Cited by 3,629Circadian rhythm and melatoninRetinal Development and DisordersPhotoreceptor and optogenetics research

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Phototransduction by Retinal Ganglion Cells That Set the Circadian Clock

Berson, David M., Dunn, Felice A., Takao, Motoharu·2002·Science

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Abstract

Light synchronizes mammalian circadian rhythms with environmental time by modulating retinal input to the circadian pacemaker-the suprachiasmatic nucleus (SCN) of the hypothalamus. Such photic entrainment requires neither rods nor cones, the only known retinal photoreceptors. Here, we show that retinal ganglion cells innervating the SCN are intrinsically photosensitive. Unlike other ganglion cells, they depolarized in response to light even when all synaptic input from rods and cones was blocked. The sensitivity, spectral tuning, and slow kinetics of this light response matched those of the photic entrainment mechanism, suggesting that these ganglion cells may be the primary photoreceptors for this system.

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“This new photoreceptor plays a major role in regulating the biological clock [5,7] and is also involved in pupillary constriction [8].”
Background

Authors: Berson, D. M., Dunn, F. A., & Takao, M.
Affiliations: Brown University (US)
Corresponding author: Berson, David M.
Dunn, Felice A.
Takao, Motoharu
ORCID: Berson, David M.
Dunn, Felice A.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2002-02-08
Volume: 295
Issue: 5557
Pages: 1070-1073
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1067262
OpenAlex: W2009077913
Cited by: 3,629
References: 28
Citations by year: 2026: 162 · 2025: 188 · 2024: 194 · 2023: 186 · 2022: 206 · 2021: 221 · 2020: 196 · 2019: 224 · 2018: 193 · 2017: 184 · 2016: 164 · 2015: 159 · 2014: 167 · 2013: 132 · 2012: 135
FWCI: 31.42
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Eye Institute (EY12793, R01EY012793)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
Keywords: retinal ganglion cells, intrinsically photosensitive retinal ganglion cells, circadian clock, suprachiasmatic nucleus, light entrainment, non-visual photoreception, rod and cone photoreceptors, spectral tuning
MeSH terms: Melanopsin, Animals, Axons, Biological Clocks, Circadian Rhythm, Dendrites, Isoquinolines, Kinetics, Light, Retinal Ganglion Cells, Suprachiasmatic Nucleus, Rats, Sprague-Dawley, Rod Opsins, Patch-Clamp Techniques, Rats, Light Signal Transduction

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Phototransduction by Retinal Ganglion Cells That Set the Circadian Clock

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