The Pharmacology and Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”)

Green, A. Richard, Mechan, Annis O., Elliott, J. Martin, O’Shea, Esther, Colado, M. Isabel·2003·Pharmacological Reviews

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Items 801–900 of 1,000

  1. The Role of The A2A Receptor in Cell Apoptosis Caused by MDMA.
    Mansooreh Soleimani, Majid Katebi, Akram Alizadeh, Farzaneh Mohammadzadeh, Mehdi Mehdizadeh · 2012 · PubMed Central
  2. In-utero exposure to the popular 'recreational' drugs MDMA (Ecstasy) and Methamphetamine (Ice, crystal): preliminary findings.
    Derek G Moore, John J. Turner, Julia E. Goodwin, Sarah E. Fulton, Lynn T. Singer, Andrew C. Parrott · 2011 · PubMed
  3. The effects of dentate granule cell destruction on behavioral activity and Fos protein expression induced by systemic MDMA in rats
    Mujun Won, Yoshio Minabe, Kunihiko Tani, Katsuaki Suzuki, Masayoshi Kawai, Yoshimoto Sekine, Charles R. Ashby, Nori Takei, Norio Mori · 2003 · Neuroscience Research
  4. Recent updates on drug abuse analyzed by neuroproteomics studies: Cocaine, Methamphetamine and MDMA
    Firas H. Kobeissy, Tarek H. Mouhieddine, Amaly Nokkari, Muhieddine M. Itani, Mohammed Mouhieddine, Zhiqun Zhang, Rui Zhu, Mark S. Gold, Kevin Wang, Yehia S. Mechref · 2014 · Translational Proteomics
  5. Differences in prefrontal blood oxygenation during an acute multitasking stressor in ecstasy polydrug users
    Carl Alexander Roberts, Mark A Wetherell, John E. Fisk, Catharine Montgomery · 2014 · Psychological Medicine
  6. 3,4-Methylenedioxymethamphetamine enhances kainic acid convulsive susceptibility
    Sònia Abad, Fèlix Junyent, Carme Auladell, David Pubill, Mercè Pallàs, Jorge Camarasa, Elena Escubedo, Antoni Camins · 2014 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
  7. Population Pharmacokinetics of 3,4-Methylenedioxymethamphetamine and Main Metabolites in Rats
    Déborah Hirt, Julien Fonsart, Marie‐Claude Menet, Marcel Debray, Florence Noble, Xavier Declèves, Jean‐Michel Scherrmann · 2009 · Toxicological Sciences
  8. MDMA treatment 6 months earlier attenuates the effects of CP-94,253, a 5-HT1B receptor agonist, on motor control but not sleep inhibition
    Norbert Gyöngyösi, Brigitta Balogh, Eszter Kirilly, Tamás Kitka, Sándor Kántor, György Bagdy · 2008 · Brain Research
  9. Roles of 3,4-methylenedioxymethamphetamine (MDMA)-induced alteration of connexin43 and intracellular Ca2+ oscillation in its cardiotoxicity
    Luo Zhuo, Quan Liu, Liang Liu, Tingyi Sun, Rongshuai Wang, Guoqiang Qu, Qian Liu, Yan Liu, Liang Ren · 2013 · Toxicology
  10. The effect of acute tryptophan depletion on mood and impulsivity in polydrug ecstasy users
    Simon N. Young, Martine Regoli, Marco Leyton, Robert O. Pihl, Chawki Benkelfat · 2013 · Psychopharmacology
  11. Selective impairment of sadness and disgust recognition in abstinent ecstasy users
    James T. H. Yip, Tatia M.C. Lee · 2005 · Neuropsychologia
  12. Identification of post-generation effect of 3,4-methylenedioxymethamphetamine on the mouse brain by large-scale gene expression analysis
    Jung Woo Eun, Seung Jun Kwack, Ji Heon Noh, Kwang Hwa Jung, Jeong Kyu Kim, Hyun Jin Bae, Hongjian Xie, Jae Chun Ryu, Young Min Ahn, Won Sang Park · 2010 · Toxicology Letters
  13. 3,4-Methylenedioxymethamphetamine (MDMA), but not morphine, alters APP processing in the rat brain
    Janos L. Kalman, Annamária Bjelik, Marietta Hugyecz, Júlia Tímár, Zsuzsanna Gyarmati, Marianna Zana, Zsuzsanna Fürst, Zoltán Janka, Zoltán Rakonczay, Zoltán Horváth et al. · 2006 · The International Journal of Neuropsychopharmacology
  14. Narcolepsy-like sleep disturbance in orexin knockout mice are normalized by the 5-HT1A receptor agonist 8-OH-DPAT
    Tomohisa Mori, Naoki Uzawa, Yoshiyuki Iwase, Daiki Masukawa, Mahardian Rahmadi, Shigeto Hirayama, Mayuna Hokazono, Kimio Higashiyama, Seiji Shioda, Tsutomu Suzuki · 2016 · Psychopharmacology
  15. Neurochemical substrates of the rewarding effects of MDMA
    C. Roger-Sánchez, María Pilar García-Pardo, Marta Rodríguez‐Arias, José Miñarro, M.A. Aguilar · 2015 · Behavioural Pharmacology
  16. Hand Function is Altered in Individuals with a History of Illicit Stimulant Use
    Verity Pearson-Dennett, Stanley C. Flavel, Robert A. Wilcox, Dominic Thewlis, Adam P. Vogel, Jason M. White, Gabrielle Todd · 2014 · PLoS ONE
  17. Hippocampal nicotinic receptors have a modulatory role for ethanol and MDMA interaction in memory retrieval
    Maryam Rostami, Ameneh Rezayof, Sakineh Alijanpour, Khadijeh Alsadat Sharifi · 2017 · Brain Research
  18. Extinction training following cocaine or MDMA self-administration produces discrete changes in D2-like and mGlu5 receptor density in the rat brain
    Małgorzata Frankowska, Joanna Miszkiel, Lucyna Pomierny-Chamioło, Bartosz Pomierny, Andrea Celeste Borelli, Agata Suder, Małgorzata Filip · 2019 · Pharmacological Reports
  19. Activation of Antioxidant and Proteolytic Pathways in the Nigrostriatal Dopaminergic System After 3,4-Methylenedioxymethamphetamine Administration: Sex-Related Differences
    Giulia Costa, Francesca Felicia Caputi, Marcello Serra, Nicola Simola, Laura Rullo, Serena Stamatakos, Fabrizio Sanna, Marc Germain, Maria‐Grazia Martinoli, Sanzio Candeletti et al. · 2021 · Frontiers in Pharmacology
  20. Electrophysiologic Changes in Ventral Midbrain Dopaminergic Neurons Resulting from (+/−) -3,4-Methylenedioxymethamphetamine (MDMA—“Ecstasy”)
    Mauro Federici, Luca Sebastianelli, Silvia Natoli, Giorgio Bernardi, Nicola Biagio Mercuri · 2007 · Biological Psychiatry
  21. Effect of repeated exposure to MDMA on the function of the 5-HT transporter as assessed by synaptosomal 5-HT uptake
    Courtney Huff, Nirmal Bhide, Allen G. Schroering, Bryan K. Yamamoto, Gary A. Gudelsky · 2013 · Brain Research Bulletin
  22. Synthesis of Fatty Acid Amides of Catechol Metabolites that Exhibit Antiobesity Properties
    Bruno Almeida, Jesús Joglar, María Jesús Luque Rojas, Juan Manuel Decara, Francisco Javier Bermúdez‐Silva, Manuel Macías‐González, Montserrat Fitó, Miguel Romero Cuevas, Magı́ Farré, María Isabel Covas et al. · 2010 · ChemMedChem
  23. Gender Differences Among MDMA Users on Psychological and Drug History Variables
    Michelle Cororve Fingeret, Frederick Gerard Moeller, Angela L. Stotts · 2005 · Addictive Disorders & Their Treatment
  24. Acute Paralysis Following Recreational MDMA (Ecstasy) Use
    Lee Hilary Goldstein, Yair Mordish, Ibrahim Abu‐Kishk, Michal Toledano, Matitiahu Berkovitch · 2006 · Clinical Toxicology
  25. Changing your mind: neuroplastic mechanisms underlying the therapeutic effect of psychedelics in depression, PTSD, and addiction
    Marta L.C. Palhas, Rémi Corne, Raymond Mongeau · 2025 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
  26. MDMA administration attenuates hippocampal IL-β immunoreactivity and subsequent stress-enhanced fear learning: An animal model of PTSD
    Shveta V. Parekh, Lydia O. Adams, Gillian A. Barkell, Donald T. Lysle · 2022 · Brain Behavior & Immunity - Health
  27. Effect of MDMA-assisted therapy on mood and anxiety symptoms in advanced-stage cancer (EMMAC): study protocol for a double-blind, randomised controlled trial
    Chiranth Bhagavan, Paul Glue, Will Evans, Lisa Reynolds, Thivya Turner, Chris King, Bruce R. Russell, Eva Morunga, Jessica Lee Mills, Geoff Layton et al. · 2024 · Trials
  28. Contribution of Caffeine to the Psychostimulant, Neuroinflammatory and Neurotoxic Effects of Amphetamine-Related Drugs
    Lucia Frau, Nicola Simola, Micaela Morelli · 2013 · Journal of Caffeine Research
  29. 3,4-Methylenedioxymethamphetamine induces a hyperthermic and hypermetabolic crisis in pigs with and without a genetic disposition for malignant hyperthermia
    Jan Karl Schütte, Ute Schäfer, Sandra Becker, Christiane Oldewurtel, Alexander Starosse, Peter Singler, Annette Richard, Frank Wappler, Mark Ulrich Gerbershagen · 2012 · European Journal of Anaesthesiology
  30. Synthesis and in Vitro Cytotoxicity Profile of theR-Enantiomer of 3,4-Dihydroxymethamphetamine (R-(−)-HHMA): Comparison with Related Catecholamines
    Anne Felim, Guadalupe Herrera, Anne Neudörffer, Manuel Blanco, José‐Enrique O’Connor, Martine Largeron · 2009 · Chemical Research in Toxicology
  31. Performance of Coopworth ewe lambs exposed to low levels of ryegrass endophyte (Neotyphodium lolii) alkaloids and allowed access to a mycotoxin deactivator
    Kevin F. M. Reed, L. J. Cummins, D. D. Moore, A. J. Clark · 2011 · Animal Production Science
  32. Increased interleukin-1β levels following low dose MDMA induces tolerance against the 5-HT neurotoxicity produced by challenge MDMA
    Andrea Mayado, Elisa Torres, María Dolores Gutiérrez‐López, María Isabel Colado, Esther O’Shea · 2011 · Journal of Neuroinflammation
  33. Methamphetamine and MDMA Neurotoxicity: Biochemical and Molecular Mechanisms
    Verónica Bisagno, Jean Lud Cadet · 2021 · Springer eBooks
  34. Drug abuse
    Matteo Anselmino, Mario Matta, Fiorenzo Gaïta · 2013 · Journal of Cardiovascular Medicine
  35. Experimental Models on Effects of Psychostimulants
    Sulev Kõks · 2015 · International review of neurobiology
  36. Increased kynurenine concentration attenuates serotonergic neurotoxicity induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats through activation of aryl hydrocarbon receptor
    Cristina Abuin-Martínez, Rebeca Vidal, María Dolores Gutiérrez‐López, Mercedes Pérez‐Hernández, Pablo Giménez‐Gómez, Nuria Morales‐Puerto, Esther O’Shea, María Isabel Colado · 2021 · Neuropharmacology
  37. Isolated persistent acute global amnesia after acute abuse of 3,4-methylenedioxy-methamphetamine (MDMA)
    Fabien Hauw, Elodie Meppiel, Olivier Steichen, P.L. Conan, Jean Capron, T. de Broucker · 2018 · Journal of the Neurological Sciences
  38. MDMA ‘ecstasy’ increases cerebral cortical perfusion determined by bolus‐tracking arterial spin labelling ( btASL ) MRI
    Jennifer Rouine, Oliviero L. Gobbo, Matthew Campbell, Valentina Gigliucci, I Ogden, K McHugh Smith, P Duffy, Brendan Behan, Daniel W. Byrne, M E Kelly et al. · 2013 · British Journal of Pharmacology
  39. Weekly γ-Hydroxybutyrate Exposure Sensitizes Locomotor Hyperactivity to Low-Dose 3,4-Methylenedioxymethamphetamine in Rats
    Petra S. Van Nieuwenhuijzen, K.M. Li, Glenn E. Hunt, Iain S. McGregor · 2009 · Neuropsychobiology
  40. Rat brain serotonin neurones that express neuronal nitric oxide synthase have increased sensitivity to the substituted amphetamine serotonin toxins 3,4-methylenedioxymethamphetamine and p-chloroamphetamine
    D.J. De Silva, Sarah Jane French, N.Y. Cheung, A.K. Swinson, Caterina Bendotti, Marcus Rattray · 2005 · Neuroscience
  41. Repeated intermittent administration of 3,4-methylenedioxymethamphetamine mitigates demyelination in the brain from cuprizone-treated mice
    Mingming Zhao, Akifumi Eguchi, Rumi Murayama, Dan Xu, Tingting Zhu, Biao Xu, Guiling Liu, Chisato Mori, Jianjun Yang, Kenji Hashimoto · 2025 · European Journal of Pharmacology
  42. Stereoselective, sex-dependent 5-HT2A receptor modulation of cortical plasticity by MDMA in mice
    Maya Gaines-Smith, Justin M. Silverman, Michael Fiorillo, Jason Younkin, K. Moore, Jessica L. Maltman, Mario de la Fuente Revenga, Jennifer T. Wolstenholme, Richard A. Glennon, Maƚgorzata Dukat et al. · 2026 · Neuropsychopharmacology
  43. A roadmap for psychedelic pharmacy in Canada: A proposed policy and operations approach for controlled access to select psychedelics for treatment of mental illness
    Jaden Brandt · 2023 · Drug Science Policy and Law
  44. Correlates of Ecstasy use in the Swedish General Population
    Tove Abrahamsson, Anders Håkansson · 2013 · Substance Use & Misuse
  45. Serotonergic neurotransmission in emotional processing: New evidence from long-term recreational poly-drug ecstasy use
    Helle Ruff Laursen, Susanne Henningsson, Julian Macoveanu, Terry L. Jernigan, Hartwig Roman Siebner, Klaus K. Holst, Arnold Skimminge, Gitte M. Knudsen, Thomas Zoëga Ramsøy, David Erritzøe · 2016 · Journal of Psychopharmacology
  46. Two Decades of Ecstasy: Shifting Demographic Trends in Decedents Using MDMA
    Patil Armenian, Luke N. Rodda · 2020 · Journal of Analytical Toxicology
  47. Effect of MDMA exposure during pregnancy on cell apoptosis, astroglia, and microglia activity in rat offspring striatum.
    Zahra Nazari, Khadijeh Bahrehbar, Mohammad Jafar Golalipour · 2022 · PubMed Central
  48. Effects of Repeated Administration of 3,4-methylenedioxymethamphetamine (MDMA) on Avoidance Memory and Cell Density in Rats' Hippocampus.
    Mehrdad Jahanshahi, Kamran Haidari, Simin Mahaki-Zadeh, EmseGol Nikmahzar, Fatemeh Babakordi · 2013 · Europe PMC (PubMed Central)
  49. Activation of 5-HT3 receptors leads to altered responses 6 months after MDMA treatment
    Norbert Gyöngyösi, Brigitta Balogh, Zita Kátai, Eszter Molnár, Rudolf Laufer, Kornélia Tekes, György Bagdy · 2010 · Journal of Neural Transmission
  50. MDMA-evoked changes in the binding of dopamine D2receptor ligands in striatum of rats with unilateral serotonin depletion
    Søren Dinesen Østergaard, Aage Kristian Olsen Alstrup, Jan Bert Gramsbergen, Luciano Minuzzi, Kasper Tholstrup Pedersen, Svend Borup Jensen, Doris J. Doudet, Paul D. Cumming · 2009 · Synapse
  51. Low ambient temperature reveals distinct mechanisms for MDMA-induced serotonergic toxicity and astroglial Hsp27 heat shock response in rat brain
    Csaba Ádori, Rómeó D. Andó, Tamás Balázsa, Csaba Sőti, Szilvia Vas, Miklós Palkovits, Gábor Géza Kovács, György Bagdy · 2011 · Neurochemistry International
  52. Amphetamine toxicity in the emergency department
    Gert-Jan Smets, Koen Bronselaer, Katja De Munnynck, Koen De Feyter, Wim Van de Voorde, Marc B. Sabbe · 2005 · European Journal of Emergency Medicine
  53. Effects of repeated MDMA administration on the motivation for palatable food and extinction of operant responding in mice
    Ainhoa Plaza‐Zabala, Xavier Viñals, Rafael J. Maldonado, Patricia Robledo · 2010 · Psychopharmacology
  54. Behavioral and Stereological Analysis of the Effects of Intermittent Feeding Diet on the Orally Administrated MDMA ("ecstasy") in Mice.
    Zeinab Ebrahimian, Zeinab Karimi, Mohammad Javad Khoshnoud, Mohammad Reza Namavar, Bahram Daraei, Mohsen Raza Haidari · 2017 · PubMed Central
  55. In utero exposure to dexamethasone causes a persistent and age-dependent exacerbation of the neurotoxic effects and glia activation induced by MDMA in dopaminergic brain regions of C57BL/6J mice
    Giulia Costa, Stefan D. Spulber, Elena Paci, Maria Antonietta Casu, Sandra Ceccatelli, Nicola Simola, Micaela Morelli · 2020 · NeuroToxicology · Retracted
  56. Amphétamines et dérivés
    M.-H. Ghysel-Laporte, Pauline Sibille, Nathalie Milan · 2012 · Elsevier eBooks
  57. Isolated non-cardiogenic pulmonary edema — A rare complication of MDMA toxicity
    Astrid Haaland, Elliot Warman, Illya Pushkar, Antonios Likourezos, Matt S. Friedman · 2017 · The American Journal of Emergency Medicine
  58. Repeated administration of the substituted amphetamine p-methoxyamphetamine produces reductions in cortical 5-HT transporter binding but not 5-HT content, unlike 3,4-methylenedioxyamethamphetamine
    Paul D. Callaghan, Kirsten Zimbardi, Abdallah Salem, Patrick A. Hughes, Lynette C. Daws, Rodney James Irvine · 2006 · European Journal of Pharmacology
  59. Manifestations cardiovasculaires des substances récréatives : alcool, cocaïne, amphétamines, ecstasy, héroïne et cannabis
    Vincent Castelain, Thierry Lavigne, Albert Jaeger, Francis Schneider · 2005 · Réanimation
  60. Hypothyroidism alters striatal dopamine release mediated by 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)
    Andrea L. Peterson, T. Lee Gilman, Matthew L. Banks, Jon E. Sprague · 2006 · Synapse
  61. Investigation of exposure to lifestyle and environmental factors on cumulus-oocyte complex function
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  62. Survey of Selective Neurotoxins
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  63. The entactogen 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) as a treatment aid in psychotherapy and its safety concerns
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  64. Effects of a combination of 3,4-methylenedioxymeth amphetamine and caffeine on real time stimulated dopamine release in the rat striatum: Studies using fast cyclic voltammetry
    John Joseph O'Connor, Kathy M. O’Boyle, J.P. Lowry · 2017 · Journal of Neuroscience Methods
  65. Prevalence of self-reported movement dysfunction among young adults with a history of ecstasy and methamphetamine use.
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  66. Dopamine D1Receptor‐Mediated Intracellular Responses in the Hypothalamus after Co‐Administration of Caffeine with MDMA
    Natacha Vanattou‐Saïfoudine, Brendan Behan, Andrew Harkin · 2011 · Basic & Clinical Pharmacology & Toxicology
  67. Usos Lícito e Ilícito dos Fármacos
    Ricardo Jorge Dinis‐Oliveira · 2014 · Acta Médica Portuguesa
  68. Mice in Ecstasy: Advanced Animal Models in the Study of MDMA
    Christophe Pol Stove, Els A. De Letter, Michel H A Piette, Willy E. Lambert · 2010 · Current Pharmaceutical Biotechnology
  69. Methylenedioxymethamphetamine (MDMA, 'Ecstasy'): Neurodegeneration versus Neuromodulation
    Elena Puerta, Norberto Aguirre · 2011 · Pharmaceuticals
  70. Administration of MDMA to ethanol-deprived rats increases ethanol operant self-administration and dopamine release during reinstatement
    Guillermo Moreno‐Sanz, Esther O’Shea, Laura Orío, Isabel Escobedo, Gustavo González‐Cuevas, Miguel Angel Navarro, María Isabel Colado, José Antonio López‐Moreno · 2009 · The International Journal of Neuropsychopharmacology
  71. Constructing the ecstasy of MDMA from its component mental organs: Proposing the primer/probe method
    Thomas S. Ray · 2015 · Medical Hypotheses
  72. The Neuropathology of Drug Abuse
    Andreas Büttner · 2014 · Elsevier eBooks
  73. Effects of adenosine A2a receptor agonist and antagonist on cerebellar nuclear factor-kB expression preceded by MDMA toxicity.
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  74. Bilateral pneumothorax, surgical emphysema and pneumomediastinum in a young male patient following MDMA intake
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  75. Substance use and abuse in pediatric transplant recipients: What the transplant provider needs to know
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  78. Mice Lacking Multidrug Resistance Protein 1a Show Altered Dopaminergic Responses to Methylenedioxymethamphetamine (MDMA) in Striatum
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  79. Rapid development of semistarvation-induced hyperactivity in Dark Agouti rats. Excessive wheel running and effect of 3,4-methylenedioxymethamphetamine (MDMA)
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  86. (±)3,4-Methylenedioxyamphetamine inhibits the TEA-sensitive K+ current in the hippocampal neuron and the Kv2.1 current expressed in H1355 cells
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  88. Inhibition of mirtazapine metabolism by Ecstasy (MDMA) in isolated perfused rat liver model
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  90. The functional connectome of 3,4‐methyldioxymethamphetamine‐related declarative memory impairments
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  91. Investigation of the mechanisms mediating MDMA “Ecstasy”-induced increases in cerebro-cortical perfusion determined by btASL MRI
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  93. Dissociation between Serotonin Neurotoxicity and Brain-Derived Neurotrophic Factor Induction following Neonatal MDMA Exposure in Rats
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  94. Acceleration of serotonin transporter transport-associated current by 3,4-methylenedioxymethanphetamine (MDMA) under acidic conditions
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  95. Serotonin transporter expression is not sufficient to confer cytotoxicity to 3,4-methylenedioxymethamphetamine (MDMA) in vitro
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  96. MDMA (ecstasy) enhances loud noise‐induced morphofunctional alterations in heart and adrenal gland
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  97. Administration of neurotoxic doses of MDMA reduces sensitivity to ethanol and increases GAT-1 immunoreactivity in mice striatum
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  99. Droge ist nicht gleich Droge
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  100. Hyperthermia Severely Affects the Vascular Effects of MDMA and Metabolites in the Human Internal Mammary Artery In Vitro
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