The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Emerging Roles of Presynaptic Proteins in Ca ++ -Triggered Exocytosis
Open accessAbstract
Molecules involved in late steps of neurotransmitter release at the synapse can be examined by noting the two speeds of the components of the exocytotic burst that are triggered by an increase in free Ca ++ . From studies of Ca ++ -dependent exocytosis of large dense-core vesicles in chromaffin cells, it seems that initiation of the SNARE complex is the molecular event underlying the priming process and that Munc13 acts as a priming factor by opening syntaxin. If synaptic mechanisms are similar, much could be learned from the molecular and kinetic studies that can be performed in chromaffin cells. The twinning of techiques from biophysics and molecular biology has led to remarkable progress in understanding the molecular mechanisms of synaptic transmission. Here we review the current picture of Ca ++ -triggered exocytosis, which has emerged from studies of a simple cellular model, the adrenal chromaffin cell. We discuss the molecular players that have been assigned a specific role in a particular step of this process and give a brief outlook on what these insights might tell us about mechanisms of short-term plasticity at classical synapses.
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Cites
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
Sutton, R. B., Fasshauer, D., Jahn, R., & Brunger, A. T. (1998) · Nature · doi:10.1038/26412 · Cited by 2,417
Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles
Augustin, I., Rosenmund, C., Südhof, T. C., & Brose, N. (1999) · Nature · doi:10.1038/22768 · Cited by 787
RIM1α forms a protein scaffold for regulating neurotransmitter release at the active zone
Schoch, S., Castillo, P. E., Jo, T., Mukherjee, K., Geppert, M., Wang, Y., Schmitz, F., Malenka, R. C., & Südhof, T. C. (2002) · Nature · doi:10.1038/415321a · Cited by 579
Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming
Betz, A., Thakur, P., Junge, H. J., Ashery, U., Rhee, J.-S., Scheuss, V., Rosenmund, C., Rettig, J., & Brose, N. (2001) · Neuron · doi:10.1016/s0896-6273(01)00272-0 · Cited by 425
Self-citationThe architecture of active zone material at the frog's neuromuscular junction
Harlow, M. L., Ress, D., Stoschek, A., Marshall, R. M., & McMahan, U. J. (2001) · Nature · doi:10.1038/35054000 · Cited by 388
Walent, J. H., Porter, B. W., & Martin, T. F. J. (1992) · Cell · doi:10.1016/0092-8674(92)90310-9 · Cited by 264
Cited by
Rizzoli, S. O., & Betz, W. J. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1583 · Cited by 975
Insulin granule dynamics in pancreatic beta cells
Rorsman, P., & Renstr�m, E. (2003) · Diabetologia · doi:10.1007/s00125-003-1153-1 · Cited by 844
Vig, M., DeHaven, W. I., Bird, G. S., Billingsley, J. M., Wang, H., Rao, P. E., Hutchings, A. B., Jouvin, M.-H., Putney, J. W., & Kinet, J.-P. (2008) · Nature Immunology · doi:10.1038/ni1550 · Cited by 403
Speese, S., Petrie, M., Schuske, K., Ailion, M., Ann, K., Iwasaki, K., Jorgensen, E. M., & Martin, T. F. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1466-07.2007 · Cited by 333
Calcium signaling and exocytosis in adrenal chromaffin cells
García, A. G., García-De-Diego, A. M., Gandía, L., Borges, R., & García-Sancho, J. (2006) · Physiological Reviews · doi:10.1152/physrev.00039.2005 · Cited by 349
Metadata
- Authors
- Rettig, J., & Neher, E.
- Venue
- Science
- Published
- 2002-10-25
- Volume
- 298
- Issue
- 5594
- Pages
- 781-785
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2033797809
- Cited by
- 327
- References
- 6
- FWCI
- 9.48
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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