
Cell-Specific Regulation of N-Methyl-D-Aspartate Receptor Maturation by Mecp2 in Cortical Circuits
Mierau, S. B., Patrizi, A., Hensch, T. K., & Fagiolini, M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.018 · Cited by 50
NMDA and AMPA Receptors Contribute to the Nicotinic Cholinergic Excitation of CA1 Interneurons in the Rat Hippocampus
Alkondon, M., Pereira, E. F. R., & Albuquerque, E. X. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00214.2003 · Cited by 50
Mutation in hotfoot‐4J mice results in retention of δ2 glutamate receptors in ER
Matsuda, S., & Yuzaki, M. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02219.x · Cited by 50
Ubiquitin-dependent trafficking and turnover of ionotropic glutamate receptors
Goo, M. S., Scudder, S. L., & Patrick, G. N. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00060 · Cited by 50
The AMPA Antagonist ZK 200775 in Patients with Acute Ischaemic Stroke: A Double-Blind, Multicentre, Placebo-Controlled Safety and Tolerability Study
Walters, M. R., Kaste, M., Lees, K. R., Diener, H., Hommel, M., Keyser, J. D., Steiner, H., & Versavel, M. (2005) · Cerebrovascular Diseases · doi:10.1159/000087929 · Cited by 50
Superactivation of AMPA receptors by auxiliary proteins
Carbone, A. L., & Plested, A. J. R. (2016) · Nature Communications · doi:10.1038/ncomms10178 · Cited by 50
Positive N-Methyl-D-Aspartate Receptor Modulation by Rapastinel Promotes Rapid and Sustained Antidepressant-Like Effects
Donello, J. E., Banerjee, P., Li, Y.-X., Guo, Y.-X., Yoshitake, T., Zhang, X.-L., Miry, O., Kehr, J., Stanton, P. K., Gross, A. L., et al. (2019) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy101 · Cited by 50
An autism-associated mutation in GluN2B prevents NMDA receptor trafficking and interferes with dendrite growth
Sceniak, M. P., Fedder-Semmes, K. N., Wang, Q., Droubi, S., Babcock, K., Patwardhan, S., Wright-Zornes, J., Pham, L., & Sabo, S. L. (2019) · Journal of Cell Science · doi:10.1242/jcs.232892 · Cited by 50
The extreme C‐terminus of GluRδ2 is essential for induction of long‐term depression in cerebellar slices
Kohda, K., Kakegawa, W., Matsuda, S., Nakagami, R., Kakiya, N., & Yuzaki, M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05412.x · Cited by 50
Glutamate-Bound NMDARs Arising from In Vivo-like Network Activity Extend Spatio-temporal Integration in a L5 Cortical Pyramidal Cell Model
Farinella, M., Ruedt, D. T., Gleeson, P., Lanore, F., & Silver, R. A. (2014) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003590 · Cited by 50
High Firing Rate of Neonatal Hippocampal Interneurons Is Caused by Attenuation of Afterhyperpolarizing Potassium Currents by Tonically Active Kainate Receptors
Segerstråle, M., Juuri, J., Lanore, F., Piepponen, P. T., Lauri, S. E., Mulle, C., & Taira, T. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4856-09.2010 · Cited by 50
CaMKII‐dependent phosphorylation of GluK5 mediates plasticity of kainate receptors
Carta, M., Opazo, P., Veran, J., Athané, A., Choquet, D., Coussen, F., & Mulle, C. (2013) · The EMBO Journal · doi:10.1038/emboj.2012.334 · Cited by 50
Cellular localization of GluR1, GluR2/3 and GluR4 glutamate receptor subunits in neurons of the rat neostriatum
Kwok, K. H. H., Tse, Y. C., Wong, R. N., et al. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00950-5 · Cited by 50
Mapping the Binding of GluN2B-Selective N-Methyl-d-aspartate Receptor Negative Allosteric Modulators
Burger, P. B., Yuan, H., Karakaş, E., Geballe, M. T., Furukawa, H., Liotta, D. C., Snyder, J. P., & Traynelis, S. F. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.078568 · Cited by 50
Self-citation
Different composition of glutamate receptors in corticothalamic and lemniscal synaptic responses and their roles in the firing responses of ventrobasal thalamic neurons in juvenile mice
Miyata, M., & Imoto, K. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.114413 · Cited by 50
Positive Allosteric Modulation as a Potential Therapeutic Strategy in Anti-NMDA Receptor Encephalitis
Warikoo, N., Brunwasser, S. J., Benz, A. M., Shu, H., Paul, S. M., Lewis, M., Doherty, J., Quirk, M. C., Piccio, L. M., Zorumski, C. F., et al. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3377-17.2018 · Cited by 50
Dose-Related Target Occupancy and Effects on Circuitry, Behavior, and Neuroplasticity of the Glycine Transporter-1 Inhibitor PF-03463275 in Healthy and Schizophrenia Subjects
D’Souza, D. C., Carson, R. E., Driesen, N. R., Johannesen, J., Ranganathan, M., Krystal, J. H., Ahn, K.-H., Forselius-Bielen, K., Carbuto, M., Deaso, E., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.12.019 · Cited by 50
The C‐terminal domains of the NMDA receptor: How intrinsically disordered tails affect signalling, plasticity and disease
Warnet, X. L., Bakke Krog, H., Sevillano‐Quispe, O. G., Poulsen, H., & Kjaergaard, M. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14842 · Cited by 50
Comparative analysis of the pharmacology of GluR1 in complex with transmembrane AMPA receptor regulatory proteins γ2, γ3, γ4, and γ8
Kott, S., Sager, C. A., Tapken, D., Werner, M., & Hollmann, M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2007.12.047 · Cited by 49
Family-based association study between GRIK2 polymorphisms and autism spectrum disorders in the Korean trios
Kim, S. A., Kim, J. H., Park, M., Cho, I. H., & Yoo, H. J. (2007) · Neuroscience Research · doi:10.1016/j.neures.2007.03.002 · Cited by 49
External Ions Are Coactivators of Kainate Receptors
Wong, A. Y. C., Fay, A.-M. L., & Bowie, D. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0301-06.2006 · Cited by 49
Self-citation
Essential role of postsynaptic NMDA receptors in developmental refinement of excitatory synapses
Zhang, Z., Peterson, M., & Liu, H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1212971110 · Cited by 49
Developmental Changes in AMPA and Kainate Receptor-Mediated Quantal Transmission at Thalamocortical Synapses in the Barrel Cortex
Bannister, N. J., Benke, T. A., Mellor, J. R., Scott, H. L., Gürdal, E., Crabtree, J. W., & Isaac, J. T. R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0827-05.2005 · Cited by 49
TARP modulation of synaptic AMPA receptor trafficking and gating depends on multiple intracellular domains
Milstein, A. D., & Nicoll, R. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905570106 · Cited by 49
Cerebellar LTD vs. motor learning - Lessons learned from studying GluD2
Yuzaki, M. (2013) · Neural Networks · doi:10.1016/j.neunet.2012.07.001 · Cited by 49
Modeling of the Pore Domain of the GLUR1 Channel: Homology with K+ Channel and Binding of Channel Blockers
Tikhonov, D. B., Mellor, J. R., Usherwood, P. N. R., & Magazanik, L. G. (2002) · Biophysical Journal · doi:10.1016/s0006-3495(02)75538-0 · Cited by 49
Kainate Receptors and Pain: From Dorsal Root Ganglion to the Anterior Cingulate Cortex
Wu, L., Ko, S. W., & Zhuo, M. (2007) · Current Pharmaceutical Design · doi:10.2174/138161207780765864 · Cited by 49
Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ions
Chaudhry, C., Plested, A. J. R., Schuck, P., & Mayer, M. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904175106 · Cited by 49
Positive Allosteric Modulators of AMPA Receptors Reduce Proton-Induced Receptor Desensitization in Rat Hippocampal Neurons
Lei, S., Orser, B. A., Thatcher, G. R., Reynolds, J. N., & MacDonald, J. F. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.5.2030 · Cited by 49
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Mechanisms of ketamine and its metabolites as antidepressants
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Authors: Hansen, K. B., Wollmuth, L. P., Bowie, D., Furukawa, H., Menniti, F. S., Sobolevsky, A. I., Swanson, G. T., Swanger, S. A., Greger, I. H., Nakagawa, T., McBain, C. J., Jayaraman, V., Low, C.-M., Dell’Acqua, M. L., Diamond, J. S., Camp, C. R., Perszyk, R. E., Yuan, H., & Traynelis, S. F.
Affiliations: Northwestern University (US)
Corresponding author: Traynelis, Stephen F.
ORCID: Hansen, Kasper B.
Wollmuth, Lonnie P.
Bowie, Derek
Furukawa, Hiro
Menniti, Frank S.
Sobolevsky, Alexander I.
Swanson, Geoffrey T.
Swanger, Sharon A.
Greger, Ingo H.
Nakagawa, Terunaga
McBain, Chris J.
Jayaraman, Vasanthi
Low, Chian-Ming
Dell’Acqua, Mark L.
Diamond, Jeffrey S.
Camp, Chad R.
Perszyk, Riley E.
Yuan, Hongjie
Traynelis, Stephen F.
Venue: Pharmacological Reviews
Publisher: Elsevier BV
Published: 2021-10
Volume: 73
Issue: 4
Pages: 1469-1658
ISSN: 0031-6997 (ISSN-L)
DOI: 10.1124/pharmrev.120.000131
PMC: PMC8626789
OpenAlex: W3214054678
Cited by: 686
References: 2,576
Citations by year: 2026: 123 · 2025: 198 · 2024: 160 · 2023: 115 · 2022: 81 · 2021: 9
FWCI: 13.86
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Pharmacological Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
Funders: National Institutes of Health (5f31ns113530-02)
Biotechnology and Biological Sciences Research Council (BB/N002113/1)
National Institute of Mental Health (R56MH123474, R21MH127404, R01MH085926, R01MH123474)
National Cancer Institute (R01CA206573)
National Institute of General Medical Sciences (P20GM103546, R35GM122528)
National Institute of Neurological Disorders and Stroke (F31‐NS113530, R01NS105804, R56NS040701, R01NS083660, R01NS040701, R01NS088479, R01NS111745, RF1NS113632, R01NS105502, R01NS107253, R35NS111619, R37NS083660, R01NS116055, R01NS097536)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD082373)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: ionotropic glutamate receptors, ligand-gated ion channels, glutamate, receptor subtypes, receptor structure, receptor pharmacology, excitatory neurotransmission, neurophysiology, neurological disorders, mental illness, therapeutic target
MeSH terms: Animals, Central Nervous System, Humans, Receptors, Glutamate, Neurotransmitter Agents, Glutamic Acid, Receptors, Ionotropic Glutamate

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Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

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