The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors

Role of reactive oxygen species and poly-ADP-ribose polymerase in the development of AZT-induced cardiomyopathy in rat

Szabados, E., Fischer, G., Tóth, K., Csete, B., Németi, B., Trombitás, K., Habon, T., Endrei, D., & Sümegi, B. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00199-3 · Cited by 137

The Expression of Poly(ADP-ribose) Polymerase during Differentiation-Linked DNA Replication Reveals That It Is a Component of the Multiprotein DNA Replication Complex

Simbulan-Rosenthal, C. M., Rosenthal, D. S., Hilz, H., Hickey, R. J., Malkas, L. H., Applegren, N., Wu, Y. Q., Bers, G., & Smulson, M. E. (1996) · Biochemistry · doi:10.1021/bi953010z · Cited by 137

Apoptosis in the Absence of Poly- (ADP-ribose) Polymerase

Leist, M., Single, B., Künstle, G., Volbracht, C., Hentze, H., & Nicotera, P. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6491 · Cited by 136

Potentiation of temozolomide-induced cytotoxicity: a comparative study of the biological effects of poly(ADP-ribose) polymerase inhibitors

Boulton, S. J., Pemberton, L., Porteous, J. K., Curtin, N. J., Griffin, R., Golding, B. T., & Durkacz, B. W. (1995) · British Journal of Cancer · doi:10.1038/bjc.1995.423 · Cited by 136

Endogenous nitric oxide induced by interleukin‐1β in rat islets of Langerhans and HIT‐T15 cells causes significant DNA damage as measured by the ‘comet’ assay

Delaney, C. A., Green, M. H. L., Lowe, J. E., & Green, I. C. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80673-i · Cited by 136

Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis

Jijon, H. B., Churchill, T. A., Malfair, D., Wessler, A., Jewell, L. D., Parsons, H. G., & Madsen, K. L. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.3.g641 · Cited by 135

DNA strand breaks induced by sustained glutamate excitotoxicity in primary neuronal cultures

Didier, M., Bursztajn, S., Adamec, E., Passani, L. A., Nixon, R. A., Coyle, J. T., Wei, J., & Berman, S. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-07-02238.1996 · Cited by 134

Mode of action of poly(ADP-ribose) glycohydrolase

Brochu, G., Duchaine, C., Thibeault, L., Lagueux, J., Shah, G. M., & Poirier, G. G. (1994) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(94)90058-2 · Cited by 134

Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase

Mabley, J. G., Jagtap, P. G., Perretti, M., Getting, S. J., Salzman, A. L., Virág, L., Szabó, É., Soriano, F. G., Liaudet, L., Abdelkarim, G. E., et al. (2001) · Inflammation Research · doi:10.1007/pl00000234 · Cited by 134

Delayed Treatment With Nicotinamide (Vitamin B 3 ) Improves Neurological Outcome and Reduces Infarct Volume After Transient Focal Cerebral Ischemia in Wistar Rats

Mokudai, T., Ayoub, I. A., Sakakibara, Y., Lee, E.-J., Ogilvy, C. S., & Maynard, K. I. (2000) · Stroke · doi:10.1161/01.str.31.7.1679 · Cited by 133

Cytopathic hypoxia: Is oxygen use impaired in sepsis as a result of an acquired intrinsic derangement in cellular respiration?

Fink, M. P. (2002) · Critical Care Clinics · doi:10.1016/s0749-0704(03)00071-x · Cited by 133

Ionising radiation induces the expression of PARP-1 and PARP-2 genes in Arabidopsis

Chabeaud, G. D., Godon, C., Brutesco, C., de MURCIA, G., & Kazmaier, M. (2001) · Molecular Genetics and Genomics · doi:10.1007/s004380100506 · Cited by 133

PolyADP-ribose polymerase is a coactivator for AP-2-mediated transcriptional activation

Kannan, P., Yu, Y., Wankhade, S., & Tainsky, M. A. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.3.866 · Cited by 131

Purines inhibit poly(ADP‐ribose) polymerase activation and modulate oxidant‐induced cell death

Virág, L., & Szabó, C. (2001) · The FASEB Journal · doi:10.1096/fj.00-0299com · Cited by 130

Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymerase

Simbulan-Rosenthal, C. M., Ly, D. H., Rosenthal, D. S., Konopka, G., Luo, R., Wang, Z., Schultz, P. G., & Smulson, M. E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.200285797 · Cited by 130

Poly(ADP-Ribose) Polymerase Impairs Early and Long-Term Experimental Stroke Recovery

Goto, S., Xue, R., Sugo, N., Sawada, M., Blizzard, K. K., Poitras, M. F., Johns, D. C., Dawson, T. M., Dawson, V. L., Crain, B. J., et al. (2002) · Stroke · doi:10.1161/01.str.0000014203.65693.1e · Cited by 129

Pharmacologic Inhibition of Poly(ADP-Ribose) Polymerase Is Neuroprotective Following Traumatic Brain Injury in Rats

LaPlaca, M. C., Zhang, J., Raghupathi, R., Li, J., Smith, F. M., Bareyre, F. M., Snyder, S. H., Graham, D. I., & McIntosh, T. K. (2001) · Journal of Neurotrauma · doi:10.1089/089771501750170912 · Cited by 127

Poly(ADP-ribose) Polymerase Is a B-MYB Coactivator

Cervellera, M. N., & Sala, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.14.10692 · Cited by 127

Mechanisms of streptozotocin- and alloxan-induced damage in rat B cells

Wilson, G. L., Patton, N. J., McCord, J. M., Mullins, D. W., & Mossman, B. T. (1984) · Diabetologia · doi:10.1007/bf00276973 · Cited by 127

Resistance-Modifying Agents. 5. Synthesis and Biological Properties of Quinazolinone Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose) Polymerase (PARP)

Griffin, R. J., Srinivasan, S., Bowman, K. J., Calvert, H., Curtin, N. J., Newell, D. R., Pemberton, L., & Golding, B. T. (1998) · Journal of Medicinal Chemistry · doi:10.1021/jm980273t · Cited by 127

A cellular survival switch: poly(ADP‐ribosyl)ation stimulates DNA repair and silences transcription

Ziegler, M., & Oei, S. L. (2001) · BioEssays · doi:10.1002/bies.1074 · Cited by 126

Inhibition of Poly(ADP-Ribose) Polymerase

Lo, E. H., Bosque-Hamilton, P., & Meng, W. (1998) · Stroke · doi:10.1161/01.str.29.4.830 · Cited by 125

Identification of a Novel Human Tankyrase through Its Interaction with the Adaptor Protein Grb14

Lyons, R. J., Deane, R., Lynch, D. K., Ye, Z.-S. J., Sanderson, G. M., Eyre, H. J., Sutherland, G. R., & Daly, R. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009756200 · Cited by 125

Inducible nitric oxide synthase (iNOS) in pancreatic islets of nonobese diabetic mice: identification of iNOS- expressing cells and relationships to cytokines expressed in the islets

Rabinovitch, A., Suarez‐Pinzon, W. L., Sørensen, O. E., & Bleackley, R. C. (1996) · Endocrinology · doi:10.1210/endo.137.5.8612552 · Cited by 124

Nicotinamide Modulates Mitochondrial Membrane Potential and Cysteine Protease Activity during Cerebral Vascular Endothelial Cell Injury

Chong, Z. Z., Lin, S., & Maiese, K. (2002) · Journal of Vascular Research · doi:10.1159/000057762 · Cited by 124

Roles of poly(ADP-ribosyl)ation and PARP in apoptosis, DNA repair, genomic stability and functions of p53 and E2F-1

Smulson, M. E., Simbulan-Rosenthal, C. M., Boulares, A. H., Yakovlev, A., Stoica, B. A., Iyer, S., Luo, R., Haddad, B. R., Wang, Z., Pang, T.-L., et al. (2000) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(99)00024-2 · Cited by 124

DNA Strand Break-Sensing Molecule Poly(ADP-Ribose) Polymerase Cooperates with p53 in Telomere Function, Chromosome Stability, and Tumor Suppression

Tong, W., Hande, M. P., Lansdorp, P. M., & Wang, Z. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.12.4046-4054.2001 · Cited by 123

ADP-ribosyl protein lyase. Purification, properties, and identification of the product.

Oka, J., Ueda, K., Hayaishi, O., et al. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43555-1 · Cited by 122

Poly(ADP‐ribose) polymerase: Early involvement in glutamate‐induced neurotoxicity in cultured cerebellar granule cells

Cosi, C., Suzuki, H., Milani, D., Facci, L., Menegazzi, M., Vantini, G., Kanai, Y., & Skaper, S. D. (1994) · Journal of Neuroscience Research · doi:10.1002/jnr.490390106 · Cited by 122

Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro

Ariumi, Y., Masutani, M., Copeland, T. D., Mimori, T., Sügimura, T., Shimotohno, K., Ueda, K., Hatanaka, M., & Noda, M. (1999) · Oncogene · doi:10.1038/sj.onc.1202823 · Cited by 122

Caspase-3-mediated Processing of Poly(ADP-ribose) Glycohydrolase during Apoptosis

Affar, E. B., Germain, M., Winstall, É., Vodenicharov, M. D., Shah, R. G., Salvesen, G. S., & Poirier, G. G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007269200 · Cited by 120

Identification of cell types producing RANTES, MIP-1α and MIP-1β in rat experimental autoimmune encephalomyelitis by in situ hybridization

Miyagishi, R., Kikuchi, S., Takayama, C., Inoue, Y., & Tashiro, K. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00040-4 · Cited by 119

Poly(ADP‐Ribose) Synthetase Activation: An Early Indicator of Neurotoxic DNA Damage

Zhang, J., Pieper, A. A., & Snyder, S. H. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65031411.x · Cited by 117

Role of peroxynitrite and neuronal nitric oxide synthase in the activation of poly(ADP-ribose) synthetase in a murine model of cerebral ischemia-reperfusion

Endres, M., Scott, G. S., Namura, S., Salzman, A. L., Huang, P. L., Moskowitz, M. A., & Szabó, C. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00224-9 · Cited by 116

Evidence for regulation of NF-κB by poly(ADP-ribose) polymerase

Kameoka, M., Ota, K., Tetsuka, T., Tanaka, Y., Itaya, A., Okamoto, T., & Yoshihara, K. (2000) · Biochemical Journal · doi:10.1042/bj3460641 · Cited by 116

Inflammation in EAE: Role of chemokine/cytokine expression by resident and infiltrating cells

Eng, L. F., Ghirnikar, R. S., & Lee, Y. L. (1996) · Neurochemical Research · doi:10.1007/bf02527717 · Cited by 115

Expression of poly(adenosine diphosphate-ribose) polymerase activity in erythroleukemic mouse cells during cell cycle and erythropoietic differentiation.

Dworkin‐Rastl, E., & Swetly, P. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34724-5 · Cited by 114

Enhanced Poly(ADP-ribosyl)ation after Focal Ischemia in Rat Brain

Tokime, T., Nozaki, K., Sugino, T., Kikuchi, H., Hashimoto, N., & Ueda, K. (1998) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199809000-00008 · Cited by 114

Poly(ADP-ribose)polymerase: a novel finger protein

Mazen, A., Murcia, J. M., Molinete, M., Simonin, F., Gradwohl, G., Poirier, G. G., & de MURCIA, G. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.12.4689 · Cited by 114

Centromere Proteins Cenpa, Cenpb, and Bub3 Interact with Poly(ADP-ribose) Polymerase-1 Protein and Are Poly(ADP-ribosyl)ated

Saxena, A., Saffery, R., Wong, L. H., Kalitsis, P., & Choo, K. H. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200620200 · Cited by 113

The NAD+ precursors, nicotinic acid and nicotinamide protect cells against apoptosis induced by a multiple stress inducer, deoxycholate

Crowley, C., Payne, C. M., Bernstein, H., Bernstein, C., & Roe, D. J. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400658 · Cited by 113

NITRIC OXIDE PRODUCTION IN CELLS DERIVED FROM THE HUMAN JOINT

Grabowski, P., Macpherson, H. K., & Ralston, S. H. (1996) · Lara D. Veeken · doi:10.1093/rheumatology/35.3.207 · Cited by 113

trans -Dominant Inhibition of Poly(ADP-Ribosyl)ation Sensitizes Cells against γ-Irradiation and N -Methyl- N ′-Nitro- N -Nitrosoguanidine but Does Not Limit DNA Replication of a Polyomavirus Replicon

Küpper, J. ‐., Müller, M. C., Jacobson, M. K., Tatsumi‐Miyajima, J., Coyle, D. L., Jacobson, E. L., & Bürkle, A. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3154 · Cited by 112

Prevention of Nitric Oxide-Induced Neuronal Injury Through the Modulation of Independent Pathways of Programmed Cell Death

Lin, S., Vincent, A. M., Shaw, T., Maynard, K. I., & Maiese, K. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200009000-00013 · Cited by 112

Secondary necrosis is a source of proteolytically modified forms of specific intracellular autoantigens: Implications for systemic autoimmunity

Wu, X., Molinaro, C. A., Johnson, N., & Casiano, C. A. (2001) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200111)44:11<2642::aid-art444>3.0.co;2-8 · Cited by 112

Memantine abrogates neurological deficits, but not CNS inflammation, in Lewis rat experimental autoimmune encephalomyelitis

Wallström, E., Diener, P., Ljungdahl, Å., Khademi, M., Nilsson, C.-G., & Olsson, T. P. (1996) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(95)00339-4 · Cited by 111

Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage

Boulton, S. J. (1999) · Carcinogenesis · doi:10.1093/carcin/20.2.199 · Cited by 111

Inhibition of poly(ADP-ribose) polymerase attenuates ischemic renal injury in rats

Martin, D. R., Lewington, A. J. P., Hammerman, M. R., & Padanilam, B. J. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.5.r1834 · Cited by 111

Combined Treatment With Nicotinamide and Desferrioxamine Prevents Islet Allograft Destruction in NOD Mice

Nomikos, I. N., Prowse, S. J., Carotenuto, P., et al. (1986) · Diabetes · doi:10.2337/diab.35.11.1302 · Cited by 109

Inhibitors of ADP-Ribosylation Impair Inducible Nitric Oxide Synthase Gene Transcription through Inhibition of NF Kappa B Activation

Page, C. L., Sancéau, J., Drapier, J., & Wietzerbin, J. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8113 · Cited by 108

Role of nitric oxide in neurodegenerative diseases

Schulz, J. B., Matthews, R. T., & Beal, M. F. (1995) · Current Opinion in Neurology · doi:10.1097/00019052-199512000-00016 · Cited by 108

Cytokines activate the nuclear factor κB (NF‐κB) and induce nitric oxide production in human pancreatic islets

Flodström‐Tullberg, M., Welsh, N., & Eizirik, D. L. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00337-7 · Cited by 108

Nicotinamide reduces infarction up to two hours after the onset of permanent focal cerebral ischemia in Wistar rats

Ayoub, I. A., Lee, E. J., Ogilvy, C. S., Beal, M. F., & Maynard, K. I. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00881-7 · Cited by 107

Human pancreatic islet beta-cell destruction by cytokines is independent of nitric oxide production.

Rabinovitch, A., Suarez‐Pinzon, W. L., Strynadka, K., et al. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.4.7962274 · Cited by 107

Inhibition of PARP prevents oxidant-induced necrosis but not apoptosis in LLC-PK1cells

Filipović, D., Meng, X., & Reeves, W. B. (1999) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1999.277.3.f428 · Cited by 106

Transcriptional regulation of human insulin receptor gene by the high‐mobility group protein HMGI(Y)

Brunetti, A., Manfioletti, G., CHIEFARI, E. D., Goldfine, I. D., & FOTI, D. P. (2001) · The FASEB Journal · doi:10.1096/fj.00-0190com · Cited by 105

Involvement of PARP and poly(ADP-ribosyl)ation in the early stages of apoptosis and DNA replication

Simbulan-Rosenthal, C. M., Rosenthal, D. S., Iyer, S., Boulares, H. A., & Smulson, M. E. (1999) · Springer eBooks · doi:10.1007/978-1-4419-8740-2_20 · Cited by 104

Activation of Poly(ADP‐Ribose) Polymerase in the Rat Hippocampus May Contribute to Cellular Recovery Following Sublethal Transient Global Ischemia

Nagayama, T., Simon, R. P., Chen, D., et al. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0741636.x · Cited by 104

Glutamate metabolism is down-regulated in astrocytes during experimental allergic encephalomyelitis

Hardin‐Pouzet, H., Krakowski, M. L., Bourbonni�re, L., Didier‐Bazès, M., Tran, E., & Owens, T. (1997) · Glia · doi:10.1002/(sici)1098-1136(199705)20:1<79::aid-glia8>3.0.co;2-0 · Cited by 102

Protective effect of a novel, potent inhibitor of poly(adenosine 5′-diphosphate-ribose) synthetase in a porcine model of severe bacterial sepsis*

Goldfarb, R. D., Marton, A., Szabó, É., Virág, L., Salzman, A. L., Glock, D., Akhter, I., McCarthy, R. J., Parrillo, J. E., & Szabó, C. (2002) · Critical Care Medicine · doi:10.1097/00003246-200205000-00004 · Cited by 102

Increased Nitrotyrosine in the Diabetic Placenta: Evidence for oxidative stress

Lyall, F., Gibson, J. L., Greer, I. A., Brockman, D. E., Eis, A., & Myatt, L. (1998) · Diabetes Care · doi:10.2337/diacare.21.10.1753 · Cited by 102

Poly(ADP-ribose) Polymerase Mediates the Suicide Response to Massive DNA Damage: Studies in Normal and DNA-repair Defective Cells

Berger, N. A., Sims, J. L., Catino, D. M., & Berger, S. J. (2020) · CRC Press eBooks · doi:10.1201/9781003079491-24 · Cited by 102

Peroxynitrite and Hydrogen Peroxide Induced Cell Death in the NSC34 Neuroblastoma × Spinal Cord Cell Line: Role of Poly(ADP‐Ribose) Polymerase

Cookson, M., Ince, P. G., & Shaw, P. J. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70020501.x · Cited by 101

Metabolic consequences of DNA damage: DNA damage induces alterations in glucose metabolism by activation of poly(ADP-ribose) polymerase

Berger, S. J., Sudar, D. C., & Berger, N. A. (1986) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(86)90551-6 · Cited by 101

Poly(ADP-ribose) polymerase-1 is required for efficient HIV-1 integration

Ha, H. C., Juluri, K. R., Zhou, Y., Leung, S., Hermankova, M., & Snyder, S. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051633498 · Cited by 101

A new look at the heart in diabetes mellitus: from ailing to failing

Standl, E., & Schnell, O. (2000) · Diabetologia · doi:10.1007/s001250051556 · Cited by 101

Toxicity of chemically generated nitric oxide towards pancreatic islet cells can be prevented by nicotinamide

Kallmann, B. A., Burkart, V., Kröncke, K. D., Kolb‐Bachofen, V., & Kolb, H. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90240-p · Cited by 100

Regulation of p53 Sequence-specific DNA-binding by Covalent Poly(ADP-ribosyl)ation

Mendoza‐Alvarez, H., & Álvarez-González, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105215200 · Cited by 100

Peroxynitrite Causes Energy Depletion and Increases Permeability via Activation of Poly (ADP-Ribose) Synthetase in Pulmonary Epithelial Cells

Szabó, C., Saunders, C., O’Connor, M. P., & Salzman, A. L. (1997) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.16.2.9032115 · Cited by 99

Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure

Pacher, P., Liaudet, L., Mabley, J. G., Komjáti, K., & Szabó, C. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02062-4 · Cited by 97

MPTP Produces Differential Oxidative Stress and Antioxidative Responses in the Nigrostriatal and Mesolimbic Dopaminergic Pathways

Hung, H.-C., & Lee, E. H. Y. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00206-2 · Cited by 95

Meta-Analysis of Nicotinamide Treatment in Patients With Recent-Onset IDDM

Pozzilli, P., Browne, P., Kolb, H., & Trialists, T. N. (1996) · Diabetes Care · doi:10.2337/diacare.19.12.1357 · Cited by 95

The stress-response proteins poly(ADP-ribose) polymerase and NF-κB protect against bile salt-induced apoptosis

Payne, C. M., Crowley, C., Washo-Stultz, D., Briehl, M. M., Bernstein, H., Bernstein, C., Beard, S. E., Holubec, H., & Warneke, J. A. (1998) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400395 · Cited by 94

Poly(ADP‐Ribose) Synthase Inhibition Reduces Ischemic Injury and Inflammation in Neonatal Rat Brain

Ducrocq, S., Benjelloun, N., Plotkine, M., Ben‐Ari, Y., & Charriaut‐Marlangue, C. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0742504.x · Cited by 93

Modeling of Poly(ADP-ribose)polymerase (PARP) Inhibitors. Docking of Ligands and Quantitative Structure−Activity Relationship Analysis

Costantino, G., Macchiarulo, A., Camaioni, E., & Pellicciari, R. (2001) · Journal of Medicinal Chemistry · doi:10.1021/jm010116l · Cited by 93

Poly(ADP-ribose) synthetase activation mediates increased permeability induced by peroxynitrite in Caco-2BBe cells

Kennedy, M., Denenberg, A. G., Szabó, C., & Salzman, A. L. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70534-7 · Cited by 93

Poly(ADP-ribosyl)ation of p53 during apoptosis in human osteosarcoma cells.

Simbulan-Rosenthal, C. M., Rosenthal, D. S., Luo, R., & Smulson, M. E. (1999) · PubMed · Cited by 93

Oxidative changes in brain pyridine nucleotides and neuroprotection using nicotinamide

Klaidman, L. K., Mukherjee, S. K., & Adams, J. D., Jr. (2001) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(00)00181-1 · Cited by 92

Oxygen Free-Radical Scavengers and Immune Destruction of Murine Islets in Allograft Rejection and Multiple Low-Dose Streptozocin-Induced Insulitis

Méndola, J., Wright, J. R., & Lacy, P. E. (1989) · Diabetes · doi:10.2337/diab.38.3.379 · Cited by 92

Inhibition of Nuclear Receptor Signalling by Poly(ADP-Ribose) Polymerase

Miyamoto, T., Kakizawa, T., & Hashizume, K. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2644 · Cited by 92

Novel inhibitors of poly(ADP-ribose) polymerase/PARP1 and PARP2 identified using a cell-based screen in yeast.

Perkins, E. L., Sun, D., Nguyen, A., Tulac, S., Francesco, M., Tavana, H., Nguyen, H., Tugendreich, S., Barthmaier, P., Couto, J., et al. (2001) · PubMed · Cited by 91

Comparison of the nitric oxide synthase inhibitors methylarginine and aminoguanidine as prophylactic and therapeutic agents in rat adjuvant arthritis.

Stefanović-Račić, M., Meyers, K., Meschter, C. L., Jw, C., Ra, H., & Evans, C. H. (1995) · PubMed · Cited by 90

Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase–deficient mice and primary cells despite increased chromosomal instability

Samper, E., Goytisolo, F. A., Murcia, J. M., González‐Suárez, E., Cigudosa, J. C., de MURCIA, G., & Blasco, M. A. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200103049 · Cited by 90

Nitric oxide production by superficial and deep articular chondrocytes

Hayashi, T., Abe, E., Yamate, T., Taguchi, Y., & Jasin, H. E. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400210 · Cited by 89

Induction of erythroid differentiation of murine erythroleukemia cells by nicotinamide and related compounds.

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Effects of 5‐aminoisoquinolinone, a water‐soluble, potent inhibitor of the activity of poly (ADP‐ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock

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