The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Regulation of Longevity and Stress Resistance by Sch9 in Yeast
Abstract
The protein kinase Akt/protein kinase B (PKB) is implicated in insulin signaling in mammals and functions in a pathway that regulates longevity and stress resistance in Caenorhabditis elegans . We screened for long-lived mutants in nondividing yeast Saccharomyces cerevisiae and identified mutations in adenylate cyclase and SCH9 , which is homologous to Akt/PKB, that increase resistance to oxidants and extend life-span by up to threefold. Stress-resistance transcription factors Msn2/Msn4 and protein kinase Rim15 were required for this life-span extension. These results indicate that longevity is associated with increased investment in maintenance and show that highly conserved genes play similar roles in life-span regulation in S. cerevisiae and higher eukaryotes.
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Zoncu, R., Efeyan, A., & Sabatini, D. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3025 · Cited by 3,941
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Self-citationInduction of autophagy by spermidine promotes longevity
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Metadata
- Authors
- Fabrizio, P., Pozza, F., Pletcher, S. D., Gendron, C. M., & Longo, V. D.
- Venue
- Science
- Published
- 2001-04-13
- Volume
- 292
- Issue
- 5515
- Pages
- 288-290
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2002622198
- Cited by
- 874
- References
- 26
- FWCI
- 11.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fabrizio, P., Pozza, F., Pletcher, S. D., Gendron, C. M., & Longo, V. D. (2001). Regulation of Longevity and Stress Resistance by Sch9 in Yeast. Science. https://doi.org/10.1126/science.1059497
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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