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T Cell Receptor Signaling Precedes Immunological Synapse Formation
Abstract
The area of contact between a T cell and an antigen-presenting cell (APC) is known as the immunological synapse. Although its exact function is unknown, one model suggests that it allows for T cell receptor (TCR) clustering and for sustained signaling in T cells for many hours. Here we demonstrate that TCR-mediated tyrosine kinase signaling in naı̈ve T cells occurred primarily at the periphery of the synapse and was largely abated before mature immunological synapses had formed. These data suggest that many hours of TCR signaling are not required for T cell activation. These observations challenge current ideas about the role of immunological synapses in T cell activation.
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Cited by
Smith-Garvin, J. E., Koretzky, G. A., & Jordan, M. S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132706 · Cited by 2,144
CTLA-4: new insights into its biological function and use in tumor immunotherapy
Egen, J. G., Kuhns, M. S., & Allison, J. P. (2002) · Nature Immunology · doi:10.1038/ni0702-611 · Cited by 940
Dustin, M. L. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0161 · Cited by 502
Self-citationBrewer, C. (2002) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(02)00364-0 · Cited by 435
Offner, S., Hofmeister, R., Romaniuk, A., Kufer, P., & Baeuerle, P. A. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2005.03.007 · Cited by 365
Metadata
- Authors
- Lee, K.-H., Holdorf, A. D., Dustin, M. L., Chan, A. C., Allen, P. M., & Shaw, A. S.
- Venue
- Science
- Published
- 2002-02-22
- Volume
- 295
- Issue
- 5559
- Pages
- 1539-1542
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2028968136
- Cited by
- 693
- References
- 0
- FWCI
- 25.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lee, K.-H., Holdorf, A. D., Dustin, M. L., Chan, A. C., Allen, P. M., & Shaw, A. S. (2002). T Cell Receptor Signaling Precedes Immunological Synapse Formation. Science. https://doi.org/10.1126/science.1067710
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
