Cited by 686Neuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors StudyReceptor Mechanisms and Signaling

The DOI matches its Crossref record; 2,576 of the 2,576 references it cites were found in a registry or an index.

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

Open access

Hansen, Kasper B., Wollmuth, Lonnie P., Bowie, Derek, Furukawa, Hiro, Menniti, Frank S., Sobolevsky, Alexander I., Swanson, Geoffrey T., Swanger, Sharon A., Greger, Ingo H., Nakagawa, Terunaga, McBain, Chris J., Jayaraman, Vasanthi, Low, Chian-Ming, Dell’Acqua, Mark L., Diamond, Jeffrey S., Camp, Chad R., Perszyk, Riley E., Yuan, Hongjie, Traynelis, Stephen F.·2021·Pharmacological Reviews

DOI 10.1124/pharmrev.120.000131PMC PMC8626789

Open this paper in CoChat — free account Open PDF

Abstract

Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the mammalian central nervous system, are mediated via signaling by ionotropic glutamate receptors (iGluRs). These ligand-gated ion channels are critical to brain function and are centrally implicated in numerous psychiatric and neurologic disorders. There are different classes of iGluRs with a variety of receptor subtypes in each class that play distinct roles in neuronal functions. The diversity in iGluR subtypes, with their unique functional properties and physiologic roles, has motivated a large number of studies. Our understanding of receptor subtypes has advanced considerably since the first iGluR subunit gene was cloned in 1989, and the research focus has expanded to encompass facets of biology that have been recently discovered and to exploit experimental paradigms made possible by technological advances. Here, we review insights from more than 3 decades of iGluR studies with an emphasis on the progress that has occurred in the past decade. We cover structure, function, pharmacology, roles in neurophysiology, and therapeutic implications for all classes of receptors assembled from the subunits encoded by the 18 ionotropic glutamate receptor genes. SIGNIFICANCE STATEMENT: Glutamate receptors play important roles in virtually all aspects of brain function and are either involved in mediating some clinical features of neurological disease or represent a therapeutic target for treatment. Therefore, understanding the structure, function, and pharmacology of this class of receptors will advance our understanding of many aspects of brain function at molecular, cellular, and system levels and provide new opportunities to treat patients.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1124/pharmrev.120.000131

Cites

2576 of 2576 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Items 601–800 of 2,576

Developmental and activity- dependent regulation of kainate receptors at thalamocortical synapses
Kidd, F. L., & Isaac, J. T. R. (1999) · Nature · doi:10.1038/23040 · Cited by 224
Glutamate modulators as potential therapeutic drugs in schizophrenia and affective disorders
Hashimoto, K., Malchow, B., Falkai, P., & Schmitt, A. (2013) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-013-0399-y · Cited by 224
Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits
Favuzzi, E., Deogracias, R., Marques–Smith, A., Maeso, P. A., Jézéquel, J., Exposito-Alonso, D., Balia, M., Kroon, T., Hinojosa, A. J., Maraver, E. F., et al. (2019) · Science · doi:10.1126/science.aau8977 · Cited by 224
Concanavalin A selectively reduces desensitization of mammalian neuronal quisqualate receptors.
Mayer, M. L., & Vyklický, L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.4.1411 · Cited by 224
N ‐methyl‐ D ‐aspartate receptor antibodies in post–herpes simplex virus encephalitis neurological relapse
Hacohen, Y., Deiva, K., Pettingill, P., Waters, P. J., Siddiqui, A. U., Chrétien, P., Menson, E. N., Lin, J., Tardieu, M., Vincent, A. C., et al. (2013) · Movement Disorders · doi:10.1002/mds.25626 · Cited by 224
AMPA Receptor Potentiators for the Treatment of CNS Disorders
O’Neill, M. J., Bleakman, D., Zimmerman, D. M., & Nisenbaum, E. S. (2004) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007043337508 · Cited by 223
Spatiotemporally Graded NMDA Spike/Plateau Potentials in Basal Dendrites of Neocortical Pyramidal Neurons
Major, G., Poleg-Polsky, A., Denk, W. T., Schiller, J., & Tank, D. W. (2008) · Journal of Neurophysiology · doi:10.1152/jn.00011.2008 · Cited by 222
Control of hippocampal gamma oscillation frequency by tonic inhibition and excitation of interneurons
Mann, E. O., & Mody, I. (2010) · Nature Neuroscience · doi:10.1038/nn.2464 · Cited by 222
Structure and gating of the glutamate receptor ion channel
Wollmuth, L. P. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.04.005 · Cited by 221
Self-citation
Memantine as Adjunctive Therapy in Children Diagnosed With Autistic Spectrum Disorders: An Observation of Initial Clinical Response and Maintenance Tolerability
Chez, M. G., Burton, Q., Dowling, T., Chang, M., Khanna, P., & Kramer, C. (2007) · Journal of Child Neurology · doi:10.1177/0883073807302611 · Cited by 221
Activation of Extrasynaptic, But Not Synaptic, NMDA Receptors Modifies Amyloid Precursor Protein Expression Pattern and Increases Amyloid-β Production
Bordji, K., Becerril-Ortega, J., Nicole, O., & Buisson, A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3021-10.2010 · Cited by 221
Differential Sensitivity of RecombinantN-Methyl-d-Aspartate Receptor Subtypes to Zinc Inhibition
Chen, N., Moshaver, A., & Raymond, L. A. (1997) · Molecular Pharmacology · doi:10.1124/mol.51.6.1015 · Cited by 221
Heterogeneity of synaptic glutamate receptors on CA3 stratum radiatum interneurones of rat hippocampus.
McBain, C. J., & Dingledine, R. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019560 · Cited by 221
Self-citation
5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition
Auberson, Y. P., Allgeier, H., Bischoff, S. F., Lingenhoehl, K., Moretti, R., & Schmutz, M. (2002) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(02)00074-4 · Cited by 221
Molecular Organization of a Zinc Binding N-Terminal Modulatory Domain in a NMDA Receptor Subunit
Paoletti, P., Perin-Dureau, F., Fayyazuddin, A., Goff, A. L., Callebaut, I., & Neyton, J. (2000) · Neuron · doi:10.1016/s0896-6273(00)00163-x · Cited by 220
Pharmacological properties and H+ sensitivity of excitatory amino acid receptor channels in rat cerebellar granule neurones.
Traynelis, S. F., & Cull-Candy, S. G. (1991) · The Journal of Physiology · doi:10.1113/jphysiol.1991.sp018453 · Cited by 219
Self-citation
Functional kainate-selective glutamate receptors in cultured hippocampal neurons.
Lerma, J., Paternain, A. V., Naranjo, J. R., & Mellström, B. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.11688 · Cited by 219
Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1
Pérez‐Otaño, I., Luján, R., Tavalin, S. J., Plomann, M., Modregger, J., Liu, X., Jones, E. G., Heinemann, S. F., Lo, D. C., & Ehlers, M. (2006) · Nature Neuroscience · doi:10.1038/nn1680 · Cited by 218
Measurement of Conformational Changes accompanying Desensitization in an Ionotropic Glutamate Receptor
Armstrong, N., Jasti, J., Beich-Frandsen, M., & Gouaux, E. (2006) · Cell · doi:10.1016/j.cell.2006.08.037 · Cited by 218
How AMPA Receptor Desensitization Depends on Receptor Occupancy
Robert, A., & Howe, J. R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00847.2003 · Cited by 218
Glutamate receptor antibodies activate a subset of receptors and reveal an agonist binding site
Twyman, R. E., Gahring, L. C., Spiess, J., & Rogers, S. W. (1995) · Neuron · doi:10.1016/0896-6273(95)90219-8 · Cited by 218
Noise and single channels activated by excitatory amino acids in rat cerebellar granule neurones.
Cull-Candy, S. G., Howe, J. R., & Ogden, D. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp017117 · Cited by 217
Neurexins
Reißner, C., Runkel, F., & Missler, M. (2013) · Genome biology · doi:10.1186/gb-2013-14-9-213 · Cited by 217
Synapse formation is regulated by the signaling adaptor GIT1
Zhang, H., Webb, D. J., Asmussen, H., & Horwitz, A. F. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211002 · Cited by 216
Kainate Receptor-Mediated Responses in the CA1 Field of Wild-Type and GluR6-Deficient Mice
Bureau, I., Bischoff, S., Heinemann, S. F., & Mulle, C. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-02-00653.1999 · Cited by 215
A kinetic analysis of the modulation of N‐methyl‐D‐aspartic acid receptors by glycine in mouse cultured hippocampal neurones.
Benveniste, M., Clements, J., Vyklický, L., & Mayer, M. L. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018215 · Cited by 215
Mutation of a glutamate receptor motif reveals its role in gating and δ2 receptor channel properties
Kohda, K., Wang, Y., & Yuzaki, M. (2000) · Nature Neuroscience · doi:10.1038/73877 · Cited by 214
Mechanisms underlying NMDA receptor synaptic/extrasynaptic distribution and function
Gladding, C. M., & Raymond, L. A. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.05.001 · Cited by 214
AMPA, KA and NMDA receptors are expressed in the rat DRG neurones
Sato, K., Kiyama, H., Park, H. T., et al. (1993) · Neuroreport · doi:10.1097/00001756-199309000-00013 · Cited by 214
Emerging roles of GluN3-containing NMDA receptors in the CNS
Pérez-Otaño, I., Larsen, R. S., & Wesseling, J. F. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.92 · Cited by 214
Dynamics of interstitial and intracellular pH in evolving brain infarct
Nedergaard, M., Kraig, R. P., Tanabe, J., & Pulsinelli, W. A. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.260.3.r581 · Cited by 213
Characterization and Comparison of the NR3A Subunit of the NMDA Receptor in Recombinant Systems and Primary Cortical Neurons
Sasaki, Y., Rothe, T., Premkumar, L. S., Das, S., Cui, J., Talantova, M. V., Wong, H. K., Gong, X., Chan, S. F., Zhang, D., et al. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00531.2001 · Cited by 213
Metabotropic-Mediated Kainate Receptor Regulation of IsAHP and Excitability in Pyramidal Cells
Melyan, Z., Wheal, H. V., & Lancaster, B. (2002) · Neuron · doi:10.1016/s0896-6273(02)00624-4 · Cited by 213
Activation of NR1/NR2B NMDA receptors
Banke, T. G., & Traynelis, S. F. (2003) · Nature Neuroscience · doi:10.1038/nn1000 · Cited by 213
Self-citation
Different forms of LTD in the CA1 region of the hippocampus: role of age and stimulus protocol
Kemp, N. M., McQueen, J., Faulkes, S., & Bashir, Z. I. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00903.x · Cited by 213
Conservation of Glutamate Receptor 2-Containing AMPA Receptors during Long-Term Potentiation
Adesnik, H., & Nicoll, R. A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0325-07.2007 · Cited by 213
Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors
Shinohara, Y., Hirase, H., Watanabe, M., Itakura, M., Takahashi, M., & Shigemoto, R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807461105 · Cited by 213
The concentration of synaptically released glutamate outside of the climbing fiber-Purkinje cell synaptic cleft
Dzubay, J. A., & Jahr, C. E. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05265.1999 · Cited by 213
The protein kinase Cα binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits
Dev, K. K., Nishimune, A., Henley, J. M., & Nakanishi, S. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(98)00230-5 · Cited by 212
Glutamate NMDA receptor dysregulation in Parkinson’s disease with dyskinesias
Ahmed, I., Bose, S. K., Pavese, N., Ramlackhansingh, A. F., Turkheimer, F., Hotton, G. R., Hammers, A., & Brooks, D. J. (2011) · Brain · doi:10.1093/brain/awr028 · Cited by 212
Pharmacology of Ampakine Modulators: From AMPA Receptors to Synapses and Behavior
Arai, A., & Kessler, M. (2007) · Current Drug Targets · doi:10.2174/138945007780618490 · Cited by 211
Subunit Composition of Kainate Receptors in Hippocampal Interneurons
Mulle, C., Sailer, A., Swanson, G. T., Brana, C., O'Gorman, S., Bettler, B., & Heinemann, S. F. (2000) · Neuron · doi:10.1016/s0896-6273(00)00126-4 · Cited by 210
Self-citation
Zinc Dynamics and Action at Excitatory Synapses
Vergnano, A. M., Rebola, N., Savtchenko, L. P., Pinheiro, P. S., Casado, M., Kieffer, B. L., Rusakov, D. A., Mulle, C., & Paoletti, P. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.034 · Cited by 210
REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors
Rodenas-Ruano, A., Chávez, A. E., Cossio, M. J., Castillo, P. E., & Zukin, R. S. (2012) · Nature Neuroscience · doi:10.1038/nn.3214 · Cited by 210
Molecular determinants of AMPA receptor subunit assembly
Greger, I. H., Ziff, E. B., & Penn, A. C. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.005 · Cited by 210
Self-citation
NMDA Receptor-Dependent LTD Requires Transient Synaptic Incorporation of Ca 2+ -Permeable AMPARs Mediated by AKAP150-Anchored PKA and Calcineurin
Sanderson, J. L., Gorski, J. A., & Dell’Acqua, M. L. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.043 · Cited by 210
Self-citation
Direct Measurement of AMPA Receptor Desensitization Induced by Glutamatergic Synaptic Transmission
Otis, T., Zhang, S., & Trussell, L. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-23-07496.1996 · Cited by 209
The NMDA receptor ‘glycine modulatory site’ in schizophrenia: d-serine, glycine, and beyond
Balu, D. T., & Coyle, J. T. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2014.12.004 · Cited by 208
Opposing roles of synaptic and extrasynaptic NMDA receptors in neuronal calcium signalling and BDNF gene regulation
Vanhoutte, P., & Bading, H. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00073-4 · Cited by 208
Presynaptic Effects of NMDA in Cerebellar Purkinje Cells and Interneurons
Glitsch, M. D., & Marty, A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-02-00511.1999 · Cited by 208
Ionotropic GABA and Glutamate Receptor Mutations and Human Neurologic Diseases
Yuan, H., Low, C., Moody, O. A., Jenkins, A., & Traynelis, S. F. (2015) · Molecular Pharmacology · doi:10.1124/mol.115.097998 · Cited by 208
Self-citation
Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States
Dürr, K. L., Chen, L., Stein, R. A., Zorzi, R. D., Folea, I. M., Walz, T., Mchaourab, H. S., & Gouaux, E. (2014) · Cell · doi:10.1016/j.cell.2014.07.023 · Cited by 207
Activity-Dependent Recruitment of Extrasynaptic NMDA Receptor Activation at an AMPA Receptor-Only Synapse
Clark, B. A., & Cull-Candy, S. G. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04428.2002 · Cited by 207
Evolution of Acid-Sensing Olfactory Circuits in Drosophilids
Prieto-Godino, L. L., Rytz, R., Cruchet, S., Bargeton, B., Abuin, L., Silbering, A. F., Ruta, V., Peraro, M. D., & Benton, R. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.024 · Cited by 207
Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin
Saitoh, Y., Suzuki, H., Tani, K., Nishikawa, K., Irie, K., Ogura, Y., Tamura, A., Tsukita, S., & Fujiyoshi, Y. (2015) · Science · doi:10.1126/science.1261833 · Cited by 207
Autonomous CaMKII Mediates Both LTP and LTD Using a Mechanism for Differential Substrate Site Selection
Coultrap, S. J., Freund, R. K., O’Leary, H., Sanderson, J. L., Roche, K. W., Dell’Acqua, M. L., & Bayer, K. U. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.01.005 · Cited by 207
Self-citation
NMDA Receptor Subunit NR2A Is Required for Rapidly Acquired Spatial Working Memory But Not Incremental Spatial Reference Memory
Bannerman, D. M., Niewoehner, B., Lyon, L., Romberg, C., Schmitt, W. B., Taylor, A. M., Sanderson, D. J., Cottam, J. C. H., Sprengel, R., Seeburg, P. H., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3639-07.2008 · Cited by 206
Temporal and regional expression of NMDA receptor subunit NR3A in the mammalian brain
Wong, H. K., Liu, X., Matos, M. F., Chan, S. F., Pérez‐Otaño, I., Boysen‐Osborn, M., Cui, J., Nakanishi, N., Trimmer, J. S., Jones, E. G., et al. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10314 · Cited by 206
Calcium-permeable AMPA receptors in the VTA and nucleus accumbens after cocaine exposure: when, how, and why?
Wolf, M. E., & Tseng, K. Y. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00072 · Cited by 206
Regulation of Rho GTPases by Crosstalk and Neuronal Activity In Vivo
Li, Z., Aizenman, C. D., & Cline, H. T. (2002) · Neuron · doi:10.1016/s0896-6273(02)00621-9 · Cited by 205
Neurotoxic lupus autoantibodies alter brain function through two distinct mechanisms
Faust, T. W., Chang, E. H., Kowal, C., Berlin, R., Gazaryan, I. G., Bertini, E., Zhang, J., Sánchez‐Guerrero, J., Fragoso-Loyo, H. E., Volpe, B. T., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006980107 · Cited by 205
Synaptic Potentiation Is Critical for Rapid Antidepressant Response to Ketamine in Treatment-Resistant Major Depression
Cornwell, B. R., Salvadore, G., Furey, M., Marquardt, C. A., Brutsché, N. E., Grillon, C., & Zarate, C. A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.03.029 · Cited by 205
Expression of NMDA and High‐affinity Kainate Receptor Subunit mRNAs in the Adult Rat Retina
Brandstätter, J. H., Hartveit, E., Sassoé‐Pognetto, M., & Wässle, H. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00607.x · Cited by 205
Stargazer: a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures
Noebels, J. L., Qiao, X., Bronson, R. T., Spencer, C., & Davisson, M. T. (1990) · Epilepsy Research · doi:10.1016/0920-1211(90)90098-g · Cited by 204
C-Terminal Truncation of NR2A Subunits Impairs Synaptic But Not Extrasynaptic Localization of NMDA Receptors
Steigerwald, F., Schulz, T. W., Schenker, L. T., Kennedy, M., Seeburg, P., & Köhr, G. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04573.2000 · Cited by 204
Disinhibition of CA1 pyramidal cells by low-dose ketamine and other antagonists with rapid antidepressant efficacy
Widman, A. J., & McMahon, L. L. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718883115 · Cited by 204
Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM
Zhao, Y., Chen, S., Swensen, A., Qian, W., & Gouaux, E. (2019) · Science · doi:10.1126/science.aaw8250 · Cited by 204
Synaptic Activation of Presynaptic Kainate Receptors on Hippocampal Mossy Fiber Synapses
Schmitz, D., Frerking, M. E., & Nicoll, R. A. (2000) · Neuron · doi:10.1016/s0896-6273(00)00040-4 · Cited by 203
Concentration of carbon dioxide, interstitial pH and synaptic transmission in hippocampal formation of the rat.
Balestrino, M., & Somjen, G. G. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp016961 · Cited by 203
Late-onset anti–NMDA receptor encephalitis
Titulaer, M. J., McCracken, L., Gabilondo, I., Iizuka, T., Kawachi, I., Bataller, L., Torrents, A., Rosenfeld, M. R., Balice‐Gordon, R. J., Graus, F., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a4a49c · Cited by 203
Extrasynaptic and synaptic NMDA receptors form stable and uniform pools in rat hippocampal slices
Harris, A. Z., & Pettit, D. L. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.137679 · Cited by 202
NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors
Zhou, X., Hollern, D. P., Liao, J., Andrechek, E. R., & Wang, H. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.82 · Cited by 202
Interaction of the N-Terminal Domain of the AMPA Receptor GluR4 Subunit with the Neuronal Pentraxin NP1 Mediates GluR4 Synaptic Recruitment
Sia, G.-M., Béïque, J.-C., Rumbaugh, G., Cho, R., Worley, P. F., & Huganir, R. L. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.020 · Cited by 201
Cell Type-Specific Development of NMDA Receptors in the Interneurons of Rat Prefrontal Cortex
Wang, H.-X., & Gao, W. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.20 · Cited by 201
A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder
Casey, J. P., Magalhaes, T., Conroy, J. M., Regan, R., Shah, N., Anney, R., Shields, D. C., Abrahams, B. S., Almeida, J., Bacchelli, E., et al. (2012) · Human Genetics · doi:10.1007/s00439-011-1094-6 · Cited by 200
NMDA receptor antagonist treatment induces a long‐lasting increase in the number of proliferating cells, PSA‐NCAM‐immunoreactive granule neurons and radial glia in the adult rat dentate gyrus
Nácher, J., Rosell, D. R., Alonso‐Llosà, G., & McEwen, B. S. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2000.01424.x · Cited by 200
Delineating the GRIN1 phenotypic spectrum: A distinct genetic NMDA receptor encephalopathy
Lemke, J. R., Geider, K., Helbig, K. L., Heyne, H. O., Schütz, H., Hentschel, J., Courage, C., Depienne, C., Nava, C., Heron, D., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000002740 · Cited by 200
Compartmentalized and Binary Behavior of Terminal Dendrites in Hippocampal Pyramidal Neurons
Wei, D.-S., Mei, Y., Bagal, A. A., Kao, J. P. Y., Thompson, S. M., & Tang, C. (2001) · Science · doi:10.1126/science.1061198 · Cited by 199
NR2B-Containing Receptors Mediate Cross Talk among Hippocampal Synapses
Scimemi, A., Fine, A., Kullmann, D. M., & Rusakov, D. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0364-04.2004 · Cited by 198
Dimensions and ion selectivity of recombinant AMPA and kainate receptor channels and their dependence on Q/R site residues.
Burnashev, N., Villarroel, A., & Sakmann, B. J. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021674 · Cited by 198
Cloning and characterization of a novel NMDA receptor subunit NR3B: a dominant subunit that reduces calcium permeability
Matsuda, K., Kamiya, Y., Matsuda, S., & Yuzaki, M. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00173-0 · Cited by 198
Structure of the zinc‐bound amino‐terminal domain of the NMDA receptor NR2B subunit
Karakaş, E., Simorowski, N., & Furukawa, H. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.338 · Cited by 198
Self-citation
In vitro analysis of optimal stimuli for phase-locking and time-delayed modulation of firing in avian nucleus laminaris neurons
Reyes, A., Rubel, E., & Spain, W. J. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-03-00993.1996 · Cited by 198
Triheteromeric NMDA Receptors at Hippocampal Synapses
Tovar, K., McGinley, M. J., & Westbrook, G. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0829-13.2013 · Cited by 197
Glial D-Serine Gates NMDA Receptors at Excitatory Synapses in Prefrontal Cortex
Fossat, P., Turpin, F. R., Sacchi, S., Dulong, J., Shi, T., Rivet, J., Sweedler, J. V., Pollegioni, L., Millan, M. J., Oliet, S. H. R., et al. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr130 · Cited by 197
Transmembrane topology of two kainate receptor subunits revealed by N-glycosylation.
Wo, Z. G., & Oswald, R. E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.7154 · Cited by 195
Characterisation of the Expression of NMDA Receptors in Human Astrocytes
Lee, M.-C., Ting, K. K., Adams, S., Brew, B. J., Chung, R. S., & Guillemin, G. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014123 · Cited by 195
Metaplasticity at Single Glutamatergic Synapses
Lee, M.-C., Yasuda, R., & Ehlers, M. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.015 · Cited by 195
TARP Subtypes Differentially and Dose-Dependently Control Synaptic AMPA Receptor Gating
Milstein, A. D., Zhou, W., Karimzadegan, S., Bredt, D. S., & Nicoll, R. A. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.022 · Cited by 195
Pharmacology of dextromethorphan: Relevance to dextromethorphan/quinidine (Nuedexta®) clinical use
Taylor, C. P., Traynelis, S. F., Siffert, J. O., Pope, L. E., & Matsumoto, R. R. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.04.010 · Cited by 195
Self-citation
Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP
Wu, D., Bacaj, T., Morishita, W., Goswami, D., Arendt, K. L., Xu, W., Chen, L., Malenka, R. C., & Südhof, T. C. (2017) · Nature · doi:10.1038/nature21720 · Cited by 195
Voltage-dependent block by intracellular Mg2+ of N-methyl-D-aspartate-activated channels
Johnson, J. W., & Ascher, P. (1990) · Biophysical Journal · doi:10.1016/s0006-3495(90)82626-6 · Cited by 195
Molecular cloning and development analysis of a new glutamate receptor subunit isoform in cerebellum
Gallo, V., Upson, L., Hayes, W., Vyklický, L., Winters, C. A., & Buonanno, A. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-03-01010.1992 · Cited by 194
Molecular dissection of the agonist binding site of an AMPA receptor.
Kuusinen, A., Arvola, M., & KEINÄNEN, K. P. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00323.x · Cited by 194
Pathway-specific variants of AMPA receptors and their contribution to neuronal signaling
Raman, I., Zhang, S., & Trussell, L. O. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-08-04998.1994 · Cited by 194
Rat GluR7 and a Carboxy-Terminal Splice Variant, GluR7b, Are Functional Kainate Receptor Subunits with a Low Sensitivity to Glutamate
Schiffer, H. H., Swanson, G. T., & Heinemann, S. F. (1997) · Neuron · doi:10.1016/s0896-6273(00)80404-3 · Cited by 194
Self-citation
Differences in AMPA and kainate receptor interactomes facilitate identification of AMPA receptor auxiliary subunit GSG1L
Shanks, N. F., Savas, J. N., Maruo, T., Cais, O., Hirao, A., Oe, S., Ghosh, A., Noda, Y., Greger, I. H., Yates, J. R., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.05.004 · Cited by 194
Self-citation
Excitotoxicity in the pathogenesis of neurological and psychiatric disorders: Therapeutic implications
Olloquequi, J., Cornejo-Córdova, E., Verdaguer, E., Soriano, F. X., Binvignat, O., Auladell, C., & Camins, A. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881118754680 · Cited by 193
Polyamine-dependent facilitation of postsynaptic AMPA receptors counteracts paired-pulse depression
Rozov, A., & Burnashev, N. (1999) · Nature · doi:10.1038/44151 · Cited by 192
Factors regulating the magnitude of long-term potentiation induced by theta pattern stimulation
Arai, A., & LYNCH, G. S. (1992) · Brain Research · doi:10.1016/0006-8993(92)90181-8 · Cited by 192
Kinetics of Mg 2+ unblock of NMDA receptors: implications for spike‐timing dependent synaptic plasticity
Kampa, B. M., Clements, J., Jónás, P., & Stuart, G. J. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.058842 · Cited by 191
GluR5 and GluR6 Kainate Receptor Subunits Coexist in Hippocampal Neurons and Coassemble to Form Functional Receptors
Paternain, A. V., Herrera, M. T., Nieto, M. A., & Lerma, J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00196.2000 · Cited by 191
Activity of 2,3-benzodiazepines at Native Rat and Recombinant Human Glutamate Receptors In Vitro : Stereospecificity and Selectivity Profiles
Bleakman, D., Ballyk, B. A., Schoepp, D. D., Palmer, A. J., Bath, C. P., Sharpe, E. F., Woolley, M. L., BUFTON, H. R., Kamboj, R. K., Tarnawa, I., et al. (1996) · Neuropharmacology · doi:10.1016/s0028-3908(96)00156-6 · Cited by 191
Evaluation of copy number variations reveals novel candidate genes in autism spectrum disorder-associated pathways
Griswold, A. J., Ma, D., Cukier, H. N., Nations, L. D., Schmidt, M. A., Chung, R.-H., Jaworski, J. M., Salyakina, D., Konidari, I., Whitehead, P. L., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds164 · Cited by 191
Acute but not chronic activation of the NMDA-coupled glycine receptor with D-cycloserine facilitates learning and retention
Quartermain, D., Mower, J., Rafferty, M. F., Herting, R. L., & Lanthorn, T. H. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90687-4 · Cited by 190
Preferential co-assembly of recombinant NMDA receptors composed of three different subunits
Wafford, K. A., Bain, C., Bourdellès, B. L., Whiting, P. J., & Kemp, J. A. (1993) · Neuroreport · doi:10.1097/00001756-199309150-00015 · Cited by 190
Hippocampal AMPA Receptor Gating Controlled by Both TARP and Cornichon Proteins
Kato, A., Gill, M. B., Ho, M. T., Yu, H. Y., Tu, Y., Siuda, E. R., Wang, H., Qian, Y., Nisenbaum, E. S., Tomita, S., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.026 · Cited by 190
Mechanism of Partial Agonist Action at the NR1 Subunit of NMDA Receptors
Inanobe, A., Furukawa, H., & Gouaux, E. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.022 · Cited by 190
Self-citation
Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites
Yang, C., Yang, J., Luo, A., & Hashimoto, K. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0624-1 · Cited by 190
Organization, control and function of extrasynaptic NMDA receptors
Papouin, T., & Oliet, S. H. R. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0601 · Cited by 189
Effect of RNA editing and subunit co‐assembly single‐channel properties of recombinant kainate receptors.
Swanson, G. T., Feldmeyer, D., Kaneda, M., & Cull-Candy, S. G. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021295 · Cited by 189
Self-citation
Stargazin attenuates intracellular polyamine block of calcium-permeable AMPA receptors
Soto, D., Coombs, I. D., Kelly, L., Farrant, M., & Cull-Candy, S. G. (2007) · Nature Neuroscience · doi:10.1038/nn1966 · Cited by 189
pH and brain function
Kaila, K., & Ransom, B. R. (1998) · Wiley-Liss eBooks · Cited by 188
Functional Properties of AMPA and NMDA Receptors Expressed in Identified Types of Basal Ganglia Neurons
Götz, T., Kraushaar, U., Geiger, J. R. P., Lübke, J. H. R., Berger, T., & Jónás, P. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-01-00204.1997 · Cited by 187
NMDA Receptor-Dependent Refinement of Somatotopic Maps
Iwasato, T., Erzurumlu, R. S., Huerta, P. T., Chen, D., Sasaoka, T., Ulupınar, E., & Tonegawa, S. (1997) · Neuron · doi:10.1016/s0896-6273(00)80412-2 · Cited by 187
Calcium/Calmodulin‐Dependent Protein Kinase II Is Associated with NR2A/B Subunits of NMDA Receptor in Postsynaptic Densities
Gardoni, F., Caputi, A., Cimino, M., Pastorino, L., Cattabeni, F., & Luca, M. D. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71041733.x · Cited by 187
Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains
Geisheker, M. R., Heymann, G., Wang, T., Coe, B. P., Turner, T. N., Stessman, H. A. F., Hoekzema, K., Kvarnung, M., Shaw, M. A., Friend, K. L., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4589 · Cited by 187
Coordinated PKA and PKC phosphorylation suppresses RXR-mediated ER retention and regulates the surface delivery of NMDA receptors
Scott, D. B., Blanpied, T. A., & Ehlers, M. D. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00250-8 · Cited by 186
Presynaptic NMDA Receptors: Newly Appreciated Roles in Cortical Synaptic Function and Plasticity
Corlew, R., Brasier, D. J., Feldman, D. E., & Philpot, B. D. (2008) · The Neuroscientist · doi:10.1177/1073858408322675 · Cited by 185
Neto1 Is a Novel CUB-Domain NMDA Receptor–Interacting Protein Required for Synaptic Plasticity and Learning
Ng, D., Pitcher, G. M., Szilard, R. K., Sertie, A. L., Kanisek, M., Clapcote, S. J., Lipina, T. V., Kalia, L. V., Joo, D. T., McKerlie, C., et al. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000041 · Cited by 185
Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block
Dravid, S. M., Erreger, K., Yuan, H., Nicholson, K., Le, P., Lyuboslavsky, P., Almonte, A., Murray, E., Mosley, C., Barber, J., et al. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2006.124958 · Cited by 184
Self-citation
Developmental Switch in the Contribution of Presynaptic and Postsynaptic NMDA Receptors to Long-Term Depression
Corlew, R., Wang, Y., Ghermazien, H., Erişir, A., & Philpot, B. D. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5494-06.2007 · Cited by 184
Discovery of 2-(2-Oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile (Perampanel): A Novel, Noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropanoic Acid (AMPA) Receptor Antagonist
Hibi, S., Ueno, K., Nagato, S., Kawano, K., Ito, K., Norimine, Y., Takenaka, O., Hanada, T., & Yonaga, M. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm301268u · Cited by 184
Quinazolines: New horizons in anticonvulsant therapy
Ugale, V. G., & Bari, S. B. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.04.072 · Cited by 184
The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults
Martel, M., Ryan, T. J., Bell, K. F. S., Fowler, J. H., McMahon, A., Al-Mubarak, B. R., Komiyama, N. H., Horsburgh, K. J., Kind, P. C., Grant, S. G. N., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.021 · Cited by 183
D-Serine regulates cerebellar LTD and motor coordination through the δ2 glutamate receptor
Kakegawa, W., Miyoshi, Y., Hamase, K., Matsuda, S., Matsuda, K., Kohda, K., Emi, K., Motohashi, J., Konno, R., Zaitsu, K., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2791 · Cited by 183
Structural determinants of barium permeation and rectification in non- NMDA glutamate receptor channels
Dingledine, R. J., Hume, R. I., & Heinemann, S. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-10-04080.1992 · Cited by 183
Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains
Swanger, S. A., Chen, W., Wells, G., Burger, P. B., Tankovic, A., Bhattacharya, S., Strong, K. L., Hu, C., Kusumoto, H., Zhang, J., et al. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2016.10.002 · Cited by 183
Self-citation
Pre-post synaptic alignment through neuroligin-1 tunes synaptic transmission efficiency
Haas, K. T., Compans, B., Letellier, M., Bartol, T. M., Grillo-Bosch, D., Sejnowski, T. J., Sainlos, M., Choquet, D., Thoumine, O., & Hosy, E. (2018) · eLife · doi:10.7554/elife.31755 · Cited by 183
Developmental regulation of cognitive abilities: Modified composition of a molecular switch turns on associative learning
Dumas, T. C. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.08.002 · Cited by 182
NMDA receptor antagonist treatment increases the production of new neurons in the aged rat hippocampus
Nácher, J., Alonso‐Llosà, G., Rosell, D. R., & McEwen, B. S. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00096-9 · Cited by 182
Primary structure and expression of the γ2 subunit of the glutamate receptor channel selective for kainate
Sakimura, K., Morita, T., Kushiya, E., & Mishina, M. (1992) · Neuron · doi:10.1016/0896-6273(92)90293-m · Cited by 182
Mechanisms of photoswitch conjugation and light activation of an ionotropic glutamate receptor
Gorostiza, P., Volgraf, M., Numano, R., Szobota, S., Trauner, D. H., & Isacoff, E. Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701274104 · Cited by 181
Different sensitivities of NMDA receptor channel subtypes to non-competitive antagonists
Yamakura, T., Mori, H., Hisashi, M., Shimoji, K., & Mishina, M. (1993) · Neuroreport · doi:10.1097/00001756-199306000-00021 · Cited by 181
Synaptic kainate receptors
Frerking, M. E., & Nicoll, R. A. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00094-5 · Cited by 181
Identification of the Kainate Receptor Subunits Underlying Modulation of Excitatory Synaptic Transmission in the CA3 Region of the Hippocampus
Contractor, A., Swanson, G. T., Sailer, A. W., O’Gorman, S., & Heinemann, S. F. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-22-08269.2000 · Cited by 181
Self-citation
Identification and Mechanism of Action of Two Histidine Residues Underlying High-Affinity Zn2+ Inhibition of the NMDA Receptor
Choi, Y.-B., & Lipton, S. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)80763-1 · Cited by 180
A Critical Role for GluN2B-Containing NMDA Receptors in Cortical Development and Function
Wang, C.-C., Held, R. G., Chang, S.-C., Yang, L., Delpire, E., Ghosh, A., & Hall, B. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.023 · Cited by 180
Differential antagonism of alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid-preferring and kainate-preferring receptors by 2,3-benzodiazepines.
Wilding, T. J., & Huettner, J. E. (1995) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08577-3 · Cited by 180
Transsynaptic modulation of kainate receptor functions by C1q-like proteins
Matsuda, K., Budisantoso, T., Mitakidis, N., Sugaya, Y., Miura, E., Kakegawa, W., Yamasaki, M., Konno, K., Uchigashima, M., Abe, M., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.001 · Cited by 180
(1S,2S)-1-(4-Hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: A Potent New Neuroprotectant Which Blocks N-Methyl-D-Aspartate Responses
Chenard, B. L., Bordner, J., Butler, T. W., Chambers, L. K., Collins, M. A., Costa, D. L. D., Ducat, M. F., Dumont, M. L., & Fox, C. B. (1995) · Journal of Medicinal Chemistry · doi:10.1021/jm00016a017 · Cited by 180
Interactions between the NR2B Receptor and CaMKII Modulate Synaptic Plasticity and Spatial Learning
Zhou, Y., Takahashi, E., Li, W., Halt, A., Wiltgen, B., Ehninger, D., Li, G.-D., Hell, J. W., Kennedy, M. B., & Silva, A. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4486-07.2007 · Cited by 179
Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites.
Laverty, D., Thomas, P., Field, M., Andersen, O. J., Gold, M. G., Biggin, P. C., Gielen, M., & Smart, T. G. (2017) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3477 · Cited by 179
Synaptically Released Glutamate Activates Extrasynaptic NMDA Receptors on Cells in the Ganglion Cell Layer of Rat Retina
Chen, S., & Diamond, J. S. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02165.2002 · Cited by 178
Self-citation
Regulation of motor neuron dendrite growth by NMDA receptor activation
Kalb, R. G. (1994) · Development · doi:10.1242/dev.120.11.3063 · Cited by 177
Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area
Mameli, M., Bellone, C., Brown, M. T. C., & Lüscher, C. (2011) · Nature Neuroscience · doi:10.1038/nn.2763 · Cited by 177
Kainate receptor‐mediated presynaptic inhibition at the mouse hippocampal mossy fibre synapse
Kamiya, H., & Ozawa, S. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00653.x · Cited by 177
Neuronal metabolism governs cortical network response state
Cunningham, M. O., Pervouchine, D. D., Racca, C., Kopell, N., Davies, C. H., Jones, R. S. G., Traub, R. D., & Whittington, M. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600604103 · Cited by 177
Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data
Black, M. D. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2065-6 · Cited by 176
Ketamine infusions for treatment resistant depression: a series of 28 patients treated weekly or twice weekly in an ECT clinic
Diamond, P. R., Farmery, A. D., Atkinson, S. A., Haldar, J., Williams, N., Cowen, P. J., Geddes, J. R., & McShane, R. H. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881114527361 · Cited by 176
Inhibition of the NMDA response by pregnenolone sulphate reveals subtype selective modulation of NMDA receptors by sulphated steroids
Malayev, A., Gibbs, T. T., & Farb, D. H. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704543 · Cited by 176
GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers
Li, D., Yuan, H., Ortiz-Gonzalez, X. R., Marsh, E. D., Tian, L., McCormick, E. M., Kosobucki, G. J., Chen, W., Schulien, A. J., Chiavacci, R. M., et al. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2016.07.013 · Cited by 176
Self-citation
Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation
Lü, W., Du, J., Goehring, A., & Gouaux, E. (2017) · Science · doi:10.1126/science.aal3729 · Cited by 176
Prevalence and clinical characteristics of serum neuronal cell surface antibodies in first-episode psychosis: a case-control study
Lennox, B., Palmer-Cooper, E. C., Pollak, T. A., Hainsworth, J., Marks, J., Jacobson, L. W., Lang, B., Fox, H., Ferry, B. L., Scoriels, L., et al. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(16)30375-3 · Cited by 176
Ampakines and the threefold path to cognitive enhancement
LYNCH, G. S., & Gall, C. M. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.07.007 · Cited by 175
A new mode of corticothalamic transmission revealed in the Gria4−/− model of absence epilepsy
Paz, J. T., Bryant, A. S., Peng, K. K., Fenno, L. E., Yizhar, O., Frankel, W. N., Deisseroth, K. A., & Huguenard, J. R. (2011) · Nature Neuroscience · doi:10.1038/nn.2896 · Cited by 175
Rules of engagement for NMDA receptor subunits
Ulbrich, M. H., & Isacoff, E. Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802075105 · Cited by 174
Serum and Cerebrospinal Fluid Autoantibodies in Patients with Neuropsychiatric Lupus Erythematosus. Implications for Diagnosis and Pathogenesis
Fragoso-Loyo, H. E., Cabiedes, J., Orozco-Narváez, A., Dávila-Maldonado, L., Atisha‐Fregoso, Y., Diamond, B., Llorente, L., & Sánchez‐Guerrero, J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003347 · Cited by 174
A GluR1-cGKII Interaction Regulates AMPA Receptor Trafficking
Serulle, Y., Zhang, S., Ninan, I., Puzzo, D., McCarthy, M., Khatri, L., Arancio, O., & Ziff, E. B. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.016 · Cited by 174
Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function
Hackos, D. H., Lupardus, P. J., Grand, T., Chen, Y., Wang, T.-M., Reynen, P., Gustafson, A. E., Wallweber, H. J. A., Volgraf, M., Sellers, B. D., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.016 · Cited by 174
Calcium-dependent inactivation of recombinant N-methyl-D-aspartate receptors is NR2 subunit specific.
Krupp, J., Vissel, B., Heinemann, S. F., & Westbrook, G. L. (1996) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09630-0 · Cited by 174
The non-N-methyl-D-aspartate receptor antagonists, GYKI 52466 and NBQX are anticonvulsant in two animal models of reflex epilepsy
Smith, S. E., Dürmüller, N., & Meldrum, B. S. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90342-n · Cited by 174
An Evaluation of Synapse Independence
Barbour, B. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-20-07969.2001 · Cited by 173
Contributions of Receptor Desensitization and Saturation to Plasticity at the Retinogeniculate Synapse
Chen, C., Blitz, D. M., & Regehr, W. G. (2002) · Neuron · doi:10.1016/s0896-6273(02)00611-6 · Cited by 173
NR3A-containing NMDARs promote neurotransmitter release and spike timing–dependent plasticity
Larsen, R. S., Corlew, R., Henson, M. A., Roberts, A. C., Mishina, M., Watanabe, M., Lipton, S. A., Nakanishi, N., Pérez‐Otaño, I., Weinberg, R. J., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2750 · Cited by 173
LY293558, a Novel AMPA/GluR5 Antagonist, is Efficacious and Well-Tolerated in Acute Migraine
Sang, C., Ramadan, N. M., Wallihan, R., Chappell, A. S., Freitag, F. G., Tr, S., Silberstein, S., Johnson, K., Phebus, L., Bleakman, D., et al. (2004) · Cephalalgia · doi:10.1111/j.1468-2982.2004.00723.x · Cited by 173
Molecular determinants of coordinated proton and zinc inhibition of N- methyl- d -aspartate NR1/NR2A receptors
Low, C., Zheng, F., Lyuboslavsky, P. N., & Traynelis, S. F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.180307497 · Cited by 173
Self-citation
A new generation of antidepressants: an update on the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA neurotransmitter systems
Wilkinson, S. T., & Sanacora, G. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2018.11.007 · Cited by 173
Zinc transporter 3 (ZnT3) and vesicular zinc in central nervous system function
McAllister, B. B., & Dyck, R. H. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.06.006 · Cited by 172
Expression of NMDAR2D glutamate receptor subunit mRNA in neurochemically identified interneurons in the rat neostriatum, neocortex and hippocampus
Standaert, D. G., Landwehrmeyer, G. B., Kerner, J. A., Penney, J. B., & Young, A. B. (1996) · Molecular Brain Research · doi:10.1016/s0169-328x(96)00117-9 · Cited by 171
Enhancement by histamine of NMDA-mediated synaptic transmission in the hippocampus
Bekkers, J. M. (1993) · Science · doi:10.1126/science.8391168 · Cited by 171
Uncoupling Dendrite Growth and Patterning: Single-Cell Knockout Analysis of NMDA Receptor 2B
Espinosa, J. S., Wheeler, D. G., Tsien, R. W., & Luo, L. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.006 · Cited by 171
NMDA and AMPA/Kainate Glutamate Receptors Modulate Dentate Neurogenesis and CA3 Synapsin-I in Normal and Ischemic Hippocampus
Bernabeu, R., & Sharp, F. R. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200012000-00006 · Cited by 171
The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms
Incontro, S., Díaz-Alonso, J., Iafrati, J., Vieira, M., Asensio, C. S., Sohal, V. S., Roche, K. W., Bender, K. J., & Nicoll, R. A. (2018) · Nature Communications · doi:10.1038/s41467-018-04439-7 · Cited by 171
Phase Separation-Mediated TARP/MAGUK Complex Condensation and AMPA Receptor Synaptic Transmission
Zeng, M., Díaz-Alonso, J., Ye, F., Chen, X., Xu, J., Ji, Z., Nicoll, R. A., & Zhang, M. (2019) · Neuron · doi:10.1016/j.neuron.2019.08.001 · Cited by 171
Modal gating of NMDA receptors and the shape of their synaptic response
Popescu, G., & Auerbach, A. L. (2003) · Nature Neuroscience · doi:10.1038/nn1044 · Cited by 170
The effect of external pH changes on responses to excitatory amino acids in mouse hippocampal neurones.
Vyklický, L., Vlachová, V., & Krůšek, J. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018304 · Cited by 170
Age‐dependent requirement of AKAP150‐anchored PKA and GluR2‐lacking AMPA receptors in LTP
Lü, Y., Allen, M., Halt, A. R., Weisenhaus, M., Dallapiazza, R. F., Hall, D. D., Usachev, Y. M., McKnight, G. S., & Hell, J. W. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601884 · Cited by 170
Neuronal Pentraxin Receptor, a Novel Putative Integral Membrane Pentraxin That Interacts with Neuronal Pentraxin 1 and 2 and Taipoxin-associated Calcium-binding Protein 49
Dodds, D. C., Omeis, I. A., Cushman, S. J., Helms, J. A., & Perin, M. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.21488 · Cited by 170
Downregulation of NR3A-Containing NMDARs Is Required for Synapse Maturation and Memory Consolidation
Roberts, A. C., Díez‐García, J., Rodriguiz, R. M., López, I. P., Luján, R., Martínez-Turrillas, R., Picó, E., Henson, M. A., Bernardo, D., Jarrett, T. M., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.016 · Cited by 169
Optimizing genomic medicine in epilepsy through a gene-customized approach to missense variant interpretationPreprint
Traynelis, J. L., Silk, M. A., Wang, Q., Berkovic, S. F., Liu, L., Ascher, D. B., Balding, D. J., & Petrovski, S. (2017) · Genome Research · doi:10.1101/gr.226589.117 · Cited by 169
The history of the pharmacology and cloning of ionotropic glutamate receptors and the development of idiosyncratic nomenclature
Lodge, D. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.08.006 · Cited by 168
Stargazin Modulates Native AMPA Receptor Functional Properties by Two Distinct Mechanisms
Turetsky, D. M., Garringer, E., & Patneau, D. K. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1108-05.2005 · Cited by 168
Four Residues of the Extracellular N-Terminal Domain of the NR2A Subunit Control High-Affinity Zn2+ Binding to NMDA Receptors
Fayyazuddin, A., Villarroel, Á., Goff, A. L., Lerma, J., & Neyton, J. (2000) · Neuron · doi:10.1016/s0896-6273(00)81070-3 · Cited by 168
Molecular basis of positive allosteric modulation of GluN2B NMDA receptors by polyamines
Mony, L., Zhu, S., Carvalho, S., & Paoletti, P. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.203 · Cited by 168
Dissociable roles for the ventromedial prefrontal cortex and amygdala in fear extinction: NR2B contribution.
Sotres-Bayon, F., Díaz‐Mataix, L., Bush, D. E. A., & LeDoux, J. E. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn099 · Cited by 168
TARP Phosphorylation Regulates Synaptic AMPA Receptors through Lipid Bilayers
Sumioka, A., Yan, D., & Tomita, S. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.035 · Cited by 167
Subunit-Specific Agonist Activity at NR2A-, NR2B-, NR2C-, and NR2D-Containing N-Methyl-d-aspartate Glutamate Receptors
Erreger, K., Geballe, M. T., Kristensen, A. S., Chen, P. E., Hansen, K. B., Lee, C. J., Yuan, H., Le, P., Lyuboslavsky, P. N., Micale, N., et al. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.037333 · Cited by 167
Self-citation
Two Families of TARP Isoforms that Have Distinct Effects on the Kinetic Properties of AMPA Receptors and Synaptic Currents
Cho, C.-H., St-Gelais, F., Zhang, W., Tomita, S., & Howe, J. R. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.024 · Cited by 167
Allosteric modulators of NMDA receptors: multiple sites and mechanisms
Zhu, S., & Paoletti, P. (2014) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2014.10.009 · Cited by 167
Zinc has opposite effects on NMDA and Non-NMDA receptors expressed in xenopus oocytes
Rassendren, F.-A., Lory, P., Pin, J., & Nargeot, J. (1990) · Neuron · doi:10.1016/0896-6273(90)90199-p · Cited by 167
Antibodies against GluR3 peptides are not specific for Rasmussen's encephalitis but are also present in epilepsy patients with severe, early onset disease and intractable seizures
Mantegazza, R., Bernasconi, P., Baggi, F., et al. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00261-8 · Cited by 167
Tonic release of glutamate by a DIDS‐sensitive mechanism in rat hippocampal slices
Cavelier, P., & Attwell, D. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.082131 · Cited by 166
Calcium-dependent inactivation of synaptic NMDA receptors in hippocampal neurons
Rosenmund, C., Feltz, A., & Westbrook, G. L. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.73.1.427 · Cited by 166
Glutamate Receptor Antagonists as Fast-Acting Therapeutic Alternatives for the Treatment of Depression: Ketamine and Other Compounds
Niciu, M. J., Henter, I. D., Luckenbaugh, D. A., Zarate, C. A., & Charney, D. S. (2014) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-135950 · Cited by 166
Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons
Koike‐Tani, M., Iino, M., & Ozawa, S. (1997) · Neuroscience Research · doi:10.1016/s0168-0102(97)00067-9 · Cited by 165
Bidirectional Regulation of Hippocampal Mossy Fiber Filopodial Motility by Kainate Receptors
Tashiro, A., Dunaevsky, A., Blazeski, R., Mason, C. A., & Yuste, R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00299-x · Cited by 165
High Probability Opening of NMDA Receptor Channels by L-Glutamate
Jahr, C. E. (1992) · Science · doi:10.1126/science.1346477 · Cited by 165
Purinergic Receptors Mediate Two Distinct Glutamate Release Pathways in Hippocampal Astrocytes
Fellin, T., Pozzan, T., & Carmignoto, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510679200 · Cited by 165
Structural determinants of allosteric regulation in alternatively spliced AMPA receptors
Partin, K. M., Bowie, D., & Mayer, M. L. (1995) · Neuron · doi:10.1016/0896-6273(95)90227-9 · Cited by 165
Self-citation

Flagged first, then by citations

Sorted by citations

Mechanisms of ketamine and its metabolites as antidepressants
Hess, E. M., Riggs, L. M., Michaelides, M., & Gould, T. D. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114892 · Cited by 175
A gain‐of‐function GRIA2 variant associated with neurodevelopmental delay and seizures: Functional characterization and targeted treatment
Coombs, I. D., Ziobro, J., Krotov, V., Surtees, T., Cull‐Candy, S. G., & Farrant, M. (2022) · Epilepsia · doi:10.1111/epi.17419 · Cited by 32
Cryo-EM structure of the human Asc-1 transporter complex
Li, Y., Guo, Y., Bröer, A., Dai, L., Brӧer, S., & Yan, R. (2024) · Nature Communications · doi:10.1038/s41467-024-47468-1 · Cited by 12
Glutamate receptor 4 as a fluid biomarker for the diagnosis of psychiatric disorders
Gómez de San José, N., Goossens, J., Al Shweiki, M. R., Halbgebauer, S., Oeckl, P., Steinacker, P., Danzer, K. M., Graf, H., Schönfeldt-Lecuona, C., Belbin, O., et al. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.10.010 · Cited by 9

See all 686

Authors: Hansen, K. B., Wollmuth, L. P., Bowie, D., Furukawa, H., Menniti, F. S., Sobolevsky, A. I., Swanson, G. T., Swanger, S. A., Greger, I. H., Nakagawa, T., McBain, C. J., Jayaraman, V., Low, C.-M., Dell’Acqua, M. L., Diamond, J. S., Camp, C. R., Perszyk, R. E., Yuan, H., & Traynelis, S. F.
Affiliations: Northwestern University (US)
Corresponding author: Traynelis, Stephen F.
ORCID: Hansen, Kasper B.
Wollmuth, Lonnie P.
Bowie, Derek
Furukawa, Hiro
Menniti, Frank S.
Sobolevsky, Alexander I.
Swanson, Geoffrey T.
Swanger, Sharon A.
Greger, Ingo H.
Nakagawa, Terunaga
McBain, Chris J.
Jayaraman, Vasanthi
Low, Chian-Ming
Dell’Acqua, Mark L.
Diamond, Jeffrey S.
Camp, Chad R.
Perszyk, Riley E.
Yuan, Hongjie
Traynelis, Stephen F.
Venue: Pharmacological Reviews
Publisher: Elsevier BV
Published: 2021-10
Volume: 73
Issue: 4
Pages: 1469-1658
ISSN: 0031-6997 (ISSN-L)
DOI: 10.1124/pharmrev.120.000131
PMC: PMC8626789
OpenAlex: W3214054678
Cited by: 686
References: 2,576
Citations by year: 2026: 123 · 2025: 198 · 2024: 160 · 2023: 115 · 2022: 81 · 2021: 9
FWCI: 13.86
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Pharmacological Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
Funders: National Institutes of Health (5f31ns113530-02)
Biotechnology and Biological Sciences Research Council (BB/N002113/1)
National Institute of Mental Health (R56MH123474, R21MH127404, R01MH085926, R01MH123474)
National Cancer Institute (R01CA206573)
National Institute of General Medical Sciences (P20GM103546, R35GM122528)
National Institute of Neurological Disorders and Stroke (F31‐NS113530, R01NS105804, R56NS040701, R01NS083660, R01NS040701, R01NS088479, R01NS111745, RF1NS113632, R01NS105502, R01NS107253, R35NS111619, R37NS083660, R01NS116055, R01NS097536)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD082373)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: ionotropic glutamate receptors, ligand-gated ion channels, glutamate, receptor subtypes, receptor structure, receptor pharmacology, excitatory neurotransmission, neurophysiology, neurological disorders, mental illness, therapeutic target
MeSH terms: Animals, Central Nervous System, Humans, Receptors, Glutamate, Neurotransmitter Agents, Glutamic Acid, Receptors, Ionotropic Glutamate

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks