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Capturing Chromosome Conformation
Abstract
We describe an approach to detect the frequency of interaction between any two genomic loci. Generation of a matrix of interaction frequencies between sites on the same or different chromosomes reveals their relative spatial disposition and provides information about the physical properties of the chromatin fiber. This methodology can be applied to the spatial organization of entire genomes in organisms from bacteria to human. Using the yeast Saccharomyces cerevisiae , we could confirm known qualitative features of chromosome organization within the nucleus and dynamic changes in that organization during meiosis. We also analyzed yeast chromosome III at the G 1 stage of the cell cycle. We found that chromatin is highly flexible throughout. Furthermore, functionally distinct AT- and GC-rich domains were found to exhibit different conformations, and a population-average 3D model of chromosome III could be determined. Chromosome III emerges as a contorted ring.
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“As applied to enhancers in vertebrate animals, this model received strong confirmation after the development of methods for studying the spatial organization of the genome using the proximity ligation technique [29].”
From Enhancer Function in the 3D Genome (2023) · cites this paper as [29]
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Cites
Statistical mechanics of chain molecules
Flory, P. J., & Volkenstein, M. V. (1969) · Biopolymers · doi:10.1002/bip.1969.360080514 · Cited by 6,449
Chromosome territories, nuclear architecture and gene regulation in mammalian cells
Cremer, T. J., & Cremer, C. G. (2001) · Nature Reviews Genetics · doi:10.1038/35066075 · Cited by 2,339
Röntgenuntersuchung gelöster Fadenmoleküle
Kratky, O., & Porod, G. (1949) · Recueil des Travaux Chimiques des Pays-Bas · doi:10.1002/recl.19490681203 · Cited by 1,994
Meiotic Chromosomes: Integrating Structure and Function
Zickler, D., & Kleckner, N. E. (1999) · Annual Review of Genetics · doi:10.1146/annurev.genet.33.1.603 · Cited by 1,256
Self-citationChromatin Structure and Function
Nicolini, C. A. (1979) · Springer eBooks · doi:10.1007/978-1-4684-0973-4 · Cited by 1,035
Hunter, N. M., & Kleckner, N. E. (2001) · Cell · doi:10.1016/s0092-8674(01)00430-5 · Cited by 663
Self-citationvan Holde, K. E. (1989) · Springer series in molecular biology · doi:10.1007/978-1-4612-3490-6 · Cited by 654
THE LEPTOTENE-ZYGOTENE TRANSITION OF MEIOSIS
Zickler, D., & Kleckner, N. E. (1998) · Annual Review of Genetics · doi:10.1146/annurev.genet.32.1.619 · Cited by 552
Self-citationThe yeast genome project: what did we learn?
Dujon, B. (1996) · Trends in Genetics · doi:10.1016/0168-9525(96)10027-5 · Cited by 547
Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae
Gerton, J. L., DeRisi, J. L., Shroff, R., Lichten, M., Brown, P. O., & Petes, T. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11383 · Cited by 481
Research works printed but not linked: 3
- Cimbora D. M., Groudine M., Cell 104, 643 (2001).
- Supplementary details of experimental procedures are available on Science Online at www.sciencemag.org/cgi/content/full/295/5558/1306/DC1.
- Holmquist G. P., Am. J. Hum. Genet. 51, 17 (1992).
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Singh, B. N., & Hampsey, M. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.013 · Cited by 182
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Tolhuis, B., Blom, M., Kerkhoven, R. M., Pagie, L., Teunissen, H., Nieuwland, M., Simonis, M., de Laat, W. L., van Lohuizen, M., & van Steensel, B. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001343 · Cited by 182
Ebralidze, A. K., Guibal, F. C., Steidl, U. G., Zhang, P., Lee, S., Bartholdy, B., Alberich-Jordà, M., Petkova, V., Rosenbauer, F., Huang, G., et al. (2008) · Genes & Development · doi:10.1101/gad.1654808 · Cited by 183
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Tjong, H., Li, W., Kalhor, R., Dai, C., Hao, S., Gong, K. Q., Zhou, Y., Li, H., Zhou, X. J., Gros, M. A. L., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1512577113 · Cited by 181
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Wang, K., & Chang, H. Y. (2018) · Circulation Research · doi:10.1161/circresaha.118.310998 · Cited by 180
Dániel, B., Nagy, G., Czimmerer, Z., Horváth, A., Hammers, D. W., Cuaranta‐Monroy, I., Póliska, S., Tzerpos, P., Kolostyák, Z., Hays, T. T., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.09.005 · Cited by 180
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Hübner, M. R., & Spector, D. L. (2010) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.093008.131348 · Cited by 179
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van Arensbergen, J., van Steensel, B., & Bussemaker, H. J. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.07.004 · Cited by 180
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Lazar‐Stefanita, L., Scolari, V. F., Mercy, G., Muller, H., Guérin, T. M., Thierry, A., Mozziconacci, J., & Koszul, R. (2017) · The EMBO Journal · doi:10.15252/embj.201797342 · Cited by 177
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Ay, F., & Noble, W. S. (2015) · Genome biology · doi:10.1186/s13059-015-0745-7 · Cited by 175
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Taberlay, P. C., Kelly, T. K., Liu, C.-C., You, J. S., De Carvalho, D. D., Miranda, T. B., Zhou, X. J., Liang, G., & Jones, P. A. (2011) · Cell · doi:10.1016/j.cell.2011.10.040 · Cited by 171
Does CTCF mediate between nuclear organization and gene expression?
OHLSSON, R. I., Lobanenkov, V. V., & Klenova, E. M. (2009) · BioEssays · doi:10.1002/bies.200900118 · Cited by 171
Austin, J. W., Lu, P., Majumder, P., Ahmed, R., & Boss, J. M. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302750 · Cited by 171
Enhancer Logic and Mechanics in Development and Disease
Rickels, R. A., & Shilatifard, A. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.04.003 · Cited by 171
Multiple interactions between regulatory regions are required to stabilize an active chromatin hub
Patrinos, G. P., de Krom, M., de Boer, E., Langeveld, A., Imam, A. M. A., Strouboulis, J., de Laat, W., & Grosveld, F. G. (2004) · Genes & Development · doi:10.1101/gad.289704 · Cited by 170
Genomics of Long-Range Regulatory Elements
Noonan, J. P., & McCallion, A. S. (2010) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-082509-141651 · Cited by 170
Electrostatic interactions in biological DNA-related systems
Cherstvy, A. G. (2011) · Physical Chemistry Chemical Physics · doi:10.1039/c0cp02796k · Cited by 170
Wang, Q., Sun, Q., Czajkowsky, D. M., & Shao, Z. (2018) · Nature Communications · doi:10.1038/s41467-017-02526-9 · Cited by 170
Predicting three-dimensional genome structure from transcriptional activity
Cook, P. R. (2002) · Nature Genetics · doi:10.1038/ng1102-347 · Cited by 169
On a chromosome far, far away: LCRs and gene expression
Dean, A. (2005) · Trends in Genetics · doi:10.1016/j.tig.2005.11.001 · Cited by 168
Zella, L. A., Kim, S., Shevde, N. K., & Pike, J. W. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0015 · Cited by 168
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Verma, S. C., Qian, Z., & Adhya, S. L. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008456 · Cited by 167
Rinzema, N. J., Sofiadis, K., Tjalsma, S. J. D., Verstegen, M. J. A. M., Oz, Y., Valdes-Quezada, C., Felder, A.-K., Filipovska, T., van der Elst, S., de Andrade dos Ramos, Z., et al. (2022) · Nature Structural & Molecular Biology · doi:10.1038/s41594-022-00787-7 · Cited by 166
Human tRNA genes function as chromatin insulators
Raab, J. R., Chiu, J., Zhu, J., Katzman, S. J., Kurukuti, S., Wade, P. A., Haussler, D. H., & Kamakaka, R. T. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.406 · Cited by 166
Chromatin-associated RNA sequencing (ChAR-seq) maps genome-wide RNA-to-DNA contacts
Bell, J. C., Jukam, D., Teran, N. A., Risca, V. I., Smith, O. K., Johnson, W. L., Skotheim, J. M., Greenleaf, W. J., & Straight, A. F. (2018) · eLife · doi:10.7554/elife.27024 · Cited by 166
A supervised learning framework for chromatin loop detection in genome-wide contact maps
Salameh, T. J., Wang, X., Song, F., Zhang, B., Wright, S. M., Khunsriraksakul, C., Ruan, Y., & Yue, F. (2020) · Nature Communications · doi:10.1038/s41467-020-17239-9 · Cited by 165
Nagano, T., Lubling, Y., Yaffe, E., Wingett, S., Dean, W., Tanay, A., & Fraser, P. (2015) · Nature Protocols · doi:10.1038/nprot.2015.127 · Cited by 165
Low, W. Y., Tearle, R. G., Bickhart, D. M., Rosen, B. D., Kingan, S. B., Swale, T., Thibaud‐Nissen, F., Murphy, T. D., Young, R. A., Lefèvre, L., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-08260-0 · Cited by 165
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Skok, J. A., Gisler, R., Novatchkova, M., Farmer, D. A., de Laat, W. L., & Busslinger, M. (2007) · Nature Immunology · doi:10.1038/ni1448 · Cited by 164
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Rousseau, M., Fraser, J., Ferraiuolo, M. A., Dostie, J., & Blanchette, M. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-414 · Cited by 162
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Melzer, R., Verelst, W., & Theißen, G. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn900 · Cited by 162
Chromatin Dynamics and Gene Positioning
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Kong, M., Cutts, E., Pan, D., Beuron, F., Kaliyappan, T., Xue, C., Morris, E. P., Musacchio, A., Vannini, A., & Greene, E. C. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.04.026 · Cited by 162
The transcriptional interactome: gene expression in 3D
Schoenfelder, S., Clay, I., & Fraser, P. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.02.002 · Cited by 161
A Predictive Computational Model of the Dynamic 3D Interphase Yeast Nucleus
Wong, H., Marie-Nelly, H., Herbert, S., Carrivain, P., Blanc, H., Koszul, R., Fabre, E., & Zimmer, C. (2012) · Current Biology · doi:10.1016/j.cub.2012.07.069 · Cited by 160
Meyer, K. B., Maia, A.-T., O’Reilly, M., Ghoussaini, M., Prathalingam, R., Porter-Gill, P. A., Ambs, S., Prokunina‐Olsson, L., Carroll, J. S., & Ponder, B. A. J. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002165 · Cited by 160
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Bottomly, D., Kyler, S. L., McWeeney, S. K., & Yochum, G. S. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq363 · Cited by 160
Sun, J., Li, W., Sun, Y., Yu, D., Wen, X., Wang, H., Cui, J., Wang, G., Hoffman, A. R., & Hu, J. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku549 · Cited by 160
Yaffe, E., & Relman, D. A. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0625-0 · Cited by 160
Gómez-Marín, C., Tena, J. J., Acemel, R. D., López-Mayorga, M., Naranjo, S., de la Calle-Mustienes, E., Maeso, I., Beccari, L., Aneas, I., Vielmas, E., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1505463112 · Cited by 159
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Noordermeer, D., de Wit, E., Klous, P., van de Werken, H. J. G., Simonis, M., Lopez-Jones, M., Eussen, B., de Klein, A., Singer, R. H., & de Laat, W. L. (2011) · Nature Cell Biology · doi:10.1038/ncb2278 · Cited by 159
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Therizols, P., Duong, T., Dujon, B., Zimmer, C., & Fabre, E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914187107 · Cited by 158
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Val, M., Marbouty, M., Martins, F. D. L., Kennedy, S., Kemble, H. E., Bland, M., Possoz, C., Koszul, R., Skovgaard, O., & Mazel, D. (2016) · Science Advances · doi:10.1126/sciadv.1501914 · Cited by 158
Lee, G. R., Spilianakis, C. G., & Flavell, R. A. (2004) · Nature Immunology · doi:10.1038/ni1148 · Cited by 158
Dekker, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806479200 · Cited by 157
Self-citationXu, J., Shao, Z., Li, D., Xie, H., Kim, W., Huang, J., Taylor, J. E., Pinello, L., Glass, K., Jaffe, J. D., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2014.12.009 · Cited by 157
AP‐2γ regulates oestrogen receptor‐mediated long‐range chromatin interaction and gene transcription
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Chromatin Organization in the Mammalian Nucleus
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Tomikawa, J., Uenoyama, Y., Ozawa, M., Fukanuma, T., Takase, K., Goto, T., Abe, H., Ieda, N., Minabe, S., Deura, C., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114245109 · Cited by 155
Genome organization and long-range regulation of gene expression by enhancers
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Giorgio, E., Robyr, D., Spielmann, M., Ferrero, E., Gregorio, E. D., Imperiale, D., Vaula, G., Stamoulis, G., Santoni, F. A., Atzori, C., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv065 · Cited by 152
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Papantonis, A., Kohro, T., Baboo, S., Larkin, J. D., Deng, B., Short, P., Tsutsumi, S., Taylor, S., Kanki, Y., Kobayashi, M., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.288 · Cited by 151
Stable Chromosome Condensation Revealed by Chromosome Conformation Capture
Eagen, K. P., Hartl, T. A., & Kornberg, R. D. (2015) · Cell · doi:10.1016/j.cell.2015.10.026 · Cited by 151
Epigenetic mechanisms regulating T-cell responses
Schmidl, C., Delacher, M., Huehn, J., & Feuerer, M. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.07.014 · Cited by 153
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Louwers, M., Bader, R., Haring, M., DRIEL, R. V., de Laat, W. L., & Stam, M. E. (2009) · The Plant Cell · doi:10.1105/tpc.108.064329 · Cited by 151
Smith, E. M., Lajoie, B. R., Jain, G., & Dekker, J. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2015.12.002 · Cited by 150
Self-citationSimilar active genes cluster in specialized transcription factories
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Dong, Q., Li, N., Li, X., Yuan, Z., Xie, D., Wang, X., Li, J., Yu, Y., Wang, J., Ding, B., et al. (2018) · The Plant Journal · doi:10.1111/tpj.13925 · Cited by 149
HiCcompare: an R-package for joint normalization and comparison of HI-C datasets
Stansfield, J. C., Cresswell, K. G., Vladimirov, V. I., & Dozmorov, M. G. (2018) · BMC Bioinformatics · doi:10.1186/s12859-018-2288-x · Cited by 149
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Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
van Berkum, N. L., Aiden, E. L., Williams, L., Imakaev, M., Gnirke, A., Mirny, L. A., Dekker, J., & Lander, E. S. (2010) · Journal of Visualized Experiments · doi:10.3791/1869-v · Cited by 148
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Grass, J. A., Jing, H., Kim, S., Martowicz, M. L., Pal, S. K., Blobel, G. A., & Bresnick, E. H. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01033-06 · Cited by 148
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Ballaré, C., Castellano, G., Gaveglia, L., Althammer, S., González‐Vallinas, J., Eyras, E., Dily, F. L., Zaurín, R., Soronellas, D., Vicent, G. P., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.10.019 · Cited by 147
Three-dimensional chromatin packing and positioning of plant genomes
Doğan, E. S., & Liu, C. (2018) · Nature Plants · doi:10.1038/s41477-018-0199-5 · Cited by 147
Detecting hierarchical genome folding with network modularity
Norton, H. K., Emerson, D. J., Huang, H., Kim, J., Titus, K. R., Gu, S., Bassett, D. S., & Phillips-Cremins, J. E. (2018) · Nature Methods · doi:10.1038/nmeth.4560 · Cited by 146
An Overview of Methods for Reconstructing 3-D Chromosome and Genome Structures from Hi-C Data
Oluwadare, O., Highsmith, M. R., & Cheng, J. (2019) · Biological Procedures Online · doi:10.1186/s12575-019-0094-0 · Cited by 147
Stadhouders, R., Kolovos, P., Brouwer, R. W. W., Zuin, J., van den Heuvel, A., Kockx, C. E. M., Palstra, R.-J. T. S., Wendt, K. S., Grosveld, F. G., van IJcken, W. F. J., et al. (2013) · Nature Protocols · doi:10.1038/nprot.2013.018 · Cited by 145
CTCF and its protein partners: divide and rule?
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Metadata
- Authors
- Dekker, J., Rippe, K., Dekker, M., & Kleckner, N.
- Affiliations
- Harvard University (US)
- German Cancer Research Center (DE)
- 2e Oosterparklaan 272, 3544 AX Utrecht, Netherlands.
- Corresponding author
- Dekker, Job
- Venue
- Science
- Published
- 2002-02-15
- Volume
- 295
- Issue
- 5558
- Pages
- 1306-1311
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2073026107
- Cited by
- 3,652
- References
- 37
- Citations by year
- 2026: 94 · 2025: 123 · 2024: 161 · 2023: 174 · 2022: 190 · 2021: 228 · 2020: 280 · 2019: 263 · 2018: 260 · 2017: 208 · 2016: 249 · 2015: 221 · 2014: 165 · 2013: 166 · 2012: 190
- FWCI
- 9.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- National Institute of General Medical Sciences (GM-44794, GM 25326, R01GM044794)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- chromosome conformation, 3D genome organization, chromatin fiber, Saccharomyces cerevisiae, meiosis
- MeSH terms
- Cell Fractionation, Cell Nucleus, Centromere, Chromatin, Cross-Linking Reagents, Formaldehyde, Mathematics, Meiosis, Mitosis, Protein Conformation, Saccharomyces cerevisiae, Deoxyribonuclease EcoRI, Chromosomes, Fungal, Polymerase Chain Reaction, G1 Phase, Telomere, Genome, Fungal, AT Rich Sequence, GC Rich Sequence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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