The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors

Protective effects of 5-iodo-6-amino-1,2-benzopyrone, an inhibitor of poly(ADP-ribose) synthetase against peroxynitrite-induced glial damage and stroke development

Endres, M., Scott, G. S., Salzman, A. L., Kun, E., Moskowitz, M. A., & Szabó, C. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00381-1 · Cited by 47

Turnover of oxidatively damaged nuclear proteins in BV‐2 microglial cells is linked to their activation state by poly(ADP‐ribose)polymerase

Ullrich, O., Diestel, A., Bechmann, I., Homberg, M., Grune, T., Hass, R., & Nitsch, R. (2001) · The FASEB Journal · doi:10.1096/fj.00-0540fje · Cited by 47

Role of ADP-ribosyl transferase in differentiation of human granulocyte- macrophage progenitors to the macrophage lineage

Francis, G. E., Gray, D. A., Berney, J. J., Wing, M., Guimarães, J. E., & Hoffbrand, A. V. (1983) · Blood · doi:10.1182/blood.v62.5.1055.1055 · Cited by 46

Inhibition of Poly(ADP-Ribose) Polymerase Attenuates Cerebral Vasospasm After Subarachnoid Hemorrhage in Rabbits

Satoh, M., Date, I., Nakajima, M., Takahashi, K., Iseda, K., Tamiya, T., Ohmoto, T., Ninomiya, Y., & Asari, S. (2001) · Stroke · doi:10.1161/01.str.32.1.225 · Cited by 46

Nicotinamide prevents the development of diabetes in the cyclophosphamide-induced NOD mouse model by reducing beta-cell apoptosis

O’Brien, B. A., HARMON, B. V., Cameron, D. P., & Allan, D. J. (2000) · The Journal of Pathology · Cited by 46

Reduction of acute photodamage in skin by topical application of a novel PARP inhibitor

Farkas, B., Magyarlaki, M., Csete, B., Németh, J., Rabloczky, G., Bernath, S., Nagy, P., & Sümegi, B. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00929-7 · Cited by 46

Role of (ADP-ribose)nCatabolism in DNA Repair

Maruta, H., Matsumura, N., & Tanuma, S.-I. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6910 · Cited by 46

Nicotinamide as a radiosensitizer in tumours and normal tissues: the importance of drug dose and timing

Horsman, M. R., Siemann, D. W., Chaplin, D. J., & Overgaard, J. (1997) · Radiotherapy and Oncology · doi:10.1016/s0167-8140(97)00127-8 · Cited by 45

Reduction of myocardial reperfusion injury by an inhibitor of poly (ADP-ribose) synthetase in the pig

Bowes, J., Ruetten, H., Martorana, P. A., Stockhausen, H., & Thiemermann, C. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00638-4 · Cited by 45

A multi-centre randomized trial of two different doses of nicotinamide in patients with recent-onset Type 1 diabetes (the IMDIAB VI)

Visalli, N., Cavallo, M. G., Signore, A., Baroni, M. G., Buzzetti, R., Fioriti, E., Mesturino, C. A., Fiori, R., Lucentini, L., Matteoli, M. C., et al. (1999) · Diabetes/Metabolism Research and Reviews · doi:10.1002/(sici)1520-7560(199905/06)15:3<181::aid-dmrr31>3.0.co;2-h · Cited by 45

Prevention of Endotoxin-Induced Lethality, but Not of Liver Apoptosis in Poly(ADP-ribose) Polymerase-Deficient Mice

Kühnle, S., Nicotera, P., Wendel, A., & Leist, M. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1393 · Cited by 45

GPI 6150 Prevents H2O2 Cytotoxicity by Inhibiting Poly(ADP-ribose) Polymerase

Zhang, J., Lautar, S. L., Huang, S. H., Ramsey, C., Cheung, A., & Li, J.-H. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3816 · Cited by 44

Protection by Thymidine, an Inhibitor of Polyadenosine Diphosphate Ribosylation, of Streptozotocin Inhibition of Insulin Secretion*

Bolaffi, J. L., Nagamatsu, S., Harris, J., & Grodsky, G. M. (1987) · Endocrinology · doi:10.1210/endo-120-5-2117 · Cited by 44

Poly(ADP-ribose) polymerase-1 regulates the stability of the wild-type p53 protein.

Węsierska‐Gądek, J., & Schmid, G. (2001) · PubMed · Cited by 43

Post-treatment at 12 or 18 hours with 3-aminobenzamide ameliorates retinal ischemia-reperfusion damage.

Chiang, S. K. S., & Lam, T. T. (2000) · PubMed · Cited by 43

Reducing the burden of diabetes: managing cardiovascular disease

KEEN, H., Clark, C. M., & Laakso, M. (1999) · Diabetes/Metabolism Research and Reviews · doi:10.1002/(sici)1520-7560(199905/06)15:3<186::aid-dmrr30>3.0.co;2-5 · Cited by 43

GPI 6150, a poly (ADP-ribose) polymerase inhibitor, exhibits an anti-inflammatory effect in rat models of inflammation

Mazzon, E., Serraino, I., Li, J., Dugo, L., Caputi, A. P., Zhang, J., & Cuzzocrea, S. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00809-3 · Cited by 42

Partial protection by poly(ADP-ribose) polymerase inhibitors from nitroxyl-induced cytotoxity in thymocytes

Bai, P. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00756-0 · Cited by 42

Proteasome activation by poly-ADP-ribose-polymerase in human myelomonocytic cells after oxidative stress

Ullrich, O., Ciftci, Ö., & Hass, R. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00399-3 · Cited by 42

Nicotinamide Increases C‐peptide Secretion in Patients with Recent Onset Type 1 Diabetes

Pozzilli, P., Visalli, N., Ghirlanda, G., Manna, R., & Andreani, D. (1989) · Diabetic Medicine · doi:10.1111/j.1464-5491.1989.tb01229.x · Cited by 42

DIFFERENTIATION AND MATURATION OF PORCINE FETAL ISLET CELLS IN VITRO AND AFTER TRANSPLANTATION1

Otonkoski, T., Ustinov, J., Rasilainen, S. K., Kallio, E., Korsgren, O., & H�yry, P. J. (1999) · Transplantation · doi:10.1097/00007890-199912150-00010 · Cited by 42

Chapter 32 The role of free radicals in NMDA-dependent neurotoxicity

Fagni, L., Lafon‐Cazal, M., Rondouin, G., Manzoni, O. J., Lerner‐Natoli, M., & Bockaert, J. (1994) · Progress in brain research · doi:10.1016/s0079-6123(08)61152-8 · Cited by 41

Role of peroxynitrite and activation of poly (ADP‐ribose) synthetase in the vascular failure induced by zymosan‐activated plasma

Cuzzocrea, S., Zingarelli, B., O'Connor, M., Salzman, A. L., Caputi, A. P., & Szabó, C. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701387 · Cited by 41

A catalyst of peroxynitrite decomposition inhibits murine experimental autoimmune encephalomyelitis

Cross, A. H., San, M., Stern, M. K., Keeling, R. M., Salvemini, D., & Misko, T. P. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00242-3 · Cited by 41

BENEFICIAL EFFECTS OF TEMPOL, A MEMBRANE-PERMEABLE RADICAL SCAVENGER, IN A RODENT MODEL OF SPLANCHNIC ARTERY OCCLUSION AND REPERFUSION

Cuzzocrea, S., McDonald, M. C., Mazzon, E., Mota‐Filipe, H., Costantino, G., Caputi, A. P., & Thiemermann, C. (2000) · Shock · doi:10.1097/00024382-200014020-00013 · Cited by 41

EFFECTS OF INHIBITORS OF POLY(ADP-RIBOSE) SYNTHETASE ACTIVITY ON HYPOTENSION AND MULTIPLE ORGAN DYSFUNCTION CAUSED BY ENDOTOXIN

Wray, G. M., Hinds, C., & Thiemermann, C. (1998) · Shock · doi:10.1097/00024382-199807000-00003 · Cited by 41

Inhibition of gene-specific repair of alkylation damage in cells deplated of poly(ADP-ribose) polymerase

Stevnsner, T., Ding, R., Smulson, M. E., & Bohr, V. A. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.22.4620 · Cited by 40

Inhibition of Homodimerization of Poly(ADP-ribose) Polymerase by Its C-terminal Cleavage Products Produced during Apoptosis

Kim, J. W., Kim, K., Kang, K.-W., & Joe, C. O. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.8121 · Cited by 40

Analysis of Oxygen Radical Toxicity in Pancreatic Islets at the Single Cell Level

Heller, B., Bürkle, A., Radons, J., Fengler, E., Jalowy, A., Müller, M. C., Burkart, V., & Kolb, H. (1994) · Biological Chemistry Hoppe-Seyler · doi:10.1515/bchm3.1994.375.9.597 · Cited by 40

Poly(ADP-ribose) synthetase is phosphorylated by protein kinase C

Tanaka, Y., KOIDE, S. S., Yoshihara, K., & Kamiya, T. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)90934-x · Cited by 39

Poly (ADP-ribose) synthetase activation mediates pulmonary microvascular and intestinal mucosal dysfunction in endotoxin shock

Szabó, A., Salzman, A. L., & Szabó, C. (1998) · Life Sciences · doi:10.1016/s0024-3205(99)80010-1 · Cited by 39

Poly (ADP-ribose) polymerase inhibitor increases apoptosis and reduces necrosis induced by a DNA minor groove binding methyl sulfonate ester

Tentori, L., Balduzzi, A., Portarena, I., Levati, L., Vernole, P., Gold, B. I., Bonmassar, E., & Graziani, G. (2001) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400863 · Cited by 39

Overexpression of poly(ADP-ribose) polymerase promotes cell cycle arrest and inhibits neutrophilic differentiation of NB4 acute promyelocytic leukemia cells.

Bhatia, M., Kirkland, J. B., & Meckling‐Gill, K. A. (1996) · PubMed · Cited by 39

Activation of poly(ADP-ribose) polymerase in severe hemorrhagic shock and resuscitation

Watts, J. A., Grattan, R. M., Whitlow, B. S., & Kline, J. A. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.2.g498 · Cited by 39

Therapeutic window for nicotinamide following transient focal cerebral ischemia

Ayoub, I. A., & Maynard, K. I. (2002) · Neuroreport · doi:10.1097/00001756-200202110-00008 · Cited by 38

Role of poly-(ADP-ribose) synthetase in lipopolysaccharide-induced vascular failure and acute lung injury in pigs

Albertini, M., Clement, M. G., Lafortuna, C. L., Caniatti, M., Magder, S. A., Abdulmalek, K., & Hussain, S. N. A. (2000) · Journal of Critical Care · doi:10.1053/jcrc.2000.7903 · Cited by 37

Synergistic effects of thalidomide and poly(ADP-ribose) polymerase inhibition on type II collagen-induced arthritis in mice

Kr�ger, H., Miesel, R., Dietrich, A., Ohde, M., Rajnav�lgyi, E., & Ockenfels, H. (1996) · Inflammation · doi:10.1007/bf01487406 · Cited by 37

Beneficial Effects Of GPI 6150, an Inhibitor of Poly(ADP-Ribose) Polymerase in a Rat Model of Splanchnic Artery Occlusion and Reperfusion

Mazzon, E., Dugo, L., Sarro, A. D., Li, J.-H., Caputi, A. P., Zhang, J., & Cuzzocrea, S. (2002) · Shock · doi:10.1097/00024382-200203000-00011 · Cited by 37

Regulation of the nuclear proteasome activity in myelomonocytic human leukemia cells after adriamycin treatment

Ciftci, Ö., Ullrich, O., Schmidt, C. A., Diestel, A., & Hass, R. (2001) · Blood · doi:10.1182/blood.v97.9.2830 · Cited by 37

Randomized Trial Comparing Nicotinamide and Nicotinamide Plus Cyclosporin in Recent Onset Insulin‐dependent Diabetes (IMDIAB 1)

Pozzilli, P., Visalli, N., Boccuni, M. L., Baroni, M. G., Buzzetti, R., Fioriti, E., Signore, A., Cavallo, M. G., Andreani, D., Lucentini, L., et al. (1994) · Diabetic Medicine · doi:10.1111/j.1464-5491.1994.tb00237.x · Cited by 37

Effects of cytokines and nitric oxide donors on insulin secretion, cyclic GMP and DNA damage: relation to nitric oxide production

Green, I. C., Cunningham, J. M., Delaney, C. A., et al. (1994) · Biochemical Society Transactions · doi:10.1042/bst0220030 · Cited by 37

[40] Mitochondria, nitric oxide, and peroxynitrite

Richter, C., Schweizer, M., & Ghafourifar, P. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)01102-7 · Cited by 36

Histone shuttle driven by the automodification cycle of poly(ADP‐ribose) polymerase

Althaus, F. R., Höfferer, L., Kleczkowska, H. E., Malanga, M., Naegeli, H., Panzeter, P. L., & Realini, C. A. (1993) · Environmental and Molecular Mutagenesis · doi:10.1002/em.2850220417 · Cited by 36

3-AMINOBENZAMIDE, AN INHIBITOR OF POLY (ADP-RIBOSE) SYNTHETASE, IMPROVES HEMODYNAMICS AND PROLONGS SURVIVAL IN A PORCINE MODEL OF HEMORRHAGIC SHOCK

Szabó, A., Hake, P. W., Salzman, A. L., & Szabó, C. (1998) · Shock · doi:10.1097/00024382-199811000-00007 · Cited by 36

Effect of 6(5H)-phenanthridinone, a poly (ADP-ribose)polymerase inhibitor, and ionizing radiation on the growth of cultured lymphoma cells

Weltin, D. (1997) · International Journal of Radiation Biology · doi:10.1080/095530097142843 · Cited by 36

Essential Role of the Mitochondrial Respiratory Chain in Peroxynitrite‐Induced Strand Scission of Genomic DNA

Guidarelli, A., Tommasini, I., Fiorani, M., & Cantoni, O. (2000) · IUBMB Life · doi:10.1080/152165400300001516 · Cited by 35

Hydrogen peroxide-induced motoneuron apoptosis is prevented by poly ADP ribosyl synthetase inhibitors

Hivert, B., Cerruti, C., & Camu, W. (1998) · Neuroreport · doi:10.1097/00001756-199806010-00031 · Cited by 35

Interrelationship of changes in islet nicotine adeninedinucleotide, insulin secretion, and cell viability induced by interleukin-1 beta.

Bolaffi, J. L., Rodd, G. G., Wang, J., et al. (1994) · Endocrinology · doi:10.1210/endo.134.2.7507826 · Cited by 35

Mechanisms of nitric oxide-induced cytotoxicity in normal human hepatocytes

D’Ambrosio, S. M., Gibson‐D'Ambrosio, R. E., Brady, T., Oberyszyn, A. S., & Robertson, F. M. (2001) · Environmental and Molecular Mutagenesis · doi:10.1002/1098-2280(2001)37:1<46::aid-em1005>3.0.co;2-6 · Cited by 35

Inhibition of poly(ADP‐ribose) synthetase (PARS) and protection against peroxynitrite‐induced cytotoxicity by zinc chelation

Virág, L., & Szabó, C. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702332 · Cited by 34

No NO prevents parkinsonism

Snyder, S. H. (1996) · Nature Medicine · doi:10.1038/nm0996-965 · Cited by 34

Involvement of peroxynitrite and hydroxyradical generated from nitric oxide in hypoxia/reoxygenation injury in rat cerebrocortical slices

Oka, M., Hirouchi, M., Itoh, Y., & Ukai, Y. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(99)00197-5 · Cited by 34

The role of poly(ADP-ribosyl)ation in the adaptive response

Kleczkowska, H. E., & Althaus, F. R. (1996) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(96)00123-6 · Cited by 33

Increased DNA strand breaks in mononuclear cells from patients with rheumatoid arthritis.

BHUSATE, L. L., Herbert, K. E., Scott, D. L., et al. (1992) · Annals of the Rheumatic Diseases · doi:10.1136/ard.51.1.8 · Cited by 32

Biochemical mechanism of irreversible cell injury caused by free radical-initiated reactions

Bhatnagar, A. (1994) · Molecular and Cellular Biochemistry · doi:10.1007/bf00926034 · Cited by 32

Erythroid differentiation and poly(ADP-ribose) synthesis in Friend leukemia cells.

Morioka, K., Tanaka, K., Nokuo, T., Ishizawa, M., & Ono, T. (1979) · PubMed · Cited by 30

Early Postischemic Dantrolene-Induced Amelioration of Poly(ADP-Ribose) Polymerase-Related Bioenergetic Failure in Neonatal Rat Brain Slices

Tasker, R. C., Sahota, S. K., Cotter, F. E., & Williams, S. R. (1998) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199812000-00009 · Cited by 30

Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy

Rosenthal, D. S. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.3.841 · Cited by 30

Combined effects of adenovirus-mediated wild-type p53 transduction, temozolomide and poly (ADP-ribose) polymerase inhibitor in mismatch repair deficient and non-proliferating tumor cells

Tentori, L., Portarena, I., Bonmassar, E., & Graziani, G. (2001) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400832 · Cited by 30

Diastolic dysfunction is not related to changes in glycaemic control over 6 months in type 2 (non-insulin-dependent) diabetes mellitus

Gough, S. C. L., Smyllie, J. H., Barker, M., Berkin, K. E., Rice, P. J., & Grant, P. J. (1995) · Acta Diabetologica · doi:10.1007/bf00569568 · Cited by 30

Taurine and Niacin Offer a Novel Therapeutic Modality in Prevention of Chemically-Induced Pulmonary Fibrosis in Hamsters

Giri, S. N., & Wang, Q. (1992) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-3436-5_39 · Cited by 29

DNA-binding activity of the N-terminal cleavage product of poly(ADP-ribose) polymerase is required for UV mediated apoptosis

Kim, J. W., Won, J., Sohn, S., & Joe, C. O. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.6.955 · Cited by 29

Long-term effects of nicotinamide-induced inhibition of poly(adenosine diphosphate-ribose) polymerase activity in rat pancreatic islets exposed to interleukin-1 beta

Reddy, S., Salari-Lak, N., & Sandler, S. (1995) · Endocrinology · doi:10.1210/en.136.5.1907 · Cited by 29

H2O2-Induced Cell Death in Human Glioma Cells: Role of Lipid Peroxidation and PARP Activation

Lee, Y. W., Ha, M. S., & Kim, Y. K. (2001) · Neurochemical Research · doi:10.1023/a:1010993428770 · Cited by 28

Poly (ADP-ribose) Polymerase Is Involved in PMA-induced Activation of HIV-1 in U1 Cells by Modulating the LTR Function

Kameoka, M., Tanaka, Y., Ota, K., Itaya, A., & Yoshihara, K. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1146 · Cited by 28

Autoantibodies to Poly(ADP-Ribose)Polymerase in Autoimmune Diseases

Negri, C., Scovassi, A. I., Cerino, A., Negroni, M., Borzı̀, R. M., Melicòni, R., Facchini, A., Montecucco, C., & Ricotti, G. C. B. A. (1990) · Autoimmunity · doi:10.3109/08916939009041040 · Cited by 28

Inhibition of the induction of collagenase by interleukin-1 ? in cultured rabbit synovial fibroblasts after treatment with the poly(ADP-ribose)-polymerase inhibitor 3-aminobenzamide

Ehrlich, W., Huser, H., & Kr�ger, H. (1995) · Rheumatology International · doi:10.1007/bf00301776 · Cited by 27

Nicotinamide: Potential for the Prevention of Type 1 Diabetes?

Gale, E. A. M. (1996) · Hormone and Metabolic Research · doi:10.1055/s-2007-979816 · Cited by 27

POLY(ADP-RIBOSE) SYNTHETASE INHIBITION REDUCES BACTERIAL TRANSLOCATION IN RATS AFTER ENDOTOXIN CHALLENGE

Taner, A. S., Cinel, İ., Özer, İ., et al. (2001) · Shock · doi:10.1097/00024382-200116020-00013 · Cited by 25

Transcriptional Regulation of the Rat Poly(ADP‐ribose) Polymerase Gene by Sp1

Bergeron, M., Leclerc, S., Laniel, M., Poirier, G. G., & Guérin, S. L. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.0342a.x · Cited by 24

Inhibition of HIV-1 IIIb replication in AA-2 and NT-2 cells in culture by two ligands of poly (ADP-ribose) polymerase: 6-amino-1,2-benzopyrone and 5-iodo-6-amino-1,2-benzopyrone

Cole, G. A., Bauer, G., Kirsten, E., Mendeleyev, J., Bauer, P. I., Büki, K. G., Hakam, A., & Kun, E. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)81093-9 · Cited by 24

Nicotinamide and 3‐aminobenzamide inhibit recombinant human interferon‐γ‐induced HLA‐DR antigen expression, but not HLA‐A, B, C antigen expression, on cultured human thyroid cells

Hiromatsu, Y., Sato, M., Yamada, K., & Nonaka, K. (1992) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1992.tb02907.x · Cited by 23

Unexpected Sensitivity of Nonobese Diabetic Mice With a Disrupted Poly(ADP-Ribose) Polymerase-1 Gene to Streptozotocin-Induced and Spontaneous Diabetes

González, C., Murcia, J. M., Janiak, P., Bidouard, J., Beauvais, C., Karray, S., Garchon, H., & Lévi‐Strauss, M. (2002) · Diabetes · doi:10.2337/diabetes.51.5.1470 · Cited by 23

Early nicotinamide treatment in the NOD mouse: effects on diabetes and insulitis suppression and autoantibody levels.

Reddy, S., Bibby, N. J., & Elliott, R. B. (1990) · PubMed · Cited by 23

Impairment of the neuronal dopamine transporter activity in MPP+-treated rat was not prevented by treatments with nitric oxide synthase or poly(ADP-ribose) polymerase inhibitors

Barc, S., Page, G., Barrier, L., Piriou, A., & Fauconneau, B. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02273-x · Cited by 21

Neuroprotective effects of poly (ADP-ribose) polymerase inhibitors in transient focal cerebral ischemia of rats.

Sun, A., & Cheng, J. (1998) · PubMed · Cited by 21

Apoptosis in the Dorsal Lateral Geniculate Nucleus after Monocular Deprivation Involves Glutamate Signaling, NO Production, and PARP Activation

Nucci, C., Piccirilli, S., Rodinò, P., Nisticò, R., Grandinetti, M., Cerulli, L., Leist, M., Nicotera, P., & Bagetta, G. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3811 · Cited by 20

Poly(ADP-ribose) Polymerase Activation and Cell Injury in the Course of Rat Heart Heterotopic Transplantation

Fiorillo, C., Pace, S., Ponziani, V., Nediani, C., Perna, A., Liguori, P., Cecchi, C., Nassi, N., Donzelli, G., Formigli, L., et al. (2002) · Free radical research · doi:10.1080/10715760210168 · Cited by 20

DNA Strand Breaks and Poly(ADP-ribose) Synthetase Activation in Pancreatic Islets—A New Aspect to Development of Insulin-dependent Diabetes and Pancreatic B-cell Tumors

Okamoto, H., & Yamamoto, H. (2020) · CRC Press eBooks · doi:10.1201/9781003079491-32 · Cited by 20

Effects of Parp Inhibition on Drug and FAS-Induced Apoptosis in Leukaemic Cells

Richardson, D. S., Allen, P. D., Kelsey, S. M., & Newland, A. C. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4811-9_29 · Cited by 19

Traumatic Brain Injury in Mice Deficient in Poly-ADP(Ribose) Polymerase: A Preliminary Report

Whalen, M. J., Clark, R. S. B., Dixon, C. E., Robichaud, P., Marion, D. W., Vagni, V., Graham, S. H., Virág, L., Haskó, G., Stachlewitz, R. F., et al. (2000) · Springer eBooks · doi:10.1007/978-3-7091-6346-7_12 · Cited by 19

Protective effect of nicotinamide against nephropathy in diabetic rats.

Wahlberg, G., Carlson, L. A., Wasserman, J., & Ljungqvist, A. (1985) · PubMed · Cited by 19

The influence of antagonists of poly(adp-ribose) metabolism on acetaminophen hepatotoxicity

Kröger, H., Ehrlich, W., Klewer, M., Grätz, R., Dietrich, A., & Miesel, R. (1996) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(94)00293-2 · Cited by 18

Induction of islet B-cell regeneration in partially pancreatectomized rats by poly(ADP-ribose) synthetase inhibitors

Yonemura, Y., Takashima, T., Matsuda, Y., Miwa, K., Sugiyama, K., Miyazaki, I., Yamamoto, H., & Okamoto, H. (1988) · International Journal of Pancreatology · doi:10.1007/bf02788225 · Cited by 17

Protection from nicotinamide inhibition of interleukin-1 beta-induced RIN cell nitric oxide formation is associated with induction of MnSOD enzyme activity

Andrade, J., Conde, M., Ramı́rez, R., Monteseirı́n, J., Condé, J., Sobrino, F., & Bedoya, F. J. (1996) · Endocrinology · doi:10.1210/endo.137.11.8895350 · Cited by 17

Contribution of ATP to oxidative stress-induced changes in action potential of isolated cardiac myocytes

Bhatnagar, A. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.272.4.h1598 · Cited by 17

Poly(ADP-ribosyl)ation as a fail-safe, transcription-independent, suicide mechanism in acutely DNA-damaged cells: A hypothesis

Nagele, A. (1995) · Radiation and Environmental Biophysics · doi:10.1007/bf01209751 · Cited by 16

Effects of poly (ADP-ribose) synthetase inhibitor on b-cells of a canine pancreas after massive pancreatectomy

Sugiyama, K., Yonemura, Y., & Okamoto, H. (1991) · International Journal of Pancreatology · doi:10.1007/bf02930227 · Cited by 15

Disruption of Poly(ADP-ribose) Polymerase (PARP) Protects Against Stress-Evoked Immunocompromise

Drazen, D. L., Bilu, D., Edwards, N., & Nelson, R. J. (2001) · Molecular Medicine · doi:10.1007/bf03401966 · Cited by 15

Poly(Adenosine Diphosphate-Ribose) Synthetase Inhibitor 3-Aminobenzamide Alleviates Cochlear Dysfunction Induced by Transient Ischemia

Ito, Z., Serizawa, F., Tabuchi, K., et al. (2001) · Annals of Otology Rhinology & Laryngology · doi:10.1177/000348940111000205 · Cited by 11

Increased poly(ADP-ribose)polymerase activity in cells infected by human immunodeficiency virus type-1.

Furlini, G., Re, M. C., & Plaça, M. L. (1991) · PubMed · Cited by 10

Benzamide, a Poly(ADP‐Ribose) Polymerase Inhibitor, Is Neuroprotective against Soman‐Induced Seizure‐Related Brain Damagea

Meier, H. L., Ballough, G. P. H., Forster, J. S., & Filbert, M. G. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb08010.x · Cited by 9

Exacerbation of acetaminophen hepatotoxicity by thalidomide and protection by nicotinic acid amide

Kröger, H., Klewer, M., Grätz, R., Dietrich, A., Ockenfels, H., & Miesel, R. (1995) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(95)00019-w · Cited by 6

3-Aminobenzamide, a poly (ADP-ribose) synthetase inhibitor, attenuates the acute inflammatory responses and brain injury in experimental Escherichiacolimeningitis in the newborn piglet

Park, W. S., Chang, Y. S., & Lee, M. (2001) · Neurological Research · doi:10.1179/016164101101198640 · Cited by 3

Increased activity of surviving locus ceruleus neurons in Alzheimer's disease

Moser (1999) · Pure Amsterdam UMC · doi:10.1002/1531-8249(199901)45:1

Nitric Oxide and Peroxynitrite in Health and Disease

Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390

Reactive oxygen species, cellular redox systems, and apoptosis

Circu, M. L., & Aw, T. Y. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.022 · Cited by 3,340

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

Galluzzi, L., Vitale, I., Abrams, J. M., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., Dawson, T. M., Dawson, V. L., El-Deiry, W. S., Fulda, S., et al. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2011.96 · Cited by 2,421

Peroxynitrite: biochemistry, pathophysiology and development of therapeutics

Szabó, C., Ischiropoulos, H., & Radi, R. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2222 · Cited by 2,134

NAD + /NADH and NADP + /NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences

Ying, W. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1672 · Cited by 1,494