Cited by 686Neuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors StudyReceptor Mechanisms and Signaling

The DOI matches its Crossref record; 2,576 of the 2,576 references it cites were found in a registry or an index.

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

Open access

Hansen, Kasper B., Wollmuth, Lonnie P., Bowie, Derek, Furukawa, Hiro, Menniti, Frank S., Sobolevsky, Alexander I., Swanson, Geoffrey T., Swanger, Sharon A., Greger, Ingo H., Nakagawa, Terunaga, McBain, Chris J., Jayaraman, Vasanthi, Low, Chian-Ming, Dell’Acqua, Mark L., Diamond, Jeffrey S., Camp, Chad R., Perszyk, Riley E., Yuan, Hongjie, Traynelis, Stephen F.·2021·Pharmacological Reviews

DOI 10.1124/pharmrev.120.000131PMC PMC8626789

Open this paper in CoChat — free account Open PDF

Abstract

Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the mammalian central nervous system, are mediated via signaling by ionotropic glutamate receptors (iGluRs). These ligand-gated ion channels are critical to brain function and are centrally implicated in numerous psychiatric and neurologic disorders. There are different classes of iGluRs with a variety of receptor subtypes in each class that play distinct roles in neuronal functions. The diversity in iGluR subtypes, with their unique functional properties and physiologic roles, has motivated a large number of studies. Our understanding of receptor subtypes has advanced considerably since the first iGluR subunit gene was cloned in 1989, and the research focus has expanded to encompass facets of biology that have been recently discovered and to exploit experimental paradigms made possible by technological advances. Here, we review insights from more than 3 decades of iGluR studies with an emphasis on the progress that has occurred in the past decade. We cover structure, function, pharmacology, roles in neurophysiology, and therapeutic implications for all classes of receptors assembled from the subunits encoded by the 18 ionotropic glutamate receptor genes. SIGNIFICANCE STATEMENT: Glutamate receptors play important roles in virtually all aspects of brain function and are either involved in mediating some clinical features of neurological disease or represent a therapeutic target for treatment. Therefore, understanding the structure, function, and pharmacology of this class of receptors will advance our understanding of many aspects of brain function at molecular, cellular, and system levels and provide new opportunities to treat patients.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1124/pharmrev.120.000131

Cites

2576 of 2576 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Items 801–1,000 of 2,576

NR2B and NR2D Subunits Coassemble in Cerebellar Golgi Cells to Form a Distinct NMDA Receptor Subtype Restricted to Extrasynaptic Sites
Brickley, S. G., Misra, C., Mok, M. H. S., Mishina, M., & Cull-Candy, S. G. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-12-04958.2003 · Cited by 165
Deriving the Glutamate Clearance Time Course from Transporter Currents in CA1 Hippocampal Astrocytes: Transmitter Uptake Gets Faster during Development
Diamond, J. S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.5125-04.2005 · Cited by 164
Self-citation
NMDA receptors inhibit synapse unsilencing during brain development
Adesnik, H., Li, G., During, M. J., Pleasure, S. J., & Nicoll, R. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800946105 · Cited by 164
Protein S -Nitrosylation as a Therapeutic Target for Neurodegenerative Diseases
Nakamura, T., & Lipton, S. A. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.10.002 · Cited by 164
Ephrin‐B2 prevents N‐methyl‐D‐aspartate receptor antibody effects on memory and neuroplasticity
Planagumà, J., Haselmann, H., Mannara, F., Petit‐Pedrol, M., Grünewald, B., Aguilar, E., Röpke, L., Martín‐García, E., Titulaer, M. J., Jercog, P. E., et al. (2016) · Annals of Neurology · doi:10.1002/ana.24721 · Cited by 164
Kainate Receptors Depress Excitatory Synaptic Transmission at CA3→CA1 Synapses in the Hippocampus via a Direct Presynaptic Action
Frerking, M. E., Schmitz, D., Zhou, Q., Johansen, J. P., & Nicoll, R. A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-09-02958.2001 · Cited by 163
Dynamic Regulation of N-Methyl-d-aspartate (NMDA) and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors by Posttranslational Modifications
Lussier, M. P., Sanz-Clemente, A., & Roche, K. W. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.652750 · Cited by 163
Subunit interaction with PICK and GRIP controls Ca2+ permeability of AMPARs at cerebellar synapses
Liu, S. J., & Cull-Candy, S. G. (2005) · Nature Neuroscience · doi:10.1038/nn1468 · Cited by 162
ZK200775: A phosphonate quinoxalinedione AMPA antagonist for neuroprotection in stroke and trauma
Turski, L., Huth, A., Sheardown, M. J., McDonald, F., Neuhaus, R., Schneider, H. H., Dirnagl, U., Wiegand, F., Jacobsen, P., & Ottow, E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10960 · Cited by 162
Huntington’s disease
Metman, L. V., Morris, M. J., Farmer, C., Gillespie, M., Mosby, K. J., Wuu, J., & Chase, T. N. (2002) · Neurology · doi:10.1212/wnl.59.5.694 · Cited by 162
Synapse-Specific Expression of Functional Presynaptic NMDA Receptors in Rat Somatosensory Cortex
Brasier, D. J., & Feldman, D. E. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3915-07.2008 · Cited by 162
Regulation of Kinetic Properties of GluR2 AMPA Receptor Channels by Alternative Splicing
Koike‐Tani, M., Tsukada, S., Tsuzuki, K., Kijima, H., & Ozawa, S. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-06-02166.2000 · Cited by 161
Structural conservation of ion conduction pathways in K channels and glutamate receptors.
Wood, M. W., VanDongen, H. M. A., & VanDongen, A. M. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.11.4882 · Cited by 161
Recurrent Mossy Fibers Establish Aberrant Kainate Receptor-Operated Synapses on Granule Cells from Epileptic Rats
Epsztein, J., Represa, A., Jorquera, I., Ben‐Ari, Y., & Crépel, V. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1469-05.2005 · Cited by 161
Cellular plasticity induced by anti–α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor encephalitis antibodies
Peng, X., Hughes, E. G., Moscato, E. H., Parsons, T. D., Dalmau, J. O., & Balice‐Gordon, R. J. (2014) · Annals of Neurology · doi:10.1002/ana.24293 · Cited by 161
Accumulation of AMPA Receptors in Autophagosomes in Neuronal Axons Lacking Adaptor Protein AP-4
Matsuda, S., Miura, E., Matsuda, K., Kakegawa, W., Kohda, K., Watanabe, M., & Yuzaki, M. (2008) · Neuron · doi:10.1016/j.neuron.2008.02.012 · Cited by 160
Structural Basis of Arc Binding to Synaptic Proteins: Implications for Cognitive Disease
Zhang, W., Wu, J., Ward, M. D., Yang, S., Chuang, Y.-A., Xiao, M.-F., Li, R., Leahy, D. J., & Worley, P. F. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.030 · Cited by 160
Synaptically Targeted Narp Plays an Essential Role in the Aggregation of AMPA Receptors at Excitatory Synapses in Cultured Spinal Neurons
O'Brien, R., Xu, D., Mi, R., Tang, X., Hopf, C., & Worley, P. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04487.2002 · Cited by 160
Time Course and Permeation of Synaptic AMPA Receptors in Cochlear Nuclear Neurons Correlate with Input
Gardner, S. M., Trussell, L. O., & Oertel, D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-20-08721.1999 · Cited by 159
N-Terminal Domains in the NR2 Subunit Control Desensitization of NMDA Receptors
Krupp, J., Vissel, B., Heinemann, S. F., & Westbrook, G. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80459-6 · Cited by 159
Differential role of NR2A and NR2B subunits in N-Methyl-D-Aspartate receptor antagonist-induced aberrant cortical gamma oscillations
Kocsis, B. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.002 · Cited by 159
Ionotropic glutamate-like receptor δ2 binds d -serine and glycine
Naur, P., Hansen, K. B., Kristensen, A. S., Dravid, S. M., Pickering, D. S., Olsen, L., Vestergaard, B., Egebjerg, J., Gajhede, M., Traynelis, S. F., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703718104 · Cited by 159
Self-citation
Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions
Matsuda, K., & Yuzaki, M. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07638.x · Cited by 158
A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors
Mullasseril, P., Hansen, K. B., Vance, K. M., Ogden, K. K., Yuan, H., Kurtkaya, N. L., Santangelo, R., Orr, A. G., Le, P., Vellano, K. M., et al. (2010) · Nature Communications · doi:10.1038/ncomms1085 · Cited by 158
Self-citation
A Defect in the Ionotropic Glutamate Receptor 6 Gene (GRIK2) Is Associated with Autosomal Recessive Mental Retardation
Motazacker, M. M., Rost, B. R., Hucho, T. B., Garshasbi, M., Kahrizi, K., Ullmann, R., Abedini, S. S., Nieh, S. E., Amini, S. H., Goswami, C., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/521275 · Cited by 158
Glutamate-based therapeutic approaches: ampakines
LYNCH, G. S. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2005.09.005 · Cited by 158
Presynaptic NMDA Receptors Modulate Glutamate Release from Primary Sensory Neurons in Rat Spinal Cord Dorsal Horn
Bardoni, R., Torsney, C., Tong, C., Prandini, M., & MacDermott, A. B. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4637-03.2004 · Cited by 158
Impaired discrimination learning in mice lacking the NMDA receptor NR2A subunitPreprint
Brigman, J. L., Feyder, M. J., Saksida, L. M., Bussey, T. J., Mishina, M., & Holmes, A. (2008) · Learning & Memory · doi:10.1101/lm.777308 · Cited by 158
Glutamate-Induced AMPA Receptor Desensitization Increases Their Mobility and Modulates Short-Term Plasticity through Unbinding from Stargazin
Constals, A., Penn, A. C., Compans, B., Toulmé, E., Philippat, A., Marais, S., Retailleau, N., Hafner, A., Coussen, F., Hosy, E., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.01.012 · Cited by 157
GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses
Pinheiro, P. S., Perrais, D., Coussen, F., Barhanin, J., Bettler, B., Mann, J. R., Malva, J. O., Heinemann, S. F., & Mulle, C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608891104 · Cited by 157
Differential activation and blockade of excitatory amino acid receptors in the mammalian and amphibian central nervous systems
Davies, J., Evans, R. H., Jones, A. W., et al. (1982) · Comparative Biochemistry and Physiology Part C Comparative Pharmacology · doi:10.1016/0306-4492(82)90086-7 · Cited by 156
Selective RNA editing and subunit assembly of native glutamate receptors
Puchalski, R. B., Louis, J., Brose, N., Traynelis, S. F., Egebjerg, J., Kukekov, V. G., Wenthold, R. J., Rogers, S. W., Lin, F., Moran, T. M., et al. (1994) · Neuron · doi:10.1016/0896-6273(94)90464-2 · Cited by 156
Self-citation
SynDIG1: An Activity-Regulated, AMPA- Receptor-Interacting Transmembrane Protein that Regulates Excitatory Synapse Development
Kalashnikova, E., Lorca, R. A., Kaur, I., Barisone, G. A., Li, B., Ishimaru, T., Trimmer, J. S., Mohapatra, D. P., & Dı́az, E. (2010) · Neuron · doi:10.1016/j.neuron.2009.12.021 · Cited by 156
Properties of excitatory postsynaptic currents recorded in vitro from rat hippocampal interneurones.
Sah, P., Hestrin, S., & Nicoll, R. A. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018310 · Cited by 156
Concanavalin A blocks desensitisation of glutamate receptors on insect muscle fibres
Mathers, D. A., & Usherwood, P. N. R. (1976) · Nature · doi:10.1038/259409a0 · Cited by 156
An Overview of Translationally Informed Treatments for Posttraumatic Stress Disorder: Animal Models of Pavlovian Fear Conditioning to Human Clinical Trials
Bowers, M. E., & Ressler, K. J. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.008 · Cited by 155
Cornichon proteins determine the subunit composition of synaptic AMPA receptors
Herring, B. E., Shi, Y., Suh, Y. H., Zheng, C.-Y., Blankenship, S. M., Roche, K. W., & Nicoll, R. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.017 · Cited by 155
Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences.
Herb, A., Higuchi, M., Sprengel, R., & SEEBURG, P. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.5.1875 · Cited by 155
Structural Basis for AMPA Receptor Activation and Ligand Selectivity: Crystal Structures of Five Agonist Complexes with the GluR2 Ligand-binding Core
Hogner, A., Kastrup, J. S., Jin, R., Liljefors, T., Mayer, M. L., Egebjerg, J., Larsen, I. K., & Gouaux, E. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00650-2 · Cited by 155
Identity of the NMDA receptor coagonist is synapse specific and developmentally regulated in the hippocampus
Bail, M. L., Martineau, M., Sacchi, S., Yatsenko, N., Radzishevsky, I. S., Conrod, S., Ouares, K. A., Wolosker, H., Pollegioni, L., Billard, J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1416668112 · Cited by 155
A Regulatory Domain (R1–R2) in the Amino Terminus of theN-Methyl-d-Aspartate Receptor: Effects of Spermine, Protons, and Ifenprodil, and Structural Similarity to Bacterial Leucine/Isoleucine/Valine Binding Protein
Masuko, T., Kashiwagi, K., Kuno, T., Nguyen, N. D., Pahk, A. J., Fukuchi, J., Igarashi, K., & Williams, K. L. (1999) · Molecular Pharmacology · doi:10.1124/mol.55.6.957 · Cited by 155
Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants
Yan, J., Bengtson, C. P., Buchthal, B., Hagenston, A. M., & Bading, H. (2020) · Science · doi:10.1126/science.aay3302 · Cited by 155
Involvement of the GluN2A and GluN2B Subunits in Synaptic and Extrasynaptic N-methyl-d-aspartate Receptor Function and Neuronal Excitotoxicity
Zhou, X., Ding, Q., Chen, Z., Yun, H., & Wang, H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.482000 · Cited by 154
Recruitment of Calcium-Permeable AMPA Receptors during Synaptic Potentiation Is Regulated by CaM-Kinase I
Guire, E. S., Oh, M. C., Soderling, T. R., & Derkach, V. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0384-08.2008 · Cited by 154
Developmental and Regional Expression of NMDA Receptor Subtypes Containing the NR2D Subunit in Rat Brain
Wenzel, A., Villa, M., Möhler, H., & Benke, D. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66031240.x · Cited by 154
Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival
Kougioumtzidou, E., Shimizu, T., Hamilton, N. B., Tohyama, K., Sprengel, R., Monyer, H., Attwell, D., & Richardson, W. D. (2017) · eLife · doi:10.7554/elife.28080 · Cited by 154
Loss of Kainate Receptor-Mediated Heterosynaptic Facilitation of Mossy-Fiber Synapses in KA2−/−Mice
Contractor, A., Sailer, A. W., Darstein, M., Maron, C., Xu, J., Swanson, G. T., & Heinemann, S. F. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-02-00422.2003 · Cited by 153
Self-citation
Crystal structure and association behaviour of the GluR2 amino‐terminal domain
Jin, R., Singh, S. K., Gu, S., Furukawa, H., Sobolevsky, A. I., Zhou, J., Jin, Y., & Gouaux, E. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.140 · Cited by 153
Self-citation
PRRT2 Is a Key Component of the Ca2+-Dependent Neurotransmitter Release Machinery
Valente, P., Castroflorio, E., Rossi, P. I. A., Fadda, M., Sterlini, B., Cervigni, R. I., Prestigio, C., Giovedı̀, S., Onofri, F., Mura, E., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.03.005 · Cited by 153
Structural basis for integration of GluD receptors within synaptic organizer complexes
Elegheert, J., Kakegawa, W., Clay, J. E., Shanks, N. F., Behiels, E., Matsuda, K., Kohda, K., Miura, E., Rossmann, M., Mitakidis, N., et al. (2016) · Science · doi:10.1126/science.aae0104 · Cited by 153
Self-citation
Activation and Desensitization Mechanism of AMPA Receptor-TARP Complex by Cryo-EM
Chen, S., Zhao, Y., Wang, Y., Shekhar, M., Tajkhorshid, E., & Gouaux, E. (2017) · Cell · doi:10.1016/j.cell.2017.07.045 · Cited by 153
Facilitative Effects of the Ampakine CX516 on Short-Term Memory in Rats: Enhancement of Delayed-Nonmatch-to-Sample Performance
Hampson, R. E., Rogers, G. A., LYNCH, G. S., & Deadwyler, S. A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02740.1998 · Cited by 152
Presynaptic Kainate Receptors Regulate Spinal Sensory Transmission
Kerchner, G. A., Wilding, T. J., Li, P., Zhuo, M., & Huettner, J. E. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-01-00059.2001 · Cited by 151
Adjacent asparagines in the NR2‐subunit of the NMDA receptor channel control the voltage‐dependent block by extracellular Mg2+
Wollmuth, L. P., Kuner, T., & Sakmann, B. J. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.013bx.x · Cited by 151
Self-citation
Distinct Subunits in Heteromeric Kainate Receptors Mediate Ionotropic and Metabotropic Function at Hippocampal Mossy Fiber Synapses
Ruiz, A. J., Sachidhanandam, S., Utvik, J. K., Coussen, F., & Mulle, C. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4041-05.2005 · Cited by 151
Esketamine for treatment resistant depression
Swainson, J., Thomas, R. K., Archer, S., Chrenek, C., MacKay, M.-A., Baker, G., Dursun, S., Klassen, L. J., Chokka, P., & Demas, M. L. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1640604 · Cited by 151
Distinct roles of GRIN2A and GRIN2B variants in neurological conditions
Myers, S. J., Yuan, H., Kang, J., Tan, F. C. K., Traynelis, S. F., & Low, C. (2019) · F1000Research · doi:10.12688/f1000research.18949.1 · Cited by 151
Self-citation
Regulation of NMDA glutamate receptor functions by the GluN2 subunits
Vieira, M., Yong, X. L. H., Roche, K. W., & Anggono, V. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.14970 · Cited by 151
Zinc: An underappreciated modulatory factor of brain function
Marger, L., Schubert, C. R., & Bertrand, D. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.08.002 · Cited by 150
Centrally active modulators of glutamate receptors facilitate the induction of long-term potentiation in vivo.
Staubli, U. V., Perez, Y., Xu, F. B., Rogers, G. A., Ingvar, M., Stone‐Elander, S., & LYNCH, G. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.11158 · Cited by 150
Noncanonical Signaling by Ionotropic Kainate Receptors
Rozas, J. L., Paternain, A. V., & Lerma, J. (2003) · Neuron · doi:10.1016/s0896-6273(03)00436-7 · Cited by 150
Quantal Release of Glutamate Generates Pure Kainate and Mixed AMPA/Kainate EPSCs in Hippocampal Neurons
Cossart, R., Epsztein, J., Tyzio, R., Becq, H., Hirsch, J., Ben-Ari, Y., & Crépel, V. (2002) · Neuron · doi:10.1016/s0896-6273(02)00753-5 · Cited by 150
Non-Ionotropic NMDA Receptor Signaling Drives Activity-Induced Dendritic Spine Shrinkage
Stein, I. S., Gray, J. A., & Zito, K. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4289-14.2015 · Cited by 150
NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity
Nakazawa, T., Komai, S., Watabe, A. M., Kiyama, Y., Fukaya, M., Arima‐Yoshida, F., Horai, R., Sudo, K., Ebine, K., Delawary, M., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601156 · Cited by 149
Olfactory receptor pseudo-pseudogenes
Prieto-Godino, L. L., Rytz, R., Bargeton, B., Abuin, L., Arguello, J. R., Peraro, M. D., & Benton, R. (2016) · Nature · doi:10.1038/nature19824 · Cited by 149
Ultrafast glutamate sensors resolve high-frequency release at Schaffer collateral synapses
Helassa, N., Dürst, C. D., Coates, C., Kerruth, S., Arif, U., Schulze, C., Wiegert, J. S., Geeves, M. A., Oertner, T. G., & Török, K. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720648115 · Cited by 149
The functional role of polyamines in eukaryotic cells
Igarashi, K., & Kashiwagi, K. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.12.012 · Cited by 149
Distribution of Kainate Receptor Subunits at Hippocampal Mossy Fiber Synapses
Darstein, M., Petralia, R. S., Swanson, G. T., Wenthold, R. J., & Heinemann, S. F. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-22-08013.2003 · Cited by 148
Self-citation
Synaptic NMDA Receptors Mediate Hypoxic Excitotoxic Death
Wroge, C. M., Hogins, J., Eisenman, L., & Mennerick, S. J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6371-11.2012 · Cited by 148
Interaction of 6-cyano-7-nitroquinoxaline-2,3-dione with the N-methyl-D-aspartate receptor-associated glycine binding site.
Lester, R. A. J., Quarum, M., Parker, J. D., Weber, E., & Jahr, C. E. (1989) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)11422-3 · Cited by 148
Unconventional NMDA Receptor Signaling
Doré, K., Stein, I. S., Brock, J. A., Castillo, P. E., Zito, K., & Sjöström, P. J. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1825-17.2017 · Cited by 148
CORNICHON sorting and regulation of GLR channels underlie pollen tube Ca 2+ homeostasis
Wudick, M. M., Portes, M. T., Michard, E., et al. (2018) · Science · doi:10.1126/science.aar6464 · Cited by 148
Mechanisms for ligand binding to GluR0 ion channels: crystal structures of the glutamate and serine complexes and a closed apo state
Mayer, M. L., Olson, R., & Gouaux, E. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4884 · Cited by 147
Functional Maturation of CA1 Synapses Involves Activity-Dependent Loss of Tonic Kainate Receptor-Mediated Inhibition of Glutamate Release
Lauri, S. E., Vesikansa, A., Segerstråle, M., Collingridge, G. L., Isaac, J. T. R., & Taira, T. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.020 · Cited by 147
Excitatory amino acid involvement in dendritic spine formation, maintenance and remodelling
McKinney, R. A. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.178905 · Cited by 147
3 alpha-Hydroxy-5 beta-pregnan-20-one sulfate: a negative modulator of the NMDA-induced current in cultured neurons.
Park-Chung, M., Wu, F., & Farb, D. H. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08656-0 · Cited by 147
Detailed phenotype–genotype study in five patients with chromosome 6q16 deletion: narrowing the critical region for Prader–Willi-like phenotype
Bonaglia, M. C., Ciccone, R., Gimelli, G., Gimelli, S., Marelli, S., Verheij, J., Giorda, R., Grasso, R., Borgatti, R., Pagone, F., et al. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.119 · Cited by 147
All naturally occurring autoantibodies against the NMDA receptor subunit NR1 have pathogenic potential irrespective of epitope and immunoglobulin class
Castillo-Gómez, E., Oliveira, B., Tapken, D., Bertrand, S., Klein-Schmidt, C., Pan, H., Zafeiriou, M.-P., Steiner, J. H., Jurek, B., Trippe, R., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.125 · Cited by 147
Presynaptic neuronal pentraxin receptor organizes excitatory and inhibitory synapses
Lee, S.-J., Wei, M., Zhang, C., Maxeiner, S., Pak, C., Calado Botelho, S., Trotter, J., Sterky, F. H., & Südhof, T. C. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2768-16.2016 · Cited by 146
Lupus antibodies induce behavioral changes mediated by microglia and blocked by ACE inhibitors
Nestor, J., Arinuma, Y., Huerta, T. S., Kowal, C., Nasiri, E., Kello, N., Fujieda, Y., Bialas, A., Hammond, T., Sriram, U., et al. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20180776 · Cited by 146
Activation and Desensitization of Hippocampal Kainate Receptors
Wilding, T. J., & Huettner, J. E. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02713.1997 · Cited by 145
Surface dynamics of GluN2B‐NMDA receptors controls plasticity of maturing glutamate synapses
Dupuis, J. P., Ladépêche, L., Seth, H., Bard, L., Varela, J. A., Mikasová, L., Bouchet, D., Rogemond, V., Honnorat, J., Hanse, E., et al. (2014) · The EMBO Journal · doi:10.1002/embj.201386356 · Cited by 145
Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patients
Jézéquel, J., Johansson, E. M., Dupuis, J. P., Rogemond, V., Gréa, H., Kellermayer, B., Hamdani, N., Guen, E. L., Rabu, C., Lepleux, M., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01700-3 · Cited by 145
Landscape of ribosome-engaged transcript isoforms reveals extensive neuronal-cell-class-specific alternative splicing programs
Furlanis, E., Traunmüller, L., Fucile, G., & Scheiffele, P. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0465-5 · Cited by 145
Developmental regulation of α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole‐propionic acid receptor subunit expression in forebrain and relationship to regional susceptibility to hypoxic/ischemic injury. I. Rodent cerebral white matter and cortex
Talos, D. M., Fishman, R. E., Park, H., Folkerth, R. D., Follett, P. L., Volpe, J. J., & Jensen, F. E. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20972 · Cited by 145
New Transmembrane AMPA Receptor Regulatory Protein Isoform, γ-7, Differentially Regulates AMPA Receptors
Kato, A., Zhou, W., Milstein, A. D., Knierman, M. D., Siuda, E. R., Dotzlaf, J. E., Yu, H. Y., Hale, J. E., Nisenbaum, E. S., Nicoll, R. A., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5561-06.2007 · Cited by 144
NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear
Dalton, G. L., Wu, D. C., Wang, Y. T., Floresco, S. B., & Phillips, A. G. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.09.001 · Cited by 144
Structure–activity analysis of a novel NR2C/NR2D‐preferring NMDA receptor antagonist: 1‐(phenanthrene‐2‐carbonyl) piperazine‐2,3‐dicarboxylic acid
Feng, B., Tse, H., Skifter, D. A., Morley, R., Jane, D. E., & Monaghan, D. T. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705644 · Cited by 144
Target-specific expression of presynaptic NMDA receptors in neocortical microcircuits
Buchanan, K. A., Blackman, A. V., Moreau, A. W., Elgar, D., Costa, R. P., Lalanne, T., Tudor Jones, A. A., Oyrer, J., & Sjöström, P. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.017 · Cited by 144
Once-weekly D-cycloserine effects on negative symptoms and cognition in schizophrenia: an exploratory study
GOFF, D., CATHER, C., GOTTLIEB, J., EVINS, A., WALSH, J., RAEKE, L., OTTO, M., SCHOENFELD, D., & GREEN, M. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.08.012 · Cited by 144
Glutamate-Mediated Extrasynaptic Inhibition
Isaacson, J. S., & Murphy, G. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00428-7 · Cited by 144
NMDA receptors: linking physiological output to biophysical operation
Iacobucci, G. J., & Popescu, G. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.24 · Cited by 144
Transport of Axl2p Depends on Erv14p, an ER–Vesicle Protein Related to the Drosophila cornichon Gene Product
Powers, J., & Barlowe, C. K. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.5.1209 · Cited by 143
Separation of .alpha.1-adrenergic and N-methyl-D-aspartate antagonist activity in a series of ifenprodil compounds
Chenard, B. L., Shalaby, I. A., Koe, B. K., Ronau, R. T., Butler, T. W., Prochniak, M. A., Schmidt, A. W., & Fox, C. B. (1991) · Journal of Medicinal Chemistry · doi:10.1021/jm00114a018 · Cited by 143
Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by Adamantane derivatives
Magazanik, L. G., Buldakova, S., Samoilova, M., Гмиро, В. Е., Mellor, I. R., & Usherwood, P. N. R. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.655ba.x · Cited by 143
Interactions between the glycine and glutamate binding sites of the NMDA receptor
Lester, R. A. J., Tong, G., & Jahr, C. E. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-03-01088.1993 · Cited by 143
Functional analysis of a de novo GRIN2A missense mutation associated with early-onset epileptic encephalopathy
Yuan, H., Hansen, K. B., Zhang, J., Pierson, T. M., Markello, T. C., Fajardo, K. V. F., Holloman, C., Golas, G. A., Adams, D. R., Boerkoel, C. F., et al. (2014) · Nature Communications · doi:10.1038/ncomms4251 · Cited by 143
Self-citation
Electrophysiological studies with a 2,3-benzodiazepine muscle relaxant: GYKI 52466
Tarnawa, I., Farkas, S., Berzsenyi, P., et al. (1989) · European Journal of Pharmacology · doi:10.1016/0014-2999(89)90579-7 · Cited by 143
Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBQX in maximal electroshock and chemoconvulsant seizure models
Yamaguchi, S., Donevan, S. D., & Rogawski, M. A. (1993) · Epilepsy Research · doi:10.1016/0920-1211(93)90054-b · Cited by 143
Ontogeny of ionotropic glutamate receptor subunit expression in the rat hippocampus
Ritter, L. M., Vázquez, D. M., & Meador‐Woodruff, J. H. (2002) · Developmental Brain Research · doi:10.1016/s0165-3806(02)00572-2 · Cited by 142
Pathway-Specific Differences in Subunit Composition of Synaptic NMDA Receptors on Pyramidal Neurons in Neocortex
Kumar, S. S., & Huguenard, J. R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-31-10074.2003 · Cited by 142
A Juvenile form of Postsynaptic Hippocampal Long‐Term Potentiation in Mice Deficient for the AMPA Receptor Subunit GluR‐A
Jensen, V., Kaiser, K. M. M., Borchardt, T., Adelmann, G., Rozov, A. V., Burnashev, N., Brix, C., Frotscher, M., Andersen, P. N., Hvalby, Ø., et al. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.053637 · Cited by 141
Effects of the Potent Ampakine CX614 on Hippocampal and Recombinant AMPA Receptors: Interactions with Cyclothiazide and GYKI 52466
Arai, A., Kessler, M., Rogers, G. A., & LYNCH, G. S. (2000) · Molecular Pharmacology · doi:10.1124/mol.58.4.802 · Cited by 141
TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response
Ma, Z., Zang, T., Birnbaum, S. G., Wang, Z., Johnson, J. E. B., Zhang, C., & Parada, L. F. (2017) · Nature Communications · doi:10.1038/s41467-017-01709-8 · Cited by 141
Seizure control by ketogenic diet-associated medium chain fatty acids
Chang, P., Terbach, N., Plant, N. J., Chen, P. E., Walker, M. C., & Williams, R. S. B. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.11.004 · Cited by 141
NMDA receptor activation limits the number of synaptic connections during hippocampal development
Lüthi, A., Schwyzer, L., Mateos, J. M., Gähwiler, B. H., & McKinney, R. A. (2001) · Nature Neuroscience · doi:10.1038/nn744 · Cited by 139
Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes
Armstrong, N., Mayer, M. L., & Gouaux, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1037393100 · Cited by 139
Abundant distribution of TARP γ‐8 in synaptic and extrasynaptic surface of hippocampal neurons and its major role in AMPA receptor expression on spines and dendrites
Fukaya, M., Tsujita, M., Yamazaki, M., Kushiya, E., Abe, M., Akashi, K., Natsume, R., Kano, M., Kamiya, H., Watanabe, M., et al. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05081.x · Cited by 139
Regulation of Calcium/Calmodulin-dependent Protein Kinase II Docking toN-Methyl-d-aspartate Receptors by Calcium/Calmodulin and α-Actinin
Leonard, A. S., Bayer, K. U., Merrill, M. A., Lim, I. A., Shea, M. A., Schulman, H., & Hell, J. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205164200 · Cited by 139
AMPA receptor structure and auxiliary subunits
Kamalova, A., & Nakagawa, T. (2020) · The Journal of Physiology · doi:10.1113/jp278701 · Cited by 139
Self-citation
Carbonic Anhydrases and Brain pH in the Control of Neuronal Excitability
Ruusuvuori, E., & Kaila, K. (2013) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-7359-2_14 · Cited by 139
Pseudobulbar affect: the spectrum of clinical presentations, etiologies and treatments
Miller, A., Pratt, H., & Schiffer, R. B. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.68 · Cited by 139
An inter‐dimer allosteric switch controls NMDA receptor activity
Esmenjaud, J., Stroebel, D., Chan, K., Grand, T., David, M., Wollmuth, L. P., Taly, A., & Paoletti, P. (2018) · The EMBO Journal · doi:10.15252/embj.201899894 · Cited by 139
Self-citation
Specific assembly with the NMDA receptor 3B subunit controls surface expression and calcium permeability of NMDA receptors
Matsuda, K., Fletcher, M., Kamiya, Y., & Yuzaki, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-31-10064.2003 · Cited by 138
Identification and Characterization of Novel NMDA Receptor Antagonists Selective for NR2A- over NR2B-Containing Receptors
Bettini, E., Sava, A., Griffante, C., Carignani, C., Buson, A., Capelli, A. M., Negri, M., Andreetta, F., Senar, S., Guiral, L., et al. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.172544 · Cited by 138
Presynaptic NMDARs in the Hippocampus Facilitate Transmitter Release at Theta Frequency
McGuinness, L., Taylor, C. J., Taylor, R. D. T., Yau, C., Langenhan, T., Hart, M. L., Christian, H., Tynan, P. W., Donnelly, P., & Emptage, N. J. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.023 · Cited by 138
Molecular bases of NMDA receptor subtype‐dependent properties
Glasgow, N. G., Retchless, B. S., & Johnson, J. W. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.273763 · Cited by 138
Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor
Jalali‐Yazdi, F., Chowdhury, S. R., Yoshioka, C., & Gouaux, E. (2018) · Cell · doi:10.1016/j.cell.2018.10.043 · Cited by 138
Anti-NR2 glutamate receptor antibodies and cognitive function in systemic lupus erythematosus.
Hanly, J. G., Robichaud, J., & Fisk, J. D. (2006) · PubMed · Cited by 138
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
Twomey, E. C., Yelshanskaya, M. V., Grassucci, R. A., Frank, J., & Sobolevsky, A. I. (2016) · Science · doi:10.1126/science.aaf8411 · Cited by 138
Self-citation
A Systematic Review of NMDA Receptor Antagonists for Treatment of Neuropathic Pain in Clinical Practice
Aiyer, R., Mehta, N. D., Güngör, S., & Gulati, A. (2017) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000547 · Cited by 138
AKAP150-Anchored Calcineurin Regulates Synaptic Plasticity by Limiting Synaptic Incorporation of Ca2+-Permeable AMPA Receptors
Sanderson, J. L., Gorski, J. A., Gibson, E. S., Lam, P., Freund, R. K., Chick, W. S., & Dell'Acqua, M. L. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3326-12.2012 · Cited by 137
Self-citation
Functional Insights from Glutamate Receptor Ion Channel Structures
Kumar, J., & Mayer, M. L. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183711 · Cited by 137
The organization of the gene for the functionally dominant alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor subunit GluR-B
Köhler, M. G., Kornau, H., & Seeburg, P. H. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32444-4 · Cited by 136
Concentration-dependent substate behavior of native AMPA receptors
Smith, T. C., & Howe, J. R. (2000) · Nature Neuroscience · doi:10.1038/79931 · Cited by 136
NR2B-Containing NMDA Autoreceptors at Synapses on Entorhinal Cortical Neurons
Woodhall, G. L., Evans, D. I., Cunningham, M. O., & Jones, R. S. G. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.4.1644 · Cited by 136
A light-gated, potassium-selective glutamate receptor for the optical inhibition of neuronal firing
Janovjak, H., Szobota, S., Wyart, C., Trauner, D. H., & Isacoff, E. Y. (2010) · Nature Neuroscience · doi:10.1038/nn.2589 · Cited by 136
D-α-Aminoadipate as a selective antagonist of amino acid-induced and synaptic excitation of mammalian spinal neurones
Biscoe, T. J., Evans, R. H., Francis, A. A., Martin, M. R., Watkins, J. C., DAVIES, J., & Dray, A. (1977) · Nature · doi:10.1038/270743a0 · Cited by 136
Subunit specificity and mechanism of action of NMDA partial agonist d-cycloserine
Sheinin, A., Shavit, S., & Benveniste, M. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00073-9 · Cited by 136
High‐affinity kainate a domoate receptors in rat brain
Lomelı́, H., Wisden, W., Köhler, M. G., KEINÄNEN, K. P., Sommer, B., & Seeburg, P. H. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80753-4 · Cited by 136
TARP Auxiliary Subunits Switch AMPA Receptor Antagonists into Partial Agonists
Menuz, K., Stroud, R. M., Nicoll, R. A., & Hays, F. A. (2007) · Science · doi:10.1126/science.1146317 · Cited by 136
Kainate receptor subunits expressed in single cultured hippocampal neurons: Molecular and functional variants by RNA editing
Ruano, D., Lambolez, B., Rossier, J., Paternain, A. V., & Lerma, J. (1995) · Neuron · doi:10.1016/0896-6273(95)90339-9 · Cited by 136
Role of the Carboxy-Terminal Region of the GluRε2 Subunit in Synaptic Localization of the NMDA Receptor Channel
Mori, H., Manabe, T., Watanabe, M., Satoh, Y., Suzuki, N., Toki, S., Nakamura, K., Yagi, T., Kushiya, E., Takahashi, T., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80567-x · Cited by 136
Short-Term Plasticity Explains Irregular Persistent Activity in Working Memory Tasks
Hansel, D., & Mato, G. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3455-12.2013 · Cited by 136
Surface trafficking of N-methyl-d-aspartate receptors: Physiological and pathological perspectives
Groc, L., Bard, L., & Choquet, D. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.05.029 · Cited by 135
NMDAR Channel Segments Forming the Extracellular Vestibule Inferred from the Accessibility of Substituted Cysteines
Beck, C., Wollmuth, L. P., SEEBURG, P. H., Sakmann, B. J., & Kuner, T. (1999) · Neuron · doi:10.1016/s0896-6273(00)80710-2 · Cited by 135
Self-citation
Opposing Roles of Synaptic and Extrasynaptic NMDA Receptor Signaling in Cocultured Striatal and Cortical Neurons
Kaufman, A. M., Milnerwood, A. J., Sepers, M. D., Coquinco, A., She, K., Wang, L., Lee, H., Craig, A. M., Cynader, M. S., & Raymond, L. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4129-11.2012 · Cited by 135
D-Cycloserine in Neuropsychiatric Diseases: A Systematic Review
Schade, S., & Paulus, W. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv102 · Cited by 135
Golgi-independent secretory trafficking through recycling endosomes in neuronal dendrites and spines
Bowen, A. B., Bourke, A. M., Hiester, B. G., Hanus, C., & Kennedy, M. J. (2017) · eLife · doi:10.7554/elife.27362 · Cited by 135
The Role of RNA Editing of Kainate Receptors in Synaptic Plasticity and Seizures
Vissel, B., Royle, G. A., Christie, B. R., Schiffer, H. H., Ghetti, A., Tritto, T., Pérez‐Otaño, I., Radcliffe, R. A., Seamans, J. K., B, T. J. S. A., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00192-1 · Cited by 135
Distinct synaptic and extrasynaptic NMDA receptors identified in dorsal horn neurones of the adult rat spinal cord
Momiyama, A. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00621.x · Cited by 134
Development and Subunit Composition of Synaptic NMDA Receptors in the Amygdala: NR2B Synapses in the Adult Central Amygdala
de Armentia, M. L., & Sah, P. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-17-06876.2003 · Cited by 134
Glial Cells in the Mouse Hippocampus Express AMPA Receptors with an Intermediate Ca2+ Permeability
Seifert, G., & Steinhäuser, C. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb00708.x · Cited by 134
The NMDA antagonist, MK-801, suppresses long-term potentiation, kindling, and kindling-induced potentiation in the perforant path of the unanesthetized rat
Gilbert, M. E., & Mack, C. M. (1990) · Brain Research · doi:10.1016/0006-8993(90)90064-i · Cited by 134
Effects of a NR2B selective NMDA glutamate antagonist, CP‐101,606, on dyskinesia and parkinsonism
Nutt, J. G., Gunzler, S. A., Kirchhoff, T., Hogarth, P., Weaver, J. L., Krams, M., Jamerson, B., Menniti, F. S., & Landen, J. W. (2008) · Movement Disorders · doi:10.1002/mds.22169 · Cited by 133
Self-citation
Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1
Straub, C., Hunt, D. L., Yamasaki, M., Kim, K. S., Watanabe, M., Castillo, P. E., & Tomita, S. (2011) · Nature Neuroscience · doi:10.1038/nn.2837 · Cited by 133
Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule
Bidoret, C., Ayon, A., Barbour, B., & Casado, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904284106 · Cited by 133
De novo mutations and rare variants occurring in NMDA receptors
XiangWei, W., Jiang, Y., & Yuan, H. (2017) · Current Opinion in Physiology · doi:10.1016/j.cophys.2017.12.013 · Cited by 133
Self-citation
Phosphonate analogues of carboxylic acids as aminoacid antagonists on rat cortical neurones
Perkins, M., Stone, T. W., Collins, J. F., et al. (1981) · Neuroscience Letters · doi:10.1016/0304-3940(81)90021-5 · Cited by 133
AMPA/Kainate Antagonist LY293558 Reduces Capsaicin-evoked Hyperalgesia but Not Pain in Normal Skin in Humans
Sang, C. N.-M., Hostetter, M. P., Gracely, R. H., et al. (1998) · Anesthesiology · doi:10.1097/00000542-199811000-00005 · Cited by 133
Physiological Roles and Therapeutic Potential of Ca2+ Activated Potassium Channels in the Nervous System
Kshatri, A. S., Gonzalez-Hernandez, A. J., & Giráldez, T. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00258 · Cited by 133
Differential Nanoscale Topography and Functional Role of GluN2-NMDA Receptor Subtypes at Glutamatergic Synapses
Kellermayer, B., Ferreira, J. S., Dupuis, J. P., Levet, F., Grillo‐Bosch, D., Bard, L., Linarès-Loyez, J., Bouchet, D., Choquet, D., Rusakov, D. A., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.012 · Cited by 133
Membrane assembly of aquaporin-4 autoantibodies regulates classical complement activation in neuromyelitis optica
Soltys, J. N., Liu, Y., Ritchie, A. M., Wemlinger, S. M., Schaller, K., Schumann, H., Owens, G. P., & Bennett, J. L. (2019) · Journal of Clinical Investigation · doi:10.1172/jci122942 · Cited by 133
Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation
Cueva Vargas, J. L., Osswald, I. K., Unsain, N., Aurousseau, M. R., Barker, P. A., Bowie, D., & Di Polo, A. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1273-15.2015 · Cited by 132
Self-citation
Distinct structural and ionotropic roles of NMDA receptors in controlling spine and synapse stability
Alvarez, V. A., Ridenour, D. A., & Sabatini, B. L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0956-07.2007 · Cited by 132
Evidence for the GluR6 gene associated with younger onset age of Huntington’s disease
MacDonald, M. E., Vonsattel, J. P., Srinidhi, J., Couropmitree, N. N., Cupples, L. A., Bird, E. D., Gusella, J. F., & Myers, R. H. (1999) · Neurology · doi:10.1212/wnl.53.6.1330 · Cited by 132
The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning
Zhou, Z., Liu, A., Xia, S., Leung, C., Qi, J., Meng, Y., Xie, W., Park, P., Collingridge, G. L., & Jia, Z. (2018) · Nature Neuroscience · doi:10.1038/s41593-017-0030-z · Cited by 132
Q/R editing of the rat GluR5 and GluR6 kainate receptors in vivo and in vitro: evidence for independent developmental, pathological and cellular regulation
Bernard, A., Ferhat, L., Dessi, F., Charton, G., Represa, A., Ben‐Ari, Y., & Khrestchatisky, M. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00479.x · Cited by 132
SOL-1 is a CUB-domain protein required for GLR-1 glutamate receptor function in C. elegans
Zheng, Y., Mellem, J. E., Brockie, P. J., Madsen, D. M., & Maricq, A. V. (2004) · Nature · doi:10.1038/nature02244 · Cited by 131
Glycine-independent and subunit-specific potentiation of NMDA responses by extracellular Mg2+
Paoletti, P., Neyton, J., & Ascher, P. (1995) · Neuron · doi:10.1016/0896-6273(95)90099-3 · Cited by 131
Distinct spatiotemporal distributions of the N‐Methyl‐ D ‐aspartate receptor channel subunit mRNAs in the mouse cervical cord
Watanabe, M., Mishina, M., & Inoue, Y. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903450212 · Cited by 131
Relationship between serum NR2a antibodies and cognitive dysfunction in systemic lupus erythematosus
Harrison, M. J., Ravdin, L., & Lockshin, M. D. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22030 · Cited by 130
Developmental changes in expression and distribution of the glutamate receptor channel δ2 subunit according to the Purkinje cell maturation
Takayama, C., Nakagawa, S., Watanabe, M., Mishina, M., & Inoue, Y. (1996) · Developmental Brain Research · doi:10.1016/0165-3806(95)00212-x · Cited by 130
Endocytosis and Degradative Sorting of NMDA Receptors by Conserved Membrane-Proximal Signals
Scott, D. B., Michailidis, I. E., Mu, Y., Logothetis, D. E., & Ehlers, M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0780-04.2004 · Cited by 130
AMPA receptor inhibition by synaptically released zinc
Kalappa, B. I., Anderson, C. T., Goldberg, J. M., Lippard, S. J., & Tzounopoulos, T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1512296112 · Cited by 130
Modulation of extrasynaptic NMDA receptors by synaptic and tonic zinc
Anderson, C. T., Radford, R. J., Zastrow, M. L., Zhang, D. Y., Apfel, U., Lippard, S. J., & Tzounopoulos, T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1503348112 · Cited by 129
Mutations in ionotropic AMPA receptor 3 alter channel properties and are associated with moderate cognitive impairment in humans
Wu, Y., Arai, A., Rumbaugh, G., Srivastava, A. K., TURNER, G. M., Hayashi, T., Suzuki, É., Jiang, Y., Zhang, L., Rodriguez, J. D., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708699104 · Cited by 129
Allosteric modulation of NMDA receptor via elevation of brain glycine and d-serine: The therapeutic potentials for schizophrenia
Yang, C. R., & Svensson, K. A. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.08.004 · Cited by 129
Expression of Cocaine-Evoked Synaptic Plasticity by GluN3A-Containing NMDA Receptors
Yuan, T., Mameli, M., O’Connor, E. C., Dey, P. N., Verpelli, C., Sala, C., Pérez‐Otaño, I., Lüscher, C., & Bellone, C. (2013) · Neuron · doi:10.1016/j.neuron.2013.07.050 · Cited by 129
AMPA Receptor Subunit-Specific Regulation by a Distinct Family of Type II TARPs
Kato, A., Siuda, E. R., Nisenbaum, E. S., & Bredt, D. S. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.034 · Cited by 129
Regulation of AMPA Receptor Gating by Ligand Binding Core Dimers
Horning, M. S., & Mayer, M. L. (2004) · Neuron · doi:10.1016/s0896-6273(04)00018-2 · Cited by 129
Distribution of Extrasynaptic NMDA Receptors on Neurons
Petralia, R. S. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/267120 · Cited by 129
Deletion of Glutamate Delta-1 Receptor in Mouse Leads to Aberrant Emotional and Social Behaviors
Yadav, R., Gupta, S. C., Hillman, B. G., Bhatt, J. M., Stairs, D. J., & Dravid, S. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032969 · Cited by 129
Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs
Yelshanskaya, M. V., Singh, A. K., Sampson, J. M., Narangoda, C., Kurnikova, M. G., & Sobolevsky, A. I. (2016) · Neuron · doi:10.1016/j.neuron.2016.08.012 · Cited by 129
Self-citation
Unconventional secretory processing diversifies neuronal ion channel properties
Hanus, C., Geptin, H., Tushev, G., Garg, S., Alvarez‐Castelao, B., Sambandan, S., Kochen, L., Hafner, A., Langer, J. D., & Schuman, E. M. (2016) · eLife · doi:10.7554/elife.20609 · Cited by 129
Glutamate Receptor Subunits GluR5 and KA-2 Are Coexpressed in Rat Trigeminal Ganglion Neurons
Sahara, Y., Noro, N., Iida, Y., Soma, K., & Nakamura, Y. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-17-06611.1997 · Cited by 128
Genome-wide association study of comorbid depressive syndrome and alcohol dependence
Edwards, A. C., Alıev, F., Bierut, L. J., Bucholz, K. K., Edenberg, H. J., HESSELBROCK, V. M., Kramer, J., Kuperman, S., Nürnberger, J. I., Schuckit, M. A., et al. (2011) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32834acd07 · Cited by 128
Neurosteroid-Induced Plasticity of Immature Synapses via Retrograde Modulation of Presynaptic NMDA Receptors
Mameli, M., Carta, M., Partridge, L. D., & Valenzuela, C. F. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3877-04.2005 · Cited by 128
Equilibrium Constants for (R)-[(S)-1-(4-Bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic Acid (NVP-AAM077) Acting at Recombinant NR1/NR2A and NR1/NR2B N-Methyl-d-aspartate Receptors: Implications for Studies of Synaptic Transmission
Frizelle, P., Chen, P. E., & Wyllie, D. J. A. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.024042 · Cited by 128
Structure and organization of heteromeric AMPA-type glutamate receptors
Herguedas, B., García‐Nafría, J., Cais, O., Fernández-Leiro, R., Krieger, J., Ho, H., & Greger, I. H. (2016) · Science · doi:10.1126/science.aad3873 · Cited by 128
Self-citation
A synthetic synaptic organizer protein restores glutamatergic neuronal circuits
Suzuki, K., Elegheert, J., Song, I., Sasakura, H., Senkov, O., Matsuda, K., Kakegawa, W., Clayton, A. J., Chang, V. T.-C., Ferrer-Ferrer, M., et al. (2020) · Science · doi:10.1126/science.abb4853 · Cited by 128
Absence of antibodies to glutamate receptor type 3 (GluR3) in Rasmussen encephalitis
Watson, R., Jiang, Y., Bermúdez, I., Houlihan, L. M., Clover, L. M., McKnight, K., Cross, J. H., Hart, I. K., Roubertie, A., Valmier, J., et al. (2004) · Neurology · doi:10.1212/01.wnl.0000132651.66689.0f · Cited by 128
Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology
Ogden, K. K., Chen, W., Swanger, S. A., McDaniel, M. J., Fan, L. Z., Hu, C., Tankovic, A., Kusumoto, H., Kosobucki, G. J., Schulien, A. J., et al. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006536 · Cited by 128
Self-citation
Distinct pharmacological and functional properties of NMDA receptors in mouse cortical astrocytes
Palygin, O., Lalo, U., & Pankratov, Y. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01374.x · Cited by 127
Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro
Alt, A. J., Weiss, B., Ogden, A. M. L., Knauss, J. L., Oler, J., Ho, K. H., Large, T. H., & Bleakman, D. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2003.11.026 · Cited by 127
A Mosaic of Functional Kainate Receptors in Hippocampal Interneurons
Christensen, J. K., Paternain, A. V., Selak, S., Ahring, P. K., & Lerma, J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2156-04.2004 · Cited by 127
Endbulb Synapses in the Anteroventral Cochlear Nucleus Express a Specific Subset of AMPA-Type Glutamate Receptor Subunits
Wang, Y., Wenthold, R. J., Ottersen, O. P., & Petralia, R. S. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-03-01148.1998 · Cited by 127
Heteromeric Kainate Receptors Formed by the Coassembly of GluR5, GluR6, and GluR7
Cui, C., & Mayer, M. L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08281.1999 · Cited by 126
Encoding and Decoding Bursts by NMDA Spikes in Basal Dendrites of Layer 5 Pyramidal Neurons
Poleg-Polsky, A., Mel, B. W., & Schiller, J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5250-08.2009 · Cited by 126
The Stoichiometry of AMPA Receptors and TARPs Varies by Neuronal Cell Type
Shi, Y. S., Lü, W., Milstein, A. D., & Nicoll, R. A. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.016 · Cited by 126
Reduced transcript expression of genes affected by inherited and de novo CNVs in autism
STAART Psychopharmacology Network, Nord, A. S., Roeb, W., Dickel, D. E., Walsh, T., Kusenda, M., O’Connor, K. L., Malhotra, D., McCarthy, S., Stray, S. M., et al. (2011) · European Journal of Human Genetics · doi:10.1038/ejhg.2011.24 · Cited by 126
Glutamate Receptor GluR3 Antibodies and Death of Cortical Cells
He, X., Patel, M., Whitney, K. D., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80443-2 · Cited by 126
NMDA receptor–independent long-term depression correlates with successful aging in rats
Lee, H., Min, S. S., Gallagher, M., & Kirkwood, A. (2005) · Nature Neuroscience · doi:10.1038/nn1586 · Cited by 126
6-(1H-Imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: structure-activity relationships for the AMPA-type non-NMDA receptor
Ohmori, J., Sakamoto, S., Kubota, H., et al. (1994) · Journal of Medicinal Chemistry · doi:10.1021/jm00030a006 · Cited by 126
Human Autoantibodies against the AMPA Receptor Subunit GluA2 Induce Receptor Reorganization and Memory Dysfunction
Haselmann, H., Mannara, F., Werner, C. D., Planagumà, J., Míguez‐Cabello, F., Schmidl, L., Grünewald, B., Petit‐Pedrol, M., Kirmse, K., Claßen, J., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.048 · Cited by 126
mGluR1/5-Dependent Long-Term Depression Requires the Regulated Ectodomain Cleavage of Neuronal Pentraxin NPR by TACE
Cho, R. W., Park, J. M., Wolff, S. B. E., Xu, D., Hopf, C., Kim, J.-A., Reddy, R. C., Petralia, R. S., Perin, M. S., Linden, D. J., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.010 · Cited by 125
Erv14p Directs a Transmembrane Secretory Protein into COPII-coated Transport Vesicles
Powers, J., & Barlowe, C. K. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-10-0499 · Cited by 125
Two Classes of Secreted Synaptic Organizers in the Central Nervous System
Yuzaki, M. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021317-121322 · Cited by 125
The mechanism of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor desensitization after removal of glutamate
Raman, I. M., & Trussell, L. O. (1995) · Biophysical Journal · doi:10.1016/s0006-3495(95)80168-2 · Cited by 125
Assessing the Extent of RNA Editing in the TMII Regions of GluR5 and GluR6 Kainate Receptors During Rat Brain Development
Bernard, A., & Khrestchatisky, M. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.62052057.x · Cited by 125

Flagged first, then by citations

Sorted by citations

Mechanisms of ketamine and its metabolites as antidepressants
Hess, E. M., Riggs, L. M., Michaelides, M., & Gould, T. D. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114892 · Cited by 175
A gain‐of‐function GRIA2 variant associated with neurodevelopmental delay and seizures: Functional characterization and targeted treatment
Coombs, I. D., Ziobro, J., Krotov, V., Surtees, T., Cull‐Candy, S. G., & Farrant, M. (2022) · Epilepsia · doi:10.1111/epi.17419 · Cited by 32
Cryo-EM structure of the human Asc-1 transporter complex
Li, Y., Guo, Y., Bröer, A., Dai, L., Brӧer, S., & Yan, R. (2024) · Nature Communications · doi:10.1038/s41467-024-47468-1 · Cited by 12
Glutamate receptor 4 as a fluid biomarker for the diagnosis of psychiatric disorders
Gómez de San José, N., Goossens, J., Al Shweiki, M. R., Halbgebauer, S., Oeckl, P., Steinacker, P., Danzer, K. M., Graf, H., Schönfeldt-Lecuona, C., Belbin, O., et al. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.10.010 · Cited by 9

See all 686

Authors: Hansen, K. B., Wollmuth, L. P., Bowie, D., Furukawa, H., Menniti, F. S., Sobolevsky, A. I., Swanson, G. T., Swanger, S. A., Greger, I. H., Nakagawa, T., McBain, C. J., Jayaraman, V., Low, C.-M., Dell’Acqua, M. L., Diamond, J. S., Camp, C. R., Perszyk, R. E., Yuan, H., & Traynelis, S. F.
Affiliations: Northwestern University (US)
Corresponding author: Traynelis, Stephen F.
ORCID: Hansen, Kasper B.
Wollmuth, Lonnie P.
Bowie, Derek
Furukawa, Hiro
Menniti, Frank S.
Sobolevsky, Alexander I.
Swanson, Geoffrey T.
Swanger, Sharon A.
Greger, Ingo H.
Nakagawa, Terunaga
McBain, Chris J.
Jayaraman, Vasanthi
Low, Chian-Ming
Dell’Acqua, Mark L.
Diamond, Jeffrey S.
Camp, Chad R.
Perszyk, Riley E.
Yuan, Hongjie
Traynelis, Stephen F.
Venue: Pharmacological Reviews
Publisher: Elsevier BV
Published: 2021-10
Volume: 73
Issue: 4
Pages: 1469-1658
ISSN: 0031-6997 (ISSN-L)
DOI: 10.1124/pharmrev.120.000131
PMC: PMC8626789
OpenAlex: W3214054678
Cited by: 686
References: 2,576
Citations by year: 2026: 123 · 2025: 198 · 2024: 160 · 2023: 115 · 2022: 81 · 2021: 9
FWCI: 13.86
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Pharmacological Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
Funders: National Institutes of Health (5f31ns113530-02)
Biotechnology and Biological Sciences Research Council (BB/N002113/1)
National Institute of Mental Health (R56MH123474, R21MH127404, R01MH085926, R01MH123474)
National Cancer Institute (R01CA206573)
National Institute of General Medical Sciences (P20GM103546, R35GM122528)
National Institute of Neurological Disorders and Stroke (F31‐NS113530, R01NS105804, R56NS040701, R01NS083660, R01NS040701, R01NS088479, R01NS111745, RF1NS113632, R01NS105502, R01NS107253, R35NS111619, R37NS083660, R01NS116055, R01NS097536)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD082373)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: ionotropic glutamate receptors, ligand-gated ion channels, glutamate, receptor subtypes, receptor structure, receptor pharmacology, excitatory neurotransmission, neurophysiology, neurological disorders, mental illness, therapeutic target
MeSH terms: Animals, Central Nervous System, Humans, Receptors, Glutamate, Neurotransmitter Agents, Glutamic Acid, Receptors, Ionotropic Glutamate

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks