The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors

Harrison's Principles of Internal Medicine.

(1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-499_2 · Cited by 12,514

Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide

Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277

Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress

Cai, H., & Harrison, D. G. (2000) · Circulation Research · doi:10.1161/01.res.87.10.840 · Cited by 3,839

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

Lazebnik, Y. A., Kaufmann, S. H., Desnoyers, S., Poirier, G. G., & Earnshaw, W. C. (1994) · Nature · doi:10.1038/371346a0 · Cited by 2,562

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

Tewari, M., Quan, L. T., O'Rourke, K., Desnoyers, S., Zeng, Z., Beidler, D. R., Poirier, G. G., Salvesen, G. S., & Dixit, V. M. (1995) · Cell · doi:10.1016/0092-8674(95)90541-3 · Cited by 2,367

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

Baekkeskov, S., Aanstoot, H.-J., Christgai, S., Reetz, A., Solimena, M., Cascalho, M., Folli, F., Richter-Olesen, H., & Camilli, P.-D. (1990) · Nature · doi:10.1038/347151a0 · Cited by 1,964

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

Bonfoco, E., Krainc, D., Ankarcrona, M., Nicotera, P., & Lipton, S. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7162 · Cited by 1,958

Oxidative Stress and Diabetic Vascular Complications

Giugliano, D., Ceriello, A., & Paolisso, G. (1996) · Diabetes Care · doi:10.2337/diacare.19.3.257 · Cited by 1,930

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

Kaufmann, S. H., Desnoyers, S., Ottaviano, Y. L., Davidson, N. E., & Poirier, G. G. (1993) · PubMed · Cited by 1,889

Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis

Leist, M., Single, B., Castoldi, A. F., Kühnle, S., & Nicotera, P. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.8.1481 · Cited by 1,871

Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor

Yu, S.-W., Wang, H., Poitras, M. F., Coombs, C., Bowers, W. J., Federoff, H. J., Poirier, G. G., Dawson, T. M., & Dawson, V. L. (2002) · Science · doi:10.1126/science.1072221 · Cited by 1,826

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

d'AMOURS, D., DESNOYERS, S., d'SILVA, I., & POIRIER, G. G. (1999) · Biochemical Journal · doi:10.1042/bj3420249 · Cited by 1,815

Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

Blum, D., Torch, S., Lambeng, N., Nissou, M.-F., Benabid, A.-L., Sadoul, R., & Verna, J.-M. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00003-x · Cited by 1,246

Endothelial dysfunction in diabetes

De Vriese, A. S., Verbeuren, T. J., Van de Voorde, J., Lameire, N. H., & Vanhoutte, P. M. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703393 · Cited by 1,165

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

Zhang, J., Dawson, V. L., Dawson, T. M., & Snyder, S. H. (1994) · Science · doi:10.1126/science.8080500 · Cited by 1,118

Peroxynitrite formation from macrophage-derived nitric oxide

Ischiropoulos, H., Zhu, L., & Beckman, J. S. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90433-w · Cited by 1,099

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

de Murcia, J. M., Niedergang, C., Trucco, C., Ricoul, M., Dutrillaux, B., Mark, M., Oliver, F. J., Masson, M., Dierich, A., LeMeur, M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7303 · Cited by 1,056

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

Liberatore, G. T., Jackson-Lewis, V., Vukosavic, S., Mandir, A. S., Vila, M., McAuliffe, W. G., Dawson, V. L., Dawson, T. M., & Przedborski, S. (1999) · Nature Medicine · doi:10.1038/70978 · Cited by 1,046 · cited 1×

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

Eliasson, M. J. L., Sampei, K., Mandir, A. S., Hurn, P. D., Traystman, R. J., Bao, J., Pieper, A., Wang, Z.-Q., Dawson, T. M., Snyder, S. H., et al. (1997) · Nature Medicine · doi:10.1038/nm1097-1089 · Cited by 1,018

Tankyrase, a Poly(ADP-Ribose) Polymerase at Human Telomeres

Smith, S., Giriat, I., Schmitt, A., & de Lange, T. (1998) · Science · doi:10.1126/science.282.5393.1484 · Cited by 1,012

XRCC1 Is Specifically Associated with Poly(ADP-Ribose) Polymerase and Negatively Regulates Its Activity following DNA Damage

Masson, M., Niedergang, C., Schreiber, V., Muller, S., Menissier-de Murcia, J., & de Murcia, G. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.6.3563 · Cited by 910

Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

Ha, H. C., & Snyder, S. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13978 · Cited by 907

Poly(ADP-ribose) polymerase: a molecular nick-sensor

de Murcia, G., & de Murcia, J. M. (1994) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(94)90280-1 · Cited by 797

Homocysteine Elicits a DNA Damage Response in Neurons That Promotes Apoptosis and Hypersensitivity to Excitotoxicity

Kruman, I. I., Culmsee, C., Chan, S. L., Kruman, Y., Guo, Z., Penix, L., & Mattson, M. P. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-18-06920.2000 · Cited by 784

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.

Wang, Z. Q., Auer, B., Stingl, L., Berghammer, H., Haidacher, D., Schweiger, M., & Wagner, E. F. (1995) · Genes & Development · doi:10.1101/gad.9.5.509 · Cited by 774

PARP-2, A Novel Mammalian DNA Damage-dependent Poly(ADP-ribose) Polymerase

Amé, J.-C., Rolli, V., Schreiber, V., Niedergang, C., Apiou, F., Decker, P., Muller, S., Höger, T., Murcia, J. M.-D., & de Murcia, G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.25.17860 · Cited by 745

DRUGS PRODUCING DIABETES THROUGH DAMAGE OF THE INSULIN SECRETING CELLS

RERUP, C. C. (1970) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06885-1 · Cited by 728

Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases.

Farrell, A. J., Blake, D. R., Palmer, R. M., & Moncada, S. (1992) · Annals of the Rheumatic Diseases · doi:10.1136/ard.51.11.1219 · Cited by 716

Evidence for nitric oxide‐mediated oxidative damage in chronic inflammation Nitrotyrosine in serum and synovial fluid from rheumatoid patients

Kaur, H., & Halliwell, B. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00722-5 · Cited by 706

Mechanisms of cell injury by activated oxygen species.

Farber, J. L. (1994) · Environmental Health Perspectives · doi:10.1289/ehp.94102s1017 · Cited by 701

Inhibition of Mitochondrial Electron Transport by Peroxynitrite

Radi, R., Rodriguez, M., Castro, L., & Telleri, R. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1013 · Cited by 693

Role of poly(ADP-ribose) synthetase in inflammation and ischaemia–reperfusion

Szabó, C., & Dawson, V. L. (1998) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(98)01193-6 · Cited by 685

Suppression of arthritis by an inhibitor of nitric oxide synthase.

McCartney-Francis, N., Allen, J. B., Mizel, D. E., Albina, J. E., Xie, Q. W., Nathan, C. F., & Wahl, S. M. (1993) · The Journal of experimental medicine · doi:10.1084/jem.178.2.749 · Cited by 645

Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity.

Przedborski, S., Jackson-Lewis, V, Yokoyama, R., Shibata, T., Dawson, V. L., & Dawson, T. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4565 · Cited by 624

Ischemic Brain Injury is Mediated by the Activation of Poly(ADP-Ribose)Polymerase

Endres, M., Wang, Z.-Q., Namura, S., Waeber, C., & Moskowitz, M. A. (1997) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199711000-00002 · Cited by 622

DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite.

Szabó, C., Zingarelli, B., O'Connor, M., & Salzman, A. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.5.1753 · Cited by 622

Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks

Lindahl, T., Satoh, M. S., Poirier, G. G., & Klungland, A. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89089-1 · Cited by 611

Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation

Garcia Soriano, F., Virág, L., Jagtap, P., Szabó, É., Mabley, J. G., Liaudet, L., Marton, A., Hoyt, D. G., Murthy, K. G. K., Salzman, A. L., et al. (2001) · Nature Medicine · doi:10.1038/83241 · Cited by 603

Resistance to endotoxic shock as a consequence of defective NF-kappa B activation in poly (ADP-ribose) polymerase-1 deficient mice

Oliver, F. J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.16.4446 · Cited by 582

Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis

Hooper, D. C., Spitsin, S., Kean, R. B., Champion, J. M., Dickson, G. M., Chaudhry, I., & Koprowski, H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.675 · Cited by 569

PARP is important for genomic stability but dispensable in apoptosis

Wang, Z.-Q., Stingl, L., Morrison, C., Jantsch, M., Los, M., Schulze-Osthoff, K., & Wagner, E. F. (1997) · Genes & Development · doi:10.1101/gad.11.18.2347 · Cited by 557

Poly(ADP-ribose) Binds to Specific Domains in DNA Damage Checkpoint Proteins

Pleschke, J. M., Kleczkowska, H. E., Strohm, M., & Althaus, F. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006520200 · Cited by 541

Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?

Shall, S., & de Murcia, G. (2000) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(00)00016-1 · Cited by 534

Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution.

Lazebnik, Y. A., Takahashi, A., Moir, R. D., Goldman, R. D., Poirier, G. G., Kaufmann, S. H., & Earnshaw, W. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9042 · Cited by 512

Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.

Schraufstatter, I. U., Hinshaw, D. B., Hyslop, P. A., Spragg, R. G., & Cochrane, C. G. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112436 · Cited by 512

Tumor Cell Death Induced by Topoisomerase-Targeting Drugs

Li, T.-K., & Liu, L. F. (2001) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.53 · Cited by 508

Base Excision Repair Is Impaired in Mammalian Cells Lacking Poly(ADP-ribose) Polymerase-1

Dantzer, F., de la Rubia, G., Ménissier-de Murcia, J., Hostomsky, Z., de Murcia, G., & Schreiber, V. (2000) · Biochemistry · doi:10.1021/bi0003442 · Cited by 505

THE PATHOPHYSIOLOGICAL ROLE OF PEROXYNITRITE IN SHOCK, INFLAMMATION, AND ISCHEMIA-REPERFUSION INJURY

Szabó, C. (1996) · Shock · doi:10.1097/00024382-199608000-00001 · Cited by 481

Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase.

Banasik, M., Komura, H., Shimoyama, M., & Ueda, K. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45983-2 · Cited by 476

In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases.

Koprowski, H., Zheng, Y. M., Heber-Katz, E., Fraser, N., Rorke, L., Fu, Z. F., Hanlon, C., & Dietzschold, B. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.7.3024 · Cited by 474

Control of apoptosis by the cellular ATP level

Richter, C., Schweizer, M., Cossarizza, A., & Franceschi, C. (1996) · FEBS Letters · doi:10.1016/0014-5793(95)01431-4 · Cited by 471

A novel gene activated in regenerating islets.

Terazono, K., Yamamoto, H., Takasawa, S., Shiga, K., Yonemura, Y., Tochino, Y., & Okamoto, H. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69176-8 · Cited by 469

Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase.

Schraufstatter, I. U., Hyslop, P. A., Hinshaw, D. B., Spragg, R. G., Sklar, L. A., & Cochrane, C. G. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.13.4908 · Cited by 459

Cleavage of Automodified Poly(ADP-ribose) Polymerase during Apoptosis

Germain, M., Affar, E. B., D'Amours, D., Dixit, V. M., Salvesen, G. S., & Poirier, G. G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28379 · Cited by 444

The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine.

Weinberg, J. B., Granger, D. L., Pisetsky, D. S., Seldin, M. F., Misukonis, M. A., Mason, S. N., Pippen, A. M., Ruiz, P., Wood, E. R., & Gilkeson, G. S. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.2.651 · Cited by 435

Tankyrase promotes telomere elongation in human cells

Smith, S., & de Lange, T. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00752-1 · Cited by 418

Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice

Schulz, J. B., Matthews, R. T., Muqit, M. M. K., Browne, S. E., & Beal, M. F. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64020936.x · Cited by 417

Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Ara, J., Przedborski, S., Naini, A. B., Jackson-Lewis, V., Trifiletti, R. R., Horwitz, J., & Ischiropoulos, H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7659 · Cited by 414

Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans.

Corbett, J. A., Sweetland, M. A., Wang, J. L., Lancaster, J. R., & McDaniel, M. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1731 · Cited by 411

Nitric Oxide Activates Metalloprotease Enzymes in Articular Cartilage

Murrell, G. A. C., Jang, D., & Williams, R. J. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1003 · Cited by 406

The 193-Kd Vault Protein, Vparp, Is a Novel Poly(Adp-Ribose) Polymerase

Kickhoefer, V. A., Siva, A. C., Kedersha, N. L., Inman, E. M., Ruland, C., Streuli, M., & Rome, L. H. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.5.917 · Cited by 405

Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood–CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis

Hooper, D. C., Scott, G. S., Zborek, A., Mikheeva, T., Kean, R. B., Koprowski, H., & Spitsin, S. V. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.5.691 · Cited by 390

Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides.

Sakurai, H., Kohsaka, H., Liu, M. F., Higashiyama, H., Hirata, Y., Kanno, K., Saito, I., & Miyasaka, N. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118292 · Cited by 387

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

Mandir, A. S., Przedborski, S., Jackson-Lewis, V., Wang, Z.-Q., Simbulan-Rosenthal, C. M., Smulson, M. E., Hoffman, B. E., Guastella, D. B., Dawson, V. L., & Dawson, T. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5774 · Cited by 382

Animal Models of Action Tremor

Elble, R. J. (2008) · Movement Disorders · doi:10.1002/mds.870131306 · Cited by 380

Graded ATP depletion can cause necrosis or apoptosis of cultured mouse proximal tubular cells

Lieberthal, W., Menza, S. A., & Levine, J. S. (1998) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1998.274.2.f315 · Cited by 377

Oxidant-induced DNA damage of target cells.

Schraufstätter, I., Hyslop, P. A., Jackson, J. H., & Cochrane, C. G. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113660 · Cited by 373

Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin

Burkart, V., Wang, Z.-Q., Radons, J., Heller, B., Herceg, Z., Stingl, L., Wagner, E. F., & Kolb, H. (1999) · Nature Medicine · doi:10.1038/6535 · Cited by 372

Inhibition of insulin secretion by interleukin‐1β and tumour necrosis factor‐α via an L‐arginine‐dependent nitric oxide generating mechanism

Southern, C., Schulster, D., & Green, I. C. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80502-a · Cited by 362

Intracellular ATP, a switch in the decision between apoptosis and necrosis

Nicotera, P., Leist, M., & Ferrando-May, E. (1998) · Toxicology Letters · doi:10.1016/s0378-4274(98)00298-7 · Cited by 360

Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite.

Szabó, C., Cuzzocrea, S., Zingarelli, B., O'Connor, M., & Salzman, A. L. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119585 · Cited by 354

Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat

Chatterjee, P. K., Cuzzocrea, S., Brown, P. A. J., Zacharowski, K., Stewart, K. N., Mota-Filipe, H., & Thiemermann, C. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00212.x · Cited by 352

DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines

Trucco, C. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.11.2644 · Cited by 348

Apoptotic Cell Death Triggered by Nitric Oxide in Pancreatic β-Cells

Kaneto, H., Fujii, J., Geuk Seo, H., Suzuki, K., Matsuko, T.-A., Masahiro, N., Tatsumi, H., Yamasaki, Y., Kamada, T., & Taniguchi, N. (1995) · Diabetes · doi:10.2337/diab.44.7.733 · Cited by 343

Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.

Gijbels, K., Galardy, R. E., & Steinman, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117578 · Cited by 339

Physiology and pathophysiology of poly(ADP‐ribosyl)ation *

Bürkle, A. (2001) · BioEssays · doi:10.1002/bies.1115 · Cited by 335

Genetic Disruption of Poly (ADP-Ribose) Synthetase Inhibits the Expression of P-Selectin and Intercellular Adhesion Molecule-1 in Myocardial Ischemia/Reperfusion Injury

Zingarelli, B., Salzman, A. L., & Szabó, C. (1998) · Circulation Research · doi:10.1161/01.res.83.1.85 · Cited by 334

Importance of Poly(ADP-Ribose) Glycohydrolase in the Control of Poly(ADP-Ribose) Metabolism

Davidovic, L., Vodenicharov, M., Affar, E. B., & Poirier, G. G. (2001) · Experimental Cell Research · doi:10.1006/excr.2001.5263 · Cited by 326

Peroxynitrite-mediated DNA strand breakage activates poly-adenosine diphosphate ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide

Zingarelli, B., O’Connor, M., Wong, H., Salzman, A. L., & Szabó, C. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.1.350 · Cited by 319

Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose

LIZASOAIN, I., MORO, M. A., KNOWLES, R. G., DARLEY-USMAR, V., & MONCADA, S. (1996) · Biochemical Journal · doi:10.1042/bj3140877 · Cited by 318

Cytokines suppress human islet function irrespective of their effects on nitric oxide generation.

Eizirik, D. L., Sandler, S., Welsh, N., Cetkovic-Cvrlje, M., Nieman, A., Geller, D. A., Pipeleers, D. G., Bendtzen, K., & Hellerström, C. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117188 · Cited by 317

The world according to PARP

Smith, S. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01780-1 · Cited by 314

Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia–reperfusion injury in the heart and skeletal muscle

Thiemermann, C., Bowes, J., Myint, F. P., & Vane, J. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.679 · Cited by 305

Nitric Oxide: A Unique Endogenous Signaling Molecule in Vascular Biology

Ignarro, L. J. (1999) · Bioscience Reports · doi:10.1023/a:1020150124721 · Cited by 304

Poly(ADP-ribose) Polymerase Null Mouse Cells Synthesize ADP-ribose Polymers

Shieh, W. M., Amé, J.-C., Wilson, M. V., Wang, Z.-Q., Koh, D. W., Jacobson, M. K., & Jacobson, E. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.46.30069 · Cited by 303

Endothelium-Derived Relaxing Factor: Discovery, Early Studies, and Identification as Nitric Oxide

Furchgott, R. F. (1999) · Bioscience Reports · doi:10.1023/a:1020537506008 · Cited by 298

Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes

Pieper, A. A., Brat, D. J., Krug, D. K., Watkins, C. C., Gupta, A., Blackshaw, S., Verma, A., Wang, Z.-Q., & Snyder, S. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3059 · Cited by 298

A Role of Poly (ADP-Ribose) Polymerase in NF- B Transcriptional Activation

Hassa, P. O., & Hottiger, M. O. (1999) · Biological Chemistry · doi:10.1515/bc.1999.118 · Cited by 296

Modulation of adjuvant arthritis by endogenous nitric oxide

Ialenti, A., Moncada, S., & Di Rosa, M. (1993) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1993.tb13868.x · Cited by 296

The Enzymatic and DNA Binding Activity of PARP-1 Are Not Required for NF-κB Coactivator Function

Hassa, P. O., Covic, M., Hasan, S., Imhof, R., & Hottiger, M. O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106528200 · Cited by 296

Peroxynitrite induces both vasodilatation and impaired vascular relaxation in the isolated perfused rat heart.

Villa, L. M., Salas, E., Darley-Usmar, V. M., Radomski, M. W., & Moncada, S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12383 · Cited by 291

Resistance-Modifying Agents. 9. Synthesis and Biological Properties of Benzimidazole Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose) Polymerase

White, A. W., Almassy, R., Calvert, A. H., Curtin, N. J., Griffin, R. J., Hostomsky, Z., Maegley, K., Newell, D. R., Srinivasan, S., & Golding, B. T. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm000950v · Cited by 288

Gain-of-function of poly(ADP-ribose) polymerase-1 upon cleavage by apoptotic proteases: implications for apoptosis

D’Amours, D., Sallmann, F. R., Dixit, V. M., & Poirier, G. G. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.20.3771 · Cited by 286

Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes

Masutani, M., Suzuki, H., Kamada, N., Watanabe, M., Ueda, O., Nozaki, T., Jishage, K.-I., Watanabe, T., Sugimoto, T., Nakagama, H., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2301 · Cited by 286

Excitotoxicity and nitric oxide in parkinson's disease pathogenesis

Beal, M. F. (1998) · Annals of Neurology · doi:10.1002/ana.410440716 · Cited by 283

Inhibition of poly (ADP-ribose) Synthetase Attenuates Neutrophil Recruitment and Exerts Antiinflammatory Effects

Szabó, C., Lim, L. H. K., Cuzzocrea, S., Getting, S. J., Zingarelli, B., Flower, R. J., Salzman, A. L., & Perretti, M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.7.1041 · Cited by 283

H2O2 and Tumor Necrosis Factor-α Activate Intercellular Adhesion Molecule 1 (ICAM-1) Gene Transcription through Distinct cis-Regulatory Elements within the ICAM-1 Promoter

Roebuck, K. A., Rahman, A., Lakshminarayanan, V., Janakidevi, K., & Malik, A. B. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.32.18966 · Cited by 282

Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo

Schulz, J., Matthews, R., Jenkins, B., Ferrante, R., Siwek, D., Henshaw, D., Cipolloni, P., Mecocci, P., Kowall, N., & Rosen, B. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-12-08419.1995 · Cited by 281

The Role of Poly(ADP-Ribose) Polymerase Activation in the Development of Myocardial and Endothelial Dysfunction in Diabetes

Pacher, P., Liaudet, L., Soriano, F. G., Mabley, J. G., Szabó, E., & Szabó, C. (2002) · Diabetes · doi:10.2337/diabetes.51.2.514 · Cited by 281

Transient Poly(ADP-ribosyl)ation of Nuclear Proteins and Role of Poly(ADP-ribose) Polymerase in the Early Stages of Apoptosis

Simbulan-Rosenthal, C. M., Rosenthal, D. S., Iyer, S., Boulares, A. H., & Smulson, M. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13703 · Cited by 279

Tankyrase Is a Golgi-associated Mitogen-activated Protein Kinase Substrate That Interacts with IRAP in GLUT4 Vesicles

Chi, N.-W., & Lodish, H. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007635200 · Cited by 277

Inhibition of Mitochondrial ATP Generation by Nitric Oxide Switches Apoptosis to Necrosis

Leist, M., Single, B., Naumann, H., Fava, E., Simon, B., Kühnle, S., & Nicotera, P. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4514 · Cited by 275

Inactivation of the Poly(ADP-ribose) Polymerase Gene Affects Oxygen Radical and Nitric Oxide Toxicity in Islet Cells

Heller, B., Wang, Z.-Q., Wagner, E. F., Radons, J., Bürkle, A., Fehsel, K., Burkart, V., & Kolb, H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.19.11176 · Cited by 266

Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease

Cassarino, D. S., Fall, C. P., Swerdlow, R. H., Smith, T. S., Halvorsen, E. M., Miller, S. W., Parks, J. P., Parker, W. D., & Bennett, J. P. (1997) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(97)00070-7 · Cited by 265

Studies of streptozotocin-induced insulitis and diabetes.

Rossini, A. A., Like, A. A., Chick, W. L., Appel, M. C., & Cahill, G. F. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.6.2485 · Cited by 263

Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase

Szabó, C., Virág, L., Cuzzocrea, S., Scott, G. S., Hake, P., O’Connor, M. P., Zingarelli, B., Salzman, A., & Kun, E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3867 · Cited by 262

Nitric oxide as a potential pathological mechanism in demyelination: Its differential effects on primary glial cellsin vitro

Mitrovic, B., Ignarro, L. J., Montestruque, S., Smoll, A., & Merrill, J. E. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90435-9 · Cited by 259

Mouse models of insulin dependent diabetes: Low‐dose streptozocin‐induced diabetes and nonobese diabetic (NOD) mice

Kolb, H. (1987) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610030308 · Cited by 259

Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability

Fagagna, F. D. D., Hande, M. P., Tong, W.-M., Lansdorp, P. M., Wang, Z.-Q., & Jackson, S. P. (1999) · Nature Genetics · doi:10.1038/12680 · Cited by 255

Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease

Love, S., Barber, R., & Wilcock, G. K. (1999) · Brain · doi:10.1093/brain/122.2.247 · Cited by 254

Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis.

Uchigata, Y., Yamamoto, H., Kawamura, A., & Okamoto, H. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)65108-0 · Cited by 249

Poly(ADP-Ribose) Synthetase Activation Mediates Mitochondrial Injury During Oxidant-Induced Cell Death

Virág, L., Salzman, A. L., & Szabó, C. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.7.3753 · Cited by 248

Role of Poly-ADP Ribosyltransferase Activation in the Vascular Contractile and Energetic Failure Elicited by Exogenous and Endogenous Nitric Oxide and Peroxynitrite

Szabó, C., Zingarelli, B., & Salzman, A. L. (1996) · Circulation Research · doi:10.1161/01.res.78.6.1051 · Cited by 247

Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.

Molinete, M., Vermeulen, W., Bürkle, A., Ménissier-de Murcia, J., Küpper, J. H., Hoeijmakers, J. H., & de Murcia, G. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05859.x · Cited by 244

Homocysteine and cardiovascular disease:

Mangoni, A. A., & Jackson, S. H. D. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01021-5 · Cited by 242

Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke

Abdelkarim, G., Gertz, K., Harms, C., Katchanov, J., Dirnagl, U., Szabo, C., & Endres, M. (2001) · International Journal of Molecular Medicine · doi:10.3892/ijmm.7.3.255 · Cited by 241

Diabetic Cardiomyopathy: A unique entity or a complication of coronary artery disease?

Bell, D. S. H. (1995) · Diabetes Care · doi:10.2337/diacare.18.5.708 · Cited by 235

Activated neutrophils induce prolonged DNA damage in neighboring cells

Shacter, E., Beecham, E. J., Covey, J. M., Kohn, K. W., & Potter, M. (1988) · Carcinogenesis · doi:10.1093/carcin/9.12.2297 · Cited by 235

Failure of Poly(ADP-Ribose) Polymerase Cleavage by Caspases Leads to Induction of Necrosis and Enhanced Apoptosis

Herceg, Z., & Wang, Z.-Q. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.5124 · Cited by 233

Preventive and Therapeutic Effects of Large-Dose Nicotinamide Injections on Diabetes Associated with Insulitis: An Observation in Nonobese Diabetic (NOD) Mice

Yamada, K., Nonaka, K., Hanafusa, T., Miyazaki, A., Toyoshima, H., & Tarui, S. (1982) · Diabetes · doi:10.2337/diab.31.9.749 · Cited by 230

Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase

Zingarelli, B. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00137-5 · Cited by 224

Poly(ADP-ribose) Binds to Specific Domains of p53 and Alters Its DNA Binding Functions

Malanga, M., Pleschke, J. M., Kleczkowska, H. E., & Althaus, F. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.19.11839 · Cited by 220

TANK2, a New TRF1-associated Poly(ADP-ribose) Polymerase, Causes Rapid Induction of Cell Death upon Overexpression

Kaminker, P. G., Kim, S.-H., Taylor, R. D., Zebarjadian, Y., Funk, W. D., Morin, G. B., Yaswen, P., & Campisi, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105968200 · Cited by 218

The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock

Zingarelli, B., Day, B. J., Crapo, J. D., Salzman, A. L., & Szabó, C. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0700872 · Cited by 217

NMDA But Not Non-NMDA Excitotoxicity is Mediated by Poly(ADP-Ribose) Polymerase

Mandir, A. S., Poitras, M. F., Berliner, A. R., Herring, W. J., Guastella, D. B., Feldman, A., Poirier, G. G., Wang, Z.-Q., Dawson, T. M., & Dawson, V. L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-21-08005.2000 · Cited by 213

Isolation and Characterization of the cDNA Encoding Bovine Poly(ADP-ribose) Glycohydrolase

Lin, W., Amé, J.-C., Aboul-Ela, N., Jacobson, E. L., & Jacobson, M. K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.18.11895 · Cited by 211

Differential Regulation and ATP Requirement for Caspase-8 and Caspase-3 Activation during CD95- and Anticancer Drug–induced Apoptosis

Ferrari, D., Stepczynska, A., Los, M., Wesselborg, S., & Schulze-Osthoff, K. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.5.979 · Cited by 211

Purification and Properties of a Glycohydrolase from Calf Thymus Splitting Ribose-Ribose Linkages of Poly(Adenosine Diphosphate Ribose)

Miwa, M., Tanaka, M., Matsushima, T., & Sugimura, T. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42597-0 · Cited by 209

Peroxynitrite‐induced thymocyte apoptosis: the role of caspases and poly (ADP‐ribose) synthetase (PARS) activation

VIRÁG, L., SCOTT, G. S., CUZZOCREA, S., MARMER, D., SALZMAN, A. L., & SZABÓ, C. (1998) · Immunology · doi:10.1046/j.1365-2567.1998.00534.x · Cited by 209

Structure and function of poly(ADP-ribose) polymerase

de Murcia, G., Schreiber, V., Molinete, M., Saulier, B., Poch, O., Masson, M., Niedergang, C., & de Murcia, J. M. (1994) · Molecular and Cellular Biochemistry · doi:10.1007/bf00928438 · Cited by 206

Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines

Delaney, C. A., Wang, L. Z., Kyle, S., White, A. W., Calvert, A. H., Curtin, N. J., Durkacz, B. W., Hostomský, Z., & Newell, D. R. (2000) · PubMed · doi:10.25405/ncl.34597155 · Cited by 205

N‐Monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats

Stefanovic‐Racic, M., Meyers, K., Meschter, C., Coffey, J. W., Hoffman, R. A., & Evans, C. H. (1994) · Arthritis & Rheumatism · doi:10.1002/art.1780370712 · Cited by 205

A dominant-negative mutant of human poly(ADP-ribose) polymerase affects cell recovery, apoptosis, and sister chromatid exchange following DNA damage.

Schreiber, V, Hunting, D., Trucco, C., Gowans, B., Grunwald, D., De Murcia, G., & De Murcia, J. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.11.4753 · Cited by 203

Modulation of chromatin superstructure induced by poly(ADP-ribose) synthesis and degradation.

de Murcia, G., Huletsky, A., Lamarre, D., Gaudreau, A., Pouyet, J., Daune, M., & Poirier, G. G. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)62715-8 · Cited by 201

Activation of Poly(ADP-Ribose) Polymerase-1 Is a Central Mechanism of Lipopolysaccharide-Induced Acute Lung Inflammation

LIAUDET, L., PACHER, P., MABLEY, J. G., VIRÁG, L., SORIANO, F. G., HASKÓ, G., & SZABÓ, C. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.3.2106050 · Cited by 201

A monoclonal antibody to α4 integrin suppresses and reverses active experimental allergic encephalomyelitis

Kent, S. J., Karlik, S. J., Cannon, C., Hines, D. K., Yednock, T. A., Fritz, L. C., & Horner, H. C. (1995) · Journal of Neuroimmunology · doi:10.1016/0165-5728(94)00165-k · Cited by 201

Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death

Ying, W., Sevigny, M. B., Chen, Y., & Swanson, R. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211202598 · Cited by 198

The Deutsche Nicotinamide Intervention Study: an attempt to prevent type 1 diabetes. DENIS Group.

Lampeter, E. F., Klinghammer, A., Scherbaum, W. A., Heinze, E., Haastert, B., Giani, G., & Kolb, H. (1998) · Diabetes · doi:10.2337/diabetes.47.6.980 · Cited by 196

Dopamine D2‐type agonists protect mesencephalic neurons from glutamate neurotoxicity: Mechanisms of neuroprotective treatment against oxidative stress

Sawada, H., Ibi, M., Kihara, T., Urushitani, M., Akaike, A., Kimura, J., & Shimohama, S. (1998) · Annals of Neurology · doi:10.1002/ana.410440117 · Cited by 193

Oxidative post‐translational modifications of α‐synuclein in the 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) mouse model of Parkinson's disease

Przedborski, S., Chen, Q., Vila, M., Giasson, B. I., Djaldatti, R., Vukosavic, S., Souza, J. M., Jackson‐Lewis, V., Lee, V. M. ‐., & Ischiropoulos, H. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00174.x · Cited by 190

Mitochondrial Creatine Kinase Is a Prime Target of Peroxynitrite-induced Modification and Inactivation

Stachowiak, O., Dolder, M., Wallimann, T., & Richter, C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.27.16694 · Cited by 190

Rapid Reversal of the Diabetic Endothelial Dysfunction by Pharmacological Inhibition of Poly(ADP-Ribose) Polymerase

Soriano, F. G., Pacher, P., Mabley, J., Liaudet, L., & Szabó, C. (2001) · Circulation Research · doi:10.1161/hh2001.097797 · Cited by 190

Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose)polymerase

Liaudet, L., Soriano, F. G., Szabó, É., Virág, L., Mabley, J. G., Salzman, A. L., & Szabó, C. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.170226797 · Cited by 190

The use of nicotinamide to modify the toxicity of streptozotocin diabetes without loss of antitumor activity.

Schein, P. S., Cooney, D. A., & Vernon, M. L. (1967) · PubMed · Cited by 189

Nitric oxide, superoxide and peroxynitrite: Putative mediators of NMDA-induced cell death in cerebellar granule cells

Lafon-Cazal, M., Culcasi, M., Gaven, F., Pietri, S., & Bockaert, J. (1993) · Neuropharmacology · doi:10.1016/0028-3908(93)90020-4 · Cited by 189

Nitric oxide availability in diabetes mellitus

Honing, M. L. H., Morrison, P. J., Banga, J. D., Stroes, E. S. G., & Rabelink, T. J. (1998) · Diabetes / Metabolism Reviews · doi:10.1002/(sici)1099-0895(1998090)14:3<241::aid-dmr216>3.0.co;2-r · Cited by 189

Activation of Poly(ADP-Ribose) Polymerase Contributes to Development of Doxorubicin-Induced Heart Failure

Pacher, P., Liaudet, L., Bai, P., Virag, L., Mabley, J. G., Haskó, G., & Szabó, C. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.300.3.862 · Cited by 188

Islet Cell DNA Is a Target of Inflammatory Attack by Nitric Oxide

Fehsel, K., Jalowy, A., Qi, S., Burkart, V., Hartmann, B., & Kolb, H. (1993) · Diabetes · doi:10.2337/diab.42.3.496 · Cited by 188

Nitric Oxide Toxicity in Islet Cells Involves Poly(ADP-Ribose) Polymerase Activation and Concomitant NAD+ Depletion

Radons, J., Heller, B., Burkle, A., Hartmann, B., Rodriguez, M. L., Kroncke, K. D., Burkart, V., & Kolb, H. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1368 · Cited by 184

Novel phenanthridinone inhibitors of poly(adenosine 5′-diphosphate-ribose) synthetase: Potent cytoprotective and antishock agents*

Jagtap, P., Soriano, F. G., Virág, L., Liaudet, L., Mabley, J., Szabó, É., Haskó, G., Marton, A., Lorigados, C. B., Gallyas, F., et al. (2002) · Critical Care Medicine · doi:10.1097/00003246-200205000-00019 · Cited by 184

Regulation of microglial expression of integrins by poly(ADP-ribose) polymerase-1

Ullrich, O., Diestel, A., Eyüpoglu, I. Y., & Nitsch, R. (2001) · Nature Cell Biology · doi:10.1038/ncb1201-1035 · Cited by 175

Diabetic Cardiomyopathy

Fein, F. S. (1990) · Diabetes Care · doi:10.2337/diacare.13.11.1169 · Cited by 174

Prevention or delay of Type 1 (insulin-dependent) diabetes mellitus in children using nicotinamide

Elliott, R. B., & Chase, H. P. (1991) · Diabetologia · doi:10.1007/bf00405010 · Cited by 173

Multiple autopoly(ADP-ribosyl)ation of rat liver poly(ADP-ribose) synthetase. Mode of modification and properties of automodified synthetase.

Kawaichi, M., Ueda, K., & Hayaishi, O. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68788-0 · Cited by 172

Resistance to Acute Septic Peritonitis in Poly(ADP-ribose) Polymerase-1-Deficient Mice

Soriano, F. G., Liaudet, L., Szab??, ?., Vir??g, L., Mabley, J. G., Pacher, P., & Szab??, C. (2002) · Shock · doi:10.1097/00024382-200204000-00008 · Cited by 172

Amelioration of Diabetes Mellitus in Partially Depancreatized Rats by Poly(ADP-ribose) Synthetase Inhibitors: Evidence of Islet B-Cell Regeneration

Yonemura, Y., Takashima, T., Miwa, K., Miyazaki, I., Yamamoto, H., & Okamoto, H. (1984) · Diabetes · doi:10.2337/diab.33.4.401 · Cited by 170

Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes.

Flodström, M., Tyrberg, B., Eizirik, D. L., & Sandler, S. (1999) · Diabetes · doi:10.2337/diabetes.48.4.706 · Cited by 166

Macrophage phagocytosis of myelin in vitro determined by flow cytometry: phagocytosis is mediated by CR3 and induces production of tumor necrosis factor-α and nitric oxide

van der Laan, L. J. W., Ruuls, S. R., Weber, K. S., Lodder, I. J., Döpp, E. A., & Dijkstra, C. D. (1996) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(96)00110-5 · Cited by 165

Purification and characterization of poly(ADP-ribose) glycohydrolase. Different modes of action on large and small poly(ADP-ribose).

Hatakeyama, K., Nemoto, Y., Ueda, K., & Hayaishi, O. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66802-4 · Cited by 164

ATP converts necrosis to apoptosis in oxidant-injured endothelial cells

Lelli, J. L., Becks, L. L., Dabrowska, M. I., & Hinshaw, D. B. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00107-5 · Cited by 164

Beneficial effects of 3‐aminobenzamide, an inhibitor of poly (ADP‐ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusion

Cuzzocrea, S., Zingarelli, B., Costantino, G., Szabó, A., Salzman, A. L., Caputi, A. P., & Szabó, C. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701234 · Cited by 164

Evidence for the production of peroxynitrite in inflammatory CNS demyelination

Cross, A. H., Manning, P. T., Stern, M. K., & Misko, T. P. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00145-8 · Cited by 163

Reduction of Cognitive and Motor Deficits after Traumatic Brain Injury in Mice Deficient in Poly(ADP-Ribose) Polymerase

Whalen, M. J., Clark, R. S. B., Dixon, C. E., Robichaud, P., Marion, D. W., Vagni, V., Graham, S. H., Virág, L., Haskó, G., Stachlewitz, R. F., et al. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199908000-00002 · Cited by 162

Poly(ADP-Ribose) Polymerase Inhibition Reduces Reperfusion Injury After Heart Transplantation

Szabó, G., Bährle, S., Stumpf, N., Sonnenberg, K., Szabó, E., Pacher, P., Csont, T., Schulz, R., Dengler, T. J., Liaudet, L., et al. (2002) · Circulation Research · doi:10.1161/hh0102.102657 · Cited by 161

Inhibition of nitric oxide synthase for treatment of experimental autoimmune encephalomyelitis

Brenner, T., Brocke, S., Szafer, F., Sobel, R. A., Parkinson, J. F., Perez, D. H., & Steinman, L. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.6.2940 · Cited by 159

Neuroprotective Effects of Inhibiting Poly(ADP-Ribose) Synthetase on Focal Cerebral Ischemia in Rats

Takahashi, K., Greenberg, J. H., Jackson, P., Maclin, K., & Zhang, J. (1997) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199711000-00001 · Cited by 158

Diabetic endothelial dysfunction: role of reactive oxygen and nitrogen species production and poly(ADP-ribose) polymerase activation

Soriano, F. G., Virág, L., & Szabó, C. (2001) · Journal of Molecular Medicine · doi:10.1007/s001090100236 · Cited by 157

Myocardial Postischemic Injury Is Reduced by PolyADPribose Polymerase-1 Gene Disruption

Pieper, A. A., Walles, T., Wei, G., Clements, E. E., Verma, A. M., Snyder, S. H., & Zweier, J. L. (2000) · Molecular Medicine · doi:10.1007/bf03401936 · Cited by 156

TCDD-Inducible Poly(ADP-ribose) Polymerase: A Novel Response to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Ma, Q., Baldwin, K. T., Renzelli, A. J., McDaniel, A., & Dong, L. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5987 · Cited by 156

Poly(ADP-ribose) polymerase enhances activator-dependent transcription in vitro

Meisterernst, M., Stelzer, G., & Roeder, R. G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2261 · Cited by 155

Extensive peroxynitrite activity during progressive stages of central nervous system inflammation

van der Veen, R. C., Hinton, D. R., Incardona, F., & Hofman, F. M. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00013-1 · Cited by 155

Excitotoxicity in the lung: N-methyl-D-aspartate-induced, nitric oxide-dependent, pulmonary edema is attenuated by vasoactive intestinal peptide and by inhibitors of poly(ADP-ribose) polymerase.

Said, S. I., Berisha, H., & PAKBAZ, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4688 · Cited by 155

Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication

Dantzer, F. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.8.1891 · Cited by 155

Apoptosis and necrosis: different execution of the same death

Nicotera, P., Leist, M., & Ferrando‐May, E. (1999) · Biochemical Society Symposia · doi:10.1042/bss0660069 · Cited by 154

Development of Autoimmune Diabetes in NOD Mice Is Associated With the Formation of Peroxynitrite in Pancreatic Islet β-Cells

Suarez‐Pinzon, W. L., Szabó, C., & Rabinovitch, A. (1997) · Diabetes · doi:10.2337/diab.46.5.907 · Cited by 154

Are Insulin Autoantibodies Markers for Insulin-Dependent Diabetes Mellitus?

Atkinson, M. A., Maclaren, N. K., Riley, W. J., Winter, W. E., Fisk, D., & Spillar, R. P. (1986) · Diabetes · doi:10.2337/diab.35.8.894 · Cited by 154

Cleavage of Poly(ADP-ribose) Polymerase by Interleukin-1β Converting Enzyme and Its Homologs TX and Nedd-2

Gu, Y., Sarnecki, C., Aldape, R. A., Livingston, D. J., & Su, M. S. S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.32.18715 · Cited by 152

Nitric oxide and proteoglycan biosynthesis by human articular chondrocytes in alginate culture

Häuselmann, H. J., Oppliger, L., Michel, B. A., Stefanović-Račić, M., & Evans, C. H. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00994-5 · Cited by 152

Transcription and translation of inducible nitric oxide synthase in the pancreas of prediabetic BB rats

Kleemann, R., Rothe, H., Kolb-Bachofen, V., Xie, Q. W., Nathan, C., Martin, S., & Kolb, H. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80954-s · Cited by 152

Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia

Takahashi, K., Pieper, A. A., Croul, S. E., Zhang, J., Snyder, S. H., & Greenberg, J. H. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01335-9 · Cited by 152

Chromatin condensation during apoptosis requires ATP

Kass, G. E. N., Eriksson, J., Weis, M., Orrenius, S., & Chow, S. C. (1996) · Biochemical Journal · doi:10.1042/bj3180749 · Cited by 150

Endocrine pancreas plasticity under physiological and pathological conditions.

Kargar, C., & Ktorza, A. (2001) · Diabetes · doi:10.2337/diabetes.50.2007.s30 · Cited by 150

Homocysteine mediated endothelial cell toxicity and its amelioration

Blundell, G. K., Jones, B. G., Rose, F. A., & Tudball, N. (1996) · Atherosclerosis · doi:10.1016/0021-9150(95)05730-7 · Cited by 149

Abnormal cardiac function in the streptozotocin-induced, non–insulin-dependent diabetic rat

Joffe, I. I., Travers, K. E., Perreault-Micale, C. L., Hampton, T., Katz, S. E., Morgan, J. P., & Douglas, P. S. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00436-2 · Cited by 147

ATP for the DNA Ligation Step in Base Excision Repair Is Generated from Poly(ADP-ribose)

Oei, S. L., & Ziegler, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002429200 · Cited by 147

The Telomeric Poly(ADP-ribose) Polymerase, Tankyrase 1, Contains Multiple Binding Sites for Telomeric Repeat Binding Factor 1 (TRF1) and a Novel Acceptor, 182-kDa Tankyrase-binding Protein (TAB182)

Seimiya, H., & Smith, S. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112266200 · Cited by 147

Involvement of NAD-poly(ADP-ribose) metabolism in p53 regulation and its consequences.

Whitacre, C. M., Hashimoto, H., Tsai, M. L., et al. (1995) · PubMed · Cited by 145

Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro

Bowman, K. J., Newell, D. R., Calvert, H., & Curtin, N. J. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2000.1555 · Cited by 144

Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia

Moroni, F., Meli, E., Peruginelli, F., Chiarugi, A., Cozzi, A., Picca, R., Romagnoli, P., Pellicciari, R., & Pellegrini-Giampietro, D. E. (2001) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400884 · Cited by 144

Partial ATP depletion induces Fas- and caspase-mediated apoptosis in MDCK cells

Feldenberg, L. R., Thevananther, S., Río, M. D., Leon, M. D., & Devarajan, P. (1999) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1999.276.6.f837 · Cited by 144

Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064

Bowman, K. J., White, A. W., Golding, B. T., Griffin, R., & Curtin, N. J. (1998) · British Journal of Cancer · doi:10.1038/bjc.1998.670 · Cited by 143

Effects of n-acetylcysteine in a rat model of ischemia and reperfusion injury

Cuzzocrea, S., Mazzon, E., Costantino, G., Serraino, I., Sarro, A. D., & Caputi, A. P. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00018-3 · Cited by 143

Base excision repair is efficient in cells lacking poly(ADP-ribose) polymerase 1

Vodenicharov, M. D., Sallmann, F. R., Satoh, M. S., & Poirier, G. G. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.20.3887 · Cited by 142

Blockade of poly(ADP-ribose) synthetase inhibits neutrophil recruitment, oxidant generation, and mucosal injury in murine colitis

Zingarelli, B., Szabó, C., & Salzman, A. L. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70130-7 · Cited by 141

A Fast Signal–Induced Activation of Poly(Adp-Ribose) Polymerase

Homburg, S., Visochek, L., Moran, N., Dantzer, F., Priel, E., Asculai, E., Schwartz, D., Rotter, V., Dekel, N., & Cohen‐Armon, M. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.2.293 · Cited by 141

Effect of Poly(ADP-Ribose) Polymerase Inhibitors on the Ischemia-Reperfusion-Induced Oxidative Cell Damage and Mitochondrial Metabolism in Langendorff Heart Perfusion System

Halmosi, R., Berente, Z., Ősz, E., Tóth, K., Literati-Nagy, P., & Sümegi, B. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.6.1497 · Cited by 140

The Sequence-specific DNA Binding of NF-κB Is Reversibly Regulated by the Automodification Reaction of Poly (ADP-ribose) Polymerase 1

Chang, W.-J., & Álvarez-González, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104666200 · Cited by 138

Nitric Oxide and Peroxynitrite in Health and Disease

Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390

Reactive oxygen species, cellular redox systems, and apoptosis

Circu, M. L., & Aw, T. Y. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.022 · Cited by 3,340

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

Galluzzi, L., Vitale, I., Abrams, J. M., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., Dawson, T. M., Dawson, V. L., El-Deiry, W. S., Fulda, S., et al. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2011.96 · Cited by 2,421

Peroxynitrite: biochemistry, pathophysiology and development of therapeutics

Szabó, C., Ischiropoulos, H., & Radi, R. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2222 · Cited by 2,134

NAD + /NADH and NADP + /NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences

Ying, W. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1672 · Cited by 1,494