Cited by 1,213T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune responses and vaccinations

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Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

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Sun, Joseph C., Bevan, Michael J.·2003·Science

DOI 10.1126/science.1083317PMC PMC2778341

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Abstract

The CD8 + cytotoxic T cell response to pathogens is thought to be CD4 + helper T cell independent because infectious agents provide their own inflammatory signals. Mice that lack CD4 + T cells mount a primary CD8 response to Listeria monocytogenes equal to that of wild-type mice and rapidly clear the infection. However, protective memory to a challenge is gradually lost in the former animals. Memory CD8 + T cells from normal mice can respond rapidly, but memory CD8 + T cells that are generated without CD4 help are defective in their ability to respond to secondary encounters with antigen. The results highlight a previously undescribed role for CD4 help in promoting protective CD8 memory development.

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Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions
Schoenberger, S. P., Toes, R. E. M., van der Voort, E. I. H., Offringa, R., & Melief, C. J. M. (1998) · Nature · doi:10.1038/31002 · Cited by 2,615
A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
Ridge, J. P., Rosa, F. D., & Matzinger, P. (1998) · Nature · doi:10.1038/30989 · Cited by 2,360
Help for cytotoxic-T-cell responses is mediated by CD40 signalling
Bennett, S. R. M., Carbone, F., Karamalis, F., Flavell, R. A., Miller, J. F. A. P., & Heath, W. R. (1998) · Nature · doi:10.1038/30996 · Cited by 2,091
Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function
Zajac, A. J., Blattman, J. N., Murali-Krishna, K., Sourdive, D. J. D., Suresh, M., Altman, J. D., & Ahmed, R. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2205 · Cited by 1,978
CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes
Janssen, E. M., Lemmens, E. E., Wolfe, T., Christen, U., von Herrath, M. G., & Schoenberger, S. P. (2003) · Nature · doi:10.1038/nature01441 · Cited by 1,635
CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection
Matloubian, M., Concepcion, R. J., & Ahmed, R. (1994) · Journal of Virology · doi:10.1128/jvi.68.12.8056-8063.1994 · Cited by 1,162
Pattern Recognition Receptors
Gordon, S. (2002) · Cell · doi:10.1016/s0092-8674(02)01201-1 · Cited by 1,153
Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4
Rahemtulla, A., Fung‐Leung, W., Schilham, M. W., Kündig, T. M., Sambhara, S. R., Narendran, A., Arabian, A., Wakeham, A. C., Paige, C. J., Zinkernagel, R. M., et al. (1991) · Nature · doi:10.1038/353180a0 · Cited by 685
The Critical Need for CD4 Help in Maintaining Effective Cytotoxic T Lymphocyte Responses
Kalams, S. A., & Walker, B. D. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2199 · Cited by 660

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Marzo, A. L., Vezys, V., Klonowski, K. D., Lee, S., Muralimohan, G., Moore, M. W., Tough, D. F., & Lefrançois, L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.2.969 · Cited by 123
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Behrens, G. M. N., Li, M., Smith, C. M., Belz, G. T., Mintern, J. D., Carbone, F., & Heath, W. R. (2004) · Immunology and Cell Biology · doi:10.1111/j.1440-1711.2004.01211.x · Cited by 118
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Authors: Sun, J. C., & Bevan, M. J.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Bevan, Michael J.
ORCID: Sun, Joseph C.
Bevan, Michael J.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2003-04-11
Volume: 300
Issue: 5617
Pages: 339-342
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1083317
PMC: PMC2778341
OpenAlex: W2076534074
Cited by: 1,213
References: 26
Citations by year: 2026: 4 · 2025: 16 · 2024: 18 · 2023: 18 · 2022: 19 · 2021: 31 · 2020: 28 · 2019: 18 · 2018: 24 · 2017: 21 · 2016: 28 · 2015: 32 · 2014: 51 · 2013: 46 · 2012: 58
FWCI: 40.97
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
National Institute of Allergy and Infectious Diseases (R01AI019335, AI-19335)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: CD8+ T cell memory, CD4+ T cell help, Listeria monocytogenes, acute infection, CD4-deficient mice, cytotoxic T lymphocytes, protective immunity
MeSH terms: Animals, Cytotoxicity, Immunologic, Genes, MHC Class II, T-Lymphocytes, Helper-Inducer, Immunization, Immunologic Memory, Interferon-gamma, Listeriosis, Listeria monocytogenes, Mice, Inbred C57BL, Ovalbumin, T-Lymphocyte Subsets, CD8-Positive T-Lymphocytes, Adoptive Transfer, Mice

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Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

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