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Phototransduction by Retinal Ganglion Cells That Set the Circadian Clock
Abstract
Light synchronizes mammalian circadian rhythms with environmental time by modulating retinal input to the circadian pacemaker-the suprachiasmatic nucleus (SCN) of the hypothalamus. Such photic entrainment requires neither rods nor cones, the only known retinal photoreceptors. Here, we show that retinal ganglion cells innervating the SCN are intrinsically photosensitive. Unlike other ganglion cells, they depolarized in response to light even when all synaptic input from rods and cones was blocked. The sensitivity, spectral tuning, and slow kinetics of this light response matched those of the photic entrainment mechanism, suggesting that these ganglion cells may be the primary photoreceptors for this system.
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In the citing paper
“Photoreceptor cells containing melanopsin play a role in the phase-shifting effects of short-wavelength light.”
In the citing paper
“NIF light effects at shorter wavelength via novel photoreceptors containing the photopigment melanopsin appear to strongly impact the human circadian timing system [11,12].”
From Dawn simulation light impacts on different cognitive domains under sleep restriction (2015) · cites this paper as [11]
In the citing paper
“This third class of photoreceptors, called intrinsically photosensitive retinal ganglion cells (ipRGCs), are engaged in several non-image-forming functions, including circadian phototransduction34.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [34]
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Hattar, S., Liao, H.-W., Takao, M., Berson, D. M., & Yau, K.-W. (2002) · Science · doi:10.1126/science.1069609 · Cited by 2,734
Self-citationA Novel Human Opsin in the Inner Retina
Provencio, I., Rodriguez, I. R., Jiang, G., Hayes, W. P., Moreira, E. F., & Rollag, M. D. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-02-00600.2000 · Cited by 1,290
Melanopsin: An opsin in melanophores, brain, and eye
Provencio, I., Jiang, G., De Grip, W. J., Hayes, W. P., & Rollag, M. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.340 · Cited by 975
Regulation of Mammalian Circadian Behavior by Non-rod, Non-cone, Ocular Photoreceptors
Freedman, M. S., Lucas, R. J., Soni, B. G., von Schantz, M., Muñoz, M., David-Gray, Z. K., & Foster, F. (1999) · Science · doi:10.1126/science.284.5413.502 · Cited by 841
Melanopsin in cells of origin of the retinohypothalamic tract
Gooley, J. J., Lü, J., Chou, T. C., Scammell, T. E., & Saper, C. B. (2001) · Nature Neuroscience · doi:10.1038/nn768 · Cited by 586
Takahashi, J. S., DeCoursey, P. J., Bauman, L., & Menaker, M. (1984) · Nature · doi:10.1038/308186a0 · Cited by 528
A schematic eye for the rabbit
Hughes, A. (1972) · Vision Research · doi:10.1016/0042-6989(72)90143-5 · Cited by 392
Twilight Times: Light and the Circadian System
Roenneberg, T., & Foster, F. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb03188.x · Cited by 379
The retinohypothalamic tract originates from a distinct subset of retinal ganglion cells
Moore, R. Y., Speh, J. C., & Card, J. P. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903520304 · Cited by 358
Hannibal, J., Hindersson, P., Knudsen, S. M., Georg, B., & Fahrenkrug, J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-01-j0002.2002 · Cited by 339
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Research works printed but not linked: 3
- von Schantz M., Provencio I., Foster R. G., Invest. Ophthalmol. Vis. Sci. 41, 1605 (2000).
- Nelson D. E., Takahashi J. S., Am. J. Physiol. 277, R1351 (1999).
- ___, J. Biol. Rhythms 15, 31 (2000).
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Sjöstedt, E., Zhong, W., Fagerberg, L., Karlsson, M., Mitsios, N., Adori, C., Oksvold, P., Edfors, F., Limiszewska, A., Hikmet, F., et al. (2020) · Science · doi:10.1126/science.aay5947 · Cited by 1,151
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Ecker, J. L., Dumitrescu, O. N., Wong, K. Y., Alam, N. M., Chen, S., LeGates, T. A., Renna, J. M., Prusky, G. T., Berson, D. M., & Hattar, S. S. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.023 · Cited by 697
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Dubocovich, M. L., Delagrange, P., Krause, D. N., Sugden, D., Cardinali, D. P., & Olcese, J. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.002832 · Cited by 636
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Gamlin, P. D. R., McDougal, D. H., Pokorny, J., Smith, V. C., Yau, K.-W., & Dacey, D. M. (2007) · Vision Research · doi:10.1016/j.visres.2006.12.015 · Cited by 617
McDougal, D. H., & Gamlin, P. D. (2014) · Comprehensive physiology · doi:10.1002/cphy.c140014 · Cited by 645
Lagali, P. S., Bálya, D., Awatramani, G. B., Münch, T. A., Kim, D. S., Busskamp, V., Cepko, C. L., & Roska, B. (2008) · Nature Neuroscience · doi:10.1038/nn.2117 · Cited by 580
Genetics of Circadian Rhythms in Mammalian Model Organisms
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Melatonin and sleep in aging population
Pandi-Perumal, S. R., Zisapel, N., Srinivasan, V. J., & Cardinali, D. P. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.08.009 · Cited by 367
Information Processing in the Primate Retina: Circuitry and Coding
Field, G. D., & Chichilnisky, E. J. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094252 · Cited by 378
Zaidi, F. H., Hull, J. T., Peirson, S. N., Wulff, K., Aeschbach, D., Gooley, J. J., Brainard, G. C., Gregory-Evans, K., Rizzo, J. F., Czeisler, C. A., et al. (2007) · Current Biology · doi:10.1016/j.cub.2007.11.034 · Cited by 385
Stevens, R. G., Blask, D. E., Brainard, G. C., Hansen, J., Lockley, S. W., Provencio, I., Rea, M. S., & Reinlib, L. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10200 · Cited by 357
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Stevens, R. G. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyp178 · Cited by 345
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Iuvone, P. M., Tosini, G., Pozdeyev, N. V., Haque, R., Klein, D. C., & Chaurasia, S. S. (2005) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2005.01.003 · Cited by 349
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Metadata
- Authors
- Berson, D. M., Dunn, F. A., & Takao, M.
- Affiliations
- Brown University (US)
- Corresponding author
- Berson, David M.
- Dunn, Felice A.
- Takao, Motoharu
- Venue
- Science
- Published
- 2002-02-08
- Volume
- 295
- Issue
- 5557
- Pages
- 1070-1073
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2009077913
- Cited by
- 3,629
- References
- 28
- Citations by year
- 2026: 162 · 2025: 188 · 2024: 194 · 2023: 186 · 2022: 206 · 2021: 221 · 2020: 196 · 2019: 224 · 2018: 193 · 2017: 184 · 2016: 164 · 2015: 159 · 2014: 167 · 2013: 132 · 2012: 135
- FWCI
- 31.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (EY12793, R01EY012793)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
- Keywords
- retinal ganglion cells, intrinsically photosensitive retinal ganglion cells, circadian clock, suprachiasmatic nucleus, light entrainment, non-visual photoreception, rod and cone photoreceptors, spectral tuning
- MeSH terms
- Melanopsin, Animals, Axons, Biological Clocks, Circadian Rhythm, Dendrites, Isoquinolines, Kinetics, Light, Retinal Ganglion Cells, Suprachiasmatic Nucleus, Rats, Sprague-Dawley, Rod Opsins, Patch-Clamp Techniques, Rats, Light Signal Transduction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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