The Pharmacology and Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”)

Green, A. Richard, Mechan, Annis O., Elliott, J. Martin, O’Shea, Esther, Colado, M. Isabel·2003·Pharmacological Reviews

DOI 10.1124/pr.55.3.3

Cited by (1,000)

Items 701–800 of 1,000

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Alinde E. Wallinga, Carolin Grahlmann, Ramon A. Granneman, Jaap M. Koolhaas, Bauke Buwalda · 2011 · Brain Research
Attenuation of MDMA-induced hyperthermia by ethanol in rats depends on ambient temperature
Jean‐Christophe Cassel, Sami Ben Hamida, Byron C. Jones · 2007 · European Journal of Pharmacology
Age differences in (±) 3,4‐methylenedioxymethamphetamine (MDMA)‐induced conditioned taste aversions and monoaminergic levels
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Abuse potential of methylenedioxymethamphetamine (MDMA) and its derivatives in zebrafish: role of serotonin 5HT2-type receptors
Luisa Ponzoni, Daniela Braida, Mariaelvina Sala · 2016 · Psychopharmacology
S(+)- and R(−)N-Methyl-1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) as discriminative stimuli: Effect of cocaine
Tatiana S Bondareva, Anna Wesołowska, Maƚgorzata Dukat, Mase Lee, Richard Young, Richard A. Glennon · 2005 · Pharmacology Biochemistry and Behavior
3,4-Methylenedioxymethamphetamine increases neuropeptide messenger RNA expression in rat striatum
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Apparent Transient Effects of Recent ???Ecstasy??? Use on Cognitive Performance and Extrapyramidal Signs in Human Subjects
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Tumour necrosis factor alpha suppression by MDMA is mediated by peripheral heteromeric nicotinic receptors
Jorge Camarasa, Clara Ros, David Pubill, Elena Escubedo · 2010 · Immunopharmacology and Immunotoxicology
The acute and long-term neurotoxic effects of MDMA on marble burying behaviour in mice
Kathryn S. Saadat, J. Martin Elliott, M. Isabel Colado, A. Richard Green · 2006 · Journal of Psychopharmacology
Actions of MDMA at glutamatergic neuromuscular junctions
Garrett M. Sparks, Sameera Dasari, Robin Lewis Cooper · 2004 · Neuroscience Research
Environmentally Friendly Expeditious One-Pot Electrochemical Synthesis of Bis-Catechol-Thioether Metabolites of Ecstasy: in vitro Neurotoxic Effects in the Rat Hippocampus
Anne Felim, Anne Neudörffer, François P. Monnet, Martine Largeron · 2008 · International Journal of Electrochemical Science
Increased anxiety-related behavior in male and female adult rats following early and late adolescent exposure to 3,4-methylenedioxymethamphetamine (MDMA)
Olga V. Kolyaduke, Robert N. Hughes · 2012 · Pharmacology Biochemistry and Behavior
fNIRS suggests increased effort during executive access in ecstasy polydrug users
Carl Alexander Roberts, Catharine Montgomery · 2014 · Psychopharmacology
Repeated administration of the 5-HT1B/1A agonist, RU 24969, facilitates the acquisition of MDMA self-administration: role of 5-HT1A and 5-HT1B receptor mechanisms
Dane Aronsen, Natasha Bukholt, Susan Schenk · 2016 · Psychopharmacology
Gene expression analysis indicates reduced memory and cognitive functions in the hippocampus and increase in synaptic reorganization in the frontal cortex 3 weeks after MDMA administration in Dark Agouti rats
Péter Petschner, Viola Tamási, Csaba Ádori, Eszter Kirilly, Rómeó D. Andó, László Tóthfalusi, György Bagdy · 2018 · BMC Genomics
Chronic ecstasy use increases neurotrophin-4 gene expression and protein levels in the rat brain
Homeira Hatami, Mohammad Ali Hossainpour-Faizi, Maryam Azarfarin, Parvin Azarfam · 2010 · Pharmacological Reports
Regulation of opioid gene expression in the rat brainstem by 3,4-methylenedioxymethamphetamine (MDMA): role of serotonin and involvement of CREB and ERK cascade
Manuela Di Benedetto, Sussy Bastias Candia, Claudio D’Addario, Elena Elettra Porticella, Chiara Cavina, Sanzio Candeletti, Patrizia Romualdi · 2010 · Naunyn-Schmiedeberg s Archives of Pharmacology
Long-term neuronal damage and recovery after a single dose of MDMA: expression and distribution of serotonin transporter in the rat brain.
Eszter Kirilly · 2010 · PubMed
Analysis of MDMA and its Metabolites in Urine and Plasma Following a Neurotoxic Dose of MDMA
Sandra Valtier, Clyde F. Phelix, John T. Cody · 2007 · Journal of Analytical Toxicology
Redesigning the designer drug ecstasy: non-psychoactive MDMA analogues exhibiting Burkitt's lymphoma cytotoxicity
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Topiramate prevents ecstasy consumption: a case report
Shahin Akhondzadeh, Ali Daliri Hampa · 2005 · Fundamental and Clinical Pharmacology
Bioisosteric analogs of MDMA : Improving the pharmacological profile?
Ana Sofia Alberto‐Silva, Selina Hemmer, Hailey A. Bock, Letícia Alves da Silva, Kenneth R. Scott, Nina Kastner, Manan Bhatt, Marco Niello, Kathrin Jäntsch, Oliver Kudlacek et al. · 2024 · Journal of Neurochemistry
MDMA and heightened cortisol: a neurohormonal perspective on the pregnancy outcomes of mothers used ‘Ecstasy’ during pregnancy
Andrew C. Parrott, Derek G. Moore, John J. Turner, Julia E. Goodwin, Meeyoung Oh Min, Lynn T. Singer · 2014 · Human Psychopharmacology Clinical and Experimental
Metabolic interactions between ethanol and MDMA in primary cultured rat hepatocytes
Helena Pontes, Paula Guedes de Pinho, Eduarda G. R. Fernandes, Paula S. Branco, Luísa Maria Ferreira, Helena Carmo, Fernando Remião, Félix Dias Carvalho, Maria de Lourdes Bastos · 2010 · Toxicology
The Role of Serotonin in Drug Addiction
Christian P. Müller, Martin E. Pum, Günter Schumann, Joseph P. Huston · 2010 · Handbook of behavioral neuroscience
Influence of chronic caffeine on MDMA-induced behavioral and neuroinflammatory response in mice
Jéssica Ruiz‐Medina, Ana Xavier Pinto, Marta Rodríguez‐Arias, José Miñarro, Olga Valverde · 2012 · Psychopharmacology
Human ecstasy (MDMA) polydrug users have altered brain activation during semantic processing
Tristan J. Watkins, Vidya Raj, Junghee Lee, Mary S. Dietrich, Aize Cao, Jennifer Urbano Blackford, Ronald M. Salomon, Sohee Park, Margaret M. Benningfield, Christina Iorio et al. · 2012 · Psychopharmacology
The Identification of a Chlorinated MDMA
V. Marešová, J. Hampl, Z. Chundela, Frantisek Zrcek, Miroslav Polášek, Jirí Chadt · 2005 · Journal of Analytical Toxicology
Acute behavioral effects of co-administration of mephedrone and MDMA in mice
Barbara Budzyńska, Agnieszka Michalak, Małgorzata Frankowska, Katarzyna Kaszubska, Grażyna Biała · 2016 · Pharmacological Reports
MDMA toxicity: management of acute and life-threatening presentations
Nicola Davies, William English, Johann Gründlingh · 2018 · British Journal of Nursing
The drug purity discounting task: Ecstasy use likelihood is reduced by probabilistic impurity according to harmfulness of adulterants
Sean B. Dolan, Matthew W. Johnson · 2020 · Drug and Alcohol Dependence
Êxtase (MDMA): efeitos farmacológicos e tóxicos, mecanismo de ação e abordagem clínica
Caroline Addison Carvalho Xavier, Patrícia Leal Dantas Lobo, Marta Maria de França Fonteles, Silvânia Maria Mendes Vasconcelos, Glauce Socorro de Barros Viana, Francisca Cléa Florenço de Sousa · 2008 · Archives of Clinical Psychiatry (São Paulo)
Sustained Exposure to 3,4-Methylenedioxymethamphetamine Induces the Augmentation of Exocytotic Serotonin Release in Rat Organotypic Raphe Slice Cultures
Kazuki Nagayasu, Maiko Kitaichi, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko · 2010 · Journal of Pharmacological Sciences
Glucose and corticosterone changes in developing and adult rats following exposure to (±)-3,4-methylendioxymethamphetamine or 5-methoxydiisopropyltryptamine
Devon L. Graham, Nicole R. Herring, Tori L. Schaefer, Charles V. Vorhees, Michael T. Williams · 2009 · Neurotoxicology and Teratology
High-dose MDMA does not result in long-term changes in impulsivity in the rat
Kathryn S. Saadat, J. Elliott, A. Green, P. Moran · 2006 · Psychopharmacology
Amphétamines et dérivés
Marie-Hélène Ghysel · 2004 · EMC - Toxicologie-Pathologie
Serotonin mediates rapid changes of striatal glucose and lactate metabolism after systemic 3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) administration in awake rats
Jan Bert Gramsbergen, Paul D. Cumming · 2007 · Neurochemistry International
Absorption and clearance of ±3,4-methylenedioxymethamphetamine from the plasma of neonatal rats
Michael T. Williams, Carrie A. Brown, Matthew R. Skelton, Alexander A. T. M. M. Vinks, Charles V. Vorhees · 2004 · Neurotoxicology and Teratology
Studies on the mechanisms underlying amiloride enhancement of 3,4-methylenedioxymethamphetamine-induced serotonin depletion in rats
Beatriz Goñi‐Allo, Elena Puerta, Isabel Hervías, Richard Di Palma, María Ramos, Berta Lasheras, Norberto Aguirre · 2007 · European Journal of Pharmacology
A Review of MDMA-Assisted Therapy for Posttraumatic Stress Disorder
Benjamin R. Lewis, Kevin Byrne · 2023 · FOCUS The Journal of Lifelong Learning in Psychiatry
Inhibition of 3,4‐methylenedioxymethamphetamine metabolism leads to marked decrease in 3,4‐dihydroxymethamphetamine formation but no change in serotonin neurotoxicity: Implications for mechanisms of neurotoxicity
Melanie Mueller, Jie Yuan, Concepción Maldonado Adrián, Una D. McCann, George A. Ricaurte · 2011 · Synapse
D1 but not D4 Dopamine Receptors are Critical for MDMA-Induced Neurotoxicity in Mice
Noelia Granado, Sara Ares‐Santos, Rosario Moratalla · 2013 · Neurotoxicity Research
Psychotomimetic effects of PCP, LSD, and Ecstasy: pharmacological models of schizophrenia?
Vibeke Sorensen Catts, Stanley Victor Catts · 2010 · Cambridge University Press eBooks
Subacute effects of ecstasy on mood: an exploration of associated risk factors
Rebecca M. Scott, Leanne M. Hides, Janice Sabura Allen, Dan Ian Lubman · 2012 · Journal of Psychopharmacology
3,4-Methylenedioxymethamphetamine (Ecstasy) Decreases Inflammation and Airway Reactivity in a Murine Model of Asthma
Daniel Stankevicius, V. Ferraz-de-Paula, Alison Ribeiro, M.L. Pinheiro, Ana Paula Ligeiro de Oliveira, Amílcar Sabino Damazo, Silvio Fernandes Lapachinske, Regina L. M. Moreau, Wothan Tavares de Lima, João Palermo‐Neto · 2012 · NeuroImmunoModulation
Behavioral profiles in rats distinguish among “ecstasy,” methamphetamine and 2,5-dimethoxy-4-iodoamphetamine: Mixed effects for “ecstasy” analogues.
David Quinteros-Muñoz, Patricio Sáez‐Briones, Gabriela Díaz‐Véliz, Sergio Mora-Gutiérrez, Marco Rebolledo-Fuentes, Bruce K. Cassels · 2010 · Behavioral Neuroscience
Direct Analysis of Conjugate Metabolites of Methamphetamine, 3,4-Methylenedioxymethamphetamine, and Their Designer Drugs in Biological Fluids
Noriaki Shima, Munehiro Katagi, Hitoshi Tsuchihashi · 2009 · Eisei kagaku
Prevention of drug priming- and cue-induced reinstatement of MDMA-seeking behaviors by the CB1 cannabinoid receptor antagonist AM251
Yoko Nawata, Kiyoyuki Kitaichi, Tsuneyuki Yamamoto · 2015 · Drug and Alcohol Dependence
MDMA decreases glutamic acid decarboxylase (GAD) 67-immunoreactive neurons in the hippocampus and increases seizure susceptibility: Role for glutamate
Courtney Huff, Rachel L. Morano, James P. Herman, Bryan K. Yamamoto, Gary A. Gudelsky · 2016 · NeuroToxicology
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Mehrak Javadi Paydar, Eric L. Harvey, Yanabel Grant, Sophia A. Vandewater, Kevin M. Creehan, Jacques D. Nguyen, Tobin J. Dickerson, Michael A. Taffe · 2018 · Psychopharmacology
Combining ecstasy and ethanol: higher risk for toxicity? A review
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Serotonin transporter availability, neurocognitive function and their correlation in abstinent 3,4‐methylenedioxymethamphetamine users
Foke L. van de Blaak, Glenn Dumont · 2021 · Human Psychopharmacology Clinical and Experimental
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Perry M. Duncan · 2020 · Cambridge University Press eBooks
ACUTE HIPPOCAMPAL SCLEROSIS FOLLOWING ECSTASY INGESTION
Helen Gardner, Nicholas D. Lawn, Daniel M Fatovich, John S. Archer · 2009 · Neurology
Effets aigus et à long terme de l’ecstasy
Julie Salzmann, Cynthia Marie-claire A, Florence Noble · 2004 · La Presse Médicale
Ecstasy versus alcohol: Tolstoy and the variations of unhappiness
Andrew C. Parrott · 2007 · Journal of Psychopharmacology
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5,7-Dihydroxitryptamine toxicity to serotonergic neurons in serum free raphe cultures
João Paulo Capela, Marion M. Lautenschlager, Ulrich Dirnagl, Maria de Lourdes Bastos, Félix Dias Carvalho, Andreas Meisel · 2008 · European Journal of Pharmacology
Effects of repeated exposure to MDMA on 5HT1a autoreceptor function: behavioral and neurochemical responses to 8-OHDPAT
Susan Schenk, Blaine Abraham, Dane Aronsen, Joyce Colussi‐Mas, Jennifer Do · 2013 · Psychopharmacology
Non-Serotonergic Neurotoxicity by MDMA (Ecstasy) in Neurons Derived from Mouse P19 Embryonal Carcinoma Cells
Dina Popova, Andréas Forsblad, Sanaz Hashemian, Stig O. P. Jacobsson · 2016 · PLoS ONE
Comparison of the effects of abstinence on MDMA and cocaine self-administration in rats
Quenten Highgate, Susan Schenk · 2018 · Psychopharmacology
A convenient biomimetic synthesis of optically active putative neurotoxic metabolites of MDMA (“ecstasy”) from R-(−)- and S-(+)-N-methyl-α-methyldopamine precursors
Claire-Marie Martinez, Anne Neudörffer, Martine Largeron · 2012 · Organic & Biomolecular Chemistry
MDMA (Ecstasy) Decreases the Number of Neurons and Stem Cells in Embryonic Cortical Cultures
Anna M. S. Kindlundh-Högberg, Chris Pickering, Grzegorz Wicher, David Hobér, Helgi B. Schiöth, Åsa Fex Svenningsen · 2009 · Cellular and Molecular Neurobiology
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Kelly Allott, BJ Canny, Jillian Helen Broadbear, Nigel K. Stepto, Brendán Murphy, Jennifer R. Redman · 2008 · Journal of Psychopharmacology
Interactions between 3,4-Methylenedioxymethamphetamine and Ethanol in Humans and Rodents
Wael M.Y. Mohamed, Sami Ben Hamida, Anne Pereira de Vasconcelos, Jean‐Christophe Cassel, Byron C. Jones · 2009 · Neuropsychobiology
Attenuation of the disruptive effects of (+/-)3,4-methylenedioxymethamphetamine and cocaine on delayed matching-to-sample performance with D1 versus D2 antagonists
David N. Harper · 2011 · Addiction Biology
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Tamara Senior, Michelle J. Botha, Alan Robert Kennedy, Jesus Calvo‐Castro · 2020 · ACS Omega
Effects of MDMA on the Human Nervous System
Una D. McCann, George A. Ricaurte · 2014 · Elsevier eBooks
Drogen- und Medikamentenabhängigkeit
Torsten Kienast, Andreas Heinz, M. Soyka · 2011 · Springer eBooks
Sleep Deprivation Differentially Impairs Cognitive Performance in Abstinent Methylenedioxymethamphetamine (“Ecstasy”) Users
Una D. McCann, Michael John Wilson, Francis P. Sgambati, George A. Ricaurte · 2009 · Journal of Neuroscience
Acute Neurochemical and Behavioral Effects of Stereoisomers of 4-Methylaminorex in Relation to Brain Drug Concentrations
Aino Kankaanpää, Satu Ellermaa, Esa Meririnne, Paula Hirsjärvi, Timo Seppälä · 2002 · Journal of Pharmacology and Experimental Therapeutics
Effects of long-term exposure of 3,4-methylenedioxymethamphetamine (MDMA; “ecstasy”) on neuronal transmitter transport, brain immuno-regulatory systems and progression of experimental periodontitis in rats
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Jordi Camarasa, Teresa Rodrigo, David Pubill, Elena Escubedo · 2011 · BioMolecular Concepts
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Rewarding effects of 3,4-methylenedioxymethamphetamine (“Ecstasy”) in dominant and subordinate OF-1 mice in the place preference conditioning paradigm
Gabriel Rodríguez-Alarcón, Juan J. Canales, Alicia Salvador · 2006 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
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Daniel Zamanillo, Enrique F. Portillo-Salido, José Miguel Vela, Luz I. Romero · 2012
RETRACTED ARTICLE: Gene expression analysis indicates CB1 receptor upregulation in the hippocampus and neurotoxic effects in the frontal cortex 3 weeks after single-dose MDMA administration in Dark Agouti rats
Péter Petschner, Viola Tamási, Csaba Ádori, Eszter Kirilly, Rómeó D. Andó, László Tóthfalusi, György Bagdy · 2013 · BMC Genomics · Retracted
Effects of chronic intracerebroventricular 3,4-methylenedioxy-N-methamphetamine (MDMA) or fluoxetine on the active avoidance test in rats with or without exposure to mild chronic stress
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State-dependent and environmental modulation of brain hyperthermic effects of psychoactive drugs of abuse
Eugene A. Kiyatkin · 2014 · Temperature
Blockade of noradrenaline transport abolishes 4‐methylthioamphetamine‐induced contraction of the rat aortain vitro
Sinéad Quinn, Patrick J. Guiry, T. Schwab, ALAN K. KEENAN, Gethin J. McBean · 2006 · Autonomic and Autacoid Pharmacology
Self-reports of Executive Dysfunction in Current Ecstasy/Polydrug Users
Florentia Hadjiefthyvoulou, John E. Fisk, Catharine Montgomery, Nikola Bridges · 2012 · Cognitive and Behavioral Neurology
Increased effects of 3,4-methylenedioxymethamphetamine (ecstasy) in a rat model of depression
Emily Joy Jaehne, Irina Majumder, Abdallah Salem, Rodney James Irvine · 2010 · Addiction Biology
Brain-derived neurotrophic factor protects serotonergic neurons against 3,4-methylenedioxymethamphetamine (“Ecstasy”) induced cytoskeletal damage
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Association of paradoxical sleep deprivation and ecstasy (MDMA) enhances genital reflexes in male rats
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Effects of 3,4-Methylenedioxymethamphetamine Administration on Retinal Physiology in the Rat
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Acute tryptophan depletion potentiates 3,4‐methylenedioxymethamphetamine‐induced cerebrovascular hyperperfusion in adult male wistar rats
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Caffeine alters the behavioural and body temperature responses to mephedrone without causing long-term neurotoxicity in rats
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MDMA, Methylone, and MDPV: Drug-Induced Brain Hyperthermia and Its Modulation by Activity State and Environment
Eugene A. Kiyatkin, Suelynn E. Ren · 2016 · Current topics in behavioral neurosciences
3,4-Methylenedioxymethamphetamine (MDMA) Alters Synaptic Dopamine Release in the Dorsal Striatum Through Nicotinic Receptors and DAT Inhibition
Francesca Romana Rizzo, Mauro Federici, Nicola Biagio Mercuri · 2018 · Neuroscience
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Pierre-Antoine Cotinet, Philippe Bizouarn, François Roux, Bertrand R Rozec · 2020 · Heart & Lung
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Ecstasy (3,4-methylenedioxymethamphetamine) limits murine gammaherpesvirus-68 induced monokine expression
Daniel A. Nelson, Jamie L. Nirmaier, Sam J. Singh, Melanie D. Tolbert, Kenneth L. Bost · 2008 · Brain Behavior and Immunity
(±)3,4-Methylenedioxyamphetamine elicits action potential bursts in a central snail neuron
Ming-Cheng Tsai, Yi‐Hung Chen · 2006 · Experimental Neurology
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Zifan Zhen, Xueqiang Sun, Shiying Yuan, Jiancheng Zhang · 2024 · Asian Journal of Psychiatry
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