The Pharmacology and Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”)

Green, A. Richard, Mechan, Annis O., Elliott, J. Martin, O’Shea, Esther, Colado, M. Isabel·2003·Pharmacological Reviews

DOI 10.1124/pr.55.3.3

Cited by (1,000)

Items 101–200 of 1,000

3,4-Methylenedioxymethamphetamine (Ecstasy) Inhibits Dyskinesia Expression and Normalizes Motor Activity in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Primates
Mahmoud M. Iravani, Michael J. Jackson, Mikko Kuoppamäki, Lance A. Smith, Peter G. Jenner · 2003 · Journal of Neuroscience
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Carson, Dean S, Guastella, Adam J, Taylor, Emily R, McGregor, Iain S · 2013 · Journal of Psychopharmacology
Dantrolene in the treatment of MDMA-related hyperpyrexia: a systematic review
Brian E. Grunau, Matthew O. Wiens, Jeffrey Reynold Brubacher · 2010 · Canadian Journal of Emergency Medicine
Electrochemical oxidation of amphetamine-like drugs and application to electroanalysis of ecstasy in human serum
E. Manuela Garrido, Jorge M. P. J. Garrido, Nuno Milhazes, Fernanda Borges, Ana Maria Oliveira‐Brett · 2009 · Bioelectrochemistry
Brain hyperthermia induced by MDMA (‘ecstasy’): modulation by environmental conditions
Paul Leon Brown, Eugene A. Kiyatkin · 2004 · European Journal of Neuroscience
Inhibition of serotonin transporters disrupts the enhancement of fear memory extinction by 3,4-methylenedioxymethamphetamine (MDMA)
Young, Matthew B., Norrholm, Seth D., Khoury, Lara M., Jovanovic, Tanja, Rauch, Sheila A.M., Reiff, Collin M., Dunlop, Boadie W., Rothbaum, Barbara O., Howell, Leonard L. · 2017 · Psychopharmacology
Methylenedioxymethamphetamine (MDMA, ‘Ecstasy’): a stressor on the immune system
Thomas J. Connor · 2004 · Immunology
Changes in ambient temperature differentially alter the thermoregulatory, cardiac and locomotor stimulant effects of 4-methylmethcathinone (mephedrone)
M.L. Miller, Kevin M. Creehan, Deepshikha Angrish, Deborah J. Barlow, Karen L. Houseknecht, Tobin J. Dickerson, Michael A. Taffe · 2012 · Drug and Alcohol Dependence
Brain temperature fluctuations during physiological and pathological conditions
Eugene A. Kiyatkin · 2007 · European Journal of Applied Physiology
3,4‐methylenedioxymethamphetamine (MDMA) administration to rats decreases brain tissue serotonin but not serotonin transporter protein and glial fibrillary acidic protein
Xiaoying Wang, Michael H. Baumann, Heng Xu, Richard B. Rothman · 2004 · Synapse
Serotonin-transporter mediated efflux: A pharmacological analysis of amphetamines and non-amphetamines
Birgit Hilber, Petra Scholze, Mario M. Dorostkar, Walter Sandtner, Marion Holy, Stefan Boehm, Ernst A. Singer, Harald H. Sitte · 2005 · Neuropharmacology
How could MDMA (ecstasy) help anxiety disorders? A neurobiological rationale
Johansen, PØ, Krebs, TS · 2009 · Journal of Psychopharmacology
Serotonin transporter polymorphism mediates vulnerability to loss of incentive motivation following acute tryptophan depletion.
Roiser, Jonathan P, Blackwell, Andrew D, Cools, Roshan, Clark, Luke, Rubinsztein, David C, Robbins, Trevor W, Sahakian, Barbara J · 2006 · Neuropsychopharmacology
MDMA and PTSD treatment
Sessa, Ben · 2017 · Neuroscience Letters
Causes and Consequences of Methamphetamine and MDMA Toxicity
Maria S. Quinton, Bryan K. Yamamoto · 2006 · The AAPS Journal
Genetic Deletion of Trace Amine 1 Receptors Reveals Their Role in Auto-Inhibiting the Actions of Ecstasy (MDMA)
Benjamin Di Cara, Roberto Maggio, Gabriella Aloisi, Jean‐Michel Rivet, Ebba Gregorsson Lundius, Takashi Yoshitake, Per Svenningsson, Mauricette Brocco, Alain Gobert, Lotte de Groote et al. · 2011 · Journal of Neuroscience
Memory deficit and reduced anxiety in young adult rats given repeated intermittent MDMA treatment during the periadolescent period
Brian J. Piper, Jerrold S. Meyer · 2004 · Pharmacology Biochemistry and Behavior
Cognition in novice ecstasy users with minimal exposure to other drugs: a prospective cohort study.
T. Schilt, M. D. de Win, M. Koeter, G. Jager, D. Korf, W. van den Brink, B. Schmand · 2007 · Archives of General Psychiatry
Cognitive impairment in substance abuse
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Solidarity and Drug Use in The Electronic Dance Music Scene
Philip R. Kavanaugh, Tammy L. Anderson · 2008 · Sociological Quarterly
High Rates of Club Drug Use and Risky Sexual Practices Among Hispanic Men Who Have Sex with Men in Miami, Florida
Maria Isabel Fernandez, G. Stephen Bowen, Leah M. Varga, Jose B. Collazo, Nilda Hernández, Tatiana Perrino, Alfredo Rehbein · 2005 · Substance Use & Misuse
Effect of Ambient Temperature on the Thermoregulatory and Locomotor Stimulant Effects of 4-Methylmethcathinone in Wistar and Sprague-Dawley Rats
M. Jerry Wright, Deepshikha Angrish, Shawn M. Aarde, Deborah J. Barlow, Matthew W. Buczynski, Kevin M. Creehan, Sophia A. Vandewater, Loren H. Parsons, Karen L. Houseknecht, Tobin J. Dickerson et al. · 2012 · PLoS ONE
3,4-methylenedioxymethamphetamine (MDMA): current perspectives
Jerry Meyer · 2013 · Substance Abuse and Rehabilitation
Combining Cognitive-Behavioral Conjoint Therapy for PTSD with 3,4-Methylenedioxymethamphetamine (MDMA): A Case Example
A. Wagner, M. Mithoefer, A. Mithoefer, C. Monson · 2019 · Journal of Psychoactive Drugs
Acute Psychological and Neurophysiological Effects of MDMA in Humans
Franz X. Vollenweider, Matthias E. Liechti, Alex Gamma, George R. Greer, Mark A. Geyer · 2002 · Journal of Psychoactive Drugs
3,4-Methylenedioxymethamphetamine Self-Administration is Abolished in Serotonin Transporter Knockout Mice
José Manuel Trigo, Thibault Renoir, Laurence Lanfumey, M. Hamon, Klaus‐Peter Lesch, Patricia Robledo, Rafael J. Maldonado · 2007 · Biological Psychiatry
Acetyl-l-carnitine provides effective in vivo neuroprotection over 3,4-methylenedioximethamphetamine-induced mitochondrial neurotoxicity in the adolescent rat brain
Emanuele Amorim Alves, ZBIGNIEW K. BINIENDA, Félix Dias Carvalho, Cecília Juliana Alves, Eduarda G. R. Fernandes, Maria de Lourdes Bastos, M.A. Tavares, Teresa Summavielle · 2008 · Neuroscience
Treating posttraumatic stress disorder with MDMA-assisted psychotherapy: A preliminary meta-analysis and comparison to prolonged exposure therapy
Timothy Amoroso, Michael Workman · 2016 · Journal of Psychopharmacology
The role of monoamines in the changes in body temperature induced by 3,4‐methylenedioxymethamphetamine (MDMA, ecstasy) and its derivatives
James R. Docherty, AR Green · 2010 · British Journal of Pharmacology
MDMA and temperature: A review of the thermal effects of ‘Ecstasy’ in humans
Andrew C. Parrott · 2011 · Drug and Alcohol Dependence
Neuroimaging research in human MDMA users: a review
Ronald L. Cowan · 2006 · Psychopharmacology
Self-reported depressive symptomatology in community samples of polysubstance misusers who report Ecstasy use: a meta-analysis
Harry R. Sumnall, Jon C. Cole · 2005 · Journal of Psychopharmacology
Implications of mechanism-based inhibition of CYP2D6 for the pharmacokinetics and toxicity of MDMA
Jiansong Yang, Masoud Jamei, Amir Heydari, Karen Rowland Yeo, Rafael de la Torre, Magı́ Farré, Geoffrey T. Tucker, Amin Rostami‐Hodjegan · 2006 · Journal of Psychopharmacology
Effect of D1-like and D2-like receptor antagonists on methamphetamine and 3,4-methylenedioxymethamphetamine self-administration in rats
Katharine Alexandra Brennan, Caleb Carati, Rod A. Lea, Paul S. Fitzmaurice, Susan Schenk · 2009 · Behavioural Pharmacology
Ecstasy-induced cell death in cortical neuronal cultures is serotonin 2A-receptor-dependent and potentiated under hyperthermia
João Paulo Capela, Karsten Ruscher, M. Lautenschlager, Dorette Freyer, Ulrich Dirnagl, Rita Gaio, Maria de Lourdes Bastos, Andreas Meisel, Félix Dias Carvalho · 2006 · Neuroscience
Alcohol and Substance Abuse in Solid-Organ Transplant Recipients
Richard Parker, Matthew James Armstrong, Chris Corbett, Ed Day, James Neuberger · 2013 · Transplantation
Behavioural and neurochemical comparison of chronic intermittent cathinone, mephedrone and MDMA administration to the rat
Sinead E. Shortall, Alice E. Macerola, Rabbi Swaby, Rebecca Jayson, Chantal Korsah, Katharine Pillidge, Peter M. Wigmore, Francis J. P. Ebling, A. Richard Green, Kevin C.F. Fone et al. · 2012 · European Neuropsychopharmacology
The psychotherapeutic potential of MDMA (3,4-methylenedioxymethamphetamine): An evidence-based review
Parrott, A. C. · 2007 · Psychopharmacology
Loss of Serotonin Transporter Protein after MDMA and Other Ring-Substituted Amphetamines
Tao Xie, Liqiong Tong, Michael W. McLane, George Hatzidimitriou, Jie Yuan, Una D. McCann, George A. Ricaurte · 2006 · Neuropsychopharmacology
The reverse operation of Na+/Cl−‐coupled neurotransmitter transporters – why amphetamines take two to tango
Harald H. Sitte, Michael Freissmuth · 2009 · Journal of Neurochemistry
Neurotoxicity of Ecstasy Metabolites in Rat Cortical Neurons, and Influence of Hyperthermia
João Paulo Capela, Andreas Meisel, Artur Reis Abreu, Paula S. Branco, Luísa Maria Ferreira, Ana Maria Lobo, Fernando Remião, Maria Lurdes Bastos, Félix Dias Carvalho · 2005 · Journal of Pharmacology and Experimental Therapeutics
In Vivo Imaging of Cerebral Serotonin Transporter and Serotonin2A Receptor Binding in 3,4-Methylenedioxymethamphetamine (MDMA or “Ecstasy”) and Hallucinogen Users
David Erritzøe, Vibe G. Frøkjær, Klaus K. Holst, M.V. Christoffersen, Sys Stybe Johansen, Claus Svarer, Jacob Madsen, Peter Mondrup Rasmussen, Thomas Zoëga Ramsøy, Terry L. Jernigan et al. · 2011 · Archives of General Psychiatry
Increased sensitivity to the acute effects of MDMA (“ecstasy”) in female rats
Tomáš Páleníček, Martin Votava, V. Bubeníková, Jiřı́ Horáček · 2005 · Physiology & Behavior
Non-pharmacological factors that determine drug use and addiction
Serge H. Ahmed, Aldo Badiani, Klaus A. Miczek, Christian P. Müller · 2018 · Neuroscience & Biobehavioral Reviews
Use of ecstasy and other psychoactive substances among school-attending adolescents in Taiwan: national surveys 2004–2006
Wei J. Chen, Tsung‐chieh Fu, Te‐Tien Ting, Wei Lun Huang, Guang Mang Tang, Chuhsing Kate Hsiao, Chuan‐Yu Chen · 2009 · BMC Public Health
Multiple MDMA (Ecstasy) Overdoses at a Rave Event
Patil Armenian, Tanya M. Mamantov, Ben T. Tsutaoka, Roy R. L. Gerona, Eric Fox Silman, Alan H.B. Wu, Kent R. Olson · 2012 · Journal of Intensive Care Medicine
Club Drug Use Among Young Men Who Have Sex with Men in NYC: A Preliminary Epidemiological Profile
Michael Craig Clatts, Lloyd A. Goldsamt, Huso Yi · 2005 · Substance Use & Misuse
MDMA (“ecstasy”), methamphetamine and their combination: long-term changes in social interaction and neurochemistry in the rat
Kelly J. Clemens, Petra S. van Nieuwenhuyzen, Kong M. Li, Jennifer Louise Cornish, Glenn E. Hunt, Iain S. McGregor · 2004 · Psychopharmacology
Association of a Functional Polymorphism in the Serotonin Transporter Gene With Abnormal Emotional Processing in Ecstasy Users
Jonathan Paul Roiser, Lynnette J. Cook, Jason D. Cooper, David Chaim Rubinsztein, Barbara Jacquelyn Sahakian · 2005 · American Journal of Psychiatry
Effect fingerprinting of new psychoactive substances (NPS): What can we learn from in vitro data?
Laura Hondebrink, Anne Zwartsen, Remco H.S. Westerink · 2017 · Pharmacology & Therapeutics
3,4‐Methylenedioxymethamphetamine increases interleukin‐1β levels and activates microglia in rat brain: studies on the relationship with acute hyperthermia and 5‐HT depletion
Laura Orío, Esther O’Shea, Verónica Sánchez, Jesus Miguel Pradillo, Isabel Escobedo, Jorge Camarero, María Ángeles Moro, A. Richard Green, M. Isabel Colado · 2004 · Journal of Neurochemistry
The role of the sympathetic nervous system and uncoupling proteins in the thermogenesis induced by 3,4-methylenedioxymethamphetamine
Edward Mills, Daniel E. Rusyniak, Jon E. Sprague · 2004 · Journal of Molecular Medicine
The Impact of Alcohol, Tobacco, and Other Drug Use and Abuse in the Emergency Department
Gail D’Onofrio, Bruce M. Becker, Robert H. Woolard · 2006 · Emergency Medicine Clinics of North America
Serotonin (1A) receptor involvement in acute 3,4-methylenedioxymethamphetamine (MDMA) facilitation of social interaction in the rat
Morley, Kirsten C., Arnold, Jonathon C., McGregor, Iain S. · 2005 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
Substance Abuse and Male Hypogonadism
Ylenia Duca, Antônio Aversa, Rosita Angela Condorelli, Aldo Eugenio Calogero, Sandro La Vignera · 2019 · Journal of Clinical Medicine
3,4-Methylenedioxymethamphetamine in Adult Rats Produces Deficits in Path Integration and Spatial Reference Memory
Jessica A. Able, Gary A. Gudelsky, Charles V. Vorhees, Michael T. Williams · 2005 · Biological Psychiatry
Ecstasy induces apoptosis via 5-HT2A-receptor stimulation in cortical neurons
João Paulo Capela, Eduarda G. R. Fernandes, Fernando Remião, Maria de Lourdes Bastos, Andreas Meisel, Félix Dias Carvalho · 2007 · NeuroToxicology
Methamphetamine-induced hyperthermia and lethal toxicity: Role of the dopamine and serotonin transporters
Yohtaro Numachi, Arihisa Ohara, Motoyasu Yamashita, Setsu Fukushima, Hideaki Kobayashi, Harumi Hata, Hidekazu Watanabe, Frank Scott Hall, Klaus‐Peter Lesch, Dennis L. Murphy et al. · 2007 · European Journal of Pharmacology
The neurotoxicity of amphetamines during the adolescent period
A. Gomes, Vera Marisa Costa, Rita Feio‐Azevedo, Maria de Lourdes Bastos, Félix Dias Carvalho, João Paulo Capela · 2014 · International Journal of Developmental Neuroscience
Pill content, dose and resulting plasma concentrations of 3,4‐methylendioxymethamphetamine (MDMA) in recreational ‘ecstasy’ users
Kate Morefield, Michael John Keane, PETER D. FELGATE, Jason M. White, Rodney James Irvine · 2011 · Addiction
Dance Clubbing on MDMA and during Abstinence from Ecstasy/MDMA: Prospective Neuroendocrine and Psychobiological Changes
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Tolerance to 3,4-methylenedioxymethamphetamine in rats exposed to single high-dose binges
Michael H. Baumann, R.D. Clark, F.H. Franken, John J. Rutter, Richard B. Rothman · 2008 · Neuroscience
Qualitative Review of Serotonin Syndrome, Ecstasy (MDMA) and the use of Other Serotonergic Substances: Hierarchy of Risk
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Symptoms of anxiety and depression in childhood and use of MDMA: prospective, population based study
Anja C. Huizink, Robert F. Ferdinand, Jan van der Ende, Frank C. Verhulst · 2006 · BMJ
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MDMA: Interactions with other psychoactive drugs
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Ruud P. W. Litjens, Tibor M. Brunt, Gerard J. Alderliefste, Remco H.S. Westerink · 2014 · European Neuropsychopharmacology
Administration of SCH 23390 into the Medial Prefrontal Cortex Blocks the Expression of MDMA-Induced Behavioral Sensitization in Rats: An Effect Mediated by 5-HT2C Receptor Stimulation and not by D1 Receptor Blockade
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Reduced memory and attention performance in a population-based sample of young adults with a moderate lifetime use of cannabis, ecstasy and alcohol
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Lost in translation: preclinical studies on 3,4‐methylenedioxymethamphetamine provide information on mechanisms of action, but do not allow accurate prediction of adverse events in humans
Andrew R. Green, Madeleine V. King, Sinead E. Shortall, Kevin C.F. Fone · 2011 · British Journal of Pharmacology
Effects of Dose and Route of Administration on Pharmacokinetics of (±)-3,4-Methylenedioxymethamphetamine in the Rat
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STEREOCHEMICAL ANALYSIS OF 3,4-METHYLENEDIOXYMETHAMPHETAMINE AND ITS MAIN METABOLITES IN HUMAN SAMPLES INCLUDING THE CATECHOL-TYPE METABOLITE (3,4-DIHYDROXYMETHAMPHETAMINE)
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Changes in Cardiovascular Responsiveness and Cardiotoxicity Elicited during Binge Administration of Ecstasy
Lisa A Badon, Alissa R. Hicks, Kevin C. Lord, Brian A Ogden, Suzanne Meleg-Smith, Kurt James Varner · 2002 · Journal of Pharmacology and Experimental Therapeutics
Ecstasy (MDMA) mimics the post-orgasmic state: impairment of sexual drive and function during acute MDMA-effects may be due to increased prolactin secretion
Passie, Torsten, Hartmann, Uwe, Schneider, Udo, Emrich, Hinderk M., Krüger, Tillmann H.C. · 2005 · Medical Hypotheses
Clozapine Reverses Hyperthermia and Sympathetically Mediated Cutaneous Vasoconstriction Induced by 3,4-Methylenedioxymethamphetamine (Ecstasy) in Rabbits and Rats
William Walter Blessing, Benjamin White Seaman, Nigel P. Pedersen, Youichirou Ootsuka · 2003 · Journal of Neuroscience
Can the Severity of Dependence Scale Be Usefully Applied to ‘Ecstasy’?
Raimondo Bruno, Allison Jane Matthews, Libby Topp, Louisa J Degenhardt, Rapson Gomez, Matthew Dunn · 2009 · Neuropsychobiology
Neurocognitive function in current and ex-users of ecstasy in comparison to both matched polydrug-using controls and drug-naïve controls
Rosa Hoshi, Kate Mullins, Catherine Boundy, Catherine M. Brignell, Paola P. Piccini, H. Valerie Curran · 2007 · Psychopharmacology
Protective effects of minocycline on 3,4-methylenedioxymethamphetamine-induced neurotoxicity in serotonergic and dopaminergic neurons of mouse brain
Lin Zhang, Yukihiko Shirayama, Eiji Shimizu, Masaomi Iyo, Kenji Hashimoto · 2006 · European Journal of Pharmacology
Review: Pharmacogenetic aspects of the effect of cytochrome P450 polymorphisms on serotonergic drug metabolism, response, interactions, and adverse effects
J. L. Pilgrim, Dimitri Gerostamoulos, Olaf H. Drummer · 2010 · Forensic Science Medicine and Pathology
Evidence for Chronically Altered Serotonin Function in the Cerebral Cortex of Female 3,4-Methylenedioxymethamphetamine Polydrug Users
Tristan J. Watkins · 2011 · Archives of General Psychiatry
Combination effects of amphetamines under hyperthermia ‐ the role played by oxidative stress
Diana Dias da Silva, Elisabete A. Silva, Helena Carmo · 2013 · Journal of Applied Toxicology
Monoamine Oxidase-B Mediates Ecstasy-Induced Neurotoxic Effects to Adolescent Rat Brain Mitochondria
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Quantitative Pharmacology or Pharmacokinetic Pharmacodynamic Integration Should Be a Vital Component in Integrative Pharmacology
Johan Gabrielsson, A. R. Green · 2009 · Journal of Pharmacology and Experimental Therapeutics
(±)-3,4-Methylenedioxymethamphetamine Administration to Rats Does Not Decrease Levels of the Serotonin Transporter Protein or Alter Its Distribution between Endosomes and the Plasma Membrane
Xiaoying Wang, Michael H. Baumann, Heng Xu, Marisela Morales, Richard B. Rothman · 2005 · Journal of Pharmacology and Experimental Therapeutics
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Andrew C. Parrott, Raffaella Margherita Milani, Euphrosyne Gouzoulis‐Mayfrank, Jörg Daumann · 2007 · Journal of Neural Transmission
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Andrew C. Parrott, Jacqui Rodgers, Tom Buchanan, Jonathan Ling, Thomas Heffernan, Andrew B Scholey · 2006 · Human Psychopharmacology Clinical and Experimental
Phase I metabolites of mephedrone display biological activity as substrates at monoamine transporters
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Studies on the effect of MDMA (‘ecstasy’) on the body temperature of rats housed at different ambient room temperatures
A. Richard Green, Esther O’Shea, Kathryn S. Saadat, J. Martin Elliott, M. Isabel Colado · 2005 · British Journal of Pharmacology
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Walsh, Jessica J., Christoffel, Daniel J., Malenka, Robert C. · 2023 · Neuropsychopharmacology
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Andrew R. Green, Madeleine V. King, Sinead E. Shortall, Kevin C.F. Fone · 2014 · British Journal of Pharmacology
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Repeated MDMA (“Ecstasy”) exposure in adolescent male rats alters temperature regulation, spontaneous motor activity, attention, and serotonin transporter binding
Brian J. Piper, Joseph Fraiman, Jerrold S. Meyer · 2005 · Developmental Psychobiology
Acute Administration of 3,4‐Methylenedioxymethamphetamine Induces Profound Hyperthermia, Blood–Brain Barrier Disruption, Brain Edema Formation, and Cell Injury
Hari Shanker Sharma, Syed F. Ali · 2008 · Annals of the New York Academy of Sciences
Effects of the α2-Adrenergic Agonist Clonidine on the Pharmacodynamics and Pharmacokinetics of 3,4-Methylenedioxymethamphetamine in Healthy Volunteers
Cédric M. Hysek, Robin Brugger, Linda D. Simmler, Marcel Bruggisser, Massimiliano Donzelli, Eric Grouzmann, Marius Christian Hoener, Matthias E. Liechti · 2011 · Journal of Pharmacology and Experimental Therapeutics
A comparative study on the acute and long‐term effects of MDMA and 3,4‐dihydroxymethamphetamine (HHMA) on brain monoamine levels after i.p. or striatal administration in mice
Isabel Escobedo, Esther O’Shea, Laura Orío, Verónica Sánchez, Mireia Segura, Rafael de la Torre, Magı́ Farré, Alfred Richard Green, María Isabel Colado · 2005 · British Journal of Pharmacology
Repeated weekly exposure to MDMA, methamphetamine or their combination: Long-term behavioural and neurochemical effects in rats
Kelly J. Clemens, Jennifer Louise Cornish, Glenn E. Hunt, Iain S. McGregor · 2006 · Drug and Alcohol Dependence