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Cited by 211Neuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors StudyAmino Acid Enzymes and Metabolism

The Molecular Pharmacology and Cell Biology of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptors

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Palmer, Claire L., Cotton, Lucy, Henley, Jeremy M.·2005·Pharmacological Reviews
DOI 10.1124/pr.57.2.7PMC PMC3314513
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Abstract

Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) are of fundamental importance in the brain. They are responsible for the majority of fast excitatory synaptic transmission, and their overactivation is potently excitotoxic. Recent findings have implicated AMPARs in synapse formation and stabilization, and regulation of functional AMPARs is the principal mechanism underlying synaptic plasticity. Changes in AMPAR activity have been described in the pathology of numerous diseases, such as Alzheimer's disease, stroke, and epilepsy. Unsurprisingly, the developmental and activity-dependent changes in the functional synaptic expression of these receptors are under tight cellular regulation. The molecular and cellular mechanisms that control the postsynaptic insertion, arrangement, and lifetime of surface-expressed AMPARs are the subject of intense and widespread investigation. For example, there has been an explosion of information about proteins that interact with AMPAR subunits, and these interactors are beginning to provide real insight into the molecular and cellular mechanisms underlying the cell biology of AMPARs. As a result, there has been considerable progress in this field, and the aim of this review is to provide an account of the current state of knowledge.

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  • NMDAR-dependent LTD involves clathrin-dependent rapid endocytosis of AMPA receptors (AMPARs).

    “NMDA receptor (NMDAR)–dependent LTD, an extensively studied form of LTD, involves a rise in postsynaptic Ca2+ concentration, activation of a serine-threonine protein phosphatase cascade, and clathrin-dependent rapid endocytosis of AMPA receptors (AMPARs) [1]–[10].”

    From Regulated RalBP1 Binding to RalA and PSD-95 Controls AMPA Receptor Endocytosis and LTD (2009) · cites this paper as [4]

    Section II.F, “Trafficking, Learning, and Memory” (page unavailable), says LTD is caused in part by NMDA receptor-induced internalization of synaptic AMPARs and links that process to clathrin-mediated endocytosis. It does not establish that the endocytosis is rapid, so the timing qualifier is unsupported. (LLM, conf=0.84)

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Authors
Palmer, C. L., Cotton, L., & Henley, J. M.
Affiliations
University of Bristol (GB)
ORCID
Henley, Jeremy M.
Venue
Pharmacological Reviews
Publisher
Elsevier BV
Published
2005-06
Volume
57
Issue
2
Pages
253-277
ISSN
0031-6997 (ISSN-L)
DOI
10.1124/pr.57.2.7
PMC
PMC3314513
OpenAlex
W2147542138
Cited by
211
References
15
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 8 · 2022: 6 · 2021: 8 · 2020: 2 · 2019: 8 · 2018: 7 · 2017: 15 · 2016: 7 · 2015: 5 · 2014: 10 · 2013: 10 · 2012: 10
FWCI
1.72
Type
journal article
Language
en
Open access
Licence
Locations
  • Pharmacological Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Research Output (Edinburgh Napier University) (submittedVersion)
  • Edinburgh Napier Research Repository (Edinburgh Napier University) (submittedVersion)
Funders
Wellcome Trust
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords
AMPA receptors, excitatory synaptic transmission, excitotoxicity, synaptic plasticity, synaptogenesis, AMPA receptor subunits, Alzheimer's disease, stroke, epilepsy
MeSH terms
Animals, Humans, Receptors, AMPA, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid, Excitatory Amino Acid Agonists, Protein Transport

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