The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Phototransduction by Retinal Ganglion Cells That Set the Circadian Clock
Abstract
Light synchronizes mammalian circadian rhythms with environmental time by modulating retinal input to the circadian pacemaker-the suprachiasmatic nucleus (SCN) of the hypothalamus. Such photic entrainment requires neither rods nor cones, the only known retinal photoreceptors. Here, we show that retinal ganglion cells innervating the SCN are intrinsically photosensitive. Unlike other ganglion cells, they depolarized in response to light even when all synaptic input from rods and cones was blocked. The sensitivity, spectral tuning, and slow kinetics of this light response matched those of the photic entrainment mechanism, suggesting that these ganglion cells may be the primary photoreceptors for this system.
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In the citing paper
“Photoreceptor cells containing melanopsin play a role in the phase-shifting effects of short-wavelength light.”
In the citing paper
“NIF light effects at shorter wavelength via novel photoreceptors containing the photopigment melanopsin appear to strongly impact the human circadian timing system [11,12].”
From Dawn simulation light impacts on different cognitive domains under sleep restriction (2015) · cites this paper as [11]
In the citing paper
“This third class of photoreceptors, called intrinsically photosensitive retinal ganglion cells (ipRGCs), are engaged in several non-image-forming functions, including circadian phototransduction34.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [34]
Citations
Cites
Hattar, S., Liao, H.-W., Takao, M., Berson, D. M., & Yau, K.-W. (2002) · Science · doi:10.1126/science.1069609 · Cited by 2,734
Self-citationA Novel Human Opsin in the Inner Retina
Provencio, I., Rodriguez, I. R., Jiang, G., Hayes, W. P., Moreira, E. F., & Rollag, M. D. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-02-00600.2000 · Cited by 1,290
Melanopsin: An opsin in melanophores, brain, and eye
Provencio, I., Jiang, G., De Grip, W. J., Hayes, W. P., & Rollag, M. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.340 · Cited by 975
Regulation of Mammalian Circadian Behavior by Non-rod, Non-cone, Ocular Photoreceptors
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Melanopsin in cells of origin of the retinohypothalamic tract
Gooley, J. J., Lü, J., Chou, T. C., Scammell, T. E., & Saper, C. B. (2001) · Nature Neuroscience · doi:10.1038/nn768 · Cited by 586
Takahashi, J. S., DeCoursey, P. J., Bauman, L., & Menaker, M. (1984) · Nature · doi:10.1038/308186a0 · Cited by 528
A schematic eye for the rabbit
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Twilight Times: Light and the Circadian System
Roenneberg, T., & Foster, F. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb03188.x · Cited by 379
The retinohypothalamic tract originates from a distinct subset of retinal ganglion cells
Moore, R. Y., Speh, J. C., & Card, J. P. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903520304 · Cited by 358
Hannibal, J., Hindersson, P., Knudsen, S. M., Georg, B., & Fahrenkrug, J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-01-j0002.2002 · Cited by 339
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Research works printed but not linked: 3
- von Schantz M., Provencio I., Foster R. G., Invest. Ophthalmol. Vis. Sci. 41, 1605 (2000).
- Nelson D. E., Takahashi J. S., Am. J. Physiol. 277, R1351 (1999).
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Cited by
Sorted by citations
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379
Solid-State Light Sources Getting Smart
Schubert, E. F., & Kim, J. K. (2005) · Science · doi:10.1126/science.1108712 · Cited by 3,513
Hattar, S., Liao, H.-W., Takao, M., Berson, D. M., & Yau, K.-W. (2002) · Science · doi:10.1126/science.1069609 · Cited by 2,734
Self-citationDibner, C., Schibler, U., & Albrecht, U. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135821 · Cited by 2,421
Molecular components of the mammalian circadian clock
Ko, C. H., & Takahashi, J. S. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl207 · Cited by 1,718
Metadata
- Authors
- Berson, D. M., Dunn, F. A., & Takao, M.
- Affiliations
- Brown University (US)
- Corresponding author
- Berson, David M.
- Dunn, Felice A.
- Takao, Motoharu
- Venue
- Science
- Published
- 2002-02-08
- Volume
- 295
- Issue
- 5557
- Pages
- 1070-1073
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2009077913
- Cited by
- 3,629
- References
- 28
- Citations by year
- 2026: 162 · 2025: 188 · 2024: 194 · 2023: 186 · 2022: 206 · 2021: 221 · 2020: 196 · 2019: 224 · 2018: 193 · 2017: 184 · 2016: 164 · 2015: 159 · 2014: 167 · 2013: 132 · 2012: 135
- FWCI
- 31.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (EY12793, R01EY012793)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
- Keywords
- retinal ganglion cells, intrinsically photosensitive retinal ganglion cells, circadian clock, suprachiasmatic nucleus, light entrainment, non-visual photoreception, rod and cone photoreceptors, spectral tuning
- MeSH terms
- Melanopsin, Animals, Axons, Biological Clocks, Circadian Rhythm, Dendrites, Isoquinolines, Kinetics, Light, Retinal Ganglion Cells, Suprachiasmatic Nucleus, Rats, Sprague-Dawley, Rod Opsins, Patch-Clamp Techniques, Rats, Light Signal Transduction
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