The Pharmacology and Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”)
Green, A. Richard, Mechan, Annis O., Elliott, J. Martin, O’Shea, Esther, Colado, M. Isabel·2003·Pharmacological Reviews
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- The Role of The A2A Receptor in Cell Apoptosis Caused by MDMA.Mansooreh Soleimani, Majid Katebi, Akram Alizadeh, Farzaneh Mohammadzadeh, Mehdi Mehdizadeh · 2012 · PubMed Central
- In-utero exposure to the popular 'recreational' drugs MDMA (Ecstasy) and Methamphetamine (Ice, crystal): preliminary findings.Derek G Moore, John J. Turner, Julia E. Goodwin, Sarah E. Fulton, Lynn T. Singer, Andrew C. Parrott · 2011 · PubMed
- The effects of dentate granule cell destruction on behavioral activity and Fos protein expression induced by systemic MDMA in ratsMujun Won, Yoshio Minabe, Kunihiko Tani, Katsuaki Suzuki, Masayoshi Kawai, Yoshimoto Sekine, Charles R. Ashby, Nori Takei, Norio Mori · 2003 · Neuroscience Research
- Recent updates on drug abuse analyzed by neuroproteomics studies: Cocaine, Methamphetamine and MDMAFiras H. Kobeissy, Tarek H. Mouhieddine, Amaly Nokkari, Muhieddine M. Itani, Mohammed Mouhieddine, Zhiqun Zhang, Rui Zhu, Mark S. Gold, Kevin Wang, Yehia S. Mechref · 2014 · Translational Proteomics
- Differences in prefrontal blood oxygenation during an acute multitasking stressor in ecstasy polydrug usersCarl Alexander Roberts, Mark A Wetherell, John E. Fisk, Catharine Montgomery · 2014 · Psychological Medicine
- 3,4-Methylenedioxymethamphetamine enhances kainic acid convulsive susceptibilitySònia Abad, Fèlix Junyent, Carme Auladell, David Pubill, Mercè Pallàs, Jorge Camarasa, Elena Escubedo, Antoni Camins · 2014 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Population Pharmacokinetics of 3,4-Methylenedioxymethamphetamine and Main Metabolites in RatsDéborah Hirt, Julien Fonsart, Marie‐Claude Menet, Marcel Debray, Florence Noble, Xavier Declèves, Jean‐Michel Scherrmann · 2009 · Toxicological Sciences
- MDMA treatment 6 months earlier attenuates the effects of CP-94,253, a 5-HT1B receptor agonist, on motor control but not sleep inhibitionNorbert Gyöngyösi, Brigitta Balogh, Eszter Kirilly, Tamás Kitka, Sándor Kántor, György Bagdy · 2008 · Brain Research
- Roles of 3,4-methylenedioxymethamphetamine (MDMA)-induced alteration of connexin43 and intracellular Ca2+ oscillation in its cardiotoxicityLuo Zhuo, Quan Liu, Liang Liu, Tingyi Sun, Rongshuai Wang, Guoqiang Qu, Qian Liu, Yan Liu, Liang Ren · 2013 · Toxicology
- The effect of acute tryptophan depletion on mood and impulsivity in polydrug ecstasy usersSimon N. Young, Martine Regoli, Marco Leyton, Robert O. Pihl, Chawki Benkelfat · 2013 · Psychopharmacology
- Selective impairment of sadness and disgust recognition in abstinent ecstasy usersJames T. H. Yip, Tatia M.C. Lee · 2005 · Neuropsychologia
- Identification of post-generation effect of 3,4-methylenedioxymethamphetamine on the mouse brain by large-scale gene expression analysisJung Woo Eun, Seung Jun Kwack, Ji Heon Noh, Kwang Hwa Jung, Jeong Kyu Kim, Hyun Jin Bae, Hongjian Xie, Jae Chun Ryu, Young Min Ahn, Won Sang Park · 2010 · Toxicology Letters
- 3,4-Methylenedioxymethamphetamine (MDMA), but not morphine, alters APP processing in the rat brainJanos L. Kalman, Annamária Bjelik, Marietta Hugyecz, Júlia Tímár, Zsuzsanna Gyarmati, Marianna Zana, Zsuzsanna Fürst, Zoltán Janka, Zoltán Rakonczay, Zoltán Horváth et al. · 2006 · The International Journal of Neuropsychopharmacology
- Narcolepsy-like sleep disturbance in orexin knockout mice are normalized by the 5-HT1A receptor agonist 8-OH-DPATTomohisa Mori, Naoki Uzawa, Yoshiyuki Iwase, Daiki Masukawa, Mahardian Rahmadi, Shigeto Hirayama, Mayuna Hokazono, Kimio Higashiyama, Seiji Shioda, Tsutomu Suzuki · 2016 · Psychopharmacology
- Neurochemical substrates of the rewarding effects of MDMAC. Roger-Sánchez, María Pilar García-Pardo, Marta Rodríguez‐Arias, José Miñarro, M.A. Aguilar · 2015 · Behavioural Pharmacology
- Hand Function is Altered in Individuals with a History of Illicit Stimulant UseVerity Pearson-Dennett, Stanley C. Flavel, Robert A. Wilcox, Dominic Thewlis, Adam P. Vogel, Jason M. White, Gabrielle Todd · 2014 · PLoS ONE
- Hippocampal nicotinic receptors have a modulatory role for ethanol and MDMA interaction in memory retrievalMaryam Rostami, Ameneh Rezayof, Sakineh Alijanpour, Khadijeh Alsadat Sharifi · 2017 · Brain Research
- Extinction training following cocaine or MDMA self-administration produces discrete changes in D2-like and mGlu5 receptor density in the rat brainMałgorzata Frankowska, Joanna Miszkiel, Lucyna Pomierny-Chamioło, Bartosz Pomierny, Andrea Celeste Borelli, Agata Suder, Małgorzata Filip · 2019 · Pharmacological Reports
- Activation of Antioxidant and Proteolytic Pathways in the Nigrostriatal Dopaminergic System After 3,4-Methylenedioxymethamphetamine Administration: Sex-Related DifferencesGiulia Costa, Francesca Felicia Caputi, Marcello Serra, Nicola Simola, Laura Rullo, Serena Stamatakos, Fabrizio Sanna, Marc Germain, Maria‐Grazia Martinoli, Sanzio Candeletti et al. · 2021 · Frontiers in Pharmacology
- Electrophysiologic Changes in Ventral Midbrain Dopaminergic Neurons Resulting from (+/−) -3,4-Methylenedioxymethamphetamine (MDMA—“Ecstasy”)Mauro Federici, Luca Sebastianelli, Silvia Natoli, Giorgio Bernardi, Nicola Biagio Mercuri · 2007 · Biological Psychiatry
- Effect of repeated exposure to MDMA on the function of the 5-HT transporter as assessed by synaptosomal 5-HT uptakeCourtney Huff, Nirmal Bhide, Allen G. Schroering, Bryan K. Yamamoto, Gary A. Gudelsky · 2013 · Brain Research Bulletin
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- Gender Differences Among MDMA Users on Psychological and Drug History VariablesMichelle Cororve Fingeret, Frederick Gerard Moeller, Angela L. Stotts · 2005 · Addictive Disorders & Their Treatment
- Acute Paralysis Following Recreational MDMA (Ecstasy) UseLee Hilary Goldstein, Yair Mordish, Ibrahim Abu‐Kishk, Michal Toledano, Matitiahu Berkovitch · 2006 · Clinical Toxicology
- Changing your mind: neuroplastic mechanisms underlying the therapeutic effect of psychedelics in depression, PTSD, and addictionMarta L.C. Palhas, Rémi Corne, Raymond Mongeau · 2025 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
- MDMA administration attenuates hippocampal IL-β immunoreactivity and subsequent stress-enhanced fear learning: An animal model of PTSDShveta V. Parekh, Lydia O. Adams, Gillian A. Barkell, Donald T. Lysle · 2022 · Brain Behavior & Immunity - Health
- Effect of MDMA-assisted therapy on mood and anxiety symptoms in advanced-stage cancer (EMMAC): study protocol for a double-blind, randomised controlled trialChiranth Bhagavan, Paul Glue, Will Evans, Lisa Reynolds, Thivya Turner, Chris King, Bruce R. Russell, Eva Morunga, Jessica Lee Mills, Geoff Layton et al. · 2024 · Trials
- Contribution of Caffeine to the Psychostimulant, Neuroinflammatory and Neurotoxic Effects of Amphetamine-Related DrugsLucia Frau, Nicola Simola, Micaela Morelli · 2013 · Journal of Caffeine Research
- 3,4-Methylenedioxymethamphetamine induces a hyperthermic and hypermetabolic crisis in pigs with and without a genetic disposition for malignant hyperthermiaJan Karl Schütte, Ute Schäfer, Sandra Becker, Christiane Oldewurtel, Alexander Starosse, Peter Singler, Annette Richard, Frank Wappler, Mark Ulrich Gerbershagen · 2012 · European Journal of Anaesthesiology
- Synthesis and in Vitro Cytotoxicity Profile of theR-Enantiomer of 3,4-Dihydroxymethamphetamine (R-(−)-HHMA): Comparison with Related CatecholaminesAnne Felim, Guadalupe Herrera, Anne Neudörffer, Manuel Blanco, José‐Enrique O’Connor, Martine Largeron · 2009 · Chemical Research in Toxicology
- Performance of Coopworth ewe lambs exposed to low levels of ryegrass endophyte (Neotyphodium lolii) alkaloids and allowed access to a mycotoxin deactivatorKevin F. M. Reed, L. J. Cummins, D. D. Moore, A. J. Clark · 2011 · Animal Production Science
- Increased interleukin-1β levels following low dose MDMA induces tolerance against the 5-HT neurotoxicity produced by challenge MDMAAndrea Mayado, Elisa Torres, María Dolores Gutiérrez‐López, María Isabel Colado, Esther O’Shea · 2011 · Journal of Neuroinflammation
- Methamphetamine and MDMA Neurotoxicity: Biochemical and Molecular MechanismsVerónica Bisagno, Jean Lud Cadet · 2021 · Springer eBooks
- Drug abuseMatteo Anselmino, Mario Matta, Fiorenzo Gaïta · 2013 · Journal of Cardiovascular Medicine
- Experimental Models on Effects of PsychostimulantsSulev Kõks · 2015 · International review of neurobiology
- Increased kynurenine concentration attenuates serotonergic neurotoxicity induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats through activation of aryl hydrocarbon receptorCristina Abuin-Martínez, Rebeca Vidal, María Dolores Gutiérrez‐López, Mercedes Pérez‐Hernández, Pablo Giménez‐Gómez, Nuria Morales‐Puerto, Esther O’Shea, María Isabel Colado · 2021 · Neuropharmacology
- Isolated persistent acute global amnesia after acute abuse of 3,4-methylenedioxy-methamphetamine (MDMA)Fabien Hauw, Elodie Meppiel, Olivier Steichen, P.L. Conan, Jean Capron, T. de Broucker · 2018 · Journal of the Neurological Sciences
- MDMA ‘ecstasy’ increases cerebral cortical perfusion determined by bolus‐tracking arterial spin labelling ( btASL ) MRIJennifer Rouine, Oliviero L. Gobbo, Matthew Campbell, Valentina Gigliucci, I Ogden, K McHugh Smith, P Duffy, Brendan Behan, Daniel W. Byrne, M E Kelly et al. · 2013 · British Journal of Pharmacology
- Weekly γ-Hydroxybutyrate Exposure Sensitizes Locomotor Hyperactivity to Low-Dose 3,4-Methylenedioxymethamphetamine in RatsPetra S. Van Nieuwenhuijzen, K.M. Li, Glenn E. Hunt, Iain S. McGregor · 2009 · Neuropsychobiology
- Rat brain serotonin neurones that express neuronal nitric oxide synthase have increased sensitivity to the substituted amphetamine serotonin toxins 3,4-methylenedioxymethamphetamine and p-chloroamphetamineD.J. De Silva, Sarah Jane French, N.Y. Cheung, A.K. Swinson, Caterina Bendotti, Marcus Rattray · 2005 · Neuroscience
- Repeated intermittent administration of 3,4-methylenedioxymethamphetamine mitigates demyelination in the brain from cuprizone-treated miceMingming Zhao, Akifumi Eguchi, Rumi Murayama, Dan Xu, Tingting Zhu, Biao Xu, Guiling Liu, Chisato Mori, Jianjun Yang, Kenji Hashimoto · 2025 · European Journal of Pharmacology
- Stereoselective, sex-dependent 5-HT2A receptor modulation of cortical plasticity by MDMA in miceMaya Gaines-Smith, Justin M. Silverman, Michael Fiorillo, Jason Younkin, K. Moore, Jessica L. Maltman, Mario de la Fuente Revenga, Jennifer T. Wolstenholme, Richard A. Glennon, Maƚgorzata Dukat et al. · 2026 · Neuropsychopharmacology
- A roadmap for psychedelic pharmacy in Canada: A proposed policy and operations approach for controlled access to select psychedelics for treatment of mental illnessJaden Brandt · 2023 · Drug Science Policy and Law
- Correlates of Ecstasy use in the Swedish General PopulationTove Abrahamsson, Anders Håkansson · 2013 · Substance Use & Misuse
- Serotonergic neurotransmission in emotional processing: New evidence from long-term recreational poly-drug ecstasy useHelle Ruff Laursen, Susanne Henningsson, Julian Macoveanu, Terry L. Jernigan, Hartwig Roman Siebner, Klaus K. Holst, Arnold Skimminge, Gitte M. Knudsen, Thomas Zoëga Ramsøy, David Erritzøe · 2016 · Journal of Psychopharmacology
- Two Decades of Ecstasy: Shifting Demographic Trends in Decedents Using MDMAPatil Armenian, Luke N. Rodda · 2020 · Journal of Analytical Toxicology
- Effect of MDMA exposure during pregnancy on cell apoptosis, astroglia, and microglia activity in rat offspring striatum.Zahra Nazari, Khadijeh Bahrehbar, Mohammad Jafar Golalipour · 2022 · PubMed Central
- Effects of Repeated Administration of 3,4-methylenedioxymethamphetamine (MDMA) on Avoidance Memory and Cell Density in Rats' Hippocampus.Mehrdad Jahanshahi, Kamran Haidari, Simin Mahaki-Zadeh, EmseGol Nikmahzar, Fatemeh Babakordi · 2013 · Europe PMC (PubMed Central)
- Activation of 5-HT3 receptors leads to altered responses 6 months after MDMA treatmentNorbert Gyöngyösi, Brigitta Balogh, Zita Kátai, Eszter Molnár, Rudolf Laufer, Kornélia Tekes, György Bagdy · 2010 · Journal of Neural Transmission
- MDMA-evoked changes in the binding of dopamine D2receptor ligands in striatum of rats with unilateral serotonin depletionSøren Dinesen Østergaard, Aage Kristian Olsen Alstrup, Jan Bert Gramsbergen, Luciano Minuzzi, Kasper Tholstrup Pedersen, Svend Borup Jensen, Doris J. Doudet, Paul D. Cumming · 2009 · Synapse
- Low ambient temperature reveals distinct mechanisms for MDMA-induced serotonergic toxicity and astroglial Hsp27 heat shock response in rat brainCsaba Ádori, Rómeó D. Andó, Tamás Balázsa, Csaba Sőti, Szilvia Vas, Miklós Palkovits, Gábor Géza Kovács, György Bagdy · 2011 · Neurochemistry International
- Amphetamine toxicity in the emergency departmentGert-Jan Smets, Koen Bronselaer, Katja De Munnynck, Koen De Feyter, Wim Van de Voorde, Marc B. Sabbe · 2005 · European Journal of Emergency Medicine
- Effects of repeated MDMA administration on the motivation for palatable food and extinction of operant responding in miceAinhoa Plaza‐Zabala, Xavier Viñals, Rafael J. Maldonado, Patricia Robledo · 2010 · Psychopharmacology
- Behavioral and Stereological Analysis of the Effects of Intermittent Feeding Diet on the Orally Administrated MDMA ("ecstasy") in Mice.Zeinab Ebrahimian, Zeinab Karimi, Mohammad Javad Khoshnoud, Mohammad Reza Namavar, Bahram Daraei, Mohsen Raza Haidari · 2017 · PubMed Central
- In utero exposure to dexamethasone causes a persistent and age-dependent exacerbation of the neurotoxic effects and glia activation induced by MDMA in dopaminergic brain regions of C57BL/6J miceGiulia Costa, Stefan D. Spulber, Elena Paci, Maria Antonietta Casu, Sandra Ceccatelli, Nicola Simola, Micaela Morelli · 2020 · NeuroToxicology · Retracted
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- Repeated administration of the substituted amphetamine p-methoxyamphetamine produces reductions in cortical 5-HT transporter binding but not 5-HT content, unlike 3,4-methylenedioxyamethamphetaminePaul D. Callaghan, Kirsten Zimbardi, Abdallah Salem, Patrick A. Hughes, Lynette C. Daws, Rodney James Irvine · 2006 · European Journal of Pharmacology
- Manifestations cardiovasculaires des substances récréatives : alcool, cocaïne, amphétamines, ecstasy, héroïne et cannabisVincent Castelain, Thierry Lavigne, Albert Jaeger, Francis Schneider · 2005 · Réanimation
- Hypothyroidism alters striatal dopamine release mediated by 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)Andrea L. Peterson, T. Lee Gilman, Matthew L. Banks, Jon E. Sprague · 2006 · Synapse
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- The entactogen 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) as a treatment aid in psychotherapy and its safety concernsBrian A. Baldo · 2024 · Archives of Toxicology
- Effects of a combination of 3,4-methylenedioxymeth amphetamine and caffeine on real time stimulated dopamine release in the rat striatum: Studies using fast cyclic voltammetryJohn Joseph O'Connor, Kathy M. O’Boyle, J.P. Lowry · 2017 · Journal of Neuroscience Methods
- Prevalence of self-reported movement dysfunction among young adults with a history of ecstasy and methamphetamine use.G. Todd, L. Burns, Verity Pearson-Dennett, A. Esterman, P. Faulkner, R. Wilcox, D. Thewlis, A. Vogel, Jason M. White · 2019 · Drug and Alcohol Dependence
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- Effects of adenosine A2a receptor agonist and antagonist on cerebellar nuclear factor-kB expression preceded by MDMA toxicity.Fatemeh Kermanian, Mansoureh Soleimani, Bagher Pourheydar, Alireza Samzadeh‐Kermani, Farzaneh Mohammadzadeh, Mehdi Mehdizadeh · 2014 · Europe PMC (PubMed Central)
- Bilateral pneumothorax, surgical emphysema and pneumomediastinum in a young male patient following MDMA intakeN Obiechina, Ahrane Jayakumar, Yusra Khan, James Bass · 2018 · BMJ Case Reports
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