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Polycomb-Repressed Genes Have Permissive Enhancers that Initiate Reprogramming
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OCT4 directly binds enhancers of Polycomb group-repressed genes to induce conversion of their associated promoters from monovalent to bivalent domains.
“Second, OCT4 directly binds enhancers of Polycomb group-repressed genes, which modify histones and silence target genes, to induce conversion of their associated promoters from monovalent to bivalent domains 40,41 .”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [40]
The Results section reports OCT4 occupancy at the MYOD1 enhancer before the MYOD1 promoter acquired a bivalent signature. But the Discussion says OCT4 may establish bivalency directly or may act through indirect global changes; the experiment does not establish a direct causal mechanism across Polycomb-repressed genes generally. (LLM, conf=0.88)
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Metadata
- Authors
- Taberlay, P. C., Kelly, T. K., Liu, C.-C., You, J. S., De Carvalho, D. D., Miranda, T. B., Zhou, X. J., Liang, G., & Jones, P. A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 147
- Issue
- 6
- Pages
- 1283-1294
- ISSN
- 0092-8674
- PMC
- PMC3240866
- Cited by
- 171
- References
- 11
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 630 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
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