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T Cell Receptor Signaling Precedes Immunological Synapse Formation
Abstract
The area of contact between a T cell and an antigen-presenting cell (APC) is known as the immunological synapse. Although its exact function is unknown, one model suggests that it allows for T cell receptor (TCR) clustering and for sustained signaling in T cells for many hours. Here we demonstrate that TCR-mediated tyrosine kinase signaling in naı̈ve T cells occurred primarily at the periphery of the synapse and was largely abated before mature immunological synapses had formed. These data suggest that many hours of TCR signaling are not required for T cell activation. These observations challenge current ideas about the role of immunological synapses in T cell activation.
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Citations
Cited by
Smith-Garvin, J. E., Koretzky, G. A., & Jordan, M. S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132706 · Cited by 2,144
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Egen, J. G., Kuhns, M. S., & Allison, J. P. (2002) · Nature Immunology · doi:10.1038/ni0702-611 · Cited by 940
Dustin, M. L. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0161 · Cited by 502
Self-citationBrewer, C. (2002) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(02)00364-0 · Cited by 435
Offner, S., Hofmeister, R., Romaniuk, A., Kufer, P., & Baeuerle, P. A. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2005.03.007 · Cited by 365
A Logical Model Provides Insights into T Cell Receptor Signaling
Saez-Rodriguez, J., Simeoni, L., Lindquist, J. A., Hemenway, R., Bommhardt, U., Arndt, B., Haus, U.-U., Weismantel, R., Gilles, E. D., Klamt, S., et al. (2007) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0030163 · Cited by 352
Tuning immune responses: diversity and adaptation of the immunological synapse
Friedl, P., den Boer, A. T., & Gunzer, M. (2005) · Nature Reviews Immunology · doi:10.1038/nri1647 · Cited by 276
Lühder, F., Huang, Y., Dennehy, K. M., Guntermann, C., Müller, I., Winkler, E., Kerkau, T., Ikemizu, S., Davis, S. J., Hanke, T., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021024 · Cited by 193
Immunological synapse and microclusters: the site for recognition and activation of T cells
Saito, T., & Yokosuka, T. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.03.014 · Cited by 124
Gu, Y., Chae, H.-D., Siefring, J. E., Jasti, A. C., Hildeman, D. A., & Williams, D. A. (2006) · Nature Immunology · doi:10.1038/ni1396 · Cited by 110
Recruitment of transferrin receptor to immunological synapse in response to TCR engagement
Batista, A., Millán, J., Mittelbrunn, M., Sánchez-Madrid, F., & Alonso, M. A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.11.6709 · Cited by 84
Rodriguez-Plata, M. T., Puigdomènech, I., Izquierdo-Useros, N., Puertas, M. C., Carrillo, J., Erkizia, I., Clotet, B., Blanco, J., & Martinez-Picado, J. (2013) · Retrovirology · doi:10.1186/1742-4690-10-42 · Cited by 45
Dennehy, K. M. (2003) · International Immunology · doi:10.1093/intimm/dxg063 · Cited by 36
Metadata
- Authors
- Lee, K.-H., Holdorf, A. D., Dustin, M. L., Chan, A. C., Allen, P. M., & Shaw, A. S.
- Venue
- Science
- Published
- 2002-02-22
- Volume
- 295
- Issue
- 5559
- Pages
- 1539-1542
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2028968136
- Cited by
- 693
- References
- 0
- FWCI
- 25.73
- Type
- journal article
- Language
- en
- Open access
- closed
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