Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

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The Critical Need for CD4 Help in Maintaining Effective Cytotoxic T Lymphocyte Responses

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Differential Effects of Dendritic Cell Transfer on Airway Hyperresponsiveness and Inflammation

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Long-Term Non-Progression and Broad HIV-1-Specific Proliferative T-Cell Responses

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TLR agonists and/or IL-15 adjuvanted mucosal SIV vaccine reduced gut CD4+ memory T cell loss in SIVmac251-challenged rhesus macaques

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Opposing positive and negative regulation of T cell activity during viral persistence

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Hepatitis C vaccines

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Priming with a Recombinant Pantothenate Auxotroph of Mycobacterium bovis BCG and Boosting with MVA Elicits HIV-1 Gag Specific CD8+ T Cells

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Impact of inducible co‐stimulatory molecule (ICOS) on T‐cell responses and protection against Mycobacterium tuberculosis infection

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Does programmed CTL proliferation optimize virus control?

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Ex vivo generation and expansion of anti‐tumor cytotoxic T‐cell lines derived from patients or their HLA‐identical sibling

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CD4 T cell help is required for primary CD8 T cell responses to vesicular antigen delivered to dendritic cells in vivo

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T inflammatory memory CD8 T cells participate to antiviral response and generate secondary memory cells with an advantage in XCL1 production

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Functional patterns of HIV-1-specific CD4 T-cell responses in children are influenced by the extent of virus suppression and exposure

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The Regulation and Maturation of Antiviral Immune Responses

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LCP1 is a prognostic biomarker correlated with immune infiltrates in gastric cancer

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An Excess of the Proinflammatory Cytokines IFN-γ and IL-12 Impairs the Development of the Memory CD8+ T Cell Response to Chlamydia trachomatis

Zhang, X., & Starnbach, M. N. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500457 · Cited by 22

Regulatory and Conventional CD4+ T Cells Show Differential Effects Correlating with PD-1 and B7-H1 Expression after Immunotherapy

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Perspectives on the development of a therapeutic HER-2 cancer vaccine

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Rescue of memory CD8+ T cell reactivity in peptide/TLR9 ligand immunization by codelivery of cytokines or CD40 ligation

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CD8+ T-cell priming regulated by cytokines of the innate immune system

Stäger, S., & Kaye, P. M. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.06.003 · Cited by 22

Disease-driven T cell activation predicts immune responses to vaccination against melanoma.

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Effects of recombinant human growth hormone on HIV-1-specific T-cell responses, thymic output and proviral DNA in patients on HAART: 48-week follow-up

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Memory programming in CD8+ T-cell differentiation is intrinsic and is not determined by CD4 help

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Chronic spinal cord injury attenuates influenza virus-specific antiviral immunity

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Principles of Memory CD8 T-Cells Generation in Relation to Protective Immunity

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Human Immunodeficiency Virus Type 1 Escapes from Interleukin-2-Producing CD4 + T-Cell Responses without High-Frequency Fixation of Mutations

Jones, R. B., Yue, F., Gu, X. X. J., Hunter, D. V., Mujib, S., Gyenes, G. T., Mason, R. D., Mohamed, R., MacDonald, K. S., Kovacs, C. M., et al. (2009) · Journal of Virology · doi:10.1128/jvi.00433-09 · Cited by 21

The Cooperation between Two CD4 T Cells Induces Tumor Protective Immunity in MUC.1 Transgenic Mice

Gerloni, M., Castiglioni, P., & Zanetti, M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.10.6551 · Cited by 21

Unravelling the mechanisms of help for CD8+ T cell responses

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Recognition of naturally processed and ovarian cancer reactive CD8+ T cell epitopes within a promiscuous HLA class II T-helper region of NY-ESO-1

Matsuzaki, J., Qian, F., Luescher, I. F., Lele, S., Ritter, G., Shrikant, P. A., Gnjatic, S., Old, L. J., & Odunsi, K. O. (2008) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-008-0450-4 · Cited by 22

Soluble branched (1,4)‐β‐D‐glucans from Acetobacter species enhance antitumor activities against MHC class I‐negative and ‐positive malignant melanoma through augmented NK activity and cytotoxic T‐cell response

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Disparate Primary and Secondary Allospecific CD8+ T Cell Cytolytic Effector Function in the Presence or Absence of Host CD4+ T Cells

Horne, P. H., Koester, M. A., Jayashankar, K., Lunsford, K. E., Dziema, H., & Bumgardner, G. L. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.1.80 · Cited by 23

Phenotype and Homing of CD4 Tumor-Specific T Cells Is Modulated by Tumor Bulk

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Presence of Distinct Subsets of Cytolytic CD8 + T Cells in Chronic HIV Infection

Jones, N. G., Eggena, M., Baker, C. A. R., Nghania, F., Baliruno, D., Mugyenyi, P. N., Ssali, F. N., Barugahare, B. J., & Cao, H. (2006) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2006.22.1007 · Cited by 20

MDM2 inhibitors in cancer immunotherapy: Current status and perspective

Zeng, Q., Zeng, S., Dai, X., Ding, Y., Huang, C., Ruan, R., Xiong, J., Tang, X., & Deng, J. (2024) · Genes & Diseases · doi:10.1016/j.gendis.2024.101279 · Cited by 20

Targeting T-cell memory: where do we stand?

Valujskikh, A. (2008) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e3283061126 · Cited by 20

Engineering superior DNA vaccines: MHC class I single chain trimers bypass antigen processing and enhance the immune response to low affinity antigens

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T cell-based gene therapy of cancer

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Epstein Barr Virus-Induced 3 (EBI3) Together with IL-12 Negatively Regulates T Helper 17-Mediated Immunity to Listeria monocytogenes Infection

Chung, Y., Yamazaki, T., Kim, B. S., Zhang, Y., Reynolds, J. M., Martínez, G., Chang, S. H., Lim, H., Birkenbach, M. P., & Dong, C. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003628 · Cited by 20

CD154 Blockade Alters Innate Immune Cell Recruitment and Programs Alloreactive CD8+ T Cells into KLRG-1high Short-Lived Effector T Cells

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HCV-Specific Interleukin-21+CD4+ T Cells Responses Associated with Viral Control through the Modulation of HCV-Specific CD8+ T Cells Function in Chronic Hepatitis C Patients

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CD4 T Cell Help via B Cells Is Required for Lymphopenia-Induced CD8 T Cell Proliferation

Ayasoufi, K., Fan, R., Fairchild, R. L., & Valujskikh, A. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501435 · Cited by 20

Coupling of HIV-1 Antigen to the Selective Autophagy Receptor SQSTM1/p62 Promotes T-Cell-Mediated Immunity

Andersen, A. N., Landsverk, O. J. B., Simonsen, A., Bogen, B., Corthay, A., & Øynebråten, I. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00167 · Cited by 22

Conversion of effector CD4+ T cells to a CD8+ MHC II-recognizing lineage

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Mechanistic understanding of innate and adaptive immune responses in SARS-CoV-2 infection

Balkhi, M. Y. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2021.04.021 · Cited by 24

Mobilizing forces - CD4+ helper T cells script adaptive immunity

Masson, F., & Belz, G. T. (2010) · Cell Research · doi:10.1038/cr.2010.1 · Cited by 20

In vivo rescue of defective memory CD8+ T cells by cognate helper T cells

Kumaraguru, U., Banerjee, K., & Rouse, B. T. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0105007 · Cited by 21

Self-Antigen Prevents CD8 T Cell Effector Differentiation by CD134 and CD137 Dual Costimulation

Bandyopadhyay, S., Long, M., Qui, H. Z., Hagymasi, A. T., Slaiby, A. M., Mihalyo, M. A., Aguila, H. L., Mittler, R. S., Vella, A. T., & Adler, A. J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.11.7728 · Cited by 20

Glucocorticoid‐Induced Tumor Necrosis Factor Receptor Family–Related Protein Triggering Enhances HIV‐Specific CD4+T Cell Cytokine Secretion and Protects HIV‐Specific CD4+T Cells from Apoptosis

Lahey, T., Loisel, S. D., & Wieland‐Alter, W. (2007) · The Journal of Infectious Diseases · doi:10.1086/518613 · Cited by 20

Spontaneous CD4+ T Cell Responses against TRAG-3 in Patients with Melanoma and Breast Cancers

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Critical Roles of NK and CD8+ T Cells in Central Nervous System Listeriosis

Hayashi, T., Nagai, S., Fujii, H., Baba, Y., Ikeda, E., Kawase, T., & Koyasu, S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803798 · Cited by 20

Dissection of cytotoxic and helper T cell responses

Schepers, K., Arens, R., & Schumacher, T. N. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5266-1 · Cited by 20

Independent Protective Effects for Tumor Necrosis Factor and Lymphotoxin Alpha in the Host Response toListeria monocytogenesInfection

Roach, D. R., Briscoe, H., Saunders, B. M., & Britton, W. J. (2005) · Infection and Immunity · doi:10.1128/iai.73.8.4787-4792.2005 · Cited by 20

How DCs control cross-regulation between lymphocytes

Creusot, R. J., & Mitchison, N. A. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.01.005 · Cited by 20

Interleukin-2 rescues helpless effector CD8+ T cells by diminishing the susceptibility to TRAIL mediated death

Wolkers, M. C., Bensinger, S. J., Green, D. R., Schoenberger, S. P., & Janssen, E. M. (2011) · Immunology Letters · doi:10.1016/j.imlet.2011.04.011 · Cited by 21

Enhanced Generation of Cytotoxic T Lymphocytes by Heat Shock Protein 70 Fusion Proteins Harboring Both CD8+ T Cell and CD4+ T Cell Epitopes

Takemoto, S., Nishikawa, M., Guan, X., Ohno, Y., Yata, T., & Takakura, Y. (2010) · Molecular Pharmaceutics · doi:10.1021/mp1001069 · Cited by 19

Regulation of cytotoxic T-Lymphocyte trafficking to tumors by chemoattractants: implications for immunotherapy

Sharma, R., Chheda, Z. S., Jala, V. R., & Haribabu, B. (2014) · Expert Review of Vaccines · doi:10.1586/14760584.2015.982101 · Cited by 20

TLR7 stimulation augments T effector‐mediated rejection of skin expressing neo‐self antigen in keratinocytes

Zhong, J., Hadis, U., Kluyver, R. L. D., Leggatt, G. R., Fernando, G. J. P., & Frazer, I. H. (2007) · European Journal of Immunology · doi:10.1002/eji.200737599 · Cited by 19

CD40 regulates human dendritic cell‐derived IL‐7 production that, in turn, contributes to CD8+ T‐cell antigen‐specific expansion

Carreno, B. M., Becker‐Hapak, M., & Linette, G. P. (2008) · Immunology and Cell Biology · doi:10.1038/icb.2008.80 · Cited by 19

DNA fusion gene vaccination mobilizes effective anti‐leukemic cytotoxic T lymphocytes from a tolerized repertoire

Rice, J., Dossett, M. L., Öhlén, C., Buchan, S. L., Kendall, T. J., Dunn, S. N., Stevenson, F. K., & Greenberg, P. D. (2008) · European Journal of Immunology · doi:10.1002/eji.200838213 · Cited by 19

Transient Enhanced IL-2R Signaling Early during Priming Rapidly Amplifies Development of Functional CD8+ T Effector-Memory Cells

Castro, I., Dee, M. J., & Malek, T. R. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202067 · Cited by 19

A soluble hexameric form of CD40 ligand activates human dendritic cells and augments memory T cell response

Miconnet, I., & Pantaleo, G. (2008) · Vaccine · doi:10.1016/j.vaccine.2008.05.028 · Cited by 19

Langerhans Cells Derived from Genetically Modified Human CD34+ Hemopoietic Progenitors Are More Potent Than Peptide-Pulsed Langerhans Cells for Inducing Antigen-Specific CD8+ Cytolytic T Lymphocyte Responses

Yuan, J. D., Latouche, J., Reagan, J. L., Heller, G., Rivière, I., Sadelain, M., & Young, J. W. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.2.758 · Cited by 19

Highly Efficient Antiviral CD8+T-Cell Induction by Peptides Coupled to the Surfaces of Liposomes

Takagi, A., Matsui, M., Ohno, S., Duan, H., Moriya, O., Kobayashi, N., Oda, H., Mori, M., Kobayashi, A., Taneichi, M., et al. (2009) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00116-09 · Cited by 19

CpG oligodeoxynucleotides activate dendritic cells in vivo and induce a functional and protective vaccine immunity against a TERT derived modified cryptic MHC class I-restricted epitope

Cornet, S., Menez-Jamet, J., Lemonnier, F. A., Kosmatopoulos, K., & Miconnet, I. (2005) · Vaccine · doi:10.1016/j.vaccine.2005.10.036 · Cited by 19

Studies on the cross-clade and cross-species conservation of HIV-1 Gag-specific CD8 and CD4 T cell responses elicited by a clade B DNA/MVA vaccine in macaques

Amara, R. R., Sharma, S., Patel, M., Smith, J. M., Chennareddi, L. S., Herndon, J. G., & Robinson, H. L. (2005) · Virology · doi:10.1016/j.virol.2005.01.026 · Cited by 19

Harnessing NKT cells for vaccination

Burn, O. K., Pankhurst, T. E., Painter, G. F., Connor, L. M., & Hermans, I. F. (2021) · Oxford Open Immunology · doi:10.1093/oxfimm/iqab013 · Cited by 18

Insight into Cancer Immunity: MHCs, Immune Cells and Commensal Microbiota

Wen, M., Li, Y., Qin, X., Qin, B., & Wang, Q. A. (2023) · Cells · doi:10.3390/cells12141882 · Cited by 20

CD8+ T cell priming that is required for curative intratumorally anchored anti-4-1BB immunotherapy is constrained by Tregs

Palmeri, J. R., Lax, B. M., Peters, J. M., Duhamel, L., Stinson, J. A., Santollani, L., Lutz, E. A., Pinney, W., Bryson, B. D., & Wittrup, K. D. (2024) · Nature Communications · doi:10.1038/s41467-024-45625-0 · Cited by 18

I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection

Mancino, A., Habbeddine, M., Johnson, E., Luron, L., Bébien, M., Mémet, S., Fong, C. H.-Y., Bajénoff, M., Wu, X., Karin, M., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.28 · Cited by 18

T cell immune discriminants of HIV reservoir size in a pediatric cohort of perinatally infected individuals

Rinaldi, S., de Armas, L. R., Domínguez‐Rodríguez, S., Pallikkuth, S., Dinh, V. B., Pan, L., Gärtner, K., Pahwa, R., Cotugno, N., Rojo, P., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009533 · Cited by 19

Anti‐idiotype antibody induced cellular immunity in mice transgenic for human carcinoembryonic antigen

Saha, A., Chatterjee, S. K., Foon, K. A., & Bhattacharya‐Chatterjee, M. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02391.x · Cited by 18

Induction of CD4-Independent E7-Specific CD8 + Memory Response by Heat Shock Fusion Protein

Liu, H., Wu, B. H., Rowse, G. J., & Emtage, P. C. R. (2007) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00029-07 · Cited by 18

The Development of Functional CD8 T Cell Memory after Listeria monocytogenes Infection Is Not Dependent on CD40

Montfort, M. J., Bouwer, H. G. A., Wagner, C. R., & Hinrichs, D. J. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.6.4084 · Cited by 18

SA-4-1BBL as a novel adjuvant for the development of therapeutic cancer vaccines

Sharma, R. K., Yolcu, E. S., & Shirwan, H. (2014) · Expert Review of Vaccines · doi:10.1586/14760584.2014.880340 · Cited by 18

Development of an AIDS vaccine using Sendai virus vectors

Ishii, H., & Matano, T. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.06.114 · Cited by 18

CTL‐Based Cancer Preventive/Therapeutic Vaccines for Carcinomas: Role of Tumour‐Associated Carbohydrate Antigens

Franco, A. (2005) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2005.01596.x · Cited by 18

Rapid qualitative and quantitative analysis of T-cell responses in HIV-1-infected individuals receiving successful HAART and HIV-1 sero-negative controls: Concomitant assessment of perforin, IFN-γ and IL-4 secretion

Burton, C., Gotch, F. M., & Imami, N. (2005) · Journal of Immunological Methods · doi:10.1016/j.jim.2005.11.005 · Cited by 18

The generation and modulation of antigen-specific memory CD8 T cell responses

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In Vitro Activation of CD8 Interphotoreceptor Retinoid-Binding Protein-Specific T Cells Requires not only Antigenic Stimulation but also Exogenous Growth Factors

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