Cited by 1,213T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune responses and vaccinations

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Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

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Sun, Joseph C., Bevan, Michael J.·2003·Science

DOI 10.1126/science.1083317PMC PMC2778341

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Abstract

The CD8 + cytotoxic T cell response to pathogens is thought to be CD4 + helper T cell independent because infectious agents provide their own inflammatory signals. Mice that lack CD4 + T cells mount a primary CD8 response to Listeria monocytogenes equal to that of wild-type mice and rapidly clear the infection. However, protective memory to a challenge is gradually lost in the former animals. Memory CD8 + T cells from normal mice can respond rapidly, but memory CD8 + T cells that are generated without CD4 help are defective in their ability to respond to secondary encounters with antigen. The results highlight a previously undescribed role for CD4 help in promoting protective CD8 memory development.

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Authors: Sun, J. C., & Bevan, M. J.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Bevan, Michael J.
ORCID: Sun, Joseph C.
Bevan, Michael J.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2003-04-11
Volume: 300
Issue: 5617
Pages: 339-342
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1083317
PMC: PMC2778341
OpenAlex: W2076534074
Cited by: 1,213
References: 26
Citations by year: 2026: 4 · 2025: 16 · 2024: 18 · 2023: 18 · 2022: 19 · 2021: 31 · 2020: 28 · 2019: 18 · 2018: 24 · 2017: 21 · 2016: 28 · 2015: 32 · 2014: 51 · 2013: 46 · 2012: 58
FWCI: 40.97
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
National Institute of Allergy and Infectious Diseases (R01AI019335, AI-19335)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: CD8+ T cell memory, CD4+ T cell help, Listeria monocytogenes, acute infection, CD4-deficient mice, cytotoxic T lymphocytes, protective immunity
MeSH terms: Animals, Cytotoxicity, Immunologic, Genes, MHC Class II, T-Lymphocytes, Helper-Inducer, Immunization, Immunologic Memory, Interferon-gamma, Listeriosis, Listeria monocytogenes, Mice, Inbred C57BL, Ovalbumin, T-Lymphocyte Subsets, CD8-Positive T-Lymphocytes, Adoptive Transfer, Mice

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Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

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