Cited by 3,629Circadian rhythm and melatoninRetinal Development and DisordersPhotoreceptor and optogenetics research

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Phototransduction by Retinal Ganglion Cells That Set the Circadian Clock

Berson, David M., Dunn, Felice A., Takao, Motoharu·2002·Science

Open this paper in CoChat — free account

Abstract

Light synchronizes mammalian circadian rhythms with environmental time by modulating retinal input to the circadian pacemaker-the suprachiasmatic nucleus (SCN) of the hypothalamus. Such photic entrainment requires neither rods nor cones, the only known retinal photoreceptors. Here, we show that retinal ganglion cells innervating the SCN are intrinsically photosensitive. Unlike other ganglion cells, they depolarized in response to light even when all synaptic input from rods and cones was blocked. The sensitivity, spectral tuning, and slow kinetics of this light response matched those of the photic entrainment mechanism, suggesting that these ganglion cells may be the primary photoreceptors for this system.

Integrity signals

Registry

Crossref · 10.1126/science.1067262

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Melanopsin-Containing Retinal Ganglion Cells: Architecture, Projections, and Intrinsic Photosensitivity
Hattar, S., Liao, H.-W., Takao, M., Berson, D. M., & Yau, K.-W. (2002) · Science · doi:10.1126/science.1069609 · Cited by 2,734
Self-citation
A Novel Human Opsin in the Inner Retina
Provencio, I., Rodriguez, I. R., Jiang, G., Hayes, W. P., Moreira, E. F., & Rollag, M. D. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-02-00600.2000 · Cited by 1,290
Melanopsin: An opsin in melanophores, brain, and eye
Provencio, I., Jiang, G., De Grip, W. J., Hayes, W. P., & Rollag, M. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.340 · Cited by 975
Regulation of Mammalian Circadian Behavior by Non-rod, Non-cone, Ocular Photoreceptors
Freedman, M. S., Lucas, R. J., Soni, B. G., von Schantz, M., Muñoz, M., David-Gray, Z. K., & Foster, F. (1999) · Science · doi:10.1126/science.284.5413.502 · Cited by 841
Melanopsin in cells of origin of the retinohypothalamic tract
Gooley, J. J., Lü, J., Chou, T. C., Scammell, T. E., & Saper, C. B. (2001) · Nature Neuroscience · doi:10.1038/nn768 · Cited by 586
Spectral sensitivity of a novel photoreceptive system mediating entrainment of mammalian circadian rhythms
Takahashi, J. S., DeCoursey, P. J., Bauman, L., & Menaker, M. (1984) · Nature · doi:10.1038/308186a0 · Cited by 528
A schematic eye for the rabbit
Hughes, A. (1972) · Vision Research · doi:10.1016/0042-6989(72)90143-5 · Cited by 392
Twilight Times: Light and the Circadian System
Roenneberg, T., & Foster, F. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb03188.x · Cited by 379
The retinohypothalamic tract originates from a distinct subset of retinal ganglion cells
Moore, R. Y., Speh, J. C., & Card, J. P. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903520304 · Cited by 358
The Photopigment Melanopsin Is Exclusively Present in Pituitary Adenylate Cyclase-Activating Polypeptide-Containing Retinal Ganglion Cells of the Retinohypothalamic Tract
Hannibal, J., Hindersson, P., Knudsen, S. M., Georg, B., & Fahrenkrug, J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-01-j0002.2002 · Cited by 339

Show all 28 references

Research works printed but not linked: 3

von Schantz M., Provencio I., Foster R. G., Invest. Ophthalmol. Vis. Sci. 41, 1605 (2000).
Nelson D. E., Takahashi J. S., Am. J. Physiol. 277, R1351 (1999).
___, J. Biol. Rhythms 15, 31 (2000).

Sorted by citations

Items 901–1,000 of 1,017

Melanopsin—Shedding Light on the Elusive Circadian Photopigment
Brown, R. L., & Robinson, P. R. (2004) · Chronobiology International · doi:10.1081/cbi-120037816 · Cited by 51
High‐intensity red light suppresses melatonin
Hanifin, J. P., Stewart, K. T., Smith, P. H., Tanner, R. D., Rollag, M. D., & Brainard, G. C. (2006) · Chronobiology International · doi:10.1080/07420520500521988 · Cited by 52
Seasonal molecular timekeeping within the rat circadian clock
Sumová, A., Bendová, Z., Sládek, M., Kovačíková, Z., & Illnerová, H. (2004) · Physiological Research · doi:10.33549/physiolres.930000.53.s167 · Cited by 53
The relationship between full field electroretinogram and perimetry-like visual thresholds in RCS rats during photoreceptor degeneration and rescue by cell transplants
Sauvé, Y., Lu, B., & Lund, R. D. (2003) · Vision Research · doi:10.1016/j.visres.2003.08.015 · Cited by 51
Pupil size as a window on neural substrates of cognitionPreprint
Joshi, S., & Gold, J. I. (2019) · PsyArXiv (OSF Preprints) · doi:10.31234/osf.io/dvsme · Cited by 52
Prolonged Inner Retinal Photoreception Depends on the Visual Retinoid Cycle
Zhao, X., Pack, W., Khan, N. W., & Wong, K. Y. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2629-14.2016 · Cited by 53
Non-visual effects of office light environment: Field evaluation, model comparison, and spectral analysis
Zeng, Y., Sun, H., Lin, B., & Zhang, Q. (2021) · Building and Environment · doi:10.1016/j.buildenv.2021.107859 · Cited by 51
Multi-Level Processes and Retina–Brain Pathways of Photic Regulation of Mood
Maruani, J., & Geoffroy, P. A. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11020448 · Cited by 52
Circadian Regulation of Macronutrient Absorption
Hussain, M. M., & Pan, X. (2015) · Journal of Biological Rhythms · doi:10.1177/0748730415599081 · Cited by 53
Integration of a luminescent solar concentrator: Effects on daylight, correlated color temperature, illuminance level and color rendering index
Aste, N., Tagliabue, L. C., Palladino, P., & Testa, D. (2015) · Solar Energy · doi:10.1016/j.solener.2015.01.042 · Cited by 52
From Blue Light to Clock Genes in Zebrafish ZEM-2S Cells
Ramos, B. C. R., Moraes, M. N., Poletini, M. O., de Lima, L. H. R. G., & Castrucci, A. M. D. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106252 · Cited by 51
Light, dark, and melatonin: emerging evidence for the importance of melatonin in ocular physiology
Brennan, R., Jan, J. E., & Lyons, C. J. (2006) · Eye · doi:10.1038/sj.eye.6702597 · Cited by 52
Outdoor Artificial Nighttime Light and Use of Hypnotic Medications in Older Adults: A Population-Based Cohort Study
Min, J., & Min, K. (2018) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.7490 · Cited by 50
Bright Light Therapy and Circadian Cycles in Institutionalized Elders
Díaz, J. Á. R., Gamundı́, A., Akaârir, M., Cañellas, F., Rial, R. V., & Nicolau, M. C. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00359 · Cited by 52
Can We See with Melanopsin?
Lucas, R. J., Allen, A. E., Milosavljevic, N., Storchi, R., & Woelders, T. (2020) · Annual Review of Vision Science · doi:10.1146/annurev-vision-030320-041239 · Cited by 51
Daily Morning Blue Light Therapy Improves Daytime Sleepiness, Sleep Quality, and Quality of Life Following a Mild Traumatic Brain Injury
Raikes, A. C., Dailey, N. S., Shane, B. R., Forbeck, B., Alkozei, A., & Killgore, W. D. S. (2020) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0000000000000579 · Cited by 53
Circadian Rhythms in the Endocrine System
Kriegsfeld, L. J., LeSauter, J., Hamada, T., Pitts, S., & Silver, R. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50020-2 · Cited by 50
Alzheimer's Disease and Glaucoma: Imaging the Biomarkers of Neurodegenerative Disease
Valenti, D. A. (2010) · International Journal of Alzheimer s Disease · doi:10.4061/2010/793931 · Cited by 50
Rhodopsin Formation inDrosophilaIs Dependent on the PINTA Retinoid-Binding Protein
Wang, T., & Montell, C. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0995-05.2005 · Cited by 50
Green light analgesia in mice is mediated by visual activation of enkephalinergic neurons in the ventrolateral geniculate nucleus
Tang, Y.-L., Liu, A., Lv, S., Zhou, Z., Cao, H., Weng, S.-J., & Zhang, Y. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abq6474 · Cited by 49
Caspase-7: a critical mediator of optic nerve injury-induced retinal ganglion cell death
Choudhury, S., Liu, Y., Clark, A. F., & Pang, I.-H. (2015) · Molecular Neurodegeneration · doi:10.1186/s13024-015-0039-2 · Cited by 49
Occupational hazards in orthodontics: A review of risks and associated pathology
Pandis, N., Pandis, B. D., Pandis, V., & Eliades, T. (2007) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/j.ajodo.2006.10.017 · Cited by 49
Late histological and functional changes in the P23H rat retina after photoreceptor loss
Kolomiets, B. P., Dubus, É., Simonutti, M., Rosolen, S. G., Sahel, J., & Picaud, S. A. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.12.025 · Cited by 49
A step forward toward smart white lighting: Combination of glass phosphor and light emitting diodes
Andrade, L. H. C., Lima, S. M., Novatski, A., Steimacher, A., Rohling, J. H., Medina, A. N., Bento, A. C., Baesso, M. L., Guyot, Y., & Boulon, G. (2009) · Applied Physics Letters · doi:10.1063/1.3186784 · Cited by 49
The ipRGC‐Driven Pupil Response with Light Exposure, Refractive Error, and Sleep
Abbott, K. S., Queener, H. M., & Ostrin, L. A. (2018) · Optometry and Vision Science · doi:10.1097/opx.0000000000001198 · Cited by 52
Survival of Alpha and Intrinsically Photosensitive Retinal Ganglion Cells in NMDA-Induced Neurotoxicity and a Mouse Model of Normal Tension Glaucoma
Honda, S., Namekata, K., Kimura, A. K., Guo, X., Harada, C., Murakami, A., Matsuda, A., & Harada, T. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.19-27145 · Cited by 49
Expression of mRNA for glutamate receptor subunits distinguishes the major classes of retinal neurons, but is less specific for individual cell types.
Jakobs, T., Ben, Y., & Masland, R. H. (2007) · PubMed Central · Cited by 49
Preservation of vision following cell-based therapies in a model of retinal degenerative disease
McGill, T. J., Lund, R. D., Douglas, R. M., Wang, S., Lü, B., & Prusky, G. T. (2004) · Vision Research · doi:10.1016/j.visres.2004.05.025 · Cited by 49
Expression of Novel Opsins and Intrinsic Light Responses in the Mammalian Retinal Ganglion Cell Line RGC-5. Presence of OPN5 in the Rat Retina
Nieto, P. S., Valdez, D. J., Acosta-Rodríguez, V. A., & Guido, M. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026417 · Cited by 51
Physiology and Morphology of Color-Opponent Ganglion Cells in a Retina Expressing a Dual Gradient of S and M Opsins
Yin, L., Smith, R. G., Sterling, P., & Brainard, D. H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5471-08.2009 · Cited by 49
Effects of Light on Attention and Reaction Time: A Systematic Review
Golmohammadi, R., Yousefi, H., Khotbesara, N. S., Nasrolahi, A., & Kurd, N. (2021) · Journal of Research in Health Sciences · doi:10.34172/jrhs.2021.66 · Cited by 51
The Light-Dosimeter: A new device to help advance research on the non-visual responses to light
Stampfli, J., Schrader, B., di Battista, C., Häfliger, R., Schälli, O., Wichmann, G., Zumbühl, C., Blattner, P., Cajochen, C., Lazar, R., et al. (2023) · Lighting Research & Technology · doi:10.1177/14771535221147140 · Cited by 48
Cardiovascular disease and lifestyle choices: Spotlight on circadian rhythms and sleep
Figueiro, M. G., & Pedler, D. R. (2023) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2023.02.004 · Cited by 51
Vesicular glutamate transporter 2 (VGLUT2) is co-stored with PACAP in projections from the rat melanopsin-containing retinal ganglion cells
Engelund, A., Fahrenkrug, J., Harrison, A. P., & Hannibal, J. (2010) · Cell and Tissue Research · doi:10.1007/s00441-010-0950-3 · Cited by 48
Alerting effects of daytime light exposure – a proposed link between light exposure and brain mechanisms
Rautkylä, E., Puolakka, M., & Halonen, L. (2011) · Lighting Research & Technology · doi:10.1177/1477153511409294 · Cited by 51
In vivo evaluation of retinal and callosal projections in early postnatal development and plasticity using manganese-enhanced MRI and diffusion tensor imaging
Chan, K. C., Cheng, J. S., Fan, S., Zhou, I. Y., Yang, J., & Wu, E. X. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.09.055 · Cited by 48
Biophysical Variation within the M1 Type of Ganglion Cell Photoreceptor
Emanuel, A. J., Kapur, K., & Do, M. T. H. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.095 · Cited by 48
Daylight Provision Requirements According to EN 17037 as a Restriction for Sustainable Urban Planning of Residential Developments
Šprah, N., & Košir, M. (2019) · Sustainability · doi:10.3390/su12010315 · Cited by 48
Genome sequence and comparative analysis of reindeer (Rangifer tarandus) in northern Eurasia
Weldenegodguad, M., Pokharel, K., Ming, Y., Honkatukia, M., Peippo, J., Reilas, T., Røed, K. H., & Kantanen, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-65487-y · Cited by 54
Absence of Normal Photic Integration in the Circadian Visual System: Response to Millisecond Light Flashes
Vidal, L., & Morin, L. P. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5496-06.2007 · Cited by 49
Calcium Dynamics and Circadian Rhythms in Suprachiasmatic Nucleus Neurons
Ikeda, M. (2004) · The Neuroscientist · doi:10.1177/10738584031262149 · Cited by 49
Short-term acute bright light exposure induces a prolonged anxiogenic effect in mice via a retinal ipRGC-CeA circuit
Wang, G., Liu, Y., Yang, Z., Yu, C.-X., Tong, Q., Tang, Y.-L., Shao, Y., Wang, L., Xu, X., Cao, H., et al. (2023) · Science Advances · doi:10.1126/sciadv.adf4651 · Cited by 48
Sleep Pharmacogenetics: Personalized Sleep-Wake Therapy
Holst, S. C., Valomon, A., & Landolt, H. (2015) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010715-103801 · Cited by 48
Health consequences of shift work and implications for structural design
Figueiro, M. G., & White, R. D. (2013) · Journal of Perinatology · doi:10.1038/jp.2013.7 · Cited by 48
Impairment of Intrinsically Photosensitive Retinal Ganglion Cells Associated With Late Stages of Retinal Degeneration
Esquiva, G., Lax, P., & Cuenca, N. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-12120 · Cited by 52
Vasoactive intestinal peptide produces long-lasting changes in neural activity in the suprachiasmatic nucleus
Kudo, T., Tahara, Y., Gamble, K. L., McMahon, D. G., Block, G. D., & Colwell, C. S. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00114.2013 · Cited by 47
Photophobia in a blind patient: an alternate visual pathway
Amini, A. H., Digre, K. B., & Couldwell, W. T. (2006) · Journal of neurosurgery · doi:10.3171/jns.2006.105.5.765 · Cited by 47
Immunohistochemical Evidence of a Melanopsin Cone in Human Retina
Dkhissi‐Benyahya, O., Rieux, C., Hut, R. A., & Cooper, H. M. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-1459 · Cited by 50
Melanopsin driven enhancement of cone-mediated visual processing
Zele, A. J., Adhikari, P., Cao, D., & Feigl, B. (2019) · Vision Research · doi:10.1016/j.visres.2019.04.009 · Cited by 47
The biological clock in cluster headache: A review and hypothesis
Naber, W. C., Fronczek, R., Haan, J., Doesborg, P. G. G., Colwell, C. S., Ferrari, M. D., & Meijer, J. H. (2019) · Cephalalgia · doi:10.1177/0333102419851815 · Cited by 51
Opsins outside the eye and the skin: a more complex scenario than originally thought for a classical light sensor
Moraes, M. N., de Assis, L. V. M., Provencio, I., & Castrucci, A. M. D. L. (2021) · Cell and Tissue Research · doi:10.1007/s00441-021-03500-0 · Cited by 47
A pilot study for circadian gene disturbance in dementia patients
Liu, H., Hu, C., Tang, Y.-C., & Chang, J. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.02.041 · Cited by 49
Circadian Phase Shifting, Alerting, and Antidepressant Effects of Bright Light Treatment
Postolache, T. T., & Oren, D. A. (2005) · Clinics in Sports Medicine · doi:10.1016/j.csm.2004.12.005 · Cited by 48
Cognition in circadian rhythm sleep disorders
Reid, K. J., Koch, L. L. M., & Zee, P. C. (2011) · Progress in brain research · doi:10.1016/b978-0-444-53817-8.00001-3 · Cited by 47
Multiple Photoreceptors Contribute to Nonimage-forming Visual Functions Predominantly through Melanopsin-containing Retinal Ganglion CellsPreprint
Güler, A. D., Altimus, C. M., Ecker, J. L., & Hattar, S. S. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.074 · Cited by 49
Circadian-independent light regulation of mammalian metabolism
Rao, F., & Xue, T. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01051-6 · Cited by 46
Delayed response of human melanopsin retinal ganglion cells on the pupillary light reflex
Tsujimura, S., & Tokuda, Y. (2011) · Ophthalmic and Physiological Optics · doi:10.1111/j.1475-1313.2011.00846.x · Cited by 51
Membrane receptors and transporters involved in the function and transport of vitamin A and its derivatives
Sun, H. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.06.010 · Cited by 47
Blue light from light-emitting diodes directed at a single eye elicits a dose-dependent suppression of melatonin in horses
Walsh, C. M., Prendergast, R. L., Sheridan, J. T., & Murphy, B. A. (2012) · The Veterinary Journal · doi:10.1016/j.tvjl.2012.09.003 · Cited by 48
Spectral optimization of the color temperature tunable white light-emitting diode (LED) cluster consisting of direct-emission blue and red LEDs and a diphosphor conversion LED
Zhong, P., He, G., & Zhang, M. (2012) · Optics Express · doi:10.1364/oe.20.00a684 · Cited by 46
The lumen seen in a new light: Making distinctions between light, lighting and neuroscience
Rea, M. S. (2014) · Lighting Research & Technology · doi:10.1177/1477153514527599 · Cited by 46
Absence of Long-Wavelength Photic Potentiation of Murine Intrinsically Photosensitive Retinal Ganglion Cell Firing In Vitro
Mawad, K., & Gelder, R. N. V. (2008) · Journal of Biological Rhythms · doi:10.1177/0748730408323063 · Cited by 46
Sensor Devices Inspired by the Five Senses: A Review
Svechtarova, M. I., Buzzacchera, I., Toebes, B. J., Lauko, J., Anton, N., & Wilson, C. (2016) · Electroanalysis · doi:10.1002/elan.201600047 · Cited by 48
Inherited Photoreceptor Degeneration Causes the Death of Melanopsin-Positive Retinal Ganglion Cells and Increases Their Coexpression of Brn3a
García‐Ayuso, D., Pierdomenico, J. D., Esquiva, G., Nadal-Nicolás, F. M., Pinilla, I., Cuenca, N., Vidal‐Sanz, M., Agudo‐Barriuso, M., & Villegas‐Pérez, M. P. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-16808 · Cited by 47
Impact of seasons on an individual’s chronotype: current perspectives
Shawa, N., Rae, D. E., & Roden, L. C. (2018) · Nature and Science of Sleep · doi:10.2147/nss.s158596 · Cited by 50
Association between solar insolation and a history of suicide attempts in bipolar I disorder
Bauer, M., Glenn, T., Alda, M., Andreassen, O. A., Angelopoulos, E. K., Ardau, R., Ayhan, Y., Baethge, C., Bauer, R., Baune, B. T., et al. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.03.001 · Cited by 47
A Blue-Enriched, Increased Intensity Light Intervention to Improve Alertness and Performance in Rotating Night Shift Workers in an Operational Setting
Sletten, T. L., Raman, B., Magee, M., Ferguson, S. A., Kennaway, D. J., Grunstein, R. R., Lockley, S. W., & Rajaratnam, S. M. W. (2021) · Nature and Science of Sleep · doi:10.2147/nss.s287097 · Cited by 47
Circadian Photoreception in Humans and Mice
Kavaklı, İ. H. (2002) · Molecular Interventions · doi:10.1124/mi.2.8.484 · Cited by 48
Short light–dark cycles affect sleep in mice
Deboer, T., Ruijgrok, G., & Meijer, J. H. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05964.x · Cited by 46
Regulation of Mammalian Physiology by Interconnected Circadian and Feeding Rhythms
Atger, F., Mauvoisin, D., Weger, B. D., Gobet, C., & Gachon, F. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00042 · Cited by 46
Dawn simulation light impacts on different cognitive domains under sleep restriction
Gabel, V., Maire, M., Reichert, C. F., Chellappa, S. L., Schmidt, C., Hommes, V., Cajochen, C., & Viola, A. U. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.12.043 · Cited by 45
Disrupted circadian rhythms and mental health
Walker, W. H., Walton, J. C., & Nelson, R. J. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819975-6.00016-9 · Cited by 48
The Ventral Tegmental Area and Nucleus Accumbens as Circadian Oscillators: Implications for Drug Abuse and Substance Use Disorders
Becker‐Krail, D. D., Walker, W. H., & Nelson, R. J. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.886704 · Cited by 48
Active interventions of dynamic lighting on human circadian rhythm and sleep quality in confined spaces
Wang, T., Li, J., Wang, Y., Dai, S., Shao, R., & Hao, L. (2022) · Building and Environment · doi:10.1016/j.buildenv.2022.109766 · Cited by 46
Afternoon Nap and Bright Light Exposure Improve Cognitive Flexibility Post Lunch
Slama, H., Deliens, G., Schmitz, R., Peigneux, P., & Leproult, R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125359 · Cited by 49
Circadian disruption: potential implications in inflammatory and metabolic diseases associated with alcohol
Voigt, R. M. (2013) · Alcohol research · doi:10.35946/arcr.v35.1.10 · Cited by 46
Comparison of acute non-visual bright light responses in patients with optic nerve disease, glaucoma and healthy controls
Münch, M. Y., Léon, L., Collomb, S., & Kawasaki, A. (2015) · Scientific Reports · doi:10.1038/srep15185 · Cited by 46
Effects of daytime light exposure on cognitive brain activity as measured by the ERP P300
Okamoto, Y., & Nakagawa, S. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.10.013 · Cited by 45
Retinal Waves Modulate an Intraretinal Circuit of Intrinsically Photosensitive Retinal Ganglion Cells
Arroyo, D. A., Kirkby, L. A., & Feller, M. B. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0572-16.2016 · Cited by 45
Influence of lighting color temperature on effort-related cardiac response
Lasauskaite, R., & Cajochen, C. (2017) · Biological Psychology · doi:10.1016/j.biopsycho.2017.11.005 · Cited by 48
The potential influence of LED lighting on mental illness
Bauer, M., Glenn, T., Monteith, S., Gottlieb, J. F., Ritter, P. S., Geddes, J. R., & Whybrow, P. C. (2017) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2017.1417639 · Cited by 47
Diurnal rodents as pertinent animal models of human retinal physiology and pathology
Verra, D. M., Sajdak, B. S., Merriman, D. K., & Hicks, D. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2019.100776 · Cited by 47
Overlapping morphological and functional properties between M4 and M5 intrinsically photosensitive retinal ganglion cells
Sonoda, T., Okabe, Y., & Schmidt, T. M. (2019) · The Journal of Comparative Neurology · doi:10.1002/cne.24806 · Cited by 45
Efficient circadian daylighting: A proposed equation, experimental validation, and the consequent importance of room surface reflectance
Yao, Q., Cai, W., Li, M., Hu, Z., Xue, P., & Dai, Q. (2020) · Energy and Buildings · doi:10.1016/j.enbuild.2020.109784 · Cited by 45
Retinal ganglion cell interactions shape the developing mammalian visual system
D’Souza, S. P., & Lang, R. A. (2020) · Development · doi:10.1242/dev.196535 · Cited by 45
Melanopsin Triggers the Release of Internal Calcium Stores in Response to Light†
Kumbalasiri, T., Rollag, M. D., Isoldi, M. C., Castrucci, A. M. D. L., & Provencio, I. (2007) · Photochemistry and Photobiology · doi:10.1562/2006-07-11-ra-964 · Cited by 48
Orexin A modulates neuronal activity of the rodent suprachiasmatic nucleus in vitro
Klisch, C., Inyushkin, A. N., Mordel, J., Karnas, D., Pévet, P., & Meissl, H. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06794.x · Cited by 46
Seeing More Clearly: Recent Advances in Understanding Retinal Circuitry
He, S., Dong, W., Deng, Q., Weng, S.-J., & Sun, W. (2003) · Science · doi:10.1126/science.1085457 · Cited by 45
The eye of the african mole‐ratCryptomys anselli: to see or not to see?
Cernuda‐Cernuda, R., García-Fernández, J. M., Gordijn, M. C. M., Bovée‐Geurts, P. H. M., & DeGrip, W. J. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02485.x · Cited by 45
Human Nonvisual Responses to Simultaneous Presentation of Blue and Red Monochromatic Light
Papamichael, C., Skene, D. J., & Revell, V. L. (2012) · Journal of Biological Rhythms · doi:10.1177/0748730411431447 · Cited by 50
Retinal Injuries from Light: Mechanisms, Hazards, and Prevention
Mainster, M. A., & Turner, P. L. (2006) · Elsevier eBooks · doi:10.1016/b978-0-323-02598-0.50115-4 · Cited by 45
Short wavelength light filtering by the natural human lens and IOLs – implications for entrainment of circadian rhythm
Brøndsted, A. E., Lundeman, J. H., & Kessel, L. (2011) · Acta Ophthalmologica · doi:10.1111/j.1755-3768.2011.02291.x · Cited by 45
Light-transduction in melanopsin-expressing photoreceptors of Amphioxus
Gómez, M. D. P., Angueyra, J. M., & Nasi, E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900708106 · Cited by 44
A role for the ciliary marginal zone in the melanopsin-dependent intrinsic pupillary light reflex
Semo, M., Gias, C., Ahmado, A., & Vugler, A. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.11.013 · Cited by 44
Full-field Chromatic Pupillometry for the Assessment of the Postillumination Pupil Response Driven by Melanopsin-Containing Retinal Ganglion Cells
Lei, S., Goltz, H. C., Chandrakumar, M., & WONG, A. M. F. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-14103 · Cited by 46
Comparison and Correction of the Light Sensor Output from 48 Wearable Light Exposure Devices by Using a Side-by-Side Field Calibration Method
Markvart, J., Hansen, Å. M., & Christoffersen, J. (2015) · LEUKOS The Journal of the Illuminating Engineering Society of North America · doi:10.1080/15502724.2015.1020948 · Cited by 44
Ghrelin and liver disease
Quiñones, M., Fernø, J., & Al–Massadi, O. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09528-6 · Cited by 46
M1 Intrinsically Photosensitive Retinal Ganglion Cells Integrate Rod and Melanopsin Inputs to Signal in Low Light
Lee, S. K., Sonoda, T., & Schmidt, T. M. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.024 · Cited by 44
The effects of light exposure on the cortisol stress response in human males
Petrowski, K., Bührer, S., Niedling, M., & Schmalbach, B. (2020) · Stress · doi:10.1080/10253890.2020.1741543 · Cited by 45
Potential Pathways for Circadian Dysfunction and Sundowning-Related Behavioral Aggression in Alzheimer’s Disease and Related Dementias
Todd, W. D. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00910 · Cited by 46

Authors: Berson, D. M., Dunn, F. A., & Takao, M.
Affiliations: Brown University (US)
Corresponding author: Berson, David M.
Dunn, Felice A.
Takao, Motoharu
ORCID: Berson, David M.
Dunn, Felice A.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2002-02-08
Volume: 295
Issue: 5557
Pages: 1070-1073
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1067262
OpenAlex: W2009077913
Cited by: 3,629
References: 28
Citations by year: 2026: 162 · 2025: 188 · 2024: 194 · 2023: 186 · 2022: 206 · 2021: 221 · 2020: 196 · 2019: 224 · 2018: 193 · 2017: 184 · 2016: 164 · 2015: 159 · 2014: 167 · 2013: 132 · 2012: 135
FWCI: 31.42
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Eye Institute (EY12793, R01EY012793)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
Keywords: retinal ganglion cells, intrinsically photosensitive retinal ganglion cells, circadian clock, suprachiasmatic nucleus, light entrainment, non-visual photoreception, rod and cone photoreceptors, spectral tuning
MeSH terms: Melanopsin, Animals, Axons, Biological Clocks, Circadian Rhythm, Dendrites, Isoquinolines, Kinetics, Light, Retinal Ganglion Cells, Suprachiasmatic Nucleus, Rats, Sprague-Dawley, Rod Opsins, Patch-Clamp Techniques, Rats, Light Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Phototransduction by Retinal Ganglion Cells That Set the Circadian Clock

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks