Cited by 686Neuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors StudyReceptor Mechanisms and Signaling

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Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

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Hansen, Kasper B., Wollmuth, Lonnie P., Bowie, Derek, Furukawa, Hiro, Menniti, Frank S., Sobolevsky, Alexander I., Swanson, Geoffrey T., Swanger, Sharon A., Greger, Ingo H., Nakagawa, Terunaga, McBain, Chris J., Jayaraman, Vasanthi, Low, Chian-Ming, Dell’Acqua, Mark L., Diamond, Jeffrey S., Camp, Chad R., Perszyk, Riley E., Yuan, Hongjie, Traynelis, Stephen F.·2021·Pharmacological Reviews

DOI 10.1124/pharmrev.120.000131PMC PMC8626789

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Abstract

Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the mammalian central nervous system, are mediated via signaling by ionotropic glutamate receptors (iGluRs). These ligand-gated ion channels are critical to brain function and are centrally implicated in numerous psychiatric and neurologic disorders. There are different classes of iGluRs with a variety of receptor subtypes in each class that play distinct roles in neuronal functions. The diversity in iGluR subtypes, with their unique functional properties and physiologic roles, has motivated a large number of studies. Our understanding of receptor subtypes has advanced considerably since the first iGluR subunit gene was cloned in 1989, and the research focus has expanded to encompass facets of biology that have been recently discovered and to exploit experimental paradigms made possible by technological advances. Here, we review insights from more than 3 decades of iGluR studies with an emphasis on the progress that has occurred in the past decade. We cover structure, function, pharmacology, roles in neurophysiology, and therapeutic implications for all classes of receptors assembled from the subunits encoded by the 18 ionotropic glutamate receptor genes. SIGNIFICANCE STATEMENT: Glutamate receptors play important roles in virtually all aspects of brain function and are either involved in mediating some clinical features of neurological disease or represent a therapeutic target for treatment. Therefore, understanding the structure, function, and pharmacology of this class of receptors will advance our understanding of many aspects of brain function at molecular, cellular, and system levels and provide new opportunities to treat patients.

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WELCH, W. M., Ewing, F. E., HUANG, J., et al. (2001) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(00)00622-3 · Cited by 125
Inhibition of the cAMP Pathway Decreases Early Long-Term Potentiation at CA1 Hippocampal Synapses
Otmakhova, N. A., Otmakhov, N., Mortenson, L. H., & Lisman, J. E. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04446.2000 · Cited by 124
Glutamate Promotes Proliferation of Striatal Neuronal Progenitors by an NMDA Receptor-Mediated Mechanism
Luk, K. C., Kennedy, T. E., & Sadikot, A. F. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-06-02239.2003 · Cited by 124
Identification of Amino Acid Residues that Control Functional Behavior in GluR5 and GluR6 Kainate Receptors
Swanson, G. T., Gereau, R. W., Green, T., & Heinemann, S. F. (1997) · Neuron · doi:10.1016/s0896-6273(00)80972-1 · Cited by 124
Self-citation
X-ray structures of AMPA receptor–cone snail toxin complexes illuminate activation mechanism
Chen, L., Dürr, K. L., & Gouaux, E. (2014) · Science · doi:10.1126/science.1258409 · Cited by 124
Neuroprotection against Traumatic Brain Injury by Xenon, but Not Argon, Is Mediated by Inhibition at the N-Methyl-d-Aspartate Receptor Glycine Site
Harris, K., Armstrong, S. P., Campos-Pires, R., Kiru, L., Franks, N. P., & Dickinson, R. (2013) · Anesthesiology · doi:10.1097/aln.0b013e3182a2a265 · Cited by 124
A randomized, double-blind, active placebo-controlled study of efficacy, safety, and durability of repeated vs single subanesthetic ketamine for treatment-resistant depression
Shiroma, P. R., THURAS, P. D., Wels, J., Albott, C. S., Erbes, C. R., Tye, S. J., & Lim, K. O. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00897-0 · Cited by 124
Structural Basis of Functional Transitions in Mammalian NMDA Receptors
Chou, T., Tajima, N., Hernandez, A. R., & Furukawa, H. (2020) · Cell · doi:10.1016/j.cell.2020.05.052 · Cited by 124
Self-citation
Visual input induces long-term potentiation of developing retinotectal synapses
Zhang, L. I., Tao, H. W., & Poo, M. (2000) · Nature Neuroscience · doi:10.1038/76665 · Cited by 124
Optogenetic Control of Synaptic Composition and Function
Sinnen, B. L., Bowen, A. B., Forte, J. S., Hiester, B. G., Crosby, K. C., Gibson, E. S., Dell’Acqua, M. L., & Kennedy, M. J. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.037 · Cited by 124
Self-citation
Augmentation Treatment of Psychotherapy for Anxiety Disorders with D‐Cycloserine
Hofmann, S. G., Pollack, M. H., & Otto, M. W. (2006) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2006.00208.x · Cited by 123
Selective block of recombinant glur6 receptors by NS-102, a novel non-NMDA receptor antagonist
Verdoorn, T. A., Johansen, T. H., Drejer, J., & Nielsen, E. Ø. (1994) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(94)90024-8 · Cited by 123
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Marco, S., Giralt, A., Petrovic, M. M., Pouladi, M. A., Martínez-Turrillas, R., Hernández, J. M., Kaltenbach, L. S., Torres-Peraza, J. F., Graham, R. K., Watanabe, M., et al. (2013) · Nature Medicine · doi:10.1038/nm.3246 · Cited by 123
Hippocampal atrophy in systemic lupus erythematosus
Appenzeller, S., Carnevalle, A. D., Li, L. M., Costallat, L. T. L., & Cendes, F. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.049486 · Cited by 123
Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release
Sigler, A., Oh, W. C., Imig, C., Altas, B., Kawabe, H., Cooper, B. H., Kwon, H., Rhee, J., & Brose, N. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.029 · Cited by 123
Activity-Dependent Modulation of Glutamate Receptors by Polyamines
Bowie, D., Lange, G. D., & Mayer, M. L. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-20-08175.1998 · Cited by 121
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Structural Rearrangements of NR1/NR2A NMDA Receptors during Allosteric Inhibition
Gielen, M. C., Goff, A. L., Stroebel, D., Johnson, J. W., Neyton, J., & Paoletti, P. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.021 · Cited by 121
Recent insights into the mode of action of memantine and ketamine
Johnson, J. W., Glasgow, N. G., & Povysheva, N. V. (2014) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2014.11.006 · Cited by 121
The Free Energy Landscapes Governing Conformational Changes in a Glutamate Receptor Ligand-Binding Domain
Lau, A. Y., & Roux, B. (2007) · Structure · doi:10.1016/j.str.2007.07.015 · Cited by 121
Control of rat GluR6 glutamate receptor open probability by protein kinase A and calcineurin
Traynelis, S. F., & Wahl, P. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.513bg.x · Cited by 121
Self-citation
CaMKII Phosphorylation of TARPγ-8 Is a Mediator of LTP and Learning and Memory
Park, J., Chávez, A. E., Mineur, Y. S., Morimoto-Tomita, M., Lutzu, S., Kim, K. S., Picciotto, M. R., Castillo, P. E., & Tomita, S. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.002 · Cited by 121
Extracellular proteolysis in structural and functional plasticity of mossy fiber synapses in hippocampus
Wiera, G., & Mozrzymas, J. W. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00427 · Cited by 121
Structural Mechanisms of Gating in Ionotropic Glutamate Receptors
Twomey, E. C., & Sobolevsky, A. I. (2017) · Biochemistry · doi:10.1021/acs.biochem.7b00891 · Cited by 121
Self-citation
Multiple Trafficking Signals Regulate Kainate Receptor KA2 Subunit Surface Expression
Ren, Z., Riley, N. J., Garcia, E. P., Sanders, J. M., Swanson, G. T., & Marshall, J. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-16-06608.2003 · Cited by 120
Self-citation
A centrally active drug that modulates AMPA receptor gated currents.
Arai, A., Kessler, M., Xiao, P., Ambros-Ingerson, J., Rogers, G., & Lynch, G. (1994) · Brain Research · doi:10.1016/0006-8993(94)90669-6 · Cited by 120
Characterization of a Soluble Ligand Binding Domain of the NMDA Receptor Regulatory Subunit NR3A
Yao, Y., & Mayer, M. L. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0560-06.2006 · Cited by 120
New Insights into the Not-So-New NR3 Subunits of N-Methyl-d-aspartate Receptor: Localization, Structure, and Function
Low, C., & Wee, K. S.-L. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.064006 · Cited by 120
Self-citation
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Sanacora, G., Johnson, M. R., Khan, A., Atkinson, S. D., Riesenberg, R. R., Schronen, J. P., Burke, M. A., Zajecka, J. M., Barra, L., Su, H.-L., et al. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.224 · Cited by 120
The hidden energetics of ligand binding and activation in a glutamate receptor
Lau, A. Y., & Roux, B. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2010 · Cited by 120
Phosphorylation-Dependent Regulation of Ca2+-Permeable AMPA Receptors During Hippocampal Synaptic Plasticity
Purkey, A., & Dell’Acqua, M. L. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.00008 · Cited by 120
Self-citation
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Levite, M. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1193-3 · Cited by 120
The regulation of glutamate receptor trafficking and function by TARPs and other transmembrane auxiliary subunits
Straub, C., & Tomita, S. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.09.005 · Cited by 119
Single-channel currents from recombinant NM DANRla /NR2D receptors expressed in Xenopus oocytes
Wyllie, D. J. A., Béhé, P., Nassar, M. A., & Schoepfer, R. (1996) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1996.0159 · Cited by 119
Endogenous Activation of Kainate Receptors Regulates Glutamate Release and Network Activity in the Developing Hippocampus
Lauri, S. E., Segerstråle, M., Vesikansa, A., Maingret, F., Mulle, C., Collingridge, G. L., Isaac, J. T. R., & Taira, T. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4050-04.2005 · Cited by 119
Subunit‐selective N‐terminal domain associations organize the formation of AMPA receptor heteromers
Rossmann, M., Sukumaran, M., Penn, A. C., Veprintsev, D. B., Babu, M. M., & Greger, I. H. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.16 · Cited by 119
Self-citation
Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes
Twomey, E. C., Yelshanskaya, M. V., Grassucci, R. A., Frank, J., & Sobolevsky, A. I. (2017) · Neuron · doi:10.1016/j.neuron.2017.04.025 · Cited by 119
Self-citation
The NMDA Receptor Channel: Molecular Design of a Coincidence Detector
SEEBURG, P. H., BURNASHEV, N., KÖHR, G., KUNER, T., SPRENGEL, R., & MONYER, H. (1995) · Proceedings of the 1993 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571150-0.50006-8 · Cited by 118
Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating
Shi, Y. S., Suh, Y. H., Milstein, A. D., Isozaki, K., Schmid, S. M., Roche, K. W., & Nicoll, R. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011706107 · Cited by 118
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Murphy, J. A., Stein, I. S., Lau, C. G., Peixoto, R. T., Aman, T. K., Kaneko, N., Aromolaran, K. A., Saulnier, J. L., Popescu, G., Sabatini, B. L., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4538-13.2014 · Cited by 118
Correlation of AMPA Receptor Subunit Composition with Synaptic Input in the Mammalian Cochlear Nuclei
Gardner, S. M., Trussell, L. O., & Oertel, D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07428.2001 · Cited by 118
CD8+ T-cell pathogenicity in Rasmussen encephalitis elucidated by large-scale T-cell receptor sequencing
Schneider‐Hohendorf, T., Mohan, H., Bien, C. G., Breuer, J., Becker, A. J., Görlich, D., Kuhlmann, T., Widman, G., Herich, S., Elpers, C., et al. (2016) · Nature Communications · doi:10.1038/ncomms11153 · Cited by 118
Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine
Patneau, D., Mayer, M., Jane, D., et al. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00595.1992 · Cited by 118
Facilitative Effects of the Ampakine CX516 on Short-Term Memory in Rats: Correlations with Hippocampal Neuronal Activity
Hampson, R. E., Rogers, G. A., LYNCH, G. S., & Deadwyler, S. A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02748.1998 · Cited by 117
Metabotropic Regulation of Intrinsic Excitability by Synaptic Activation of Kainate Receptors
Melyan, Z., Lancaster, B., & Wheal, H. V. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5356-03.2004 · Cited by 117
Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A
Zheng, F., Erreger, K., Low, C. M., Banke, T. G., Lee, C. J., Conn, P. J., & Traynelis, S. F. (2001) · Nature Neuroscience · doi:10.1038/nn0901-894 · Cited by 117
Self-citation
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Greger, I. H., Akamine, P., Khatri, L., & Ziff, E. B. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.020 · Cited by 117
Self-citation
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Plested, A. J. R., & Mayer, M. L. (2007) · Neuron · doi:10.1016/j.neuron.2007.02.025 · Cited by 117
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Sensory inputs control the integration of neurogliaform interneurons into cortical circuits
De Marco García, N. V., Priya, R., Tuncdemir, S. N., Fishell, G., & Karayannis, T. (2015) · Nature Neuroscience · doi:10.1038/nn.3946 · Cited by 117
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Hanus, C., & Ehlers, M. (2008) · Traffic · doi:10.1111/j.1600-0854.2008.00775.x · Cited by 117
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A single amino acid determines the subunit-specific spider toxin block of α-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor channels.
Blaschke, N. (1993) · Medical Entomology and Zoology · Cited by 117
Structure and Assembly Mechanism for Heteromeric Kainate Receptors
Kumar, J., Schuck, P., & Mayer, M. L. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.038 · Cited by 117
Synaptic release of zinc from brain slices: Factors governing release, imaging, and accurate calculation of concentration
Frederickson, C. J., Giblin, L. J., Rengarajan, B., Masalha, R., Frederickson, C. J., Zeng, Y., Varea, E., Koh, J., Chorin, U., Besser, L., et al. (2006) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2005.11.014 · Cited by 117
Synaptic transmission and plasticity require AMPA receptor anchoring via its N-terminal domain
Watson, J. F., Ho, H., & Greger, I. H. (2017) · eLife · doi:10.7554/elife.23024 · Cited by 117
Self-citation
Postnatal maturation of mossy fibre excitatory transmission in mouse CA3 pyramidal cells: a potential role for kainate receptors
Marchal, C., & Mulle, C. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.069922 · Cited by 116
Identification of Molecular Determinants That Are Important in the Assembly of N-Methyl-d-aspartate Receptors
Meddows, E., Bourdellès, B. L., Grimwood, S., Wafford, K. A., Sandhu, S., Whiting, P. J., & McIlhinney, R. A. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101382200 · Cited by 116
GluN2D-Containing N-methyl-d-Aspartate Receptors Mediate Synaptic Transmission in Hippocampal Interneurons and Regulate Interneuron Activity
Perszyk, R. E., DiRaddo, J. O., Strong, K. L., Low, C.-M., Ogden, K. K., Khatri, A., Vargish, G. A., Pelkey, K. A., Tricoire, L., Liotta, D. C., et al. (2016) · Molecular Pharmacology · doi:10.1124/mol.116.105130 · Cited by 116
Self-citation
Autoantibodies to a NR2A peptide of the glutamate/NMDA receptor in sera of patients with systemic lupus erythematosus
Husebye, E. S., Sthoeger, Z. M., Dayan, M., Zinger, H., Elbirt, D., Levite, M., & Mozes, E. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2004.029280 · Cited by 116
Decahydroisoquinolines: novel competitive AMPA/kainate antagonists with neuroprotective effects in global cerebral ischaemia
O’Neill, M. J., Bond, A., Ornstein, P. L., Ward, M., Hicks, C. A., Hoo, K. H., Bleakman, D., & Lodge, D. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00134-8 · Cited by 115
Architecture of fully occupied GluA2 AMPA receptor–TARP complex elucidated by cryo-EM
Zhao, Y., Chen, S., Yoshioka, C., Baconguis, I., & Gouaux, E. (2016) · Nature · doi:10.1038/nature18961 · Cited by 115
Spermine potentiation of recombinant N-methyl-D-aspartate receptors is affected by subunit composition.
Zhang, L., Zheng, X., Paupard, M. C., et al. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.10883 · Cited by 114
Sulfated steroids as endogenous neuromodulators
Gibbs, T. T., Russek, S. J., & Farb, D. H. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.07.031 · Cited by 114
High-Affinity Kainate Receptor Subunits Are Necessary for Ionotropic but Not Metabotropic Signaling
Fernandes, H. B., Catches, J. S., Petralia, R. S., Copits, B. A., Xu, J., Russell, T. A., Swanson, G. T., & Contractor, A. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.010 · Cited by 114
Self-citation
Trapping of glutamate and glycine during open channel block of rat hippocampal neuron NMDA receptors by 9‐aminoacridine.
Benveniste, M., & Mayer, M. L. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020591 · Cited by 114
A MicroRNA gene is hosted in an intron of a schizophrenia-susceptibility gene
Zhu, Y., Kalbfleisch, T., Brennan, M. D., & Li, Y. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.01.022 · Cited by 114
Nucleotide Sequence, Genomic Organization, and Chromosomal Localization of Genes Encoding the Human NMDA Receptor Subunits NR3A and NR3B
Andersson, O., Stenqvist, A., Attersand, A., & von Euler, G. (2001) · Genomics · doi:10.1006/geno.2001.6666 · Cited by 114
Facilitation of currents through rat Ca2+‐permeable AMPA receptor channels by activity‐dependent relief from polyamine block
Rozov, A., Zilberter, Y., Wollmuth, L. P., & Burnashev, N. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.361bh.x · Cited by 114
Self-citation
Control of Assembly and Function of Glutamate Receptors by the Amino-Terminal Domain
Hansen, K. B., Furukawa, H., & Traynelis, S. F. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.067157 · Cited by 114
Self-citation
Genotype–phenotype analysis of 4q deletion syndrome: Proposal of a critical region
Strehle, E., Yu, L., Rosenfeld, J. A., Donkervoort, S. C., Zhou, Y., Chen, T., Martinez, J. E., Fan, Y., Barbouth, D., Zhu, H., et al. (2012) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.35502 · Cited by 114
A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists
Stroebel, D., Buhl, D. L., Knafels, J. D., Chanda, P. K., Green, M., Sciabola, S., Mony, L., Paoletti, P., & Pandit, J. (2016) · Molecular Pharmacology · doi:10.1124/mol.115.103036 · Cited by 114
Crystal Structures of the Kainate Receptor GluR5 Ligand Binding Core Dimer with Novel GluR5-Selective Antagonists
Mayer, M. L., Ghosal, A., Dolman, N. P., & Jane, D. E. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0123-06.2005 · Cited by 113
Control of Synaptic Connection by Glutamate Receptor δ2 in the Adult Cerebellum
Takeuchi, T., Miyazaki, T., Watanabe, M., Mori, H., Sakimura, K., & Mishina, M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4740-04.2005 · Cited by 113
Subunit-Selective Allosteric Inhibition of Glycine Binding to NMDA Receptors
Hansen, K. B., Ogden, K. K., & Traynelis, S. F. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5757-11.2012 · Cited by 113
Self-citation
Benzamide-Type AMPA Receptor Modulators Form Two Subfamilies with Distinct Modes of Action
Arai, A., Xia, Y., Rogers, G. A., LYNCH, G. S., & Kessler, M. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.040360 · Cited by 113
NR2A and NR2B receptor gene variations modify age at onset in Huntington disease
Arning, L., Kraus, P. H., Valentin, S., Carsten Saft, C., Andrich, J., & Epplen, J. T. (2004) · Neurogenetics · doi:10.1007/s10048-004-0198-8 · Cited by 113
Glutamate Acting on AMPA But Not NMDA Receptors Modulates the Migration of Hippocampal Interneurons
Manent, J.-B., Jorquera, I., Ben-Ari, Y., Aniksztejn, L., & Represa, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1033-06.2006 · Cited by 112
Extinction Training in Conjunction with a Partial Agonist of the Glycine Site on the NMDA Receptor Erases Memory Trace
Mao, S.-C., Hsiao, Y., & Gean, P. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0365-06.2006 · Cited by 112
Subtype-specific Assembly of α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid Receptor Subunits Is Mediated by Their N-terminal Domains
Leuschner, W. D., & Hoch, W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.16907 · Cited by 112
Glutamate enhances proliferation and neurogenesis in human neural progenitor cell cultures derived from the fetal cortex
Suzuki, M., Nelson, A. D., Eickstaedt, J. B., Wallace, K., Wright, L. S., & Svendsen, C. N. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04957.x · Cited by 112
Bidirectional Modulation of GABA Release by Presynaptic Glutamate Receptor 5 Kainate Receptors in the Basolateral Amygdala
Braga, M. F. M., Aroniadou‐Anderjaska, V., Xie, J., & Li, H. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-02-00442.2003 · Cited by 112
Neto1 Is an Auxiliary Subunit of Native Synaptic Kainate Receptors
Tang, M., Pelkey, K. A., Ng, D., Ivakine, E., McBain, C. J., Salter, M. W., & McInnes, R. R. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6617-10.2011 · Cited by 112
Self-citation
Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors
Yao, Y., Harrison, C. B., Freddolino, P. L., Schulten, K. J., & Mayer, M. L. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.140 · Cited by 112
Recurrent 10q22-q23 Deletions: A Genomic Disorder on 10q Associated with Cognitive and Behavioral Abnormalities
Balciuniene, J., Feng, N., Iyadurai, K., Hirsch, B. A., Charnas, L. R., Bill, B. R., Easterday, M. C., Staaf, J., Oseth, L., Czapansky-Beilman, D., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/513607 · Cited by 112
Structure of an agonist-bound ionotropic glutamate receptor
Yelshanskaya, M. V., Li, M., & Sobolevsky, A. I. (2014) · Science · doi:10.1126/science.1256508 · Cited by 112
Self-citation
Nanoscale co-organization and coactivation of AMPAR, NMDAR, and mGluR at excitatory synapses
Goncalves, J., Bartol, T. M., Camus, C., Levet, F., Menegolla, A. P., Sejnowski, T. J., Sibarita, J.-B., Vivaudou, M., Choquet, D., & Hosy, E. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922563117 · Cited by 112
Separating dual effects of zinc at recombinant N-methyl-d-aspartate receptors
Williams, K. L. (1996) · Neuroscience Letters · doi:10.1016/s0304-3940(96)12924-4 · Cited by 111
IV glycine and oral d-cycloserine effects on plasma and CSF amino acids in healthy humans
D’Souza, D. C., Gil, R. B., Cassello, K., Morrissey, K., Abi‐Saab, D., White, J., Sturwold, R., Bennett, A., Karper, L. P., Zuzarte, E., et al. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00133-x · Cited by 111
Differential contribution of the NR1‐ and NR2A‐subunits to the selectivity filter of recombinant NMDA receptor channels.
Wollmuth, L. P., Kuner, T., Seeburg, P. H., & Sakmann, B. J. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021257 · Cited by 111
Self-citation
Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, γ-5
Soto, D., Coombs, I. D., Renzi, M., Zonouzi, M., Farrant, M., & Cull-Candy, S. G. (2009) · Nature Neuroscience · doi:10.1038/nn.2266 · Cited by 111
Conformational restriction blocks glutamate receptor desensitization
Weston, M. C., Schuck, P., Ghosal, A., Rosenmund, C., & Mayer, M. L. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1178 · Cited by 111
Unmasking GluN1/GluN3A excitatory glycine NMDA receptors
Grand, T., Gerges, S. A., David, M., Diana, M. A., & Paoletti, P. (2018) · Nature Communications · doi:10.1038/s41467-018-07236-4 · Cited by 111
Two-photon brightness of azobenzene photoswitches designed for glutamate receptor optogenetics
Carroll, E. C., Berlin, S., Levitz, J., Kienzler, M. A., Yuan, Z., Madsen, D., Larsen, D. S., & Isacoff, E. Y. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1416942112 · Cited by 111
Spatial diversity in gene expression for VDCCγ subunit family in developing and adult mouse brains
Fukaya, M., Yamazaki, M., Sakimura, K., & Watanabe, M. (2005) · Neuroscience Research · doi:10.1016/j.neures.2005.08.009 · Cited by 110
Molecular Determinants of Proton-Sensitive N-Methyl-d-aspartate Receptor Gating
Low, C., Lyuboslavsky, P. N., French, A. M., Le, P., Wyatte, K., Thiel, W. H., Marchan, E. M., Igarashi, K., Kashiwagi, K., Gernert, K. M., et al. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.6.1212 · Cited by 110
Self-citation
Mechanism of Activation and Selectivity in a Ligand-Gated Ion Channel: Structural and Functional Studies of GluR2 and Quisqualate,
Jin, R., Horning, M. S., Mayer, M. L., & Gouaux, E. (2002) · Biochemistry · doi:10.1021/bi020583k · Cited by 110
Agonist-induced Isomerization in a Glutamate Receptor Ligand-binding Domain
Abele, R., KEINÄNEN, K. P., & Madden, D. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909883199 · Cited by 110
Calcium‐mediated modulation of N‐methyl‐D‐aspartate (NMDA) responses in cultured rat hippocampal neurones.
Vyklický, L. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019876 · Cited by 110
Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP γ8
Herguedas, B., Watson, J. F., Ho, H., Cais, O., García‐Nafría, J., & Greger, I. H. (2019) · Science · doi:10.1126/science.aav9011 · Cited by 110
Self-citation
Glycine-insensitive desensitization of NMDA responses in cultured mouse embryonic neurons
Sather, W. A., Johnson, J. W., Henderson, G., et al. (1990) · Neuron · doi:10.1016/0896-6273(90)90198-o · Cited by 110
Activation of recombinant NR1/NR2C NMDA receptors
Dravid, S. M., Prakash, A., & Traynelis, S. F. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.158634 · Cited by 109
Self-citation
Exon 5 and Spermine Regulate Deactivation of NMDA Receptor Subtypes
Rumbaugh, G., Prybylowski, K., Wang, J. F., & Vicini, S. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.3.1300 · Cited by 109
Neurobiological effects of a null mutation depend on genetic context: comparison between two hotfoot alleles of the delta-2 ionotropic glutamate receptor
Lalouette, A., Lohof, A. M., Sotelo, C., Guénet, J., & Mariani, J. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00193-2 · Cited by 109
Activation and desensitization properties of native and recombinant kainate receptors
Paternain, A. V., Moreno, A. R., Villarroel, Á., & Lerma, J. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00098-7 · Cited by 109
A drug that facilitates glutamatergic transmission reduces exploratory activity and improves performance in a learning‐dependent task
Granger, R., Staubli, U. V., Davis, M., Perez, Y., Nilsson, L. M., Rogers, G. A., & LYNCH, G. S. (1993) · Synapse · doi:10.1002/syn.890150409 · Cited by 109
Evolution of NMDA receptor cytoplasmic interaction domains: implications for organisation of synaptic signalling complexes
Ryan, T. J., Emes, R. D., Grant, S. G. N., & Komiyama, N. H. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-6 · Cited by 109
Molecular Rearrangements of the Extracellular Vestibule in NMDAR Channels during Gating
Sobolevsky, A. I., Beck, C., & Wollmuth, L. P. (2002) · Neuron · doi:10.1016/s0896-6273(01)00560-8 · Cited by 109
Self-citation
An NMDA Receptor Signaling Complex with Protein Phosphatase 2A
Chan, S. F., & Sucher, N. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-20-07985.2001 · Cited by 109
Agonist binding to the NMDA receptor drives movement of its cytoplasmic domain without ion flow
Doré, K., Aow, J., & Malinow, R. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520023112 · Cited by 109
Arrangement of Subunits in Functional NMDA Receptors
Salussolia, C. L., Prodromou, M. L., Borker, P., & Wollmuth, L. P. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5612-10.2011 · Cited by 109
Self-citation
Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus
Park, P., Sanderson, T. M., Amici, M., Choi, S.-L., Bortolotto, Z. A., Zhuo, M., Kaang, B., & Collingridge, G. L. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3625-15.2016 · Cited by 109
The kainate receptor subunit GluR6 mediates metabotropic regulation of the slow and medium AHP currents in mouse hippocampal neurones
Fisahn, A., Heinemann, S. F., & McBain, C. J. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.077412 · Cited by 108
Self-citation
Structural Determinants of d-Cycloserine Efficacy at the NR1/NR2C NMDA Receptors
Dravid, S. M., Burger, P. B., Prakash, A., Geballe, M. T., Yadav, R., Le, P., Vellano, K. M., Snyder, J. P., & Traynelis, S. F. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5390-09.2010 · Cited by 108
Self-citation
Developmental origin dictates interneuron AMPA and NMDA receptor subunit composition and plasticity
Matta, J. A., Pelkey, K. A., Craig, M. T., Chittajallu, R., Jeffries, B. W., & McBain, C. J. (2013) · Nature Neuroscience · doi:10.1038/nn.3459 · Cited by 108
Self-citation
Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior
Ryan, T. J., Kopanitsa, M. V., Indersmitten, T., Nithianantharajah, J., Afinowi, N. O., Pettit, C., Stanford, L. E., Sprengel, R., Saksida, L. M., Bussey, T. J., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3277 · Cited by 108
Immunoprecipitation, immunoblotting, and immunocytochemistry studies suggest that glutamate receptor delta subunits form novel postsynaptic receptor complexes
Mayat, E., Petralia, R. S., Wang, Y., & Wenthold, R. J. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-02533.1995 · Cited by 108
A novel anti-epileptic agent, perampanel, selectively inhibits AMPA receptor-mediated synaptic transmission in the hippocampus
Ceolin, L., Bortolotto, Z. A., Bannister, N. J., Collingridge, G. L., Lodge, D., & Volianskis, A. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.02.035 · Cited by 108
PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum
Tan, G., Liu, Y.-Y., Wang, L., Li, K., Zhang, Z.-Q., Li, H., Yang, Z., Li, Y., Li, D., Wu, M., et al. (2017) · Cell Research · doi:10.1038/cr.2017.128 · Cited by 108
Identification of a long variant of mRNA encoding the NR3 subunit of the NMDA receptor: its regional distribution and developmental expression in the rat brain
Sun, L., Margolis, F. L., Shipley, M. T., & Lidow, M. S. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01590-7 · Cited by 107
A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral–CA1 synapses in hippocampus
Zhang, X.-L., Sullivan, J. A., Moskal, J. R., & Stanton, P. K. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.08.018 · Cited by 107
Functional NR2B‐ and NR2D‐containing NMDA receptor channels in rat substantia nigra dopaminergic neurones
Jones, S., & Gibb, A. J. (2005) · Journal of Physiology · doi:10.1113/jphysiol.2005.095554 · Cited by 107
Expanding Role of NMDA Receptor Antagonists in the Management of Pain
Kreutzwiser, D., & Tawfic, Q. A. (2019) · CNS Drugs · doi:10.1007/s40263-019-00618-2 · Cited by 107
A Novel Allosteric Potentiator of AMPA Receptors: 4-[2-(Phenylsulfonylamino)ethylthio]-2,6-Difluoro-Phenoxyacetamide
Sekiguchi, M., Fleck, M. W., Mayer, M. L., Takeo, J., Chiba, Y., Yamashita, S., & Wada, K. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-15-05760.1997 · Cited by 106
Multiple Forms of Activity-Dependent Competition Refine Hippocampal Circuits In Vivo
Yasuda, M., Johnson‐Venkatesh, E., Zhang, H., Parent, J. M., Sutton, M. A., & Umemori, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.027 · Cited by 106
Permeation and block of rat glur6 glutamate receptor channels by internal and external polyamines
Bähring, R., Bowie, D., Benveniste, M., & Mayer, M. L. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.575bj.x · Cited by 106
Self-citation
Interactions among GYKI-52466, cyclothiazide, and aniracetam at recombinant AMPA and kainate receptors.
Johansen, T. H., Chaudhary, A., & Verdoorn, T. A. (1995) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10553-1 · Cited by 106
CRMPs: critical molecules for neurite morphogenesis and neuropsychiatric diseases
Quach, T., Honnorat, J., Kolattukudy, P. E., Khanna, R., & Duchemin, A. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.77 · Cited by 106
NMDA-R1 subunit of the cerebral cortex co-localizes with neuronal nitric oxide synthase at pre- and postsynaptic sites and in spines
Aoki, C. J., Rhee, J., Lubin, M., & Dawson, T. M. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01147-x · Cited by 106
Synaptic profiles during neurite extension, refinement and retraction in the developing cochlea
Huang, L.-C., Barclay, M., Lee, K. C., Peter, S., Housley, G. D., Thorne, P. R., & Montgomery, J. M. (2012) · Neural Development · doi:10.1186/1749-8104-7-38 · Cited by 106
Purkinje Cell Signaling Deficits in Animal Models of Ataxia
Hoxha, E., Balbo, I., Miniaci, M. C., & Tempia, F. (2018) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2018.00006 · Cited by 106
Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors
Twomey, E. C., Yelshanskaya, M. V., Vassilevski, A. A., & Sobolevsky, A. I. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.027 · Cited by 106
Self-citation
Control of aversion by glycine-gated GluN1/GluN3A NMDA receptors in the adult medial habenula
Otsu, Y., Darcq, E., Pietrajtis, K., et al. (2019) · Science · doi:10.1126/science.aax1522 · Cited by 106
d-Serine as the gatekeeper of NMDA receptor activity: implications for the pharmacologic management of anxiety disorders
Wolosker, H., & Balu, D. T. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00870-x · Cited by 106
Conformational Analysis of NMDA Receptor GluN1, GluN2, and GluN3 Ligand-Binding Domains Reveals Subtype-Specific Characteristics
Yao, Y., Belcher, J., Berger, A. J., Mayer, M. L., & Lau, A. Y. (2013) · Structure · doi:10.1016/j.str.2013.07.011 · Cited by 105
Kainate Receptor-Mediated Synaptic Transmission in the Adult Anterior Cingulate Cortex
Wu, L., Zhao, M., Toyoda, H., Ko, S. W., & Zhuo, M. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00091.2005 · Cited by 105
Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design
Volgraf, M., Sellers, B. D., Jiang, Y., Wu, G., Ly, C. Q., Villemure, E., Pastor, R. M., Yuen, P., Lu, A., Luo, X., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b02010 · Cited by 105
Distribution, Density, and Clustering of Functional Glutamate Receptors Before and After Synaptogenesis in Hippocampal Neurons
Cottrell, J. R., Dubé, G., Egles, C., & Liu, G. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.3.1573 · Cited by 105
De novo mutations in GRIN1 cause extensive bilateral polymicrogyria
Fry, A. E., Fawcett, K. A., Zelnik, N., Yuan, H., Thompson, B. A. N., Shemer-Meiri, L., Cushion, T. D., Mugalaasi, H., Sims, D., Stoodley, N., et al. (2017) · Brain · doi:10.1093/brain/awx358 · Cited by 105
Self-citation
Missense mutations in transmembrane domains of proteins: Phenotypic propensity of polar residues for human disease
Partridge, A. W., Therien, A. G., & Deber, C. M. (2004) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.10611 · Cited by 105
Synaptic Targeting and Functional Modulation of GluK1 Kainate Receptors by the Auxiliary Neuropilin and Tolloid-Like (NETO) Proteins
Copits, B. A., Robbins, J. S., Frausto, S. F., & Swanson, G. T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0100-11.2011 · Cited by 104
Self-citation
Family‐based association study between autism and glutamate receptor 6 gene in Chinese Han trios
Mei, S., Liu, J., Jia, M. X., Yang, J. Z., Wu, S., Gong, X. H., Ling, Y., Ruan, Y., Yang, X., & Zhang, D. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30025 · Cited by 104
Subtype-dependence of N-methyl-d-aspartate receptor modulation by pregnenolone sulfate
Hořák, M., Vlček, K., Chodounská, H., & Vyklický, L. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.058 · Cited by 104
Formation of NR1/NR2 and NR1/NR3 Heterodimers Constitutes the Initial Step in N-Methyl-D-aspartate Receptor Assembly
Schüler, T., Mesic, I., Madry, C., Bartholomäus, I., & Laube, B. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703539200 · Cited by 104
Impaired cerebellar synapse maturation in waggler , a mutant mouse with a disrupted neuronal calcium channel γ subunit
Chen, L., Bao, S., Qiao, X., & Thompson, R. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.12132 · Cited by 104
Taking The Time To Study Competitive Antagonism
Wyllie, D. J. A., & Chen, P. E. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706997 · Cited by 104
Prolonged Physiological Entrapment of Glutamate in the Synaptic Cleft of Cerebellar Unipolar Brush Cells
Kinney, G. A., Overstreet, L. S., & Slater, N. T. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.78.3.1320 · Cited by 104
Non-competitive AMPA Antagonists of 2,3-Benzodiazepine Type
Sólyom, S., & Tarnawa, I. (2002) · Current Pharmaceutical Design · doi:10.2174/1381612024607081 · Cited by 104
Time and space profiling of NMDA receptor co‐agonist functions
Mothet, J., Bail, M. L., & Billard, J. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13204 · Cited by 103
Cornichons Modify Channel Properties of Recombinant and Glial AMPA Receptors
Coombs, I. D., Soto, D., Zonouzi, M., Renzi, M., Shelley, C., Farrant, M., & Cull-Candy, S. G. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0345-12.2012 · Cited by 103
The N-terminal domain of GluR6-subtype glutamate receptor ion channels
Kumar, J., Schuck, P., Jin, R., & Mayer, M. L. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1613 · Cited by 103
GluN2D-containing NMDA receptors-mediate synaptic currents in hippocampal interneurons and pyramidal cells in juvenile mice
Engelhardt, J. V., Bocklisch, C., TÃ¶nges, L., Herb, A., Mishina, M., & Monyer, H. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00095 · Cited by 103
Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed inXenopus laevisoocytes
Chen, P. E., Geballe, M. T., Katz, E., Erreger, K., Livesey, M. R., O’Toole, K. K., Le, P., Lee, C. J., Snyder, J. P., Traynelis, S. F., et al. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.143172 · Cited by 103
Self-citation
Differences in Degree of Trapping of Low-Affinity Uncompetitive N-Methyl-d-aspartic Acid Receptor Antagonists with Similar Kinetics of Block
Mealing, G. A. R., Lanthorn, T. H., Murray, C. L., Small, D. L., & Morley, P. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37943-1 · Cited by 103
Dlx1andDlx2Promote Interneuron GABA Synthesis, Synaptogenesis, and Dendritogenesis
Pla, R., Stanco, A., Howard, M. A., Rubin, A. N., Vogt, D. L., Mortimer, N., Cobos, I., Potter, G. B., Lindtner, S., Price, J. D., et al. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx241 · Cited by 103
Autoantibodies to the Glutamate Receptor Kill Neurons via Activation of the Receptor Ion Channel
Levite, M., Fleidervish, I. A., Schwarz, A., Pelled, D., & Futerman, A. H. (1999) · Journal of Autoimmunity · doi:10.1006/jaut.1999.0301 · Cited by 103
Enriched Expression of GluD1 in Higher Brain Regions and Its Involvement in Parallel Fiber–Interneuron Synapse Formation in the Cerebellum
Konno, K., Matsuda, K., Nakamoto, C., Uchigashima, M., Miyazaki, T., Yamasaki, M., Sakimura, K., Yuzaki, M., & Watanabe, M. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0628-14.2014 · Cited by 103
Subunit Composition and Alternative Splicing Regulate Membrane Delivery of Kainate Receptors
Jaskolski, F., Coussen, F., Nagarajan, N., Normand, E., Rosenmund, C., & Mulle, C. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5116-03.2004 · Cited by 103
Mechanism for Noncompetitive Inhibition by Novel GluN2C/D N-Methyl-d-aspartate Receptor Subunit-Selective Modulators
Acker, T. M., Yuan, H., Hansen, K. B., Vance, K. M., Ogden, K. K., Jensen, H. S., Burger, P. B., Mullasseril, P., Snyder, J. P., Liotta, D. C., et al. (2011) · Molecular Pharmacology · doi:10.1124/mol.111.073239 · Cited by 103
Self-citation
Non-canonical Signaling, the Hidden Life of Ligand-Gated Ion Channels
Valbuena, S., & Lerma, J. (2016) · Neuron · doi:10.1016/j.neuron.2016.10.016 · Cited by 103
Modulation of the time course of fast EPSCs and glutamate channel kinetics by aniracetam
Tang, C. M., Shi, Q., Katchman, A., et al. (1991) · Science · doi:10.1126/science.254.5029.288 · Cited by 103
Excitatory Glycine Responses of CNS Myelin Mediated by NR1/NR3 “NMDA” Receptor Subunits
Piña-Crespo, J., Talantova, M. V., Micu, I., States, B. A., Chen, H.-S. V., Tu, S., Nakanishi, N., Tong, G., Zhang, D., Heinemann, S. F., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1593-10.2010 · Cited by 102
Pharmacological Characterization of Glycine-Activated Currents in HEK 293 Cells Expressing N-Methyl-D-aspartate NR1 and NR3 Subunits
Smothers, C. T., & Woodward, J. J. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.123836 · Cited by 102
A Double‐Blind, Placebo‐Controlled Study of the Safety, Tolerability and Pharmacokinetics of CP‐101,606 in Patients with a Mild or Moderate Traumatic Brain Injury
Merchant, R. E., Bullock, M. R., Carmack, C. A., SHAH, A. K., Wilner, K. D., Ko, G. N., & Williams, S. A. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07979.x · Cited by 102
Paired-pulse depression of unitary quantal amplitude at single hippocampal synapses
Chen, G., Harata, N. C., & Tsien, R. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307149101 · Cited by 102
Competitive Antagonism of AMPA Receptors by Ligands of Different Classes: Crystal Structure of ATPO Bound to the GluR2 Ligand-Binding Core, in Comparison with DNQX
Hogner, A., Greenwood, J. R., Liljefors, T., Lunn, M.-L., Egebjerg, J., Larsen, I. K., Gouaux, E., & Kastrup, J. S. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm020989v · Cited by 102
Identification of a High Affinity Divalent Cation Binding Site near the Entrance of the NMDA Receptor Channel
Premkumar, L. S., & Auerbach, A. L. (1996) · Neuron · doi:10.1016/s0896-6273(00)80107-5 · Cited by 102
Deactivation and desensitization of non‐NMDA receptors in patches and the time course of EPSCs in rat cerebellar granule cells.
Silver, R. A., Colquhoun, D., Cull-Candy, S. G., & Edmonds, B. W. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021372 · Cited by 102
Drosophila Cornichon acts as cargo receptor for ER export of the TGFα-like growth factor Gurken
Bökel, C., Dass, S., Wilsch‐Bräuninger, M., & Roth, S. (2006) · Development · doi:10.1242/dev.02219 · Cited by 102
Differential Regulation of Evoked and Spontaneous Release by Presynaptic NMDA Receptors
Abrahamsson, T., Chou, C. Y. C., Li, S. S. Y., Mancino, A. S., Costa, R. P., Brock, J. A., Nuro, E., Buchanan, K. A., Elgar, D., Blackman, A. V., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.030 · Cited by 102
Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons
Fossati, M., Assendorp, N., Gemin, O., Colasse, S., Dingli, F., Arras, G., Loew, D., & Charrier, C. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.027 · Cited by 102
Competitive Inhibition at the Glycine Site of the N -Methyl-d-Aspartate Receptor Mediates Xenon Neuroprotection against Hypoxia–Ischemia
Banks, P. J., Franks, N. P., & Dickinson, R. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181cea398 · Cited by 102
Arrest of neuronal migration by excitatory amino acids in hamster developing brain
Marret, S., Gressèns, P., & Evrard, P. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.26.15463 · Cited by 102
Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors
Yi, F., Mou, T., Dorsett, K. N., Volkmann, R. A., Menniti, F. S., Sprang, S. R., & Hansen, K. B. (2016) · Neuron · doi:10.1016/j.neuron.2016.08.014 · Cited by 102
Self-citation
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Jaskolski, F., Coussen, F., & Mulle, C. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.11.008 · Cited by 101
A calcineurin/AKAP complex is required for NMDA receptor-dependent long-term depression
Jurado, S., Biou, V., & Malenka, R. C. (2010) · Nature Neuroscience · doi:10.1038/nn.2613 · Cited by 101
Mutagenesis rescues spermine and Zn2+ potentiation of recombinant NMDA receptors
Zhang, X., Zhang, L., Durand, G. M., Bennett, M. V. L., & Zukin, R. S. (1994) · Neuron · doi:10.1016/0896-6273(94)90334-4 · Cited by 101
Subunit Interactions and AMPA Receptor Desensitization
Robert, A., Irizarry, S. N., Hughes, T. E., & Howe, J. R. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-15-05574.2001 · Cited by 101
Deletions in GRID2 lead to a recessive syndrome of cerebellar ataxia and tonic upgaze in humans
Hills, L. B., Masri, A. T., Konno, K., Kakegawa, W., Lam, A.-T. N., Lim-Melia, E. R., Chandy, N., Hill, R. S., Partlow, J. N., Al‐Saffar, M., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a841a3 · Cited by 101
Block and Modulation ofN-Methyl-d-Aspartate Receptors by Polyamines and Protons: Role of Amino Acid Residues in the Transmembrane and Pore-Forming Regions of NR1 and NR2 Subunits
Kashiwagi, K., Pahk, A. J., Masuko, T., Igarashi, K., & Williams, K. L. (1997) · Molecular Pharmacology · doi:10.1124/mol.52.4.701 · Cited by 101
Biology of the NMDA Receptor
VanDongen, A. M. J. (2008) · CRC Press eBooks · doi:10.1201/9781420044157 · Cited by 101
Correction: Genic Intolerance to Functional Variation and the Interpretation of Personal Genomes
Petrovski, S., Wang, Q., Heinzen, E. L., Allen, A. S., & Goldstein, D. B. (2013) · PLoS Genetics · doi:10.1371/annotation/32c8d343-9e1d-46c6-bfd4-b0cd3fb7a97e · Cited by 100
Kainate receptor-mediated synaptic currents in cerebellar Golgi cells are not shaped by diffusion of glutamate
Bureau, I., Dieudonné, S., Coussen, F., & Mulle, C. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.12.6838 · Cited by 100
AMPA receptor protein in developing rat brain: glutamate receptor-1 expression and localization change at regional, cellular, and subcellular levels with maturation
Martin, L. J., Furuta, A., & Blackstone, C. D. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00411-9 · Cited by 100
Molecular Mechanism of AMPA Receptor Noncompetitive Antagonism
Balannik, V., Menniti, F. S., Paternain, A. V., Lerma, J., & Stern-Bach, Y. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.024 · Cited by 100
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Vargas‐Caballero, M., & Robinson, H. P. C. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1380-04.2004 · Cited by 100
Extensive phosphorylation of AMPA receptors in neurons
Diering, G. H., Heo, S., Hussain, N. K., Liu, B., & Huganir, R. L. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1610631113 · Cited by 100
GluN2C / GluN2D subunit‐selective NMDA receptor potentiator CIQ reverses MK ‐801‐induced impairment in prepulse inhibition and working memory in Y ‐maze test in mice
Suryavanshi, P. S., Ugale, R. R., Yilmazer‐Hanke, D., Stairs, D. J., & Dravid, S. M. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12518 · Cited by 99
GluR3 Autoantibodies Destroy Neural Cells in a Complement-Dependent Manner Modulated by Complement Regulatory Proteins
Whitney, K. D., & McNamara, J. O. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07307.2000 · Cited by 99
Glycine-Independent NMDA Receptor Desensitization: Localization of Structural Determinants
Villarroel, Á., Regalado, M. P., & Lerma, J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80460-2 · Cited by 99
A single GluN2 subunit residue controls NMDA receptor channel properties via intersubunit interaction
Retchless, B. S., Gao, W., & Johnson, J. W. (2012) · Nature Neuroscience · doi:10.1038/nn.3025 · Cited by 99
Immunolocalization of NMDA receptor subunit NR3B in selected structures in the rat forebrain, cerebellum, and lumbar spinal cord
Wee, K. S.-L., Zhang, Y., Khanna, S., & Low, C. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21747 · Cited by 99
Self-citation
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Fujiyama, F., Kuramoto, E., Okamoto, K., Hioki, H., Furuta, T., Zhou, L., Nomura, S., & Kaneko, T. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03807.x · Cited by 99
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Maher, M. P., Wu, N., Ravula, S., Ameriks, M. K., Savall, B. M., Liu, C., Lord, B., Wyatt, R. M., Matta, J. A., Dugovic, C., et al. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.231712 · Cited by 99
Cholesterol modulates open probability and desensitization of NMDA receptors
Kořı́nek, M., Vyklický, V., Borovská, J., Hemelíková, K., Kaniaková, M., Krausová, B. H., Krůšek, J., Balík, A., Smejkalová, T., Hořák, M., et al. (2015) · The Journal of Physiology · doi:10.1113/jphysiol.2014.288209 · Cited by 99
Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors
Vance, K. M., Simorowski, N., Traynelis, S. F., & Furukawa, H. (2011) · Nature Communications · doi:10.1038/ncomms1295 · Cited by 99
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Huang, Y. H., Dykes‐Hoberg, M., Tanaka, K., Rothstein, J. D., & Bergles, D. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4473-03.2004 · Cited by 99
Calpains and neuronal damage in the ischemic brain: The swiss knife in synaptic injury
Curcio, M., Salazar, I. L., Mele, M., Canzoniero, L. M. T., & Duarte, C. B. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.06.001 · Cited by 99
Determinants of trapping block of N‐methyl‐ d ‐aspartate receptor channels
Bolshakov, K. V., Гмиро, В. Е., Tikhonov, D. B., & Magazanik, L. G. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01956.x · Cited by 98
Glutamate activation of a single NMDA receptorchannel produces a cluster of channel openings
Gibb, A. J., & Colquhoun, D. M. (1991) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1991.0007 · Cited by 98
Modulation of NMDA Receptor Properties and Synaptic Transmission by the NR3A Subunit in Mouse Hippocampal and Cerebrocortical Neurons
Tong, G., Takahashi, H., Tu, S., Shin, Y., Talantova, M. V., Zago, W. M., Xia, P., Nie, Z., Goetz, T., Zhang, D., et al. (2007) · Journal of Neurophysiology · doi:10.1152/jn.01044.2006 · Cited by 98

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Authors: Hansen, K. B., Wollmuth, L. P., Bowie, D., Furukawa, H., Menniti, F. S., Sobolevsky, A. I., Swanson, G. T., Swanger, S. A., Greger, I. H., Nakagawa, T., McBain, C. J., Jayaraman, V., Low, C.-M., Dell’Acqua, M. L., Diamond, J. S., Camp, C. R., Perszyk, R. E., Yuan, H., & Traynelis, S. F.
Affiliations: Northwestern University (US)
Corresponding author: Traynelis, Stephen F.
ORCID: Hansen, Kasper B.
Wollmuth, Lonnie P.
Bowie, Derek
Furukawa, Hiro
Menniti, Frank S.
Sobolevsky, Alexander I.
Swanson, Geoffrey T.
Swanger, Sharon A.
Greger, Ingo H.
Nakagawa, Terunaga
McBain, Chris J.
Jayaraman, Vasanthi
Low, Chian-Ming
Dell’Acqua, Mark L.
Diamond, Jeffrey S.
Camp, Chad R.
Perszyk, Riley E.
Yuan, Hongjie
Traynelis, Stephen F.
Venue: Pharmacological Reviews
Publisher: Elsevier BV
Published: 2021-10
Volume: 73
Issue: 4
Pages: 1469-1658
ISSN: 0031-6997 (ISSN-L)
DOI: 10.1124/pharmrev.120.000131
PMC: PMC8626789
OpenAlex: W3214054678
Cited by: 686
References: 2,576
Citations by year: 2026: 123 · 2025: 198 · 2024: 160 · 2023: 115 · 2022: 81 · 2021: 9
FWCI: 13.86
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Pharmacological Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
Funders: National Institutes of Health (5f31ns113530-02)
Biotechnology and Biological Sciences Research Council (BB/N002113/1)
National Institute of Mental Health (R56MH123474, R21MH127404, R01MH085926, R01MH123474)
National Cancer Institute (R01CA206573)
National Institute of General Medical Sciences (P20GM103546, R35GM122528)
National Institute of Neurological Disorders and Stroke (F31‐NS113530, R01NS105804, R56NS040701, R01NS083660, R01NS040701, R01NS088479, R01NS111745, RF1NS113632, R01NS105502, R01NS107253, R35NS111619, R37NS083660, R01NS116055, R01NS097536)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD082373)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: ionotropic glutamate receptors, ligand-gated ion channels, glutamate, receptor subtypes, receptor structure, receptor pharmacology, excitatory neurotransmission, neurophysiology, neurological disorders, mental illness, therapeutic target
MeSH terms: Animals, Central Nervous System, Humans, Receptors, Glutamate, Neurotransmitter Agents, Glutamic Acid, Receptors, Ionotropic Glutamate

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Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

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