The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Heterodimeric GTPase Core of the SRP Targeting Complex
Open accessAbstract
Two structurally homologous guanosine triphosphatase (GTPase) domains interact directly during signal recognition particle (SRP)–mediated cotranslational targeting of proteins to the membrane. The 2.05 angstrom structure of a complex of the NG GTPase domains of Ffh and FtsY reveals a remarkably symmetric heterodimer sequestering a composite active site that contains two bound nucleotides. The structure explains the coordinate activation of the two GTPases. Conformational changes coupled to formation of their extensive interface may function allosterically to signal formation of the targeting complex to the signal-sequence binding site and the translocon. We propose that the complex represents a molecular “latch” and that its disengagement is regulated by completion of assembly of the GTPase active site.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Guanine Nucleotide-Binding Switch in Three Dimensions
Vetter, I. R., & Wittinghofer, A. (2001) · Science · doi:10.1126/science.1062023 · Cited by 1,875
The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants
Scheffzek, K., Ahmadian, M. R., Kabsch, W., Wiesmüller, L., Lautwein, A., Schmitz, F., & Wittinghofer, A. (1997) · Science · doi:10.1126/science.277.5324.333 · Cited by 1,543
G PROTEIN MECHANISMS: Insights from Structural Analysis
Sprang, S. R. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.639 · Cited by 1,065
Tesmer, J. J. G., Berman, D. M., Gilman, A. G., & Sprang, S. R. (1997) · Cell · doi:10.1016/s0092-8674(00)80204-4 · Cited by 779
The Signal Recognition Particle
Keenan, R. J., Freymann, D. M., Stroud, R. M., & Walter, P. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.755 · Cited by 633
Self-citationBernstein, H. D., Poritz, M. A., Strub, K., Hoben, P. J., Brenner, S., & Walter, P. (1989) · Nature · doi:10.1038/340482a0 · Cited by 470
Perrakis, A., Sixma, T. K., Wilson, K. S., & Lamzin, V. S. (1997) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444997005696 · Cited by 444
Römisch, K., Webb, J., Herz, J., Prehn, S., Frank, R., Vingron, M., & Dobberstein, B. (1989) · Nature · doi:10.1038/340478a0 · Cited by 346
The Escherichia coli SRP and SecB targeting pathways converge at the translocon
Valent, Q. A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.9.2504 · Cited by 291
Substrate twinning activates the signal recognition particle and its receptor
Egea, P. F., Shan, S.-O., Napetschnig, J., Savage, D. F., Walter, P., & Stroud, R. M. (2004) · Nature · doi:10.1038/nature02250 · Cited by 288
Cited by
Substrate twinning activates the signal recognition particle and its receptor
Egea, P. F., Shan, S.-O., Napetschnig, J., Savage, D. F., Walter, P., & Stroud, R. M. (2004) · Nature · doi:10.1038/nature02250 · Cited by 288
Tail-anchored membrane protein insertion into the endoplasmic reticulum
Hegde, R. S., & Keenan, R. J. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3226 · Cited by 262
Kudva, R., Denks, K., Kuhn, P., Vogt, A., Müller, M., & Koch, H.-G. (2013) · Research in Microbiology · doi:10.1016/j.resmic.2013.03.016 · Cited by 177
The Sec translocon mediated protein transport in prokaryotes and eukaryotes.
Denks, K., Vogt, A., Sachelaru, I., Petriman, N.-A., Kudva, R., & Koch, H.-G. (2014) · Molecular Membrane Biology · doi:10.3109/09687688.2014.907455 · Cited by 170
Diversity and evolution of protein translocation.
Pohlschröder, M., Hartmann, E., Hand, N. J., Dilks, K., & Haddad, A. (2005) · Annual Review of Microbiology · doi:10.1146/annurev.micro.59.030804.121353 · Cited by 122
Metadata
- Authors
- Focia, P. J., Shepotinovskaya, I. V., Seidler, J. A., & Freymann, D. M.
- Venue
- Science
- Published
- 2004-01-16
- Volume
- 303
- Issue
- 5656
- Pages
- 373-377
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2041781518
- Cited by
- 255
- References
- 33
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Heterodimeric GTPase Core of the SRP Targeting Complex. https://app.cochat.ai/papers/10.1126/science.1090827
- The paper
- Focia, P. J., Shepotinovskaya, I. V., Seidler, J. A., & Freymann, D. M. (2004). Heterodimeric GTPase Core of the SRP Targeting Complex. Science. https://doi.org/10.1126/science.1090827
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
