The Pharmacology and Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”)

Green, A. Richard, Mechan, Annis O., Elliott, J. Martin, O’Shea, Esther, Colado, M. Isabel·2003·Pharmacological Reviews

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Items 401–500 of 1,000

  1. MDMA enhances empathy-like behaviors in mice via 5-HT release in the nucleus accumbens
    Benjamin A. Rein, Kendall B. Raymond, Cali Boustani, Sabrena Tuy, Jie Zhang, Robyn St. Laurent, Matthew B. Pomrenze, Parnaz Boroon, Boris Dov Heifets, Monique L. Smith et al. · 2024 · Science Advances
  2. PRECLINICAL STUDY: Acquisition and reinstatement of MDMA‐induced conditioned place preference in mice pre‐treated with MDMA or cocaine during adolescence
    Manuel Daza‐Losada, Marta Rodríguez‐Arias, M.A. Aguilar, José Miñarro · 2009 · Addiction Biology
  3. Can MDMA Play a Role in the Treatment of Substance Abuse?
    Lisa Jerome, Shira Schuster, Berra Yazar‐Klosinski · 2013 · Current Drug Abuse Reviews
  4. Behavioral and neurochemical consequences of multiple MDMA administrations in the rat: Role of individual differences in anxiety-related behavior
    V. Ludwig, Yoan Mihov, Rainer K.W. Schwarting · 2007 · Behavioural Brain Research
  5. Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
    Ximena Perfetti, Brian O’Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks et al. · 2009 · Drug Metabolism and Disposition
  6. Cocaine, metamfetamine, and MDMA abuse: the role and clinical importance of neuroadaptation
    Donna Seger · 2010 · Clinical Toxicology
  7. Psilocybin and MDMA reduce costly punishment in the Ultimatum Game
    Anthony S. Gabay, Robin Lester Carhart-Harris, Ndaba Mazibuko, Matthew J. Kempton, Paul D. Morrison, David Nutt, Mitul Ashok Mehta · 2018 · Scientific Reports
  8. Neuronal and peripheral damages induced by synthetic psychoactive substances: an update of recent findings from human and animal studies
    Nicola Simola, Giulia Costa, Maria Antonietta De Luca, Gessica Piras, Jacopo Marongiu, Liana Fattore · 2019 · Neural Regeneration Research
  9. GENETIC STUDY: 5‐HTTLPR polymorphism, mood disorders and MDMA use in a 3‐year follow‐up study
    Rocío Martín‐Santos, Marta Torrens, Sandra Poudevida, Klaus Langohr, Elisabet Cuyàs, Roberta Pacifici, Magı́ Farré, Simona Pichini, Rafael de la Torre · 2009 · Addiction Biology
  10. Psychedelics for treatment resistant depression: are they game changers?
    Michail Kalfas, Rosie H. Taylor, Dimosthenis Tsapekos, Allan Hunter Young · 2023 · Expert Opinion on Pharmacotherapy
  11. 5-hydroxytryptamine- and dopamine-releasing effects of ring-substituted amphetamines on rat brain: A comparative study using in vivo microdialysis
    Takashi Matsumoto, Yoshitaka Maeno, H. Kato, Yoshimi Seko‐Nakamura, Jun Monma-Ohtaki, Atsushi Ishiba, Masataka Nagao, Y. Aoki · 2014 · European Neuropsychopharmacology
  12. (±)-3,4-Methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: A comparison of single vs once per week treatment for 5 weeks
    Matthew R. Skelton, Jessica A. Able, Curtis E. Grace, Nicole R. Herring, Tori L. Schaefer, Gary A. Gudelsky, Charles V. Vorhees, Michael T. Williams · 2008 · Neuropharmacology
  13. Effect of the CB1 cannabinoid agonist WIN 55212-2 on the acquisition and reinstatement of MDMA-induced conditioned place preference in mice
    Carmen Manzanedo, Marta Rodríguez‐Arias, Manuel Daza‐Losada, Concepción Maldonado, M.A. Aguilar, José Miñarro · 2010 · Behavioral and Brain Functions
  14. Alcohol Interactions with Psychostimulants: An Overview of Animal and Human Studies
    Yusuf S. Althobaiti, Youssef Sari · 2016 · Journal of Addiction Research & Therapy
  15. MDMA interactions with pharmaceuticals and drugs of abuse
    Esther Papaseit, Clara Pérez‐Mañá, Marta Torrens, Adriana Farré, Lourdes Poyatos, Olga Hladun, Arantza Sanvisens, Roberto Muga, Magı́ Farré · 2020 · Expert Opinion on Drug Metabolism & Toxicology
  16. Physiological and pathological brain hyperthermia
    Eugene A. Kiyatkin · 2007 · Progress in brain research
  17. The P3 in ‘ecstasy’ polydrug users during response inhibition and execution
    Alex Gamma, Daniel Brandeis, Ruven Brandeis, Franz X. Vollenweider · 2005 · Journal of Psychopharmacology
  18. The intriguing effects of ecstasy (MDMA) on cognitive function in mice subjected to a minimal traumatic brain injury (mTBI)
    Shahaf Edut, Vardit Rubovitch, Shaul Schreiber, Chaim G. Pick · 2010 · Psychopharmacology
  19. Synthesis and Cyclic Voltammetry Studies of 3,4-Methylenedioxymethamphetamine (MDMA) Human Metabolites
    Carla Macedo, Paula S. Branco, Luísa Maria Ferreira, Ana Maria Lobo, João Paulo Capela, Eduarda G. R. Fernandes, Maria de Lourdes Bastos, Félix Dias Carvalho · 2007 · Eisei kagaku
  20. Auditory event-related potentials (P3) and cognitive performance in recreational ecstasy polydrug users: evidence from a 12-month longitudinal study
    Susana de Sola, Thais Tarancón, Jordi Peña‐Casanova, Josep María Espadaler, Klaus Langohr, Sandra Poudevida, Magı́ Farré, Antonio Verdejo‐García, Rafael de la Torre · 2008 · Psychopharmacology
  21. MDMA (“Ecstasy”) suppresses the innate IFN-γ response in vivo: A critical role for the anti-inflammatory cytokine IL-10
    Noreen T. Boyle, Thomas J. Connor · 2007 · European Journal of Pharmacology
  22. Neuroimaging in Drug and Substance Abuse Part I
    Rafael Rojas, Roy Riascos, Daniel Vargas, Hugo Cuellar, Jessica Borne · 2005 · Topics in Magnetic Resonance Imaging
  23. Urinary excretion of the main metabolites of 3,4-methylenedioxymethamphetamine (MDMA), including the sulfate and glucuronide of 4-hydroxy-3-methoxymethamphetamine (HMMA), in humans and rats
    Noriaki Shima, Munehiro Katagi, Hiroe Kamata, Kei Zaitsu, Tooru Kamata, Mayumi Nishikawa, Akihiro Miki, Hitoshi Tsuchihashi, Takeo Sakuma, Nobuo Nemoto · 2008 · Xenobiotica
  24. Memory Trace for Fear Extinction: Fragile yet Reinforceable
    Ying Liu, Shuai Ye, Xin-Ni Li, Wei‐Guang Li · 2023 · Neuroscience Bulletin
  25. An investigation into the sub-acute effects of ecstasy on aggressive interpretative bias and aggressive mood – are there gender differences?
    Rosa Hoshi, Hannah Pratt, Sachin Mehta, Alyson J. Bond, H. Valerie Curran · 2006 · Journal of Psychopharmacology
  26. "Ecstasy"-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites
    Daniel José Barbosa, João Paulo Capela, Renata Silva, Luísa Maria Ferreira, Paula S. Branco, Eduarda G. R. Fernandes, Maria de Lourdes Bastos, Félix Dias Carvalho · 2013 · Archives of Toxicology
  27. Verbal Memory Deficits Are Correlated with Prefrontal Hypometabolism in 18FDG PET of Recreational MDMA Users
    Oliver Gero Bosch, Michael Wagner, Frank Jessen, Kai-Uwe Kühn, Alexius Joe, Erich Seifritz, Wolfgang Maier, Hans‐Jürgen Biersack, Boris B. Quednow · 2013 · PLoS ONE
  28. Effect of drugs of abuse on social behaviour
    M. Carmen Blanco-Gandía, Ana Mateos-García, María Pilar García-Pardo, Sandra Montagud‐Romero, Marta Rodríguez‐Arias, José Miñarro, M.A. Aguilar · 2015 · Behavioural Pharmacology
  29. Effects of 3,4‐methylenedioxymethamphetamine ( MDMA ) and its main metabolites on cardiovascular function in conscious rats
    Charles W. Schindler, Eric B. Thorndike, Bruce E. Blough, Srihari R. Tella, Steven R. Goldberg, Michael H. Baumann · 2013 · British Journal of Pharmacology
  30. Comparison of (+)‐methamphetamine, ±‐Methylenedioxymethamphetamine, (+)‐amphetamine and ±‐fenfluramine in rats on egocentric learning in the Cincinnati water maze
    Charles V. Vorhees, Elizabeth C. He, Matthew R. Skelton, Devon L. Graham, Tori L. Schaefer, Curtis E. Grace, Amanda A. Braun, Robyn M. Amos‐Kroohs, Michael T. Williams · 2010 · Synapse
  31. 3 cases of primary intracranial hemorrhage associated with “Molly”, a purified form of 3,4-methylenedioxymethamphetamine (MDMA)
    D. Ethan Kahn, Nicholas C. Ferraro, Ronald Jay Benveniste · 2012 · Journal of the Neurological Sciences
  32. Acute psychomotor effects of MDMA and ethanol (co-) administration over time in healthy volunteers
    Glenn Dumont, Rik C. Schoemaker, Daan Johannes Touw, FCGJ Sweep, Jan K. Buitelaar, JMA van Gerven, Robbert‐Jan Verkes · 2009 · Journal of Psychopharmacology
  33. The Recreational Drug Ecstasy Disrupts the Hypothalamic-Pituitary-Gonadal Reproductive Axis in Adult Male Rats
    Sarah M. Dickerson, Deena M. Walker, Maria Elena Reveron, Christine L. Duvauchelle, Andrea C. Gore · 2008 · Neuroendocrinology
  34. Effects of 3,4-methylenedioxymethamphetamine (MDMA, ‘Ecstasy’) and para-methoxyamphetamine on striatal 5-HT when co-administered with moclobemide
    Alexander Freezer, Abdallah Salem, Rodney James Irvine · 2005 · Brain Research
  35. Increased cortisol levels in hair of recent Ecstasy/MDMA users
    Andrew C. Parrott, Helen Sands, Lewis L. Jones, Angela Clow, Phil D. Evans, Luke A. Downey, Tobias Stalder A · 2013 · European Neuropsychopharmacology
  36. 4-Methyl-amphetamine: a health threat for recreational amphetamine users
    Peter Blanckaert, J. van Amsterdam, Tibor M. Brunt, van den Berg Jdj, Filip Van Durme, Kristof E.K. Maudens, J.C.H. van Bussel · 2013 · Journal of Psychopharmacology
  37. Animal Models of Depression Vulnerability
    Jaanus Harro · 2012 · Current topics in behavioral neurosciences
  38. Neurological and cognitive alterations induced by MDMA in humans
    Catharine Montgomery, Carl Alexander Roberts · 2021 · Experimental Neurology
  39. Neuroleptic malignant syndrome and serotonin syndrome
    Koichi Nisijima, Katsutoshi Shioda, Tatsunori Iwamura · 2007 · Progress in brain research
  40. Comparative potencies of 3,4‐methylenedioxymethamphetamine (MDMA) analogues as inhibitors of [3H]noradrenaline and [3H]5‐HT transport in mammalian cell lines
    Therese Montgomery, Christophe Buon, S Eibauer, Patrick J. Guiry, ALAN K. KEENAN, Gethin J. McBean · 2007 · British Journal of Pharmacology
  41. Methamphetamine- and 3,4-Methylenedioxymethamphetamine–Induced Behavioral Changes in Histamine H3–Receptor Knockout Mice
    Tomohiro Okuda, Dongying Zhang, He Shao, Nobuyuki Okamura, Naoko Takino, Tatsunori Iwamura, Eiko Sakurai, Takeo Yoshikawa, Kazuhiko Yanai · 2009 · Journal of Pharmacological Sciences
  42. Pharmacological aspects of the combined use of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and gamma-hydroxybutyric acid (GHB): a review of the literature
    Joachim D. K. Uys, Raymond J.M. Niesink · 2005 · Drug and Alcohol Review
  43. Methylenedioxymethamphetamine Suppresses Production of the Proinflammatory Cytokine Tumor Necrosis Factor-α Independent of a β-Adrenoceptor-Mediated Increase in Interleukin-10
    Thomas J. Connor, Andrew Harkin, John P. Kelly · 2004 · Journal of Pharmacology and Experimental Therapeutics
  44. MDMA, cortisol, and heightened stress in recreational ecstasy users
    Andrew C. Parrott, Cathy Montgomery, Mark A Wetherell, Luke A. Downey, Con K. K. Stough, Andrew B Scholey · 2014 · Behavioural Pharmacology
  45. Understanding the Alteration and Decline of a Music Scene: Observations from Rave Culture1
    Tammy L. Anderson · 2009 · Sociological Forum
  46. Association of caffeine to MDMA does not increase antinociception but potentiates adverse effects of this recreational drug
    Jordi Camarasa, David Pubill, Elena Escubedo · 2006 · Brain Research
  47. Sprague–Dawley rats display metabolism-mediated sex differences in the acute toxicity of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)
    Julien Fonsart, Marie‐Claude Menet, Xavier Declèves, Hervé Galons, Dominique Crété, Marcel Debray, Jean‐Michel Scherrmann, Florence Noble · 2008 · Toxicology and Applied Pharmacology
  48. MDMA causes a redistribution of serotonin transporter from the cell surface to the intracellular compartment by a mechanism independent of phospho-p38-mitogen activated protein kinase activation
    Bronwyn Maree Kivell, Darren J. Day, Peter Bösch, Susan Schenk, Jeffrey D. Miller · 2010 · Neuroscience
  49. Nonlinear Pharmacokinetics of (±)3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”) and Its Major Metabolites in Squirrel Monkeys at Plasma Concentrations of MDMA That Develop After Typical Psychoactive Doses
    Melanie Mueller, Frank T. Peters, Hans H. Maurer, Una D. McCann, George A. Ricaurte · 2008 · Journal of Pharmacology and Experimental Therapeutics
  50. Discriminative Stimulus Effects of Psychostimulants and Hallucinogens in S(+)-3,4-Methylenedioxymethamphetamine (MDMA) and R(−)-MDMA Trained Mice
    Kevin Sean Murnane, N. Murai, Leonard Lee Howell, William Edward Fantegrossi · 2009 · Journal of Pharmacology and Experimental Therapeutics
  51. Memory and mood during MDMA intoxication, with and without memantine pretreatment
    Elizabeth B. de Sousa Fernandes Perna, Eef Lien Theunissen, Kim P. C. Kuypers, Pim R.A. Heckman, Rafael de la Torre, Magı́ Farré, Johannes Gerardus Ramaekers · 2014 · Neuropharmacology
  52. The relationship between hyperthermia and glycogenolysis in 3,4-methylenedioxymethamphetamine-induced serotonin depletion in rats
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  53. Somatostatin interneurons activated by 5-HT2A receptor suppress slow oscillations in medial entorhinal cortex
    Roberto De Filippo, Benjamin R. Rost, Alexander Stumpf, Claire Cooper, John J. Tukker, Christoph Harms, Prateep Sanker Beed, Dietmar Schmitz · 2021 · eLife
  54. MDMA (“ecstasy”) impairs learning in the Morris Water Maze and reduces hippocampal LTP in young rats
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  55. The A2a adenosine receptor modulates the reinforcement efficacy and neurotoxicity of MDMA
    Jéssica Ruiz‐Medina, Catherine A. Ledent, Olga Carretón, Olga Valverde · 2011 · Journal of Psychopharmacology
  56. MDMA-induced neurotoxicity of serotonin neurons involves autophagy and rilmenidine is protective against its pathobiology
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  57. Synthesis, in vitro formation, and behavioural effects of glutathione regioisomers of alpha-methyldopamine with relevance to MDA and MDMA (ecstasy)
    Neil Easton, J. R. Fry, Esther O’Shea, Adam J. Watkins, Shaun Kingston, Charles Alexander Marsden · 2003 · Brain Research
  58. Differences in the in vivo dynamics of neurotransmitter release and serotonin uptake after acute para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine revealed by chronoamperometry
    Paul D. Callaghan, Rodney James Irvine, Lynette C. Daws · 2005 · Neurochemistry International
  59. Direct determination of glucuronide and sulfate of 4-hydroxy-3-methoxymethamphetamine, the main metabolite of MDMA, in human urine
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  60. 3,4-Methylenedioxymethamphetamine administration on postnatal day 11 in rats increases pituitary–adrenal output and reduces striatal and hippocampal serotonin without altering SERT activity
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  61. The effects of MDMA pretreatment on the behavioural effects of other drugs of abuse in the rat elevated plus-maze test
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  62. Metabolism and Disposition of 3,4-Methylenedioxymethamphetamine (“Ecstasy”) in Baboons after Oral Administration: Comparison with Humans Reveals Marked Differences
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  64. Repeated intermittent MDMA binges reduce DAT density in mice and SERT density in rats in reward regions of the adolescent brain
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  65. Comparison of the developmental effects of 5-methoxy-N,N-diisopropyltryptamine (Foxy) to (±)-3,4-methylenedioxymethamphetamine (ecstasy) in rats
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  66. Identification and Characterization of Metallothionein-1 and -2 Gene Expression in the Context of (±)3,4-Methylenedioxymethamphetamine-Induced Toxicity to Brain Dopaminergic Neurons
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  88. Oral administration of (±)3,4-methylenedioxymethamphetamine and (+)methamphetamine alters temperature and activity in rhesus macaques
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  89. Caffeine induces a profound and persistent tachycardia in response to MDMA (“Ecstasy”) administration
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