Glutamate receptor subunit 2 Serine 880 phosphorylation modulates synaptic transmission and mediates plasticity in CA1 pyramidal cells
Open accessAbstract
The cytoplasmic C termini of AMPA receptor subunits contain PDZ (postsynaptic density 95/Discs large/zona occludens 1) ligand domains that can control their synaptic trafficking during plasticity. The glutamate receptor subunit 2 (GluR2) PDZ ligand domain can be phosphorylated at serine 880 (S880), and this disrupts interactions with GRIP/ABP (glutamate receptor-interacting protein/AMPA-binding protein) but not with PICK1 (PKC-interacting protein 1). Here, the impact of GluR2 S880 phosphorylation on synaptic transmission and plasticity was explored by expressing, in hippocampal slice cultures, GluR2 subunits containing point mutations that mimic or prevent phosphorylation at this residue. Our results indicate that mimicking GluR2 S880 phosphorylation excludes these receptors from synapses, depresses transmission, and partially occludes long-term depression (LTD). Conversely, mutations that prevent phosphorylation reduce LTD. Disruption of the interaction between GluR2 and GRIP/ABP by S880 phosphorylation may thus facilitate removal of synaptic AMPA receptors and mediate some forms of activity-dependent synaptic depression.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Phosphorylation of GluA2 S880 prevents GRIP1/2 binding, promotes interaction of the GluA2 PDZ ligand with PICK1, destabilizes GluA2 within the PSD, and promotes GluA2 endocytosis.
“Phosphorylation of GluA2 S880 prevents GRIP1/2 binding and promotes the interaction of the GluA2 PDZ ligand with PICK1 (Seidenman et al., 2003, Chung et al., 2000, Steinberg et al., 2006), destabilizing GluA2 within the PSD and promoting GluA2 endocytosis.”
From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Seidenman et al., 2003
The GluA2 S880 phosphorylation site is important in hippocampal LTD.
“The GluA2 S880 phosphorylation site has also been shown to be important in hippocampal LTD (Seidenman et al., 2003, Chung et al., 2000, Steinberg et al., 2006).”
From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Seidenman et al., 2003
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hollmann, M., & Heinemann, S. F. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.000335 · Cited by 4,011 · see citing works
Glutamate receptor ion channels
Mayer, M. L. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.05.004 · Cited by 3,645 · see citing works
The Glutamate Receptor Ion Channels
Dingledine, R., Borges, K., Bowie, D., & Traynelis, S. F. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01394-2 · Cited by 3,554 · see citing works
AMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588 · see citing works
Self-citationHayashi, Y., Shi, S.-H., Esteban, J. A., Piccini, A., Poncer, J.-C., & Malinow, R. (2000) · Science · doi:10.1126/science.287.5461.2262 · Cited by 1,524 · see citing works
Self-citationRapid Spine Delivery and Redistribution of AMPA Receptors After Synaptic NMDA Receptor Activation
Shi, S.-H., Hayashi, Y., Petralia, R. S., Zaman, S. H., Wenthold, R. J., Svoboda, K., & Malinow, R. (1999) · Science · doi:10.1126/science.284.5421.1811 · Cited by 1,276 · see citing works
Self-citationRegulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity
Lee, H.-K., Barbarosie, M., Kameyama, K., Bear, M. F., & Huganir, R. L. (2000) · Nature · doi:10.1038/35016089 · Cited by 1,116 · see citing works
Self-citationReinsertion or Degradation of AMPA Receptors Determined by Activity-Dependent Endocytic Sorting
Ehlers, M. D. (2000) · Neuron · doi:10.1016/s0896-6273(00)00129-x · Cited by 1,096 · see citing works
Shi, S.-H., Hayashi, Y., Esteban, J. A., & Malinow, R. (2001) · Cell · doi:10.1016/s0092-8674(01)00321-x · Cited by 1,094 · see citing works
Self-citationInvolvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression
Mulkey, R. M., Endo, S., Shenolikar, S., & Malenka, R. C. (1994) · Nature · doi:10.1038/369486a0 · Cited by 1,083 · see citing works
The TINS/TiPS Lecture the molecular biology of mammalian glutamate receptor channels
Seeburg, P. H. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90093-2 · Cited by 881 · see citing works
GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors
Dong, H., O’Brien, R., Fung, E. T., Lanahan, A. A., Worley, P. F., & Huganir, R. L. (1997) · Nature · doi:10.1038/386279a0 · Cited by 871 · see citing works
Self-citationEvidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons
Wenthold, R., Petralia, R., Blahos J, II, & Niedzielski, A. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-01982.1996 · Cited by 850 · see citing works
The Tetrameric Structure of a Glutamate Receptor Channel
Rosenmund, C., Stern-Bach, Y., & Stevens, C. F. (1998) · Science · doi:10.1126/science.280.5369.1596 · Cited by 794 · see citing works
Ras and Rap control AMPA receptor trafficking during synaptic plasticity
Zhu, J. J., Qin, Y., Zhao, M., Van Aelst, L., & Malinow, R. (2002) · Cell · doi:10.1016/s0092-8674(02)00897-8 · Cited by 769 · see citing works
Self-citationRegulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD
Beattie, E. C., Carroll, R. C., Yu, X., Morishita, W., Yasuda, H., von Zastrow, M., & Malenka, R. C. (2000) · Nature Neuroscience · doi:10.1038/81823 · Cited by 745 · see citing works
An Essential Role for Protein Phosphatases in Hippocampal Long-Term Depression
Mulkey, R. M., Herron, C. E., & Malenka, R. C. (1993) · Science · doi:10.1126/science.8394601 · Cited by 699 · see citing works
Man, H., Lin, J., Ju, W. H., Ahmadian, G., Liu, L., Becker, L. E., Sheng, M., & Wang, Y. T. (2000) · Neuron · doi:10.1016/s0896-6273(00)81067-3 · Cited by 698 · see citing works
Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity
Lüscher, C., Xia, H., Beattie, E. C., Carroll, R. C., von Zastrow, M., Malenka, R. C., & Nicoll, R. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)81119-8 · Cited by 692 · see citing works
Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number
Schnell, E., Sizemore, M., Karimzadegan, S., Chen, L., Bredt, D. S., & Nicoll, R. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172511199 · Cited by 691 · see citing works
Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons
Passafaro, M., Piëch, V., & Sheng, M. (2001) · Nature Neuroscience · doi:10.1038/nn0901-917 · Cited by 655 · see citing works
Synaptic Strength Regulated by Palmitate Cycling on PSD-95
El-Husseini, A., Schnell, E., Dakoji, S., Sweeney, N. T., Zhou, Q., Prange, O., Gauthier-Campbell, C., Aguilera-Moreno, A., Nicoll, R. A., & Bredt, D. S. (2002) · Cell · doi:10.1016/s0092-8674(02)00683-9 · Cited by 569 · see citing works
Chung, H. J., Xia, J., Scannevin, R. H., Zhang, X., & Huganir, R. L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07258.2000 · Cited by 558 · see citing works
Self-citationDistinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization
Lin, J., Ju, W. H., Foster, K. A., Lee, S. H., Ahmadian, G., Wyszynski, M. W., Wang, Y. T., & Sheng, M. (2000) · Nature Neuroscience · doi:10.1038/81814 · Cited by 554 · see citing works
Clustering of AMPA Receptors by the Synaptic PDZ Domain–Containing Protein PICK1
Xia, J., Zhang, X., Staudinger, J. L., & Huganir, R. L. (1999) · Neuron · doi:10.1016/s0896-6273(00)80689-3 · Cited by 554 · see citing works
Self-citationSubstrate specificity of protein kinase C
Woodgett, J. R., Gould, K. L., & Hunter, T. R. (1986) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1986.tb10139.x · Cited by 510 · see citing works
Enhanced LTP in Mice Deficient in the AMPA Receptor GluR2
Jia, Z., Agopyan, N., Miu, P., Xiong, Z., Henderson, J., Gerlai, R. T., Taverna, F. A., Velumian, A. A., MacDonald, J. F., Carlen, P. L., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80225-1 · Cited by 488 · see citing works
Lee, S. H., Liu, L., Wang, Y. T., & Sheng, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)01024-3 · Cited by 441 · see citing works
Kishimoto, A., Nishiyama, K., Nakanishi, H., Uratsuji, Y., Nomura, H., Takeyama, Y., & Nishizuka, Y. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38898-1 · Cited by 417 · see citing works
Interaction of the N-Ethylmaleimide–Sensitive Factor with AMPA Receptors
Song, I., Kamboj, S. K., Xia, J., Dong, H., Liao, D., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80548-6 · Cited by 398 · see citing works
Self-citationLTP mechanisms: from silence to four-lane traffic.
Malinow, R., Mainen, Z., & Hayashi, Y. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00099-4 · Cited by 397 · see citing works
Self-citationXia, J., Chung, H. J., Wihler, C., Huganir, R. L., & Linden, D. J. (2000) · Neuron · doi:10.1016/s0896-6273(00)00128-8 · Cited by 383 · see citing works
Self-citationOsten, P., Srivastava, S., Inman, G. J., Vilim, F. S., Khatri, L., Lee, L. M., States, B. A., Einheber, S., Milner, T. A., Hanson, P. I., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80518-8 · Cited by 358 · see citing works
Novel Anchorage of GluR2/3 to the Postsynaptic Density by the AMPA Receptor–Binding Protein ABP
Srivastava, S., Osten, P., Vilim, F. S., Khatri, L., Inman, G. J., States, B. A., Daly, C., deSouza, S., Abagyan, R. A., Valtschanoff, J. G., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80568-1 · Cited by 357 · see citing works
Kim, C., Chung, H. J., Lee, H., & Huganir, R. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211132798 · Cited by 355 · see citing works
Self-citationRNA Editing at Arg607 Controls AMPA Receptor Exit from the Endoplasmic Reticulum
Greger, I. H., Khatri, L., & Ziff, E. B. (2002) · Neuron · doi:10.1016/s0896-6273(02)00693-1 · Cited by 350 · see citing works
Requirement of AMPA Receptor GluR2 Phosphorylation for Cerebellar Long-Term Depression
Chung, H. J., Steinberg, J. P., Huganir, R. L., & Linden, D. J. (2003) · Science · doi:10.1126/science.1082915 · Cited by 335 · see citing works
Self-citationPerez, J. L., Khatri, L., Chang, C., Srivastava, S., Osten, P., & Ziff, E. B. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-15-05417.2001 · Cited by 330 · see citing works
Daw, M. I., Chittajallu, R., Bortolotto, Z. A., Dev, K. K., Duprat, F., Henley, J. M., Collingridge, G. L., & Isaac, J. T. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00160-4 · Cited by 318 · see citing works
Staudinger, J. L., Zhou, J., Burgess, R., Elledge, S. J., & Olson, E. N. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.128.3.263 · Cited by 297 · see citing works
Osten, P., Khatri, L., Perez, J. L., Köhr, G., Giese, G., Daly, C., Schulz, T. W., Wensky, A. K., Lee, L. M., & Ziff, E. B. (2000) · Neuron · doi:10.1016/s0896-6273(00)00039-8 · Cited by 295 · see citing works
Hippocampal LTD Expression Involves a Pool of AMPARs Regulated by the NSF–GluR2 Interaction
Lüthi, A., Chittajallu, R., Duprat, F., Palmer, M. J., Benke, T. A., Kidd, F. L., Henley, J. M., Isaac, J. T. R., & Collingridge, G. L. (1999) · Neuron · doi:10.1016/s0896-6273(00)80852-1 · Cited by 295 · see citing works
Matsuda, S., Launey, T., Mikawa, S., & Hirai, H. (2000) · The EMBO Journal · doi:10.1093/emboj/19.12.2765 · Cited by 272 · see citing works
Matsuda, S., Mikawa, S., & Hirai, H. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.731765.x · Cited by 263 · see citing works
Specific Interaction of the PDZ Domain Protein PICK1 with the COOH Terminus of Protein Kinase C-α
Staudinger, J. L., Lu, J., & Olson, E. N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.51.32019 · Cited by 254 · see citing works
Regulation of Synaptic Strength by Protein Phosphatase 1
Morishita, W., Connor, J. H., Xia, H., Quinlan, E. M., Shenolikar, S., & Malenka, R. C. (2001) · Neuron · doi:10.1016/s0896-6273(01)00554-2 · Cited by 227 · see citing works
Dev, K. K., Nishimune, A., Henley, J. M., & Nakanishi, S. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(98)00230-5 · Cited by 212 · see citing works
Association of AMPA Receptors with a Subset of Glutamate Receptor-Interacting ProteinIn Vivo
Wyszynski, M. W., Valtschanoff, J. G., Naisbitt, S. R., Dunah, A. W., Kim, E., Standaert, D. G., Weinberg, R. J., & Sheng, M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-15-06528.1999 · Cited by 167 · see citing works
Statistical analysis of protein kinase specificity determinants
Kreegipuu, A., Blom, N., Brunak, S., & Järv, J. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00503-1 · Cited by 134 · see citing works
Differential roles for NSF and GRIP/ABP in AMPA receptor cycling
Braithwaite, S. P., Xia, H., & Malenka, R. C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102156099 · Cited by 131 · see citing works
deSouza, S., Fu, J., States, B. A., & Ziff, E. B. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03493.2002 · Cited by 123 · see citing works
Yamazaki, M., Fukaya, M., Abe, M., Ikeno, K., Kakizaki, T., Watanabe, M., & Sakimura, K. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01766-9 · Cited by 72 · see citing works
Burette, A., Khatri, L., Wyszynski, M. W., Sheng, M., Ziff, E. B., & Weinberg, R. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-02-00495.2001 · Cited by 47 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Shi S (2001) Molecular mechanisms for synaptic regulation of AMPA recep- tors. PhD thesis, State University of New York, Stony Brook.
Cited by
Sorted by citations
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968 · see citing works
Glutamate receptor ion channels
Mayer, M. L. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.05.004 · Cited by 3,645 · see citing works
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Traynelis, S. F., Wollmuth, L. P., McBain, C. J., Menniti, F. S., Vance, K. M., Ogden, K. K., Hansen, K. B., Yuan, H., Myers, S. J., & Dingledine, R. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002451 · Cited by 3,568 · see citing works
PDZ domain proteins of synapses
Kim, E., & Sheng, M. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1517 · Cited by 1,566 · see citing works
AMPAR Removal Underlies Aβ-Induced Synaptic Depression and Dendritic Spine Loss
Hsieh, H., Boehm, J., Sato, C., Iwatsubo, T., Tomita, T., Sisodia, S., & Malinow, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.035 · Cited by 1,042 · see citing works
Self-citationSynaptic AMPA receptor plasticity and behavior
Kessels, H. W., & Malinow, R. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.015 · Cited by 993 · see citing works
Self-citationThe cell biology of synaptic plasticity: AMPA receptor trafficking
Shepherd, J. D., & Huganir, R. L. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123516 · Cited by 978 · see citing works
Self-citationAMPARs and Synaptic Plasticity: The Last 25 Years
Huganir, R. L., & Nicoll, R. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.025 · Cited by 968 · see citing works
Self-citationThe AMPA Receptor Code of Synaptic Plasticity
Diering, G. H., & Huganir, R. L. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.018 · Cited by 844 · see citing works
Self-citationThe role of the GluR2 subunit in AMPA receptor function and synaptic plasticity
Isaac, J. T. R., Ashby, M. C., & McBain, C. J. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.001 · Cited by 802 · see citing works
Seminars in Cell & Developmental Biology
Lee, H., & Kirkwood, A. (2011) · Cited by 692 · see citing works
The interaction between Stargazin and PSD-95 regulates AMPA receptor surface trafficking
Bats, C., Groc, L., & Choquet, D. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.030 · Cited by 590 · see citing works
Regulation of AMPA receptor trafficking and synaptic plasticity
Anggono, V., & Huganir, R. L. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.12.006 · Cited by 588 · see citing works
Self-citationGlutamate and GABA Imbalance Following Traumatic Brain Injury
Guerriero, R. M., Giza, C. C., & Rotenberg, A. (2015) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-015-0545-1 · Cited by 471 · see citing works
Verde, E. R., Lee‐Osbourne, J., Worley, P. F., Malinow, R., & Cline, H. T. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.031 · Cited by 403 · see citing works
Self-citationNEURONAL SUBSTRATES OF COMPLEX BEHAVIORS IN C. ELEGANS
de Bono, M., & Maricq, A. V. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144259 · Cited by 401 · see citing works
Jörntell, H., & Hansel, C. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.032 · Cited by 382 · see citing works
Glutamate receptor dynamics in dendritic microdomains.
Newpher, T. M., & Ehlers, M. D. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.030 · Cited by 356 · see citing works
Chung, H. J., Huang, Y., Lau, L., & Huganir, R. L. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0546-04.2004 · Cited by 315 · see citing works
Self-citationSteinberg, J. P., Takamiya, K., Shen, Y., Xia, J., Rubio, M. E., Yu, S., Jin, W., Thomas, G. M., Linden, D. J., & Huganir, R. L. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.025 · Cited by 288 · see citing works
Self-citationLee, H.-K., Takamiya, K., He, K., Song, L., & Huganir, R. L. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00835.2009 · Cited by 261 · see citing works
Self-citationAMPA receptor trafficking and the mechanisms underlying synaptic plasticity and cognitive aging
Henley, J. M., & Wilkinson, K. A. (2013) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2013.15.1/jhenley · Cited by 236 · see citing works
PICK1 Interacts with ABP/GRIP to Regulate AMPA Receptor Trafficking
Lü, W., & Ziff, E. B. (2005) · Neuron · doi:10.1016/j.neuron.2005.07.006 · Cited by 224 · see citing works
Casein Kinase 2 Regulates the NR2 Subunit Composition of Synaptic NMDA Receptors
Sanz-Clemente, A., Matta, J. A., Isaac, J. T. R., & Roche, K. W. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.011 · Cited by 223 · see citing works
Brown, T. C., Tran, I. C., Backos, D. S., & Esteban, J. A. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.023 · Cited by 221 · see citing works
Synaptic plasticity and phosphorylation
Lee, H. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.06.003 · Cited by 215 · see citing works
Enhancing neuroplasticity in the basal ganglia: The role of exercise in Parkinson's disease
Petzinger, G. M., Fisher, B. E., Leeuwen, J. V., Vukovic, M., Akopian, G. K., Meshul, C. K., Holschneider, D. P., Nacca, A., Walsh, J. P., & Jakowec, M. W. (2010) · Movement Disorders · doi:10.1002/mds.22782 · Cited by 217 · see citing works
Palmer, C. L., Cotton, L., & Henley, J. M. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.7 · Cited by 211 · see citing works
Tau Phosphorylation at Serine 396 Residue Is Required for Hippocampal LTD
Regan, P., Piers, T., Yi, J.-H., Kim, D.-H., Huh, S., Park, S. J., Ryu, J. H., Whitcomb, D. J., & Cho, K. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2842-14.2015 · Cited by 202 · see citing works
Ischemic Insults Direct Glutamate Receptor Subunit 2-Lacking AMPA Receptors to Synaptic Sites
Liu, B., Liao, M., Mielke, J. G., Ning, K., Chen, Y., Li, L., El-Hayek, Y. H., Gomez, E., Zukin, R. S., Fehlings, M. G., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0567-06.2006 · Cited by 192 · see citing works
The developmental stages of synaptic plasticity
Löhmann, C., & Kessels, H. W. H. G. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.235119 · Cited by 176 · see citing works
Early Alterations of AMPA Receptors Mediate Synaptic Potentiation Induced by Neonatal Seizures
Rakhade, S. N., Zhou, C., Aujla, P. K., Fishman, R. E., Sucher, N. J., & Jensen, F. E. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1734-08.2008 · Cited by 180 · see citing works
Lin, D.-T., & Huganir, R. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1750-07.2007 · Cited by 186 · see citing works
Self-citationAge‐dependent requirement of AKAP150‐anchored PKA and GluR2‐lacking AMPA receptors in LTP
Lü, Y., Allen, M., Halt, A. R., Weisenhaus, M., Dallapiazza, R. F., Hall, D. D., Usachev, Y. M., McKnight, G. S., & Hell, J. W. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601884 · Cited by 166 · see citing works
PICK1 is a calcium‐sensor for NMDA‐induced AMPA receptor trafficking
Hanley, J. G., & Henley, J. M. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600801 · Cited by 162 · see citing works
Ras and Rap Signaling in Synaptic Plasticity and Mental Disorders
Stornetta, R. L., & Zhu, J. (2010) · The Neuroscientist · doi:10.1177/1073858410365562 · Cited by 159 · see citing works
Routes, destinations and delays: recent advances in AMPA receptor trafficking
Henley, J. M., Barker, E. A., & Glebov, O. O. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.02.004 · Cited by 158 · see citing works
Diering, G. H., Gustina, A. S., & Huganir, R. L. (2014) · Neuron · doi:10.1016/j.neuron.2014.09.024 · Cited by 153 · see citing works
Self-citationAMPA receptor biogenesis and trafficking
Greger, I. H., & Esteban, J. A. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.04.007 · Cited by 145 · see citing works
Divergent and convergent signaling by the diacylglycerol second messenger pathway in mammals
Brose, N., Betz, A., & Wegmeyer, H. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.05.006 · Cited by 140 · see citing works
Regulation of AMPA receptors and synaptic plasticity
Santos, S. D., Carvalho, A. L., Caldeira, M. V., & Duarte, C. B. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.037 · Cited by 139 · see citing works
Phosphorylation of AMPA Receptors: Mechanisms and Synaptic Plasticity
Wang, J. Q., Arora, A. K., Yang, L., Parelkar, N. K., Zhang, G., Liu, X., Choe, E. S., & Mao, L. (2005) · Molecular Neurobiology · doi:10.1385/mn:32:3:237 · Cited by 135 · see citing works
PICK1: a multi-talented modulator of AMPA receptor trafficking.
Hanley, J. (2008) · Pharmacology and Therapeutics · doi:10.1016/j.pharmthera.2008.02.002 · Cited by 141 · see citing works
AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking
Bissen, D., Foss, F., & Acker-Palmer, A. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03068-7 · Cited by 92 · see citing works
Purkey, A., & Dell’Acqua, M. L. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.00008 · Cited by 113 · see citing works
Davidkova, G., & Carroll, R. C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3334-07.2007 · Cited by 112 · see citing works
Amyloid-<i>β</i>-Induced Dysregulation of AMPA Receptor Trafficking
Guntupalli, S., Widagdo, J., & Anggono, V. (2016) · Neural Plasticity · doi:10.1155/2016/3204519 · Cited by 110 · see citing works
Taylor, E. W., Wang, K., Nelson, A. R., Bredemann, T. M., Fraser, K. B., Clinton, S. M., Puckett, R. E., Marchase, R. B., Chatham, J. C., & McMahon, L. L. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4761-12.2014 · Cited by 112 · see citing works
Structure and Function of PICK1
Xu, J., & Xia, J. (2007) · Neurosignals · doi:10.1159/000098482 · Cited by 113 · see citing works
Pugh, J. R., & Raman, I. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2061-08.2008 · Cited by 106 · see citing works
PICK1-mediated GluR2 endocytosis contributes to cellular injury after neuronal trauma
Bell, J., Park, E., Ai, J., & BAKER, A. J. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.106 · Cited by 102 · see citing works
Cellular mechanisms of burst firing‐mediated long‐term depression in rat neocortical pyramidal cells
Czarnecki, A., Birtoli, B., & Ulrich, D. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.123588 · Cited by 99 · see citing works
PICK1 inhibition of the Arp2/3 complex controls dendritic spine size and synaptic plasticity
Nakamura, Y., Wood, C. L., Patton, A. P., Jaafari, N., Henley, J. M., Mellor, J. R., & Hanley, J. G. (2011) · The EMBO Journal · doi:10.1038/emboj.2010.357 · Cited by 97 · see citing works
Roles of stargazin and phosphorylation in the control of AMPA receptor subcellular distribution
Kessels, H. W. H. G., Kopec, C. D., Klein, M. E., & Malinow, R. (2009) · Nature Neuroscience · doi:10.1038/nn.2340 · Cited by 96 · see citing works
Self-citationVanLeeuwen, J., Petzinger, G. M., Walsh, J. P., Akopian, G. K., Vuckovic, M., & Jakowec, M. W. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22216 · Cited by 94 · see citing works
Roles of subunit phosphorylation in regulating glutamate receptor function
Wang, J. Q., Guo, M., Jin, D.-Z., Xue, B., Fibuch, E. E., & Mao, L. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.11.019 · Cited by 91 · see citing works
Araki, Y., Lin, D.-T., & Huganir, R. L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006584107 · Cited by 92 · see citing works
Self-citationScaffold Proteins at the Postsynaptic Density
Verpelli, C., Schmeisser, M. J., Sala, C., & Boeckers, T. M. (2012) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-7091-0932-8_2 · Cited by 92 · see citing works
Lü, W., Isozaki, K., Roche, K. W., & Nicoll, R. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016289107 · Cited by 92 · see citing works
Synaptic AMPA Receptor Exchange Maintains Bidirectional Plasticity
McCormack, S. G., Stornetta, R. L., & Zhu, J. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.027 · Cited by 92 · see citing works
Toward Predictive Models of Mammalian Cells
Ma’ayan, A., Blitzer, R. D., & Iyengar, R. (2005) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.34.040204.144415 · Cited by 91 · see citing works
Kohda, K., Kakegawa, W., Matsuda, S., Yamamoto, T., Hirano, H., & Yuzaki, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218380110 · Cited by 90 · see citing works
GRIP1 regulates synaptic plasticity and learning and memory
Tan, H. L., Chiu, S.-L., Zhu, Q.-W., & Huganir, R. (2020) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.2014827117 · Cited by 76 · see citing works
Self-citationVolk, L., Kim, C.-H., Takamiya, K., Yu, Y., & Huganir, R. L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016103107 · Cited by 85 · see citing works
Self-citationGerges, N. Z., Tran, I. C., Backos, D. S., Harrell, J. M., Chinkers, M., Pratt, W. B., & Esteban, J. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0594-04.2004 · Cited by 85 · see citing works
Emerging Themes in PDZ Domain Signaling
Liu, X., & Fuentes, E. J. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.05.013 · Cited by 82 · see citing works
AMPAR trafficking in synapse maturation and plasticity
Bassani, S., Folci, A., Zapata, J., & Passafaro, M. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1309-1 · Cited by 81 · see citing works
M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss
Bradley, S. J., Bourgognon, J.-M., Sanger, H., Verity, N., Mogg, A. J., White, D., Butcher, A. J., Moreno, J. A., Molloy, C., Macedo-Hatch, T., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87526 · Cited by 81 · see citing works
Ras and Rap signal bidirectional synaptic plasticity via distinct subcellular microdomains
Zhang, L., Zhang, P., Wang, G.-F., Zhang, H.-Y., Zhang, Y., Yu, Y., Zhang, M.-X., Xiao, J., Crespo, P., Hell, J. W., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.03.049 · Cited by 77 · see citing works
Self-citationAMPA receptor regulation during synaptic plasticity in hippocampus and neocortex
Lee, H., & Kirkwood, A. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.06.007 · Cited by 769 · see citing works
Hu, X.-D., Huang, Q., Yang, X., & Xia, H.-H. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5365-06.2007 · Cited by 67 · see citing works
Cuadra, A. E., Kuo, S., Kawasaki, Y., Bredt, D. S., & Chetkovich, D. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1255-04.2004 · Cited by 78 · see citing works
Pan, L., Wu, H., Shen, C., Shi, Y.-W., Jin, W., Xia, J., & Zhang, M.-J. (2007) · EMBO Journal · doi:10.1038/sj.emboj.7601860 · Cited by 81 · see citing works
Axonal targeting of Caspr2 in hippocampal neurons via selective somatodendritic endocytosis
Bel, C., Oguievetskaia, K., Pitaval, C., Goutebroze, L., & Faivre‐Sarrailh, C. (2009) · Journal of Cell Science · doi:10.1242/jcs.050526 · Cited by 74 · see citing works
Dickinson, B. A., Jo, J., Seok, H., Son, G. H., Whitcomb, D. J., Davies, C. H., Sheng, M., Collingridge, G. L., & Cho, K. (2009) · Molecular Brain · doi:10.1186/1756-6606-2-18 · Cited by 71 · see citing works
Sustained Activation of Postsynaptic 5-HT2A Receptors Gates Plasticity at Prefrontal Cortex Synapses
Berthoux, C., Barre, A., Bockaert, J., Marin, P., & Bécamel, C. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy064 · Cited by 68 · see citing works
Goforth, P. B., Ren, J., Schwartz, B. S., & Satin, L. S. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00467.2010 · Cited by 69 · see citing works
Ca2+-permeable AMPA receptors in homeostatic synaptic plasticity
Lee, H. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00017 · Cited by 68 · see citing works
Jiang, J., Suppiramaniam, V. D., & Wooten, M. W. (2006) · Neurosignals · doi:10.1159/000105517 · Cited by 65 · see citing works
Exercise-induced plasticity of AMPA-type glutamate receptor subunits in the rat brain
Real, C. C., Ferreira, A. F. B., Hernandes, M. S., Britto, L. R. G., & Pires, R. S. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.060 · Cited by 64 · see citing works
Early-life seizures alter synaptic calcium-permeable AMPA receptor function and plasticity
Bell, J. J. L., Zhou, C., Sun, H., Feske, J. S., & Jensen, F. E. (2016) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2016.08.002 · Cited by 62 · see citing works
Hemby, S. E., Tang, W., Muly, E. C., Kuhar, M. J., Howell, L. L., & Mash, D. C. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03517.x · Cited by 62 · see citing works
Mauna, J. C., Miyamae, T., Pulli, B., & Thiels, E. (2010) · Hippocampus · doi:10.1002/hipo.20823 · Cited by 60 · see citing works
Clusters of interacting receptors can stabilize synaptic efficacies
Shouval, H. Z. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506934102 · Cited by 58 · see citing works
Shimshek, D. R., Bus, T., Kim, J., Mihaljević, A. L., Mack, V., Seeburg, P. H., Sprengel, R., & Schaefer, A. T. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030354 · Cited by 61 · see citing works
Synaptic Plasticity 101: The Story of the AMPA Receptor for the Brain Stimulation Practitioner
Brown, J. C., Higgins, E. S., & George, M. S. (2022) · Neuromodulation Technology at the Neural Interface · doi:10.1016/j.neurom.2021.09.003 · Cited by 59 · see citing works
Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1
Bassan, M., Liu, H., Madsen, K. L., Armsen, W., Zhou, J., DeSilva, T., Chen, W.-Z., Paradise, A., Brasch, M. A., Staudinger, J., et al. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05986.x · Cited by 58 · see citing works
Gainey, M. A., Tatavarty, V., Nahmani, M., Lin, H., & Turrigiano, G. (2015) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1510754112 · Cited by 55 · see citing works
Wang, J. Q., Liu, X., Zhang, G., Parelkar, N. K., Arora, A. K., Haines, M. M., Fibuch, E. E., & Mao, L. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.21050 · Cited by 56 · see citing works
Martínez-Rivera, A., Hao, J., Tropea, T. F., Giordano, T. P., Kosovsky, M., Rice, R. C., Lee, A., Huganir, R. L., Striessnig, J., Addy, N. A., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.9 · Cited by 55 · see citing works
Self-citationCaudal, D., Godsil, B. P., Mailliet, F., Bergerot, D., & Jay, T. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015282 · Cited by 56 · see citing works
Deng, Y. P., Xie, J., Wang, H. B., Lei, W., Chen, Q., & Reiner, A. (2007) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2007.02.008 · Cited by 55 · see citing works
Tavalin, S. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709253200 · Cited by 51 · see citing works
Lee, H., Takamiya, K., Kameyama, K., He, K., Yu, S., Rossetti, L., Wilen, D., & Huganir, R. L. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.06.003 · Cited by 49 · see citing works
Self-citationSun, L., & Liu, S. J. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.136788 · Cited by 48 · see citing works
Role of Phosphoinositides at the Neuronal Synapse
Frère, S. G. A., Chang-Ileto, B., & Paolo, G. D. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-3015-1_5 · Cited by 48 · see citing works
Phosphorylation and Assembly of Glutamate Receptors After Brain Ischemia
Zhang, F., Guo, A., Liu, C., Comb, M., & Hu, B. (2012) · Stroke · doi:10.1161/strokeaha.112.667253 · Cited by 44 · see citing works
2,3-Benzodiazepine-type AMPA receptor antagonists and their neuroprotective effects
Szénási, G., Végh, M., Szabo, G., Kertész, S., Kapus, G. L., Albert, M., Greff, Z., Ling, I., Barkóczy, J., Simig, G., et al. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.07.002 · Cited by 43 · see citing works
Zhang, G., Wang, X., Kong, L., Lu, X.-G., Lee, B. K., Liu, M., Sun, M., Franklin, C., Cook, R. G., & Geller, A. I. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2271-05.2005 · Cited by 42 · see citing works
Wigerblad, G., Huie, J. R., Yin, H. Z., Leinders, M., Pritchard, R. A., Koehrn, F. J., Xiao, W. H., Bennett, G. J., Huganir, R. L., Ferguson, A. R., et al. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.04.004 · Cited by 40 · see citing works
Self-citation
- Authors
- Seidenman, K. J., Steinberg, J. P., Huganir, R., & Malinow, R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-10-08
- Volume
- 23
- Issue
- 27
- Pages
- 9220-9228
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6740838
- OpenAlex
- W1805816820
- Cited by
- 225
- References
- 53
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 11 · 2020: 11 · 2019: 1 · 2018: 11 · 2017: 4 · 2016: 9 · 2015: 11 · 2014: 4 · 2013: 12 · 2012: 11
- FWCI
- 5.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- GluR2, AMPA receptors, PICK1, synaptic plasticity, long-term depression, synaptic transmission, CA1 pyramidal neurons, hippocampus
- MeSH terms
- Animals, Carrier Proteins, Cells, Cultured, Cytoskeletal Proteins, Hippocampus, Nerve Tissue Proteins, Synaptic Transmission, Neuronal Plasticity, Nuclear Proteins, Phosphorylation, Serine, Synapses, Mutagenesis, Site-Directed, Protein Structure, Tertiary, Pyramidal Cells, Receptors, AMPA, Patch-Clamp Techniques, Molecular Mimicry, Protein Subunits, Long-Term Synaptic Depression, Intracellular Signaling Peptides and Proteins, Adaptor Proteins, Signal Transducing, Rats, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
