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Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging
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Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging.
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“Potentially, some of the rejuvenating mechanisms occurring in MPTR may mirror those that occur during embryonic development as epigenetic rejuvenation during embryonic development coincides with de novo methylation of the genome (Kerepesi et al., 2021).”
From Multi-omic rejuvenation of human cells by maturation phase transient reprogramming (2022) · cites this paper as Kerepesi et al., 2021
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Self-citation
Metadata
- Authors
- Kerepesi, C., Zhang, B., Lee, S.-G., Trapp, A., & Gladyshev, V. N.
- Affiliations
- Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
- Venue
- Science Advances
- Published
- 2021-06-25
- Volume
- 7
- Issue
- 26
- ISSN
- 2375-2548
- PMC
- PMC8232908
- Cited by
- 130
- References
- 18
- Language
- en
- Funders
- National Institutes of Health (AG064223)
- National Institute on Aging (AG067782, AG065403)
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