Molecular and functional signatures in a novel Alzheimer’s disease mouse model assessed by quantitative proteomics
Open accessAbstract
Alzheimer’s disease (AD), the most common neurodegenerative disorder, is characterized by the deposition of extracellular amyloid plaques and intracellular neurofibrillary tangles. To understand the pathological mechanisms underlying AD, developing animal models that completely encompass the main features of AD pathologies is indispensable. Although mouse models that display pathological hallmarks of AD (amyloid plaques, neurofibrillary tangles, or both) have been developed and investigated, a systematic approach for understanding the molecular characteristics of AD mouse models is lacking. To elucidate the mechanisms underlying the contribution of amyloid beta (Aβ) and tau in AD pathogenesis, we herein generated a novel animal model of AD, namely the AD-like pathology with amyloid and neurofibrillary tangles (ADLP APT ) mice. The ADLP APT mice carry three human transgenes, including amyloid precursor protein, presenilin-1, and tau, with six mutations. To characterize the molecular and functional signatures of AD in ADLP APT mice, we analyzed the hippocampal proteome and performed comparisons with individual-pathology transgenic mice (i.e., amyloid or neurofibrillary tangles) and wild-type mice using quantitative proteomics with 10-plex tandem mass tag. The ADLP APT mice exhibited accelerated neurofibrillary tangle formation in addition to amyloid plaques, neuronal loss in the CA1 area, and memory deficit at an early age. In addition, our proteomic analysis identified nearly 10,000 protein groups, which enabled the identification of hundreds of differentially expressed proteins (DEPs) in ADLP APT mice. Bioinformatics analysis of DEPs revealed that ADLP APT mice experienced age-dependent active immune responses and synaptic dysfunctions. Our study is the first to compare and describe the proteomic characteristics in amyloid and neurofibrillary tangle pathologies using isobaric label-based quantitative proteomics. Furthermore, we analyzed the hippocampal proteome of the newly developed ADLP APT model mice to investigate how both Aβ and tau pathologies regulate the hippocampal proteome. Because the ADLP APT mouse model recapitulates the main features of AD pathogenesis, the proteomic data derived from its hippocampus has significant utility as a novel resource for the research on the Aβ-tau axis and pathophysiological changes in vivo.
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ADLPAPT mice carry six human mutations affecting amyloid precursor protein, presenilin-1, and tau protein.
“The ADLPAPT mice carry six human mutations affecting amyloid precursor protein, presenilin-1, and tau protein, and develop an AD-like pathology with amyloid and neurofibrillary tangles (167).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [167]
ADLPAPT mice develop an AD-like pathology with amyloid and neurofibrillary tangles.
“The ADLPAPT mice carry six human mutations affecting amyloid precursor protein, presenilin-1, and tau protein, and develop an AD-like pathology with amyloid and neurofibrillary tangles (167).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [167]
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- Authors
- Kim, D. K., Park, J., Han, D., Yang, J., Kim, A., Woo, J., Kim, Y., & Mook-Jung, I.
- Affiliations
- Seoul National University (KR)
- Corresponding author
- Kim, Youngsoo
- Venue
- Molecular Neurodegeneration
- Published
- 2018-01-16
- Volume
- 13
- Issue
- 1
- Pages
- 2-2
- ISSN
- 1750-1326 (ISSN-L)
- PMC
- PMC5771139
- OpenAlex
- W2782632913
- Cited by
- 95
- References
- 78
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 11 · 2023: 10 · 2022: 19 · 2021: 14 · 2020: 16 · 2019: 9 · 2018: 3
- FWCI
- 7.20
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Molecular Neurodegeneration (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- National Research Foundation of Korea (2011-0030738, 2017M3C9A5031597, 2011-0030740, 2015R1A2A1A05001794, 2014M3C7A1046047, 2015M3C7A1028790)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, amyloid plaques, neurofibrillary tangles, amyloid-beta, tau protein, hippocampal proteome, differentially expressed proteins, synaptic dysfunction, neuroinflammation, memory impairment, transgenic mouse model
- MeSH terms
- Alzheimer Disease, Animals, Disease Models, Animal, Hippocampus, Humans, Mice, Transgenic, Mutation, Amyloid beta-Protein Precursor, tau Proteins, Transgenes, Proteomics, Mice, Presenilin-1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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